Potassium chloride slow release capsule

Abstract

The invention discloses a potassium chloride slow release capsule. A content of the potassium chloride slow release capsule is a slow release micro-pill; and the slow release micro-pill consists of 70-97 percent by weight of the potassium chloride used as a raw material, 0-10 percent by weight of forming materials, 2-20 percent of slow release materials, 0.5-5 percent of plasticizers and 0-10 percent of antisticking agents. The potassium chloride and the forming materials are uniformly mixed; a medicine carrier micro-pill is prepared into a dry type granulator; the slow release materials, the plasticizers and the antisticking agents are mixed to prepare slow release layer coating solution; the medicine carrier micro-pill is put into a fluidized bed; the prepared slow release layer coating solution is ejected into the fluidized bed; the medicine carrier micro-pill is coated according to the conventional method so as to prepare the slow release micro-pill; and the slow release micro-pill is filled into the capsule so as to obtain the potassium chloride slow release capsule. The prepared potassium chloride slow release capsule is low in toxin side effects, convenient to treat patients for a long time, improves the medicine safety and improves the compliance of the medicines.

Description

technical field [0001] The invention relates to pharmaceutical preparation technology in the pharmaceutical field, in particular to a potassium chloride sustained-release capsule. Background technique [0002] Potassium chloride is the most commonly used salt to compensate for potassium deficiency. It has a chemical formula of KCl and a molecular weight of 74.55. It is a colorless elongated rhomboid, cubic crystal or small white crystalline powder. It looks like table salt, odorless, and tastes salty. Soluble in water, insoluble in ethanol or ether, magnesium chloride, sodium chloride can reduce its solubility in water. [0003] Potassium chloride is a commonly used electrolyte balance regulating drug in clinical practice. It has definite clinical curative effect and is widely used in various clinical departments. It is used to treat and prevent hypokalemia caused by various reasons (lack of food, vomiting, severe diarrhea, application of potassium-sparing diuretics or long...

AI Technical Summary

Problems solved by technology

Sustained-release tablets of potassium chloride have been on the market in China, but they are often found to cause symptoms such as gastrointestinal ulcers, bleeding and perforation due to the local large concentration of cationic potassium in the gastrointestinal system, and because the sustained-release tablets belong to a single Unit system, when gastrointestinal obstruction, esophageal stricture, diverticulum, and lack of intestinal tone further increase the stimulation of the gastrointestinal tract, which can aggravate the condition

[0006] When potassium chloride crystals are used to directly coat the sustained-release pellets in a fluidized bed, the particle size of the potassium chloride crystals will have an impact on the preparation process. If it is too small, it will be difficult to complete the coating process, and the particles will stick together to form granules, the weight gain of the coating is too large, the production process is difficult to control, and the difference between batches is large, and the yield is low

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