53results about How to "Mild implementation conditions" patented technology

The invention discloses a double controlled release film agent of implanted antineoplastic agent mitomycin and a manufacturing method; the invention relates to a medicinal controlled release film agent. The invention provides a double controlled release film agent of implanted antineoplastic agent mitomycin, which relates to a medicinal controlled release film agent with high enveloping ratio, long continuous release duration, small incidence of burst release, few toxic and side effects, high medicine concentration on tumor lesions and low recrudescence probability of tumor, and a manufacturing method. The film agent includes mitomycin, polymer, lecithin, chitosan and collagen. The mitomycin and the lecithin are dissolved, lyophilized in order to obtain a colloidal mixture; the polymer is dissolved in organic solvent in order to obtain a polymer solution; the polymer solution is then added in the colloidal mixture in order to obtain a reverse micelle; the reverse micelle is further added to a polyvinyl alcohol solution, and an O/W latex is obtained by emulsification; the latex is lyophilized in order to obtain carrier micro-spheres; the collagen is dissolved in the acid solution in order to obtain a collagen solution; the chitosan is dissolved in the acid solution in order to obtain a chitosan solution; the collagen solution and the chitosan solution are mixed in order to obtain a collagen-chitosan mixture solution; finally the carrier micro-spheres are dispersed in the collagen-chitosan mixture solution which is then poured in a mould and dried.

The invention relates to a polyimide film with an electromagnetic shielding function and a preparation method thereof. The polyimide composite film is characterized by being composed of the following components in percentage by weight: 17 to 95% of polyimide, 4 to 80% of nano filler (tetrapod-like zinc oxide), 0 to 75% of other nano filler, and 0.01 to 3% of coupling agent. The target product is obtained through an in-situ polymerization method and thermal imidization. The reaction raw materials comprise diamine, dianhydride, nano filler dispersed in polymer, and a coupling agent for improving the dispersibility. The reaction process is controller, the doping amount of nano filler is high, the components in the composite material are evenly mixed, the structure and property of the film are stable, moreover, the film has an electromagnetic shielding function, and thus the film has a high application value in the fields of electronic/electromagnetic shielding and electrochemistry.

The invention discloses a preparation method of a hydroxy apatite / polylactic acid / chitosan composite microballoon. The hydroxy apatite / polylactic acid / chitosan composite microballoon is prepared by using hydroxy apatite HA, polylactic acid PLA and chitosan CS as raw materials and employing manufacturing principles of a solution blending method and an emulsion method. The method comprises steps of: dropping a prepared apatite / polylactic acid / chitosan acetate acid gracial solution into a stirred liquid paraffin / petroleum ether mixed liquor ; carrying out stewing; removing the liquid paraffin / petroleum ether mixed liquor; washing; carrying out stewing; and refrigerating drying to obtain the composite microballoon product. The hydroxy apatite / polylactic acid / chitosan composite microballoon of the invention compounds three materials with different performances to solve problems of strength, toughness and biocompatibility of the material; and the hydroxy apatite / polylactic acid / chitosan composite microballoon is mainly used in bone tissue restoration material, cell engineering and transmission of medicament and bioactive molecule.

The invention discloses an injectable myocardial tissue engineering product used for treating myocardial infarction, in particular, the product applies OPF hydrogel as a scaffold and carries one or more different angiogenic growth factors such as bFGF, PDGF-BB, VEGF and the like, and the repair effect of the product on myocardial infarction regions is observed after the product is injected and transplanted into the certain regions of an animal myocardial infarction model. The product built by the scaffold can promote generation of myocardial capillary and arteriola, enhance generation of myofibroblast, promote regeneration of the myocardial tissues, increase the ventricular wall thickness of the infarction regions, reshape the original ventricle and improve the cardiac function. The invention is simple in operating process and mild in implementation conditions, provides a new product for the myocardial tissue engineering and is of great significance in the development of clinically treating heart diseases by tissue-engineered myocardium.

