Sirolimus self-microemulsion preparation and preparation method thereof
A technology for sirolimus and an emulsion preparation, applied in the field of medicine, can solve the problems of harsh production conditions, low human bioavailability, difficult transportation and storage, etc., and achieves simple and feasible preparation process, improved in vivo bioavailability, and improved bioavailability. The effect of in vitro dissolution
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Embodiment 1
[0024] Embodiment 1: Preparation of sirolimus self-microemulsion soft capsule
[0025]
[0026] Preparation Process:
[0027] Add sirolimus into linoleic acid monoglyceride and stir to dissolve, then add caprylic capric acid macrogol glyceride and diethylene glycol monoethyl ether in turn, stir to mix evenly, and fill in Available in soft capsules.
Embodiment 2
[0028] Embodiment 2: Preparation of sirolimus self-microemulsion soft capsule
[0029]
[0030] Preparation Process:
[0031] Add sirolimus to macrogol glyceride oleate and stir to dissolve, then add ethyl oleate, Tween-80, and propylene glycol in sequence, stir to mix evenly, and fill in soft capsules to obtain .
Embodiment 3
[0032] Embodiment 3: Preparation of sirolimus self-microemulsion soft capsule
[0033]
[0034] Preparation Process:
[0035] Add sirolimus into polyethylene glycol 15-hydroxystearate and stir to dissolve, then add caprylic triglyceride, oleic acid, polyoxyethylene 35 castor oil, polyethylene glycol 400 in sequence, and stir After making it mix evenly, it can be filled into soft capsules.
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