An assembly for targeted delivery of doxorubicin anticancer drug and its preparation method

Abstract

The invention discloses a targeted transmission assembly of an adriamycin anticancer medicine. The targeted transmission assembly is a ternary supermolecular assembly synthesized by using graphene oxide, folic acid modified cyclodextrin compound and adamantine modified porphyrin compound. The preparation method comprises: synthesizing folic acid modified beta-cyclodextrin and adamantine modified porphyrin respectively, absorbing the folic acid modified beta-cyclodextrin onto the graphene oxide under pi-pi action by using porphyrin as a medium, introducing folic acid onto the surface of graphene by using the strong noncovalent action of the adamantine and beta-cyclodextrin, and preparing the assembly by using the surface of the graphene oxide as the carrier of the pi-system adriamycin anticancer medicine. The invention has the advantages that: the synthesis route of the targeted medicine transmission assembly is simple, the yield of the targeted medicine transmission assembly is high, and the targeted medicine transmission assembly is suitable for amplified synthesis and use in actual production; and the assembly 1 / 2 / DOX / GO is brought into a targeted cancer cell under endocytosis with a folic acid receptor in a malignant cell as a medium, so that the protection of normal cells and the targeted selective killing of cancer cells are realized.

Description

technical field [0001] The invention relates to the technical field of targeted delivery of anticancer drugs, in particular to an assembly for targeted delivery of doxorubicin anticancer drugs and a preparation method thereof. Background technique [0002] Cancer is one of the major diseases that threaten human health. Its diagnosis and treatment have always been the focus and difficulty of many biologists and medical workers. Cancer treatment methods currently mainly include surgery, radiotherapy and chemotherapy. Chemotherapy drugs generally have great cytotoxicity. The drugs are carried to the whole body through blood vessels, and have a great destructive effect on cancer cells and normal cells in the body, and the toxic and side effects are very obvious. Therefore, how to bring chemotherapy drugs to malignant tumor tissues to target and kill cancer cells without affecting normal cells, so as to improve the survival rate and quality of life of patients has become the di...

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Problems solved by technology

Chemotherapy drugs generally have great cytotoxicity. The drugs are carried to the whole body through blood vessels, and have a great destructive effect on cancer cells and normal cells in the body. The toxic and side effects are very obvious.

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