59 results about "Silk sutures" patented technology

An absorbable silk suture for skin is prepared from high-molecular material polypropylene collagen extracted from tendon (8-12g), chitin (4-6g), polyacrylamide hydrophilic gel (2-3g) through mixing and shaping to form the silk. Its advantages are naturally dropping off in 5-15 days after operation and no residual scar.

The invention relates to a chemical grafted type long-acting sustained-release silk suture with an antibacterial function and a preparation method of the silk suture. The chemical grafted type long-acting sustained-release silk suture comprises braiding yarn and nanoparticles with the antibacterial function. The silk suture is activated in a buffer solution containing EDC and NHS, the nanoparticles with the antibacterial function are added for grafting, and the chemical grafted type long-acting sustained-release silk suture is obtained. The silk suture contains an antibacterial agent on the surface, thus having sterilizing and bacterial inhibition functions; the antibacterial agent is uniformly dispersed in the nanoparticles and antibacterial drugs are continuously and slowly released with the continuous biodegradation of nanoparticles, so that the silk suture has long-acting and stable sustained release and antibacterial functions.

The invention discloses an absorbable suture . The suture is prepared from a suture body which is obtained by the mutual winding weaving of multiple yarns processed, the number of yarn is 8-140, and the yarns are natural mulberry silks. The invention further provides a preparation method of the absorbable suture, the natural mulberry silks are taken as the raw material, the absorbable mulberry silk suture with high purity and strength is obtained, the suture can be used for the suturing of normal soft tissue surgical operation and the suturing of tissue operation with slower repairing and higher mechanical demands of meniscus, shoulder sleeve tissues, tendon ligament tissues and the like, and clinical demands are met.

The invention discloses an end effector for natural orifice surgery. The end effector comprises a wrist base, a wrist first pitch joint, a wrist first deflection joint, a rotation mechanism, first drive silk sutures and a control motor; the wrist first pitch joint includes a first upper base, a first lower base, first upper gears and first lower gears; the wrist first deflection joint includes a second upper base, a second lower base, second upper gears and second lower gears; the first drive silk sutures penetrate through the first upper base, the first lower base, the second upper base and the second lower base in sequence and are connected with the rotation mechanism; and middle-upper parts of the four first drive silk sutures are circumferentially arranged in an array, and the four first drive silk sutures are used for providing rotation torque for the rotation mechanism. According to the end effector for the natural orifice surgery provided by the invention, by utilizing the fourfirst drive silk sutures penetrating through the multiple bases and circumferentially arranged in an array, pitch rotation of the wrist first pitch joint, deflection rotation of the wrist first deflection joint and rotation motion of the rotation mechanism can be realized.

The invention discloses an anastomosis fastening ring for main arteries and an artificial blood vessel assembly with the anastomosis fastening ring, and relates to the technical field of medical apparatus and instruments. The anastomosis fastening ring for the main arteries comprises a fastening ring body. The fastening ring body is of an annular opening structure, and first instrument operating holes are respectively formed in two sides of an opening in the fastening ring body; a first fastener is arranged at one tail end of the fastening ring body, a second fastener is arranged at the other tail end of the fastening ring body, and the first fastener and the second fastener are locked with each other in an insertion manner, so that the anastomosis fastening ring for the main arteries can be used for sleeving sleeve rings of artificial blood vessels; the diameter of the anastomosis fastening ring for the main arteries can be decreased along with increase of the quantity of mutual insertion locking overlapped portions of the first fastener and the second fastener; the diameter of the anastomosis fastening ring for the main arteries can be increased along with decrease of the quantity of the mutual insertion locking overlapped portions of the first fastener and the second fastener. The anastomosis fastening ring and the artificial blood vessel assembly have the advantage that the technical problems of inconvenience in operation and difficulty in adjustment when existing sleeve rings of existing artificial blood vessels are fixedly tied off by existing silk sutures (or silk ribbons) can be solved by the aid of the anastomosis fastening ring and the artificial blood vessel assembly.

