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Method for preparing double medicine-carrying composite fibrous membrane through emulsion electrospinning technology

A composite fiber membrane, double drug-loading technology, which can be used in electrospinning, fiber processing, pharmaceutical formulations, etc., can solve unseen problems and achieve the effect of good cell compatibility

Active Publication Date: 2018-02-09
TIANJIN POLYTECHNIC UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, there is no research on the fiber with "coexistence of silk beads" as a drug carrier.

Method used

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  • Method for preparing double medicine-carrying composite fibrous membrane through emulsion electrospinning technology
  • Method for preparing double medicine-carrying composite fibrous membrane through emulsion electrospinning technology
  • Method for preparing double medicine-carrying composite fibrous membrane through emulsion electrospinning technology

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0037] A research method for preparing double drug-loaded composite fiber membranes by emulsion electrospinning comprises the following steps:

[0038] The polylactic acid (PLA) that takes by weighing 0.5g is dissolved in the mixed solution of 10mL acetone and DMF (V Ace =V DMF =5mL), stirred at 300rpm for 15min, and dissolved completely. Add 0.5mL of Span80, continue to stir for 20min, then add 0.005g of hydrophobic drug CPT, continue to stir, this is the O phase.

[0039] Weigh 1g of gelatin and dissolve it in 40mL of distilled water, heat and stir until completely dissolved, filter, add 10mL of emulsifier styrene-maleic anhydride copolymer, stir until it is completely miscible with the gelatin aqueous solution, and then add 0.005g of hydrophilic drug CPT , continue to stir, this is W phase.

[0040] Add the W phase into the O phase drop by drop, continue to stir for 2 hours, and the stirring speed is 900rpm. With the dropwise addition of the W phase, the system will comp...

Embodiment 2

[0066] The difference from Example 1 is that the hydrophobic model drug is replaced by sinomenine, and the other steps are the same.

Embodiment 3

[0068] The difference from Example 1 is that PEG is replaced by polyvinyl alcohol (PVA), the hydrophobic model drug is replaced by sinomenine, and other steps are the same.

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Abstract

The invention discloses a method for preparing double medicine-carrying composite fibrous membrane through an emulsion electrospinning technology. The method includes the following steps that 1, a polylactic acid solution is prepared, an emulsifying agent I is added, the mixture is stirred evenly, hydrophobic medicine is added, an oil-phase solution is obtained after stirring, a gelatin solution is prepared, filtering is performed, an emulsifying agent II is added, the mixture is stirred evenly, hydrophilic medicine is added, and a water-phase solution is obtained after stirring; 2, under thecondition that stirring speed is 800 rpm-1000 rpm, the water-phase solution is dropwise added into the oil-phase solution, stirring is continued after dripping is completed, and then O / W emulsion is obtained; 3, PEG or PVA with the molecular weight being 8000 is added, and a spinning solution is obtained after even mixing is performed; 4, by the utilization of the electrostatic spinning method, the spinning solution is prepared into the double medicine-carrying composite fibrous membrane of a yarn and bead coexisting structure. In the method, the oil-in-water type emulsion is prepared througha phase reversal method; by adjusting polyethylene glycol, yarn-bead coexisting fibers can be prepared through emulsion electrospinning, the preparation method is simple, and the medicine-carrying effect is good.

Description

technical field [0001] The invention relates to the fields of textile and medicine, in particular to a method for preparing double drug-loaded composite fiber membranes by using emulsion electrospinning technology. Background technique [0002] Electrospinning is currently one of the most important technologies for preparing polymer fibers. It has attracted much attention in recent years. At present, a wide variety of fibers can be prepared, including organic, inorganic and organic / inorganic composite fibers, and are used in drug-loaded, biological Many fields such as dressings and tissue engineering scaffolds have the characteristics of porous structure and large specific surface area. [0003] Emulsion electrospinning replaces the traditional spinning solution with an oil-in-water emulsion or a water-in-oil emulsion, and can prepare bicomponent micro-nano fibers with a certain composite structure. Polylactic acid (PLA) is a synthetic aliphatic polyester polymer material w...

Claims

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Application Information

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IPC IPC(8): D04H3/005D04H3/011D01D5/00A61K9/70A61K47/34A61K47/42
CPCA61K9/70A61K47/34A61K47/42D01D5/003D04H3/005D04H3/011
Inventor 张雯高燕张华李祥鹏岳盼李婵
Owner TIANJIN POLYTECHNIC UNIV
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