The invention discloses a liner of refrigerating equipment and a preparation method thereof. The liner of the refrigerating equipment is formed by a HIPS (High Impact Polystyrene) two-layer composite board. The HIPS two-layer composite board comprises a surface layer and a bottom layer, wherein the surface layer is formed by surface layer HIPS; the surface layer HIPS is selected from one or more of natural color HIPS, dyed HIPS and modified extrusion-grade HIPS; and the bottom layer comprises natural color extrusion-grade HIPS and return materials. According to the liner of the refrigerating equipment, which is disclosed by the embodiment of the invention, the HIPS two-layer composite board is adopted to form the liner, both the surface layer and the bottom layer of the HIPS two-layer composite board are made of the HIPS materials, various screened HIPS materials have excellent compatibilities and can be mutually blended without obviously influencing the appearance and the processing performance of the board, and thus, the strength of the board can be improved and the cracking risk can be reduced.

The invention belongs to the field of tissue engineering and regenerative medicine, and discloses an injectable tissue engineered cardiac muscle which uses low oligo(poly(ethylene glycol) fumarate (OPF) hydrogel as a support material and contains OPF hydrogel and iPS (Induced Pluripotent Stem) cells or cardiac muscle cells originating from the iPS cells. A preparation method of the tissue engineered cardiac muscle specifically comprises the steps of: adding the OPF and a crosslinking agent into a PBS (Poly-Butylene Succinate) solution; then adding an ammonium persulfate solution and a TEMED (Tetramethylethylenediamine) solution; and adding PBS suspension containing the iPS cells and slightly and uniformly mixing. The invention also discloses the preparation method and application of the tissue engineered cardiac muscle. In the invention, by adopting the OPF hydrogel as a carrier, the detension ratio and the survival ratio of the iPS cell are improved and a good repairing effect on heart functions of an infarcted zone is good; secondly, the tissue engineered cardiac muscle disclosed by the invention can be injected so that the operation is convenient; and in addition, because the iPS cells are used as seed cells, the problems on ethical morals and immunological rejection do not exist. In the invention, the preparation method is simple and the implementation conditions are mild.

A slow-release epidoxorubicin-polylactic acid microball is prepared through dissolving epidoxorubicin hydrochloride in DMF, adding triethylamine, adding polylactic acid, adding water, dialyzing in water while stirring and exchanging water every 1-3 hr, centrifugal dewatering, ultrasonic treating, water washing, removing uncoated epidoxorubicin, and freeze-drying of deposit.

The invention discloses a tissue engineering lymph node model and a construction method thereof and belongs to the technical field of tissue engineering and regenerative medicine. The tissue engineering lymph node model comprises lymphocytes separated from lymphoid tissues and a collagen-Matrigel scaffold. The construction method for the tissue engineering lymph node model comprises the following steps of: preparing lymphocyte suspension and primary generation mouse fibroblast cell suspension; and compounding mixed cell suspension and the collagen-Matrigel scaffold, and culturing in a mold subjected to static stretching to obtain the tissue engineering lymph node model. The scaffold system subjected to static stretching can better simulate in-vivo environment and support the growth and proliferation of the lymphocytes, secretion of cell factors and the expression of surface markers, and has important significance for applying the tissue engineering lymph node model to immunotoxicity evaluation of biological materials, immune medicine screening and the like. The construction method has the advantages of simple operating process and mild implementation conditions.

The invention discloses an HIPS (high impact polystyrene) three-layer composite board for the inner container of a refrigerating device and a preparation method of the HIPS three-layer composite board. The HIPS three-layer composite board for the inner container of the refrigerating device comprises a surface layer, a base layer and bottom layer, wherein the surface layer is made from the surface layer HIPS, and the surface layer HIPS is selected from at least one or more of natural color HIPS, dyeing HIPS and modified extrusion grade HIPS; the base layer comprises natural color extrusion grade HIPS and feed material; and the bottom layer is made from foaming agent corrosion-resistant HIPS. According to the HIPS three-layer composite board for the inner container of the refrigerating device of the embodiments of the invention, the surface layer, the base layer and the bottom layer are made from the HIPS material, the various screened HIPS materials are good in compatibility, and can be mixed with one another, and the appearance and the machining performance of the board can not be obviously influenced, so that the strength of the board can be improved, and the cracking risk can be reduced.

