Carboxymethyl chitosan-alginate injectable dual-network temperature-sensitive hydrogel and preparation method and application thereof

Abstract

The invention discloses carboxymethyl chitosan- barium alginate injectable dual-network temperature-sensitive hydrogel and a preparation method and application thereof. The hydrogel is prepared from carboxymethyl chitosan, sodium glycerophosphate, alginate and barium chloride, and the mass ratio of carboxymethyl chitosan to sodium glycerophosphate to alginate to barium chloride is (60-100): (350-450): (25-40): (10-60). The gel material effectively improves the problems of poor mechanical strength and uncontrollable temperature-sensitive phase change of the prepared injectable temperature-sensitive gel, and can effectively solve some practical problems encountered clinically at present when being applied to the treatment of xerophthalmia.

Description

technical field

[0001] The invention relates to an injectable temperature-sensitive gel preparation for ophthalmology, in particular to a carboxymethyl chitosan-alginate injectable double-network temperature-sensitive hydrogel and its preparation method and application. Background technique

[0002] In recent years, the incidence of dry eye has been increasing year by year, and it has become one of the most common ophthalmic diseases. The symptoms of dry eye syndrome are mainly dryness, foreign body sensation, burning sensation in the eyes, often accompanied by sticky secretions in the eyes, which are aggravated by poor sleep quality and excessive eye use, and even affect vision and normal life in severe cases. The disease is a frequently-occurring disease in today's society, and is usually closely related to factors such as age, gender, living environment, excessive use of electronic equipment, various inflammations, and eye surgery. The methods of clinical treatment of dr...

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