Individual drug dosage adjustment method and device
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A drug and dosage technology, applied in the field of pharmacology, can solve problems such as adjustment, specific dosage of drugs, unpredictable usage and prediction, etc.
Inactive Publication Date: 2016-08-10
BEIJING DRYAS PHARMA TECH CO LTD
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[0008] In the process of realizing the present invention, the inventors found that: adjusting by drug concentration detection is a kind of after-the-fact adjustment. During the adjustment, there is a great possibility that adverse reactions have occurred or the treatment is ineffective. Drugs) bring great risks; and through the adjustment of indicators such as genes, it is impossible to quantitatively adjust the dosage and regimen of drugs
For example, if the patient's gene test result is wild type, the method of adjusting according to the gene and other indicators, the corresponding drug regimen is plan A, but the specific dosage and usage of the drug in plan A cannot be known, so it is impossible to properly Adjust the patient's medication regimen
[0009] In the related art, there is no scheme that accurately predicts the drug concentration in each patient's body based on the individual information of each patient, and then adjusts the medication regimen in advance
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Embodiment 1
[0058] see figure 1 As shown, it is a flow chart of a method for individualized dose adjustment of medicine provided by the embodiment of the present invention, which specifically includes the following steps:
[0059] Step 101. Obtain the patient's individualized information on the prescribed medicine.
[0060] Wherein, the individualized information includes: the basic information required by the patient for the specified drug, the patient's historical medication information for the specified drug, and the drug concentration information in the body corresponding to the historical medication information.
[0061] It should be noted that the basic information required by the patient for the specified drug means that different drugs will be affected by different basic information, for example, some drugs need to be prescribed according to the weight and age of the user, therefore, After the prescribed drug is determined, obtain basic information on patients who may be affected...
Embodiment 2
[0101] see image 3 , a drug individualized dose adjustment device provided in an embodiment of the present invention, comprising:
[0102] An acquisition module 31, configured to acquire the individualized information of the patient for the specified medicine;
[0103] A determination module 32, configured to determine the individual characteristic value of the patient's pharmacokinetic parameters for the specified drug according to the individualized information and the population pharmacokinetic model of the specified drug;
[0104] Prediction module 33, for determining the drug concentration level in the body of the patient for the specified drug according to the individual characteristic value of the patient's pharmacokinetic parameters for the specified drug and the preset medication regimen for the drug prediction equation over time;
[0105] An adjustment module 34, configured to adjust the patient's individualized dose of the specified drug based on the prediction e...
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Abstract
The invention provides an individual drug dosage adjustment method and device. The method comprises steps as follows: the individual feature value of a pharmacokinetic parameter of a designated drug for a patient is determined according to individual information and a group pharmacokinetic model of the designated drug; a time-variable prediction equation of the drug concentration level of the designated drug for the patient is determined according to the individual feature value of the pharmacokinetic parameter of the designated drug for the patient as well as a preset medication plan of the drug; individual dosage adjustment of the designated drug is performed on the patient on the basis of the prediction equation. The concentration of the drug in every patient corresponding to a preset medication plan is accurately predicted according to the individual information of the patient, accordingly, the preset medication plan is adjusted according to a prediction result, and risks caused by adjustment afterwards are avoided.
Description
technical field [0001] The embodiments of the present application relate to the field of pharmacology, in particular to a method and device for adjusting individualized doses of medicines. Background technique [0002] At present, the development of science and technology has promoted the development of pharmacology. [0003] In related technologies, methods for individualized dose adjustment of clinical drugs include: [0004] (1) Adjust through drug concentration detection; [0005] During the treatment of patients, the drug concentration level in the body is monitored, and the dosage and regimen are adjusted according to the concentration change. [0006] (2) Adjust through indicators such as genes; [0007] Before the treatment, the patient's gene etc. are tested, and the patient is classified according to the test result of the gene etc., and the treatment plan of the patient's classification is implemented for the patient. [0008] In the process of realizing the p...
Claims
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Application Information
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