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Carboxymethyl chitosan-alginate injectable dual-network temperature-sensitive hydrogel and preparation method and application thereof

A technology of carboxymethyl chitosan and temperature-sensitive hydrogel, which is applied in pharmaceutical formulation, medical science, surgery, etc., can solve the problems of poor mechanical strength and uncontrollable temperature-sensitive phase transition of injectable temperature-sensitive gels, and achieve good water solubility , good biocompatibility and mechanical properties, the effect of high mechanical strength

Pending Publication Date: 2020-12-08
NORTHWEST UNIV(CN)
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] The main purpose of the present invention is to provide and relate to a kind of carboxymethyl chitosan-alginate injectable double-network thermosensitive hydrogel and its preparation method and application, to overcome the problems existing in the prior art, the gel material of the present invention effectively It improves the problems of poor mechanical strength and uncontrollable temperature-sensitive phase transition in the preparation of injectable thermosensitive gel, and it can be applied to the treatment of dry eye disease, which can effectively solve some practical problems currently encountered in clinical practice

Method used

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  • Carboxymethyl chitosan-alginate injectable dual-network temperature-sensitive hydrogel and preparation method and application thereof
  • Carboxymethyl chitosan-alginate injectable dual-network temperature-sensitive hydrogel and preparation method and application thereof
  • Carboxymethyl chitosan-alginate injectable dual-network temperature-sensitive hydrogel and preparation method and application thereof

Examples

Experimental program
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Effect test

Embodiment 1

[0034] Accurately weigh 1 g of CMCS powder and dissolve it in 10 mL of deionized water, stir evenly, and measure the pH value of the solution. If the pH value is less than 6.5, adjust the pH value with 1 mol / L NaOH solution to make the pH value 6.5. After adjusting the pH value, if the added solvent is not enough for 10mL, add distilled water to make up 10mL, stir evenly, and set aside. Prepare 400mg / mL β-GP solution, accurately weigh 2g β-GP powder and dissolve in 5mL deionized water, set aside. Prepare a 30mg / mL SA solution, weigh 0.6g of SA powder and add it to 20mL of deionized water, fully stir with a magnetic stirrer for 3h at room temperature, and set aside. Prepare 20mg / mL BaCl 2 Solution, weigh 0.2g and dissolve in 10mL deionized water, set aside.

[0035] Gel preparation process, take 1mL 100mg / mL CMCS solution, mix the CMCS solution and β-GP solution with a volume ratio of 1:1, then add 2.5mL 30mg / mL SA solution and stir with a mechanical stirrer, and finally stir...

Embodiment 2

[0037] Accurately weigh 0.8g of CMCS powder and dissolve it in 8mL of deionized water, stir evenly, measure the pH value of the solution, if the pH value is 2 Solution, weigh 0.15g and dissolve in 5mL deionized water, set aside.

[0038] Gel preparation process, take 1mL 100mg / mL CMCS solution, mix the CMCS solution and α-GP solution with a volume ratio of 1:1.2, then add 3mL 30mg / mL Ca-Alg solution and stir with a mechanical stirrer, and finally in Add 0.8mL 30mg / mL BaCl under stirring 2 The solution, mixed evenly, was transferred into the mold, and the mold was placed in an oven at 35°C to allow gelation to occur for the subsequent measurement of gel properties. Part of it was transferred into a test tube, and the gelation time was measured by the test tube inversion method.

Embodiment 3

[0040] Accurately weigh 0.6g CMCS powder and dissolve it in 10mL deionized water, stir evenly, measure the pH value of the solution, if the pH value is 2 Solution, weigh 0.05g and dissolve in 5mL deionized water, set aside.

[0041] During the gel preparation process, take 1mL of 60mg / mL CMCS solution, mix the CMCS solution with a volume ratio of 1:0.8 and the α,β-GP solution evenly, then add 2mL of 35mg / mL SA solution and stir with a mechanical stirrer, and finally in Add 0.3mL 10mg / mL BaCl under stirring 2 The solution, mixed evenly, was transferred into a mold, and the mold was placed in an oven at 39°C to allow gelation to occur for subsequent gel performance measurements. A part was transferred into a test tube, and the gelation time was measured by the test tube inversion method.

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Abstract

The invention discloses carboxymethyl chitosan- barium alginate injectable dual-network temperature-sensitive hydrogel and a preparation method and application thereof. The hydrogel is prepared from carboxymethyl chitosan, sodium glycerophosphate, alginate and barium chloride, and the mass ratio of carboxymethyl chitosan to sodium glycerophosphate to alginate to barium chloride is (60-100): (350-450): (25-40): (10-60). The gel material effectively improves the problems of poor mechanical strength and uncontrollable temperature-sensitive phase change of the prepared injectable temperature-sensitive gel, and can effectively solve some practical problems encountered clinically at present when being applied to the treatment of xerophthalmia.

Description

technical field [0001] The invention relates to an injectable temperature-sensitive gel preparation for ophthalmology, in particular to a carboxymethyl chitosan-alginate injectable double-network temperature-sensitive hydrogel and its preparation method and application. Background technique [0002] In recent years, the incidence of dry eye has been increasing year by year, and it has become one of the most common ophthalmic diseases. The symptoms of dry eye syndrome are mainly dryness, foreign body sensation, burning sensation in the eyes, often accompanied by sticky secretions in the eyes, which are aggravated by poor sleep quality and excessive eye use, and even affect vision and normal life in severe cases. The disease is a frequently-occurring disease in today's society, and is usually closely related to factors such as age, gender, living environment, excessive use of electronic equipment, various inflammations, and eye surgery. The methods of clinical treatment of dr...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08J3/075C08J3/24C08L5/08C08L5/04C08K5/52C08K3/16A61L31/14A61L31/04A61L31/02
CPCC08J3/075C08J3/246A61L31/145A61L31/148A61L31/042A61L31/028C08J2305/08C08J2405/04C08K5/52C08K2003/162A61L2400/06C08L5/04C08L5/08
Inventor 薛伟明王瑞杰高娟娟闫宇斌王恩民温惠云黄赛朋骆艳娥
Owner NORTHWEST UNIV(CN)
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