67 results about "Cefoxitin Sodium" patented technology

The invention provides a method for preparing cefoxitin sodium, which comprises the following steps: 1, using deacetyl7-ACA as a raw material, and introducing thiopheneacetyls to obtain an deacetylthiophene acid I; 2, introducing carbamoymethoxyls to the positions 3 of molecules of deacetylthiophene acid I to obtain an intermediate of (6R, 7S)-3-carbamoymethoxyl-7-[2-(2-theiophene) acetamino]-8-oxo-5-thia-1-azabicyclo[4.2.0]octa-2-en-2-methanoic acid II; 3, reacting the intermediate II with lithium methoxide to introduce methoxyls into positions 7 of the molecules of the intermediate to obtain cefoxitin acid III; and 4, adding ethanol solution of a sodium salt into an organic solvent containing the cefoxitin acid and obtaining the cefoxitin sodium IV through suction filtration and drying.

The invention discloses a preparation method of cefoxitin sodium. The preparation method comprises the following steps: (1) bromizing, for example, the site 7 of a main nucleus of cefalotin by using an NBS (N-bromosuccinimide) reagent to form a bromination compound; performing nucleophilic substitution at the site 5 by using a methoxyl group to generate an intermediate IV; (2) performing acyl group hydrolysis on the site 3 of the intermediate IV to obtain an intermediate V; (3) substituting hydrogen atoms on the hydroxyl group by using chloriosulfonyl isocyanate, and then hydrolyzing to obtain the cefoxitin sodium. The method has the advantages of simple process, high product yield, high purity and high reaction selectivity; no special equipment is used in the production; the preparation method is suitable for industrial production.

The invention relates to a cefoxitin sodium crystal compound. The method of powder X-ray diffractometry is utilized to determine the cefoxitin sodium crystal compound, and an X-ray powder diffraction pattern represented by the diffraction angle of 2theta+-0.2 degrees has characteristic diffraction peaks at 5.3 degrees, 8.6 degrees, 11.9 degrees, 13.2 degrees, 15.5 degrees, 16.1 degrees, 19.0 degrees, 22.3 degrees and 24.4 degrees. The invention also relates to a cefoxitin sodium composition powder injection containing the cefoxitin sodium crystal compound, and the cefoxitin sodium composition powder injection comprises 95 to 100 parts of the cefoxitin sodium crystal compound and 0.1 to 1 part of sodium benzoate.

The invention relates to a method for preparing cefoxitin acid serving as the key raw material of cefoxitin sodium, and belongs to the field of chemical Chinese herbal medicines. In the method, 7-a-methoxyl cefalotin is subjected to deacetylation and carbamylation directly and simultaneously by isocyanide ester, and the processes of independent 3-position deacetylation and carbamylation are savedso as to obtain the cefoxitin acid directly. The cefoxitin sodium is obtained by the known method. A production process is simplified, the yield is high and the cost is low. In addition, the production link is reduced obviously and the cost is saved.

The invention relates to a method for preparing cefoxitin sodium for injection, comprising the steps of bottle washing, rubber plug treating, aluminium cap treating, cefoxitin sodium separate loading and capping to obtain cefoxitin sodium for the injection. The preparation method disclosed by the invention has the advantages that through the reasonable design of the process and the control of a plurality of parameters in the process, the pH value range of prepared cefoxitin sodium for the injection can be controlled between 6.7-7.0; the clarity, the visible foreign matter and the sterile determination of prepard cefoxitin sodium for the injection all meet the requirements; the impurity content, the endotoxin content and the quantity of insoluble particles are remarkably lower than the requirements established by the conventional standard; and the product quality is further increased and the injection safety of cefoxitin sodium for the injection is enhanced.

The invention provides a preparation method of high-purity cefoxitin sodium (I), belonging to the field of chemical pharmaceutical technology. The method comprises the following steps: taking cefoxitin acid as a raw material, adsorbing and purifying the cefoxitin acid with a resin column, and allowing the purified cefoxitin acid to react with sodium salt at the temperature of -20-20 DEG C to obtain the high-purity cefoxitin sodium.

