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Hydroxypropyl chitosan-barium alginate injectable temperature-sensitive dual-network hydrogel as well as preparation method and application thereof

A technology of hydroxypropyl chitosan and barium alginate, which is applied in the fields of pharmaceutical formulations, medical preparations of non-active ingredients, inorganic non-active ingredients, etc., can solve the problem of poor mechanical strength of injectable temperature-sensitive gels and impossibility of temperature-sensitive phase transitions. Control and other issues, to achieve good biocompatibility and mechanical properties, simple preparation method, high mechanical strength

Pending Publication Date: 2019-11-15
NORTHWEST UNIV(CN)
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] The object of the present invention is to provide a kind of hydroxypropyl chitosan-barium alginate injectable temperature-sensitive double network hydrogel and its preparation method and application, to overcome the defects in the prior art, the gel material of the present invention effectively improves the Injectable thermosensitive gel has poor mechanical strength and uncontrollable temperature-sensitive phase transition, and its application to the treatment of dry eye disease can effectively solve some practical problems currently encountered in clinical practice

Method used

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  • Hydroxypropyl chitosan-barium alginate injectable temperature-sensitive dual-network hydrogel as well as preparation method and application thereof
  • Hydroxypropyl chitosan-barium alginate injectable temperature-sensitive dual-network hydrogel as well as preparation method and application thereof
  • Hydroxypropyl chitosan-barium alginate injectable temperature-sensitive dual-network hydrogel as well as preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0040] Accurately weigh 1g of HPCS powder and dissolve it in 10mL of deionized water, stir evenly, and measure the pH value of the solution. If the pH value is 2 Solution, weigh 0.3g and dissolve in 5mL deionized water, set aside.

[0041] During the gel preparation process, take 1mL of 100mg / mL HPCS solution, mix the HPCS solution and β-GP solution with a volume ratio of 1:1, then add 2.5mL of 30mg / mL SA solution and stir with a mechanical stirrer, and finally Add 0.5mL 60mg / mL BaCl 2 After the solution is mixed evenly, part of it is transferred into the mold, and the mold is placed in a constant temperature water bath at 37°C to make it gel for subsequent gel performance measurement. Part of it is transferred into a test tube, and the gelation time is measured by the test tube inversion method.

Embodiment 2

[0043] Accurately weigh 0.8g of HPCS powder and dissolve it in 10mL of deionized water, stir evenly, measure the pH value of the solution, if the pH value is 2 Solution, weigh 0.1g and dissolve in 5mL deionized water, set aside.

[0044] Gel preparation process, take 1mL 80mg / mL HPCS solution, mix the HPCS solution and α-GP solution with a volume ratio of 1:1.2, then add 3mL 25mg / mL Ca-Alg solution and stir with a mechanical stirrer, and finally in Add 0.8mL 20mg / mL BaCl under stirring 2 The solution, mixed evenly, was transferred into the mold, and the mold was placed in a constant temperature water bath at 35°C to allow gelation to occur for the subsequent measurement of gel properties. Part of it was transferred into a test tube, and the gelation time was measured by the test tube inversion method.

Embodiment 3

[0046] Accurately weigh 1.2g of HPCS powder and dissolve it in 10mL of deionized water, stir evenly, measure the pH value of the solution, if the pH value is 2 Solution, weigh 0.15g and dissolve in 5mL deionized water, set aside.

[0047] During the gel preparation process, take 1mL of 120mg / mL HPCS solution, mix the HPCS solution and α,β-GP solution with a volume ratio of 1:0.8, then add 2mL of 35mg / mL SA solution and stir with a mechanical stirrer, and finally in Add 0.3mL 30mg / mL BaCl under stirring 2 The solution, mixed evenly, was transferred into the mold, and the mold was placed in a 39°C constant temperature water bath to make it gel for subsequent gel performance measurement. A part was transferred into a test tube, and the gelation time was measured by the test tube inversion method.

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Abstract

The invention discloses a hydroxypropyl chitosan-barium alginate injectable temperature-sensitive dual-network hydrogel as well as a preparation method and an application thereof. The preparation rawmaterials comprise hydroxypropyl chitosan, sodium glycerophosphate, alginate and barium chloride. The double-network hydrogel is low in toxicity, tasteless, degradable, simple in preparation method, mild in implementation condition and good in biocompatibility, mechanical property and temperature-sensitive response performance, and by means of the temperature-sensitive gelling characteristic of the double-network hydrogel, the double-network hydrogel is injected into lacrimal punctum at the room temperature or the low temperature, a gel state is formed at the body temperature, lacrimal ducts are blocked, and the purpose of treating xerophthalmia is achieved. The lacrimal passage suppository material can effectively reduce the cost, and is wide in application range, simple to operate and small in trauma. And moreover, by changing the concentration of barium chloride, controllable operation on the pore diameter, the mechanical strength and the like of the gel can be realized, so that thepurpose of adapting to practical application to a greater extent is achieved.

Description

technical field [0001] The invention relates to an injectable temperature-sensitive gel preparation for ophthalmology, in particular to a hydroxypropyl chitosan-barium alginate injectable temperature-sensitive double network hydrogel and its preparation method and application. Background technique [0002] Dry eye syndrome is a multifactorial disease of tears and ocular surface. Objects are blurred, etc. The disease is a frequently-occurring disease in today's society, and is usually closely related to factors such as age, gender, living environment, excessive use of electronic equipment, various inflammations, and eye surgery. [0003] The treatment methods for dry eye often include artificial tears instead, surgical transplantation, and lacrimal embolism implantation. The main problems in the clinical application of artificial tears are: the physiological quantity of tears required for the ocular surface cannot be maintained stably, the antibacterial agents and preservat...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/06A61K47/36A61K47/24A61K47/02A61P27/02
CPCA61K9/0019A61K9/0048A61K9/06A61K47/02A61K47/24A61K47/36A61P27/02
Inventor 薛伟明李可欣杜幸王瑞杰温惠云黄赛朋杨华潘士印
Owner NORTHWEST UNIV(CN)
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