Method for preparing double medicine-carrying composite fibrous membrane through emulsion electrospinning technology
A composite fiber membrane, double drug-loading technology, which can be used in electrospinning, fiber processing, pharmaceutical formulations, etc., can solve unseen problems and achieve the effect of good cell compatibility
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Embodiment 1
[0037] A research method for preparing double drug-loaded composite fiber membranes by emulsion electrospinning comprises the following steps:
[0038] The polylactic acid (PLA) that takes by weighing 0.5g is dissolved in the mixed solution of 10mL acetone and DMF (V Ace =V DMF =5mL), stirred at 300rpm for 15min, and dissolved completely. Add 0.5mL of Span80, continue to stir for 20min, then add 0.005g of hydrophobic drug CPT, continue to stir, this is the O phase.
[0039] Weigh 1g of gelatin and dissolve it in 40mL of distilled water, heat and stir until completely dissolved, filter, add 10mL of emulsifier styrene-maleic anhydride copolymer, stir until it is completely miscible with the gelatin aqueous solution, and then add 0.005g of hydrophilic drug CPT , continue to stir, this is W phase.
[0040] Add the W phase into the O phase drop by drop, continue to stir for 2 hours, and the stirring speed is 900rpm. With the dropwise addition of the W phase, the system will comp...
Embodiment 2
[0066] The difference from Example 1 is that the hydrophobic model drug is replaced by sinomenine, and the other steps are the same.
Embodiment 3
[0068] The difference from Example 1 is that PEG is replaced by polyvinyl alcohol (PVA), the hydrophobic model drug is replaced by sinomenine, and other steps are the same.
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