The invention provides a novel synthesis method of cefoxitin acid. Cefoxitin acid is used as a raw material for synthesizing cefoxitin sodium and belongs to second-generation cephalosporin. The cefoxitin acid has balanced antibacterial spectra and has a strong antibacterial effect on gram-negative bacteria. Due to the existence of 7alpha methoxy in the cefoxitin acid, the hydrolysis action of the cefoxitin acid on beta-lactamase can be reduced greatly, so that the beta-lactamase can exist stably in the cefoxitin acid. In the invention, 3-deacetylase cefoxitin acid which is an intermediate is produced by adopting an enzyme process through two-step continuous reaction, materials react in a mild reaction condition, and the process is simple and is convenient to operate. By adopting the novel synthesis method, time and labor can be saved, and the yield and quality of the product can be improved. Because the two-step reaction is carried out in a water phase at room temperature, the consumption of energy and the discharge of organic wastewater can be reduced greatly. The novel synthesis method meets the requirements of large-scale industrial production.

The invention discloses a preparation method for Cefoxintin sodium. The preparation method particularly comprises the steps of preparing acidic solution, decoloring, filtering and washing, performing crystallization for the first time, cultivating a crystal, performing crystallization again, performing suction filtration and washing, and drying. The preparation method for the Cefoxintin sodium is simple and practicable. The prepared finished product has few solvent residues, high content and high color grade.

The invention relates to the field of medicines, and particularly relates to a cefoxitin sodium crystal compound and a preparation method thereof. The structural formula of the cefoxitin sodium crystal compound is shown as formula (I). The cefoxitin sodium crystal compound has high purity, is not easy to absorb water, has good stability, and is safe and reliable for clinical application.

The invention discloses a Clostridium difficile chromogenic medium and an application thereof. The chromogenic medium consists of 1-20g/L of tryptone, 1-20g/L of digested animal tissue, and 0.1-5.5g/L of glucose. L, yeast extract 0.2‑5.5g/L, sodium chloride 0.5‑15g/L, sodium sulfite 0.05‑1g/L, escin 0.1‑20g/L, iron 0.1‑5g/L, amino acid 0.2‑25g/L , agar powder 5-20g/L, cycloserine 0.1-2.5g/L and cefoxitin sodium 0.01-0.15g/L, the solvent is deionized water, pH value 7.0~7.6; the medium culture period of the present invention is 24 hours, Colonies are specifically black, and C. difficile isolates can be accurately obtained from clinical stool samples by color when using this medium.

The invention discloses a cefoxitin sodium powder preparation for injection. The cefoxitin sodium powder preparation is prepared by the following steps: (1) controlling the temperature, and preparing a sodium-forming agent solution; (2) adding acetone and methyl alcohol to a reaction tank, cooling, stirring under nitrogen protection, adding cefoxitin acid until dissolving, adding activated carbon, decolorizing, filtering, mixing a solvent and washing; (3) controlling the temperature of a crystallization tank, the stirring speed and the nitrogen pressure by molecular assembly and shape optimization techniques for crystal products in a grain process by Hebei Huamin Pharmaceutical Co.,Ltd. in North China, dropwise adding the sodium-forming agent solution, and adding acetone according to a feeding rate form; (4) filtering and drying crystalline liquid, detecting and discharging; and (5) carrying out sub-package of preparations with different specifications, and controlling the environment temperature and humidity to obtain cefoxitin sodium for injection. The cefoxitin sodium for injection, prepared by the preparation method, has good hydrodynamics performance, and is perfect in crystalline form and uniform in particle size distribution; and the color grade, the clarity, the purity and the stability are greatly improved.

