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A kind of preparation method of micron polymethyl methacrylate microsphere

A polymethyl methacrylate, micron-scale technology, applied in the field of biomedical materials, achieves the effect of simple operation process and mild implementation conditions

Active Publication Date: 2012-02-15
广东天昊药业有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, there is no precedent for preparing PMMA microspheres with a particle size range of 10-100 μm by solvent evaporation.

Method used

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  • A kind of preparation method of micron polymethyl methacrylate microsphere
  • A kind of preparation method of micron polymethyl methacrylate microsphere
  • A kind of preparation method of micron polymethyl methacrylate microsphere

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preparation example Construction

[0017] A preparation method of micron polymethyl methacrylate microspheres, comprising the following steps:

[0018] (1) Polymethyl methacrylate (PMMA) is dissolved in organic solvent, and the mass fraction range of polymethyl methacrylate solution is 0.5~5.0%; Organic solvent can be dichloromethane, dichloroethane, chloroform , tetrahydrofuran, toluene, acetone or both; the preferred range of the mass fraction of the polymethyl methacrylate solution is 0.7-3.0%, and the more preferred range is 0.9-1.5%.

[0019] (2) Polyvinyl alcohol is dissolved in deionized water to prepare a polyvinyl alcohol solution with a mass percentage (weight) concentration of 0.5 to 2.5%; polymethyl methacrylate solution (PMMA solution) is added dropwise under magnetic stirring Add polyvinyl alcohol solution, the volume ratio of water phase to organic phase is 1-10:1; wherein the water phase is polyvinyl alcohol solution, and the organic phase is polymethyl methacrylate solution; after adding polyme...

Embodiment 1

[0023] Weigh 1 g of polymethyl methacrylate (PMMA) with a relative molecular mass of 410,000, dissolve it in 100 mL of chloroform, and dissolve it completely. Measure 20 mL of 1% polyvinyl alcohol (PVA) aqueous solution, put it into a 500 mL Erlenmeyer flask, and stir with a magnetic stirrer at a stirring speed of 1400 r / min. Add 10 mL of the completely dissolved PMMA solution dropwise into the PVA aqueous dispersion medium. Cover the mixture after the addition, and keep stirring evenly at room temperature for about 120 minutes. The evenly distributed and stable emulsion was ultrasonically treated for 10 minutes (ultrasonic power 150W), then the lid was opened, and stirring was continued for 6-8 hours at 40-50°C. After the solvent evaporated, filter with a glass sand funnel to collect the microspheres. At room temperature, the PMMA microspheres were dispersed in distilled water, and then centrifuged with a high-speed refrigerated centrifuge, and the operation was repeated th...

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Abstract

The invention provides a method for preparing monodisperse micron-sized polymethyl methacrylate microspheres, which uses polymethyl methacrylate as a raw material, polyvinyl alcohol solution as a dispersion medium, and is prepared by an emulsion dispersion solvent volatilization method. Under high-speed stirring, PMMA solution is added to the aqueous solution of polyvinyl alcohol at a certain flow rate to form a uniform and stable emulsion. After ultrasonic dispersion, solvent volatilization, suction filtration, water washing, vacuum drying, etc. Regular, non-adhesive microspheres. The particle diameter of the microsphere is 10-100 μm, and the particle size and particle size distribution can be controlled. Compared with the prior art, the invention has the advantages of simple operation process and mild implementation conditions, and provides a simple and feasible new method for preparing monodisperse and micron-sized polymethyl methacrylate microspheres. The obtained polymethyl methacrylate microspheres can be used in the fields of biomedical materials such as drug carriers, bone repair, orthopedic materials.

Description

technical field [0001] The invention belongs to the field of biomedical materials, in particular to a preparation method of micron-sized polymethyl methacrylate microspheres. Background technique [0002] Polymethyl methacrylate (PMMA) is the most important and most commonly used material in acrylates. It has excellent performance and a wide range of uses. It has become one of the plastic products widely used in various sectors of the national economy. Polished PMMA is widely used in the production of medical utensils, transparent covers of medical equipment (such as incubators, operation boxes, etc.), observation mirrors, surgical tools, etc. Because PMMA has good compatibility with human tissue, is non-toxic to human body, has good light transmittance, stable chemical properties, and is easy to process into the desired shape, so PMMA can be used in medicine to make artificial corneas, orthopedic bonding and fixed joint prostheses. Body, bone cement, dentures, dentures, mo...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C08J3/12C08L33/12
Inventor 王秀梅金玉顺夏雪崔福斋
Owner 广东天昊药业有限公司
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