1/4 water cefoxitin sodium compound

A technology of cefoxitin sodium and its compound, which is applied in the field of 1/4 water cefoxitin sodium compound and its preparation, and can solve the problems of backward preparation method, instability between batches, poor stability, etc.
CN109096310AInactive Publication Date: 2018-12-28梁怡
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
梁怡
Publication Date
2018-12-28
Estimated Expiration
Not applicable · inactive patent

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Abstract

The invention discloses a 1 / 4 water cefoxitin sodium compound and a preparation method thereof. Each mole of the cefoxitin sodium contains 1 / 4 mole of water. The preparation method is simple, reactants are easy to obtain, reaction conditions are mild, and the yield is high. The 1 / 4 water cefoxitin sodium compound has good particle size distribution, good fluidity, low impurity content, thermodynamic stability and wide application prospects.
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Description

technical field

[0001] The invention belongs to the technical field of chemical engineering medicine crystallization, and relates to a 1 / 4 hydrocefoxitin sodium compound and a preparation method thereof. Background technique

[0002] Cefoxitin Sodium (Cefoxitin Sodium) is developed by American Merck Company, CAS No. 33564-30-6, molecular formula C 16 h 16 N 3 NaO 7 S 2 , the molecular weight is 449.43, and the chemical name is (6R,7S)-3-(carbamoyloxymethyl)-7-methoxy-8-oxo-7-[2-(2-thienyl)acetamido] -5-Thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid sodium salt, its structural formula is as follows:

[0003]

[0004] Cefoxitin sodium is a new type of antibiotic produced by semi-synthesis of methoxycephalosporin C produced by Streptomyces. It kills bacteria by inhibiting the synthesis of bacterial cell walls. Cefoxitin sodium, as a second-generation cephalosporin antibiotic, has a broader antibacterial spectrum than the first-generation cephalosporins. The drug ...

Claims

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