Preparation method of high-purity cefoxitin sodium
A technology of cefoxitin sodium and cefoxitin acid, which is applied in the direction of organic chemistry to achieve the effect of simple operation and improved product quality
Active Publication Date: 2011-01-12
ZHEJIANG WHITESON PHARMA
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The invention provides a preparation method of high-purity cefoxitin sodium (I), belonging to the field of chemical pharmaceutical technology. The method comprises the following steps: taking cefoxitin acid as a raw material, adsorbing and purifying the cefoxitin acid with a resin column, and allowing the purified cefoxitin acid to react with sodium salt at the temperature of -20-20 DEG C to obtain the high-purity cefoxitin sodium.
Description
technical field The invention relates to a preparation method of a high-purity compound, in particular to a preparation method of cephalosporin compound cefoxitin sodium. It belongs to the technical field of chemical pharmacy. Background technique Cefoxitin sodium (Cefoxitin sodium), chemical name: (6R, 7S)-3-carbamoyloxymethyl-7-methoxy-8-oxo-7-[2-(2-thiazolyl) Acetamido]-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid sodium salt. Its chemical structural formula is as follows: It is a second-generation cephalosporin antibiotic developed by Merck Company of the United States. It has a balanced antibacterial spectrum and is stable to β-lactamase. At present, due to the increasing bacterial resistance to cephalosporins, cefoxitin, which is different from the first-generation and third-generation cephalosporins, has once again attracted people's attention. Contents of the invention The invention adopts a new production process, uses cefoxitin acid as a raw mate...
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Inventor 芦红代王超魏曾光
Owner ZHEJIANG WHITESON PHARMA
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