Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Preparation method of high-purity cefoxitin sodium

A technology of cefoxitin sodium and cefoxitin acid, which is applied in the direction of organic chemistry to achieve the effect of simple operation and improved product quality

Active Publication Date: 2011-01-12
ZHEJIANG WHITESON PHARMA
View PDF3 Cites 9 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The first step: resin adsorption purification

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Preparation method of high-purity cefoxitin sodium
  • Preparation method of high-purity cefoxitin sodium
  • Preparation method of high-purity cefoxitin sodium

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

Embodiment 2

Embodiment 3

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The invention provides a preparation method of high-purity cefoxitin sodium (I), belonging to the field of chemical pharmaceutical technology. The method comprises the following steps: taking cefoxitin acid as a raw material, adsorbing and purifying the cefoxitin acid with a resin column, and allowing the purified cefoxitin acid to react with sodium salt at the temperature of -20-20 DEG C to obtain the high-purity cefoxitin sodium.

Description

technical field The invention relates to a preparation method of a high-purity compound, in particular to a preparation method of cephalosporin compound cefoxitin sodium. It belongs to the technical field of chemical pharmacy. Background technique Cefoxitin sodium (Cefoxitin sodium), chemical name: (6R, 7S)-3-carbamoyloxymethyl-7-methoxy-8-oxo-7-[2-(2-thiazolyl) Acetamido]-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid sodium salt. Its chemical structural formula is as follows: It is a second-generation cephalosporin antibiotic developed by Merck Company of the United States. It has a balanced antibacterial spectrum and is stable to β-lactamase. At present, due to the increasing bacterial resistance to cephalosporins, cefoxitin, which is different from the first-generation and third-generation cephalosporins, has once again attracted people's attention. Contents of the invention The invention adopts a new production process, uses cefoxitin acid as a raw mate...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
IPC IPC(8): C07D501/57C07D501/04
Inventor 芦红代王超魏曾光
Owner ZHEJIANG WHITESON PHARMA
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com