Hydroxypropyl chitosan-barium alginate injectable temperature-sensitive dual-network hydrogel as well as preparation method and application thereof

Abstract

The invention discloses a hydroxypropyl chitosan-barium alginate injectable temperature-sensitive dual-network hydrogel as well as a preparation method and an application thereof. The preparation rawmaterials comprise hydroxypropyl chitosan, sodium glycerophosphate, alginate and barium chloride. The double-network hydrogel is low in toxicity, tasteless, degradable, simple in preparation method, mild in implementation condition and good in biocompatibility, mechanical property and temperature-sensitive response performance, and by means of the temperature-sensitive gelling characteristic of the double-network hydrogel, the double-network hydrogel is injected into lacrimal punctum at the room temperature or the low temperature, a gel state is formed at the body temperature, lacrimal ducts are blocked, and the purpose of treating xerophthalmia is achieved. The lacrimal passage suppository material can effectively reduce the cost, and is wide in application range, simple to operate and small in trauma. And moreover, by changing the concentration of barium chloride, controllable operation on the pore diameter, the mechanical strength and the like of the gel can be realized, so that thepurpose of adapting to practical application to a greater extent is achieved.

Description

technical field

[0001] The invention relates to an injectable temperature-sensitive gel preparation for ophthalmology, in particular to a hydroxypropyl chitosan-barium alginate injectable temperature-sensitive double network hydrogel and its preparation method and application. Background technique

[0002] Dry eye syndrome is a multifactorial disease of tears and ocular surface. Objects are blurred, etc. The disease is a frequently-occurring disease in today's society, and is usually closely related to factors such as age, gender, living environment, excessive use of electronic equipment, various inflammations, and eye surgery.

[0003] The treatment methods for dry eye often include artificial tears instead, surgical transplantation, and lacrimal embolism implantation. The main problems in the clinical application of artificial tears are: the physiological quantity of tears required for the ocular surface cannot be maintained stably, the antibacterial agents and preservat...

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