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Trace element-doped porous calcium carbonate ceramic, and preparation method and application thereof

A technology of porous calcium carbonate and trace elements, applied in the field of bone repair medical materials, to achieve the effects of inducing bone formation, promoting vascularization, and meeting strength requirements

Inactive Publication Date: 2014-09-10
GUANGZHOU MEDICAL UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, there has not been any research or report on doping inorganic ions such as Mg, Sr, Zn, Si, Cu, etc. into calcium carbonate ceramic materials.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0028] Step 1: According to Mg / (Mg+Ca) molar ratio is 1:10 and (Mg+Ca) / CO 3 The molar ratio is 1:1 to Mg(NO 3 ) 2 , Ca(NO 3 ) 2· 4H 2 O, and Na 2 CO 3 Dosing; the Mg(NO 3 ) 2 and Ca(NO 3 ) 2 Soluble in water together to form 1# solution, Ca in 1# solution 2+ with M g 2+ The concentration sum is 0.4mol / L; the Na 2 CO 3 Dissolve in water to form 2# solution; under the condition of stirring, slowly add 1# solution to 2# solution to form a precipitate, dry the obtained precipitate at 100°C, grind it into powder, and pass it through a 1000-mesh sieve; the obtained Heat the powder to 300-500°C, keep it warm for 1-3 hours, and cool down naturally to get Mg-doped calcium carbonate powder.

[0029] Step 2: with (NH 4 ) 2 HPO 4 , CaCO 3 , MgCO 3 、Na 2 CO 3 For the raw material, each substance corresponds to the oxide CaO:P 2 o 5 :MgO:Na 2 The molar percentage of O is 42:40:10:8. After weighing the raw materials, mix the raw materials evenly, put them in the furn...

Embodiment 2

[0033] Step 1: According to (Sr+Zn) / (Sr+Zn+Ca) molar ratio is 1:10, the molar ratio of Sr and Zn is 2:1, (Sr+Zn+Ca) / CO 3 The molar ratio is 1:1, to SrCl 2 , ZnCl 2 , CaCl 2 , and K 2 CO 3 Dosing; the SrCl 2 , ZnCl 2 , CaCl 2 Soluble in water together to form 1# solution, Ca in 1# solution 2+ 、Sr 2+ and Zn 2+ The concentration sum is 0.5mol / L; the K 2 CO 3 Dissolve in water to form 2# solution; under the condition of stirring, slowly add 1# solution to 2# solution to form a precipitate: dry the obtained precipitate at 100°C, grind it into powder, and pass it through a 1000-mesh sieve; The powder is heated to 300-500°C, kept warm for 1-3 hours, and after natural cooling, it is calcium carbonate powder doped with Sr and Zn.

[0034] Step 2: with (NH 4 ) 2 HPO 4 , CaCO 3 , SrCO3, K 2 CO 3 For the raw material, each substance corresponds to the oxide CaO:P 2 o 5 :SrO:Na 2 The molar percentage of O is 47:40:5:8. After weighing the raw materials, mix the raw mate...

Embodiment 3

[0038] Step 1: Press SiO 3 / (CO 3 +SiO2 3 ) molar ratio of 1:15 and Ca / (CO 3 +SiO2 3 ) molar ratio is 1:1 to Ca(NO 3 ) 2· 4H 2 O, Na 2 CO 3 and Na 2 SiO 3· 9H 2O for batching; Ca(NO 3 ) 2· 4H 2 O is dissolved in water to form 1# solution; the Na 2 SiO 3· 9H 2 O and Na 2 CO 3 Dissolved in water to form 2# solution, the CO of 2# solution 3 2- on SiO 3 2- The sum of the concentrations is 0.8mol / L; under the condition of stirring, slowly add the 1# solution to the 2# solution to form a precipitate: dry the obtained precipitate at 100°C, grind it into powder, and pass it through a 1000-mesh sieve; The obtained powder is heated to 300-500°C, kept for 1-3 hours, and cooled naturally to obtain Si-doped calcium carbonate powder.

[0039] Step 2: with (NH 4 ) 2 HPO 4 , CaCO 3 、Na 2 SiO 3· 9H 2 O, Na 2 CO 3 For the raw material, each substance corresponds to the oxide CaO:P 2 o 5 : SiO 2 : Na 2 The molar percentage of O is 52:30:10:8. After weighing t...

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Abstract

The invention discloses a trace element-doped porous calcium carbonate ceramic, and a preparation method and application thereof, belonging to the field of medical materials for bone repair. The preparation method disclosed by the invention comprises the following steps: doping Mg, Sr, Zn, Si, Cu and other trace elements in a human body into calcium carbonate through a chemical precipitation method, or doping trace elements into low-temperature phosphate bioglass used as a sintering binder, uniformly mixing the trace element-doped calcium carbonate powder, the glass binder and pore forming agent, then forming, performing isostatic pressing treatment, sintering, and removing the pore forming agent to obtain the trace element-doped porous calcium carbonate ceramic. The trace element-doped porous calcium carbonate ceramic prepared by the invention has high strength and porosity, controllable degradation rate, long-term slow release of the doped trace element ions and favorable bone conductibility and inductivity, and is a novel artificially synthesized bone repair material.

Description

technical field [0001] The invention belongs to the field of bone repair medical materials, in particular to a porous calcium carbonate ceramic doped with trace elements, a preparation method and application thereof. Background technique [0002] The main component of marine biomaterials such as coral and shell nacre is calcium carbonate, which has been widely used in spinal fusion, teeth, maxillofacial and other bone defect repairs (Clarke SA, et al.BiotechnolAdv, 2011, 29:610 -617.). Calcium phosphate ceramics, especially hydroxyapatite, are widely used and researched clinically for bone repair, which have good biocompatibility and osteoconductivity. However, the degradation rate of hydroxyapatite is slow, and it cannot be degraded and replaced by new bone after several years of implantation. Other synthetic bone repair materials, such as calcium sulfate, degrade too quickly to support cell adhesion and bone ingrowth. The degradation rate of calcium carbonate is signifi...

Claims

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Application Information

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IPC IPC(8): C04B38/00C04B35/01C04B35/622A61L27/10A61L27/56
Inventor 陈晓明何福坡阳范文朱继翔彭晔田秀梅
Owner GUANGZHOU MEDICAL UNIV
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