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Preparation and application of a near-infrared photopolymerizable injectable hydrogel

A near-infrared light and water injection technology, applied in the field of medicine, can solve problems such as large human injury, achieve the effects of less human injury, simple method and improved treatment effect

Active Publication Date: 2021-06-08
深圳禾义科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, the most studied are ultraviolet light and near-infrared light, but ultraviolet light is more harmful to the human body.

Method used

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  • Preparation and application of a near-infrared photopolymerizable injectable hydrogel
  • Preparation and application of a near-infrared photopolymerizable injectable hydrogel
  • Preparation and application of a near-infrared photopolymerizable injectable hydrogel

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0050] 1) Preparation of gold nanorods:

[0051] Take 5ml, 0.0005M chloroauric acid solution and 5ml, 0.2M cetyl ammonium bromide solution, mix them, quickly add 0.60ml, 0.020M sodium borohydride solution, stir vigorously for 2min, and stand at 25°C for 2h (Not more than 3h) A gold nanometer seed solution was prepared. Then add 5.0ml, 0.001M chloroauric acid solution, 0.15ml, 0.0020M silver nitrate solution to 5ml, 0.20M cetyl ammonium bromide solution and mix, then add 70μl, 0.08M ascorbic acid solution and 20μl seeds After solution, gold nanorods are obtained;

[0052] 2) Modification of gold nanorods:

[0053] To improve the stability and cytocompatibility of gold nanorods. 2 mM potassium carbonate and 1 mM ARM-PEGSH aqueous solution were added to the 1 mM gold nanorod solution at a volume ratio of 1:0.1:1. After standing at room temperature for 24 hours, the solution was centrifuged at 12000 rpm for 15 minutes. The pellet was collected and resuspended in DDI water. C...

Embodiment 2

[0073] 1) Preparation of gold nanorods:

[0074] Take 5ml, 0.0005M chloroauric acid solution and 5ml, 0.15M cetyl ammonium bromide solution, mix them, quickly add 0.60ml, 0.010M sodium borohydride solution, stir vigorously for 2min, and stand at 25°C for 2h (Not more than 3h) A gold nanometer seed solution was prepared. Then add 5.0ml, 0.001M chloroauric acid solution, 0.15ml, 0.0010M silver nitrate solution to 5ml, 0.15M cetyl ammonium bromide solution and mix, then add 70μl, 0.08M ascorbic acid solution and 20μl seeds After solution, gold nanorods are obtained;

[0075] 2) Modification of gold nanorods:

[0076] To improve the stability and cytocompatibility of gold nanorods. 2 mM potassium carbonate and 1 mM ARM-PEGSH aqueous solution were added to the gold nanorod solution at a volume ratio of 1:0.2:1. After standing at room temperature for 24 hours, the solution was centrifuged at 12000 rpm for 15 minutes. The pellet was collected and resuspended in DDI water. Centr...

Embodiment 3

[0084] 1) Preparation of gold nanorods:

[0085] Take 5ml, 0.0005M chloroauric acid solution and 5ml, 0.25M hexadecyl ammonium bromide solution, mix them, quickly add 0.60ml, 0.020M sodium borohydride solution, stir vigorously for 2min, and stand at 25°C for 2h (Not more than 3h) A gold nanometer seed solution was prepared. Then add 5.0ml, 0.001M chloroauric acid solution, 0.15ml, 0.0030M silver nitrate solution to 5ml, 0.25M cetyl ammonium bromide solution and mix, then add 70μl, 0.08M ascorbic acid solution and 20μl seeds After solution, gold nanorods are obtained;

[0086] 2) Modification of gold nanorods:

[0087] To improve the stability and cytocompatibility of gold nanorods. 2 mM potassium carbonate and 1 mM ARM-PEGSH aqueous solution were added to the 1 mM gold nanorod solution at a volume ratio of 1:0.3:1. After standing at room temperature for 24 hours, the solution was centrifuged at 12000 rpm for 15 minutes. The pellet was collected and resuspended in DDI wate...

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Abstract

The invention discloses the preparation and application of a near-infrared photopolymerizable injectable hydrogel, which is a methacryloyl carboxymethyl chitosan solution with double bonds introduced under near-infrared light, and the modified hydrogel prepared above Gold nanorods, 4ARM‑PEGSH, and VAZO44 solutions are added with the required amount of antineoplastic drugs. The hydrogel is obtained by near-infrared photopolymerization, and after being injected into the tumor site, a photothermal treatment can be completed. When near-infrared photopolymerized hydrogels are obtained in vivo, antitumor drugs can be chemotherapeutic through sustained release. In this way, the combined treatment of photothermal + chemotherapy can be completed to achieve the purpose of treating tumors.

Description

technical field [0001] The invention relates to the field of medicines, in particular to the preparation of a near-infrared photopolymerizable in-situ injectable hydrogel and its application in tumor treatment. Background technique [0002] Malignant tumor is a major disease that threatens human life and health, and its incidence is still increasing year by year. At present, malignant tumors are mostly treated with a combination of surgery and chemotherapy, among which chemotherapy is a must-use treatment, because it is powerful and can quickly kill or kill tumor cells, it plays an important role in clinical treatment, but Chemotherapeutic drugs can cause severe systemic toxicity due to their short blood circulation time and no specific biodistribution. Due to the high osmotic pressure inside malignant tumors, it is difficult for chemotherapy drugs to reach the center of solid tumors, resulting in tumor apoptosis in the whole region. Generally speaking, traditional chemoth...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K41/00A61K9/06A61K47/36B22F9/24A61P35/00A61K31/704
CPCA61K9/0019A61K9/06A61K31/704A61K41/0052A61K47/36A61P35/00B22F9/24A61K2300/00
Inventor 许沛虎马小慧徐海星黄志军郑芙蓉向梅赵梦刘梦婕董杰鹏宁偲偲张婉婷
Owner 深圳禾义科技有限公司
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