A drug and screening method for improving immunity under microgravity environment

Abstract

The invention discloses a medicine for improving the immunity in a microgravity environment and a screening method thereof, belonging to the field of aerospace medicine and tissue engineering. The medicine disclosed by the invention is prepared by mixing astragalus polysaccharides, ginseng polysaccharides, ganoderma lucidum polysaccharides, pachymaran and lentinan together. The screening method comprises the following steps of: firstly preparing lymphocyte suspension, then culturing the lymphocyte suspension in the microgravity environment of a rotary type bioreactor, adding a mixture of polysaccharides in different proportions, and finally obtaining a medicine prescription for improving the immunity in the microgravity environment by change of the immunologic function of lymphocyte. The invention has the beneficial effects that the construction method and the operation process are simple, the implementation conditions are mild, the medicine for resisting against the reduction of the immunologic function in the microgravity environment can be efficiently and quickly screened, and the medicine and the screening method have the important significance for health protection of astronauts against the weightlessness effect.

Description

technical field

[0001] The invention belongs to the fields of aerospace medicine and tissue engineering, and in particular relates to a drug for improving immunity in a microgravity environment and a screening method thereof. Background technique

[0002] Sustained weightlessness, space radiation, high vacuum, micro-magnetic fields, and circadian rhythm changes have all become factors that affect the health of astronauts in the space environment. During space flight in orbit, the immune system of astronauts will be inhibited in the weightlessness environment. As a result, the body's chances of suffering from various infectious diseases and autoimmune diseases are greatly increased. Therefore, screening for drugs that can improve immune function in microgravity environments is an important research aspect for effective countermeasures against weightlessness. However, so far, there has been no report on using a rotating bioreactor to simulate a microgravity environment for dr...