7 results about "Silk sutures" patented technology

The application discloses a preparation method of barbed silk suture, which comprises the following steps: after degumming and activation, the silk suture is immersed in a ginsenoside finishing liquid for padding treatment, and then is baked and dried; the drug-loaded silk suture is put into a mold, a silk fibroin solution is poured into the mold, and after removing bubbles, the silk suture is dried; the dried silk suture is taken out and subjected to wet heat treatment to obtain the barbed silk suture; during the degumming process, an alkali solution with a mass concentration of 0.02-0.08% is used for degumming; and during the activation process, a strong alkali solution with a concentration of 5g / L-50g / L is used for activation. The preparation method of the barbed silk suture applies ginsenoside and silk fibroin to the production and formation of the barbed suture; the polysaccharide chain in the ginsenoside can form stable hydrogen bonds with the silk fibroin, so that the ginsenoside can act on a wound for a long time (long-term sustained release), the drug effect is prolonged, the inflammation of the wound is effectively improved, and the wound healing is promoted.

This invention discloses a polyglycolic acid (PGA) suture-silk suture composite braided surgical suture and its preparation method. The suture is composed of two absorbable surgical sutures (PGA) and two non-absorbable surgical sutures (silk threads) in a multi-strand braided structure. The silk threads are black in color, and their main component is silk fibroin with a molecular weight greater than 30,000. The PGA sutures are pre-dyed with D&C Violet No. 2 dye before braiding, and then heat-set and sterilized with ethylene oxide after braiding. This invention utilizes the dense structure formed by the multi-strand braid to effectively prevent wound exudate from seeping into the suture interior, reducing the corrosive effect of liquid on the internal materials. Simultaneously, through the synergistic composite of PGA sutures and silk threads, a coordinated match is achieved between the suture's mechanical strength and degradation characteristics, resulting in a suture that combines stable support with suitable degradability, better meeting the needs of general soft tissue suturing and ligation in clinical practice.

The invention belongs to the technical field of medical materials, and relates to an antibacterial suture line for surgical suture and a preparation method thereof. The preparation method comprises the following steps: dissolving 2-amino-5-acetylpyridine in a hydrobromic acid glacial acetic acid solution, adding a bromine-containing acetic acid solution, and reacting to obtain an intermediate 1; adding the intermediate 1 into tetrahydrofuran, adding triethylamine and acetic anhydride, and reacting to obtain an intermediate 2; adding the intermediate 2 and thiourea into absolute ethyl alcohol to react to obtain an intermediate 3; adding the intermediate 3 and p-nitrobenzaldehyde into absolute methanol, and adding glacial acetic acid to react to obtain an intermediate 4; adding phosphorus oxychloride into N, N-dimethylformamide, and adding the intermediate 4 to react to obtain an intermediate 5; dissolving the intermediate 5 in a mixed solvent, and adding cystamine to react to obtain an antibacterial agent; the medical silk suture line is soaked in dimethyl sulfoxide dissolved with the antibacterial agent, and the medical silk suture line is obtained through ultrasonic treatment, soaking, rinsing and drying. The antibacterial suture line disclosed by the invention has multi-mechanism synergistic enhanced antibacterial performance, an environment response type active release mechanism and excellent interface affinity.

The application belongs to the technical field of medical materials and relates to a bacteriostatic suture for surgical suturing and a preparation method thereof. The preparation method comprises the following steps: 2-amino-5-acetylpyridine is dissolved in a hydrobromic acid glacial acetic acid solution, an acetic acid solution containing bromine is added, and an intermediate 1 is obtained through reaction; the intermediate 1 is added to tetrahydrofuran, triethylamine and acetic anhydride are added, and an intermediate 2 is obtained through reaction; the intermediate 2 and thiourea are added to anhydrous ethanol, and an intermediate 3 is obtained through reaction; the intermediate 3 and p-nitrobenzaldehyde are added to anhydrous methanol, and an intermediate 4 is obtained through reaction; phosphorus oxychloride is added to N,N-dimethylformamide, and the intermediate 4 is added to obtain an intermediate 5 through reaction; the intermediate 5 is dissolved in a mixed solvent, and cystamine is added to obtain an antibacterial agent; and the medical silk suture is immersed in dimethyl sulfoxide containing the antibacterial agent, and is subjected to ultrasonic treatment, soaking, rinsing and drying to obtain the bacteriostatic suture. The bacteriostatic suture has the advantages of multi-mechanism synergistic enhanced bacteriostatic performance, an environment-responsive active release mechanism and excellent interface affinity.

The utility model provides an intrauterine device placer which comprises a handle, a push rod, a sleeve, a fixing assembly and an intrauterine device. The sleeve and the silk thread are fixed at the same time through the fixing assembly, and the plug on the limiting rod is clamped in the corresponding limiting hole in the sleeve, so that the sleeve is fixed; the button is provided with a threading hole for a silk thread to penetrate through, the button is limited through the lower fixing ring, the fixing ring is blocked at the threading hole when the spring naturally stretches out and draws back, at the moment, the silk thread is clamped between the upper fixing ring and the button, the function of fixing the silk thread is achieved, and when the spring is pressed down, the threading hole is located below the upper fixing ring, and the threading hole and the lower fixing ring are staggered. And the silk thread is not fixed any more, so that the intrauterine device can be placed. The degradation cone of the intrauterine device is inserted into the insertion column of the solid body and is in surface contact with the bottom of the degradation cone, so that the contact area is increased, the stress in the implanting process is reduced and dispersed, and the problem that the degradation cone is broken due to concentrated stress in the product implanting process is solved.

The utility model relates to the field of surgical suture needles and threads, and discloses a needle and thread assembly based on cervical cerclage surgical suture, which comprises a suture line and a suture needle, the cross section of the suture line is circular, the suture line comprises a main line section, and two ends of the main line section are respectively connected with a transition section. The diameter of the transition section is gradually reduced along the extension direction; the large-diameter end of the transition section is connected with the main line section; the small-diameter end of the transition section is connected with the needle threading section; according to the scheme, the main line section serves as a main body of the suture line, the diameter of the main line section is relatively large, the section of the main line section is round, and the problem that due to the fact that the suture line is thin, tension is large, and cutting wounds of the thin line to cervical tissue are likely to happen can be solved, and particularly under the condition that suture and binding retention time is long, the thin line is likely to damage the tissue and cause infection; the needle threading section is used for being connected with a suture needle, the diameter of the needle threading section is relatively small, the needle threading section can more conveniently penetrate into a needle eye of the suture needle, and compared with a thick thread, the thin thread is easier to knot.

The invention discloses a preparation method of a tussah silk medical suture with glucose response and healing promotion functions. The preparation method comprises the following steps: synthesizing 3-APBA and HA to prepare HA / 3-APBA; hA / 3-APBA, PVA and insulin are mixed to prepare hydrogel, a phenylboronic acid group is stably combined with a homeopathic glycol structure, so that an insulin drug is loaded in a hydrogel coating, glucose and PVA compete for the phenylboronic acid group in a hyperglycemia environment, the crosslinking degree of the hydrogel is reduced, and finally the hydrogel is degraded to release the drug. The preparation method comprises the following steps: weaving tussah silk to obtain a tussah silk suture line, degumming the tussah silk suture line, carrying out surface modification treatment on the suture line by using DA, and grafting drug-loaded hydrogel on the surface of the tussah silk suture line to form a uniform and stable coating on the surface of the suture line, thereby preparing the glucose-responsive and healing-promoting medical suture line.