The invention provides a production process of cefoxitin sodium for injection with simple production process, stable and reliable quality, and a method for determining related substances in cefoxitin sodium by high performance liquid chromatography. The method adopts a chromatographic column with phenylsilane-bonded silica gel as the filler, the mobile phase A is water (adjusted to pH 2.7 with formic acid), and the mobile phase B is acetonitrile; linear gradient elution, high performance liquid chromatography for the determination of cefoxitin related substances in sodium. The specificity of this law is good, and the relevant substances are basically completely detected.

According to the present invention, on the process basis of the conventional cefoxitin sodium preparation method using a methanol and acetone mixing solvent or similar mixing solvent to carry out reaction crystallization, C1-C4 alkanol or tetrahydrofuran is adopted as a precipitating agent, and solvent crystallization is performed to prepare cefoxitin sodium; the obtained cefoxitin sodium has characteristics of good crystal form uniformity, good fluidity, stable quality, easy filtration, and easy drying; and the method is suitable for industrial production.

The invention discloses a cefoxitin sodium drug combination, which consists of the following effective ingredients in part by weight: 1000 to 2000 parts of cefoxitin sodium, 100 to 200 parts of lidocaine, 50 to 120 parts of reduced glutathione and 80 to 120 parts of diammonium glycyrrhizinate. The drug combination cannot cause adverse reactions, and has a high curative effect, and moreover, the preparation method is simple and environment-friendly.

The invention relates to a cefoxitin acid composition which is characterized by comprising the combination of cefoxitin acid and arginine. The preparation method of the composition mainly comprises the following steps: weighing the aseptic raw material medicines of the cefoxitin acid and the arginine according to the proportion of a recipe in an aseptic environment, mixing evenly and then subpackaging. The composition solves the problem that the active component of the cefoxitin acid is not dissolved in water, also solves the problem that the original medicine of cefoxitin sodium is unstable,can effectively lower the impurity content and obviously enhance the stability of a product, thereby reducing the generation rate of side reactions, such as anaphylactic reactions, effectively; a safety testing result shows that compared with the original pharmaceutical preparation, the preparation has smaller local irritability and very important clinical application value.

The invention discloses a cefoxitin sodium new chemical compound entity and a composition thereof, the cefoxitin sodium new chemical compound storage has better stability less hygroscopicity, and is suitable for preparation of drugs for the treatment or prevention of human or animal respiratory tract infection, endocarditis, peritonitis, pyelonephritis, urinary tract infection, blood poisoning and bone, joint, skin and soft tissue infection and the like caused by gram positive or negative bacteria sensitive bacteria.

The invention provides a synthesis method of cefoxitin sodium. The synthesis method is characterized in that cefalotin acid is taken as the raw material to sequentially synthesize 7-a-methoxyl cefalotin cyclohexane salt, 7-a-methoxyl-3-deacetyl cefalotin benzathine salt, and cefoxitin acid to obtain the target product; cefalotin acid reacts with tert.-butyl hypochloric acid to obtain 7-a-methoxylcefalotin cyclohexane salt, and after reactions, the reaction product is purified by a post treatment. The provided synthesis method can largely reduce the happening rate of side reactions, hydrolysis, and degradation, reduces the impurities, improves the product quality, and increases the yield. Moreover, the product quality is stable, the operation is simple, and the synthesis method is suitablefor industrial production.

The invention belongs to the technical field of pharmaceutical analysis, and particularly relates to a method for detecting polymers in cefoxitin sodium for injection. The method comprises three steps of detection condition, solution preparation, system applicability requirement and limit. According to the present invention, the high performance liquid chromatography is adopted, such that the operation is simple, the sensitivity is high, the specificity is good, the content of the single polymer and the total polymer in the product can be accurately controlled, the product quality can be effectively controlled, and the clinical use safety can be ensured.

The invention belongs to the technical field of medicine and particularly relates to a cefoxitin sodium crystalline compound shown as formula (I) in the description. An X-ray powder diffraction pattern of the compound under measurement with Cu-Kalpha rays is shown as figure 1. The cefoxitin sodium crystalline compound has better stability and can be stored at room temperature, and storage cost andtransport cost of the drug are reduced effectively.