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A kind of cefminox sodium crystalline compound and its composition powder injection

A technology of cefminox sodium and compound, applied in the field of medicine, can solve the problems of high price and the like, and achieve the effects of improving bioavailability, improving drug safety, and good dissolution stability

Active Publication Date: 2011-12-14
SHANDONG LUOXIN PARMACEUTICAL GROUP STOCK CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] At present, the domestic cephalosporin market is mainly imported except for the first-generation cephalosporins, and the price is expensive.

Method used

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  • A kind of cefminox sodium crystalline compound and its composition powder injection
  • A kind of cefminox sodium crystalline compound and its composition powder injection
  • A kind of cefminox sodium crystalline compound and its composition powder injection

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0047] The preparation of cefminox sodium crystalline compound: get cefminox sodium crude product 1kg, add volume and be that the volume ratio of 8 times of cefminox sodium crude product weight is the water of 6.4: 3.6: methanol mixed solution, be heated to reflux; Cefminox sodium After the crude product dissolves clear, add volume and be the acetone of 2.2 times of cefminox sodium crude product weight, stop heating, under stirring, drip the acetone that volume is 1.2 times of cefminox sodium crude product weight: ethanol solution, described stirring is 27rmp, described Dropping is to control the dropping time for 7 minutes and drop at a constant speed; after dropping, stir and cool down. The stirring and cooling is to cool down to 52°C for 10 minutes while stirring at a rotating speed of 22rmp, and then cool down to 23°C for 20min while stirring at a rotating speed of 7rmp, and let it stand for 19 hours. Filter, wash twice with 8:2 methanol:ethanol solution, 0.5 times each tim...

Embodiment 2

[0050] The preparation of cefminox sodium crystalline compound: get cefminox sodium crude product 2kg, add volume and be that the volume ratio of 8 times of cefminox sodium crude product weight is the water of 6.4: 3.6: methanol mixed solution, be heated to reflux; Cefminox sodium After the crude product dissolves clear, add volume and be the acetone of 2.2 times of cefminox sodium crude product weight, stop heating, add dropwise volume under stirring and be the acetone of 1.2 times of cefminox sodium crude product weight: ethanol solution, described stirring is 25rmp, described Dropping is to control the dropping time for 7 minutes and drop at a constant speed; after dropping, stir and cool down. The stirring and cooling is to cool down to 51°C for 10 minutes under stirring at a rotating speed of 20rmp, and then cool down to 23°C for 20min under stirring at a rotating speed of 7rmp, and stand for 19 hours. Filter, wash twice with 8:2 methanol:ethanol solution, 0.5 times each t...

Embodiment 3

[0053] The preparation of cefminox sodium crystalline compound: get cefminox sodium crude product 10kg, add volume and be that the volume ratio of 8 times of cefminox sodium crude product weight is the water of 6.4: 3.6: methanol mixed solution, be heated to reflux; Cefminox sodium After the crude product dissolves clear, add volume and be the acetone of 2.0 times of cefminox sodium crude product weight, stop heating, add dropwise volume under stirring and be the acetone of 1.0 times of cefminox sodium crude product weight: ethanol solution, described stirring is 24rmp, described Dropping is to control the dropping time for 6 minutes and drop at a constant speed; after dropping, stir and cool down. The stirring and cooling is to cool down to 53°C for 10 minutes under stirring at a rotating speed of 22rmp, and then cool down to 24°C for 20min under stirring at a rotating speed of 8rmp, and stand for 20 hours. Filter, wash twice with 8:2 methanol:ethanol solution, 0.4 times each ...

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Abstract

The invention relates to a cefminox sodium crystalline compound. The cefminox sodium crystalline compound is determined by a powder X-ray diffraction determination method; and characteristic diffraction peaks are displayed at 5.1, 6.9, 8.5, 10.3, 12.1, 15.1, 15.9, 17.4, 19.5, 21.7 and 24.6 degrees in an X-ray powder diffraction pattern represented by a diffraction angle of 2 theta+ / -0.2 degree. The invention also relates to cefminox sodium composition powder injection containing the cefminox sodium crystalline compound. The composition powder injection comprises the following components: 95 to 100 parts of cefminox sodium crystalline compound and 0.1 to 1 part of sodium benzoate.

Description

technical field [0001] The invention relates to the field of medicine, in particular to a cefminox sodium crystalline compound and its composition powder injection. Background technique [0002] Cefminox sodium is a derivative of cefamycin, which is made into heptahydrate sodium salt by semi-synthetic method, and has a dual bactericidal mechanism. It has good antibacterial effect on Gram-negative and positive bacteria. It is especially stable against lactamase produced by various bacteria such as Escherichia coli, Klebsiella, Haemophilus influenzae, Proteus, and Bacteroides fragilis. Susceptible to streptococci (except enterococci). This product can hinder the production of lipoprotein from peptidoglycan in the bacterial cell wall, and the lipoprotein structure is unique to Gram-negative bacteria, so the effect on Gram-negative bacteria is stronger than other similar drugs. [0003] Its mechanism of action is: it has a strong affinity with penicillin-binding protein, inhi...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07D501/36C07D501/12A61K31/546A61K9/14A61P31/04
Inventor 李明杰刘明霞武玉梅
Owner SHANDONG LUOXIN PARMACEUTICAL GROUP STOCK CO LTD
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