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Cefoxitin sodium drug combination

A technology of cefoxitin sodium and medicine, which is applied in the field of cefoxitin sodium combination medicine and its preparation, to achieve the effects of high medicine quality, pain relief and adverse reactions, and stable quality

Inactive Publication Date: 2010-09-08
邓学峰
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] In order to overcome the defects of the above-mentioned adverse reactions existing in the application of cefoxitin or cefoxitin sodium in the course of drug application, and to improve the curative effect of the drug, the invention provides a combination drug for cefoxitin sodium and a preparation method thereof

Method used

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Effect test

Embodiment 1

[0029] The cefoxitin sodium combination medicine provided by the present embodiment comprises the effective medicinal ingredients of the following parts by weight:

[0030] Cefoxitin Sodium 1000;

[0031] Lidocaine 100;

[0032] Reduced Glutathione 50;

[0033] Diammonium Glycyrrhizinate 80.

[0034] The above-mentioned cefoxitin sodium can be replaced by cefoxitin.

[0035] The preparation method of the above-mentioned combination medicine comprises the following steps:

[0036] (1). Get the water for injection of 50~200 times of the weight of the cefoxitin sodium, under stirring, put the cefoxitin sodium, lidocaine, reduced glutathione and diammonium glycyrrhizinate respectively Dissolve completely to obtain a solution of the drug.

[0037] The antioxidant reduced glutathione protects the oxidation and peroxidation of cefoxitin sodium in the manufacture, storage, transportation, use, and body, so that the adverse reactions are greatly reduced, and the reduced glutathion...

Embodiment 2

[0055] The cefoxitin sodium combination medicine provided by the present embodiment comprises the effective medicinal ingredients of the following parts by weight:

[0056] Cefoxitin Sodium 2000;

[0057] Lidocaine 100;

[0058] Reduced Glutathione 120;

[0059] Diammonium Glycyrrhizinate 200.

[0060] The above-mentioned cefoxitin sodium can be replaced by cefoxitin.

[0061] The preparation method of the above-mentioned combination medicine comprises the following steps:

[0062] (1). Get the water for injection of 50~200 times of the weight of the cefoxitin sodium, under stirring, put the cefoxitin sodium, lidocaine, reduced glutathione and diammonium glycyrrhizinate respectively Dissolve completely to obtain a solution of the drug.

[0063] The antioxidant reduced glutathione protects the oxidation and peroxidation of cefoxitin sodium in the manufacture, storage, transportation, use, and body, so that the adverse reactions are greatly reduced, and the reduced glutathion...

Embodiment 3

[0081] The cefoxitin sodium combination medicine provided by the present embodiment comprises the effective medicinal ingredients of the following parts by weight:

[0082] Cefoxitin Sodium 1550;

[0083] Lidocaine 135;

[0084] Reduced Glutathione 90;

[0085] Diammonium Glycyrrhizinate 173.

[0086] The above-mentioned cefoxitin sodium can be replaced by cefoxitin.

[0087] The preparation method of the above-mentioned combination medicine comprises the following steps:

[0088] (1). Take water for injection 50-200 times of the weight of the cefoxitin sodium, under stirring, respectively add the cefoxitin sodium or its pharmaceutically acceptable salt, lidocaine, reduced glutamate Glutathione and diammonium glycyrrhizinate were completely dissolved to obtain a drug solution.

[0089] The antioxidant reduced glutathione protects the oxidation and peroxidation of cefoxitin sodium in the manufacture, storage, transportation, use, and body, so that the adverse reactions are...

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Abstract

The invention discloses a cefoxitin sodium drug combination, which consists of the following effective ingredients in part by weight: 1000 to 2000 parts of cefoxitin sodium, 100 to 200 parts of lidocaine, 50 to 120 parts of reduced glutathione and 80 to 120 parts of diammonium glycyrrhizinate. The drug combination cannot cause adverse reactions, and has a high curative effect, and moreover, the preparation method is simple and environment-friendly.

Description

technical field [0001] The invention relates to a cefoxitin sodium combination medicine and a preparation method thereof. Background technique [0002] Cefoxitin and cefoxitin sodium are currently clinically used antibacterial drugs. Cefoxitin is traditionally called a second-generation cephalosporin. English name Cefoxitin. It has a broad antibacterial spectrum, strong antibacterial effect, no absorption when taken orally, and good absorption when administered intravenously and intramuscularly. [0003] However, the existing cefoxitin sodium injection is not stable when stored at room temperature, and the following adverse reactions may occur during administration: drug allergy, adverse effects on the gastrointestinal tract, liver, kidney, blood, nervous system, etc. Drug thermal reaction, intravenous infusion pain and phlebitis. Contents of the invention [0004] In order to overcome the disadvantages of the above-mentioned adverse reactions existing in the applicati...

Claims

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Application Information

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IPC IPC(8): A61K31/546A61K47/42A61K47/18A61K47/28A61P31/04
Inventor 蔡海德邓学峰
Owner 邓学峰
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