The invention relates to a preparation method of a solution-dispersible polypyrrole copolymer. The method comprises the following steps: mixing a soluble polymer, an initiator and a pyrrole monomer under an air condition, and carrying out irradiation treatment by utilizing high-energy rays to obtain the polypyrrole copolymer. Compared with the prior art, the raw materials, the pyrrole monomer, the soluble polymer, the initiator and the like used in the method are commercially available reagents easy to obtain, special treatment is not needed, the reaction condition is mild and easy to control, one-step completion is achieved, and the method has the advantages of being easy and convenient to operate, capable of saving energy consumption, environmentally friendly, wide in application range and the like; and the polypyrrole copolymer prepared by the method can be stably dispersed in water or most of organic solvents, the defect that polypyrrole is insoluble and non-meltable is overcome, and the polypyrrole material is endowed with good processability.

The invention provides a cationic polymer polyelectrolyte which is high in dielectric constant and ionic conductivity and a manufacturing method for the cationic polymer polyelectrolyte and belongs to the field of macromolecular materials. The cationic polymer polyelectrolyte comprises the following steps: by taking a fluorine-containing ferroelectric polymer polyvinylidene fluoride (PVDF) and a copolymer of the polymer as raw materials, grafting a polycationic side chain through atom transfer radical polymerization; and carrying out settling, washing and drying to obtain a product. The cationic polyelectrolyte and a carbon material are compounded to prepare a super capacitor electrode which can realize good electrochemical energy storage. The cationic polyelectrolyte manufactured according to the technical scheme can effectively replace common fluorine-containing polymers in the super capacitor, so that the cationic polyelectrolyte is suitable for processing a high-performance super capacitor.

The invention discloses carboxymethyl chitosan- barium alginate injectable dual-network temperature-sensitive hydrogel and a preparation method and application thereof. The hydrogel is prepared from carboxymethyl chitosan, sodium glycerophosphate, alginate and barium chloride, and the mass ratio of carboxymethyl chitosan to sodium glycerophosphate to alginate to barium chloride is (60-100): (350-450): (25-40): (10-60). The gel material effectively improves the problems of poor mechanical strength and uncontrollable temperature-sensitive phase change of the prepared injectable temperature-sensitive gel, and can effectively solve some practical problems encountered clinically at present when being applied to the treatment of xerophthalmia.

The invention discloses a hydroxypropyl chitosan-barium alginate injectable temperature-sensitive dual-network hydrogel as well as a preparation method and an application thereof. The preparation rawmaterials comprise hydroxypropyl chitosan, sodium glycerophosphate, alginate and barium chloride. The double-network hydrogel is low in toxicity, tasteless, degradable, simple in preparation method, mild in implementation condition and good in biocompatibility, mechanical property and temperature-sensitive response performance, and by means of the temperature-sensitive gelling characteristic of the double-network hydrogel, the double-network hydrogel is injected into lacrimal punctum at the room temperature or the low temperature, a gel state is formed at the body temperature, lacrimal ducts are blocked, and the purpose of treating xerophthalmia is achieved. The lacrimal passage suppository material can effectively reduce the cost, and is wide in application range, simple to operate and small in trauma. And moreover, by changing the concentration of barium chloride, controllable operation on the pore diameter, the mechanical strength and the like of the gel can be realized, so that thepurpose of adapting to practical application to a greater extent is achieved.

The invention discloses an HIPS (High Impact Polystyrene) double-layer composite board for a liner of a refrigerating device and a preparation method of the HIPS double-layer composite board. The HIPS double-layer composite board for the liner of the refrigerating device comprises a surface layer and a bottom layer, wherein the surface layer is composed of a surface layer HIPS; the surface layer HIPS is selected from one or more of a natural-color HIPS, a dyeing HIPS and a modified extruded-grade HIPS; and the bottom layer comprises a natural-color extruded-grade HIPS and a recirculation scrap.. According to the HIPS double-layer composite board for the liner of the refrigerating device disclosed by the embodiment of the invention, the surface layer and the bottom layer are made of HIPS materials and all the sieved HIPS materials have good compatibility, so that the HIPS materials can be mutually mixed and the appearance and the machining performance of the board can not be obviously influenced; and therefore, the board strength can be improved and the cracking risk is reduced.

The invention relates to a preparation method of tannin grafted draping double bonds. According to the preparation method, allyl glycidyl ether (AGE) is initiated to be subjected to ring opening grafting to tannin (TA) under the condition of taking triphenylphosphine as a catalyst, so that the tannin is endowed with hyperbranched draping double bonds with reaction activity, and a graft modification product is pure and is easily to separat. The preparation method disclosed by the invention is simple and feasible, the implementation conditions are mild, and no pollution is generated in the production and use processes.