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Preparation method of hydroxy apatite / polylactic acid / chitosan composite microballoon

A technology of hydroxyapatite and composite microspheres, applied in the field of materials science, can solve problems such as the preparation method of composite microspheres without three components, and achieve the effects of good three-phase bonding, good mechanical properties of materials, and mild implementation conditions.

Inactive Publication Date: 2012-06-13
CHONGQING UNIVERSITY OF SCIENCE AND TECHNOLOGY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

"Chinese Tissue Engineering Research and Clinical Rehabilitation" published the article "Performance Test of Nano-hydroxyapatite / PLA Composite Material" by Qiang Xiaohu in the 5th issue of 2007. The above materials are only HA, PLA and other organic substances. Composite materials, or preparation of microspheres involving chitosan and other organic substances, without involving hydroxyapatite / polylactic acid / chitosan components, that is, chitosan is used to improve the degradation acidity of polylactic acid, and at the same time Also there is no preparation method of this three-component composite microsphere

Method used

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  • Preparation method of hydroxy apatite / polylactic acid / chitosan composite microballoon
  • Preparation method of hydroxy apatite / polylactic acid / chitosan composite microballoon
  • Preparation method of hydroxy apatite / polylactic acid / chitosan composite microballoon

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0029] Accurately weigh polylactic acid, chitosan, and hydroxyapatite according to the proportioning in Example 1 in Table 1 for subsequent use.

[0030]Measure 25 mL of glacial acetic acid to dissolve polylactic acid, add spare chitosan, stir and mix for 20 minutes, keep the ultrasonic water temperature not exceeding 25°C, and ultrasonically oscillate for 2 hours until chitosan is completely dissolved, add spare hydroxyapatite, keep Ultrasonic water temperature does not exceed 25 ° C, ultrasonic vibration 2h, until the mixture is milky white and no hydroxyapatite particles are precipitated.

[0031] According to the ratio of Example 1 in Table 1, measure liquid paraffin, petroleum ether, and Span80 and add them to the beaker, and stir and mix evenly, inject the hydroxyapatite / polylactic acid / chitosan mixture with a 0.8mm diameter injection needle , drop into the liquid paraffin / petroleum ether mixture with a stirring speed of 1500r / min, and continue to stir for 40 minutes; le...

Embodiment 2

[0033] Accurately weigh polylactic acid, chitosan, and hydroxyapatite according to the proportioning in Example 2 in Table 1 for subsequent use.

[0034] Measure 10 mL of glacial acetic acid to dissolve polylactic acid, add spare chitosan, stir and mix for 15 minutes, keep the ultrasonic water temperature not exceeding 25°C, and ultrasonically oscillate for 1 hour. The following operations are the same as in Example 1.

[0035] According to the ratio of Example 2 in Table 1, measure liquid paraffin, petroleum ether, and Span80 and add them to the beaker, and stir and mix evenly, inject the hydroxyapatite / polylactic acid / chitosan mixture with a needle with a diameter of 0.6mm , drop into the liquid paraffin / petroleum ether mixed solution with a stirring speed of 1500r / min, and continue to stir for 35min; operate according to Example 1 to obtain hydroxyapatite HA / polylactic acid PLA / chitosan CS composite microspheres, see figure 2 . The particle size of the product is mainly b...

Embodiment 3

[0039] Accurately weigh polylactic acid, chitosan, and hydroxyapatite according to the proportioning in Example 3 in Table 1 for subsequent use.

[0040] Measure 10 mL of glacial acetic acid to dissolve polylactic acid, add spare chitosan, stir and mix for 10 minutes, keep the ultrasonic water temperature not exceeding 25°C, and ultrasonically oscillate for 1.5 hours. The following operations are the same as in Example 1.

[0041] According to the ratio of Example 2 in Table 1, measure liquid paraffin, petroleum ether, and Span80 and add them to the beaker, and stir and mix evenly, inject the hydroxyapatite / polylactic acid / chitosan mixture with a needle with a diameter of 0.6mm , drop into the liquid paraffin / petroleum ether mixed solution with a stirring speed of 1500r / min, and continue to stir for 35min; operate according to Example 1 to obtain hydroxyapatite HA / polylactic acid PLA / chitosan CS composite microspheres, see Figure 4 . The particle size of the product is mainly...

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Abstract

The invention discloses a preparation method of a hydroxy apatite / polylactic acid / chitosan composite microballoon. The hydroxy apatite / polylactic acid / chitosan composite microballoon is prepared by using hydroxy apatite HA, polylactic acid PLA and chitosan CS as raw materials and employing manufacturing principles of a solution blending method and an emulsion method. The method comprises steps of: dropping a prepared apatite / polylactic acid / chitosan acetate acid gracial solution into a stirred liquid paraffin / petroleum ether mixed liquor ; carrying out stewing; removing the liquid paraffin / petroleum ether mixed liquor; washing; carrying out stewing; and refrigerating drying to obtain the composite microballoon product. The hydroxy apatite / polylactic acid / chitosan composite microballoon of the invention compounds three materials with different performances to solve problems of strength, toughness and biocompatibility of the material; and the hydroxy apatite / polylactic acid / chitosan composite microballoon is mainly used in bone tissue restoration material, cell engineering and transmission of medicament and bioactive molecule.

Description

technical field [0001] The invention relates to a preparation method of a material, in particular to a preparation method of a hydroxyapatite / polylactic acid / chitosan composite microsphere, and belongs to the field of materials science. Background technique [0002] Microspheres play a very important role in the field of biomedical engineering due to their particularity in structure, variability in performance, and wide range of applications. The preparation methods of microspheres mainly include phase separation method, emulsification-solvent evaporation method, freezing method and spraying method. Among them, the emulsification-solvent evaporation method is the most widely used method. The method is to dissolve the complex in a solvent, and then inject it into the stirring reverse solvent to emulsify into a complex emulsion, and form composite microspheres by volatilizing the original solvent. [0003] Polylactic acid (PLA) has been widely used in the preparation of tissu...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): B01J13/02A61L27/50A61L27/46A61L27/20A61L27/18A61K47/36
Inventor 廖晓玲徐文峰
Owner CHONGQING UNIVERSITY OF SCIENCE AND TECHNOLOGY
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