The invention discloses strile absorbent sutures for gynaecology and obstetrics and a preparation method of the strile absorbent sutures. The strile absorbent sutures for the gynaecology and obstetrics are prepared by taking chitosan silk threads as core threads, taking modified polylactic acid silk threads as shell threads, after stranding braiding, immersing the chitosan silk threads and the modified polylactic acid silk threads into coating liquid containing calcium stearate and polylactic acid and drying the liquid. Through the preparation method, the mechanical properties and hydrophilicproperties of the polylactic acid can be improved, and the prepared sutures have high strength and good biocompatibility; chitosan in the inner part of the sutures degrades slowly, while long-term antibacterial action is achieved, the sutures can further gradually form a hollow structure, thus ingrowth and healing of tissue is promoted, and the effect of accelerating the healing of the tissue is achieved; and the overall preparation process is simple and convenient to control, and needs of practical production and application can be met.

The invention discloses a manufacturing method of an antibacterial medical real silk suture line. The antibacterial main ingredient is extracted from the mixture obtained by mixing natural plants: gallnuts, radix sophorae flavescentis, honeysuckle flowers and wild chrysanthemum flowers according to certain weight percentages, the extraction solution of the natural plants and one or two kinds of fatty acid and ethyl alcohol with certain percentages are prepared into an antibacterial agent coating solution, a core line and a line body are soaked in the coating respectively, and the efficient and broad-spectrum antibacterial real silk suture line with a bacteria killing and restraining effect is made.

The invention discloses an intravascular stent overlay film for in-situ intima regeneration and a preparation method of the intravascular stent overlay film. The method comprises the following steps:dividing silkworm natural silk into two groups, performing twisting and combining into silk thread groups, taking the other group as a monofilament group, performing degumming, performing dissolving in a lithium bromide neutral salt solution to prepare a silk fibroin dissolving solution, and then pouring the silk fibroin dissolving solution into a dialysis bag with a certain molecular weight cut-off; performing dialyzing to obtain a purified silkworm silk fibroin aqueous solution, and then concentrating the silk fibroin to a proper mass fraction by adopting a rotary evaporator; adding a hydrophilic flexible molecule cross-linking agent into the silk fibroin aqueous solution, performing uniform mixing, removing bubbles to obtain a modified silk fibroin solution, knitting monofilaments intoa tubular structure by adopting a knitting machine, performing coating to the fibroin tubular structure, performing rotary air drying on each coating in the circumferential direction under low-temperature hot air, and controlling the coating to be a uniform molecular layer, so as to obtain the intravascular stent overlay film for in-situ intima regeneration. The overlay film has excellent toughness, and in-situ induction of endovascular regeneration for regulating balance of a blood system is realized.

The invention discloses an anticoagulant intravascular stent coating and a preparation method thereof. The preparation method comprises the following steps: dividing silkworm silk into two groups, twisting and combining one group of silkworm silk to obtain a silk thread group, taking the other group of silkworm silk as a monofilament group, boiling the silk thread group and the monofilament groupby using deionized water for degumming, and weaving the silk thread group into a tubular structure by using a braiding machine, dissolving silk of the monofilament group in a lithium bromide neutral salt solution to prepare a silk fibroin dissolving solution, pouring the silk fibroin dissolving solution into a dialysis bag and placing in a container containing deionized water for continuous dialysis, obtaining a purified silkworm silk fibroin aqueous solution, then concentrating the silk fibroin aqueous solution through a rotary evaporator, and obtaining the silk fibroin aqueous solution; adding a proper amount of cross-linking agent into the silk fibroin aqueous solution for reaction, coating or spinning the tubular structure with the coating or spinning coating, spinning the coating withhirudin again after hot air spinning and air drying, and spinning and air drying at room temperature to obtain the anticoagulant intravascular stent coating. The coating has excellent biomechanical properties and lasting anticoagulant activity.

The invention discloses a bionic multichannel electroactive nerve conduit and a preparation method thereof. The preparation method comprises the following steps: secondary degumming of a silk thread; preparing a silk fibroin solution by taking the secondary degummed silk threads as raw materials; preparing a multi-channel silk fibroin frozen gel; preparing the multi-channel conductive frozen gel; preparing the bionic multi-channel conductive nerve scaffold; a PVDF / PLCL thin film is prepared; and fixing the bionic multi-channel conductive nerve scaffold and the PVDF / PLCL film through a surgical suture to obtain the bionic multi-channel electroactive nerve conduit. The nerve conduit has excellent biocompatibility, mechanical performance and degradation performance, the four-channel structure of the nerve conduit can limit dispersion of axons and prevent the axons from being regenerated to wrong branches, the conductive effect can stimulate maturation of Schwann cells and myelination of the axons, the piezoelectric effect can provide in-vivo electrical stimulation, the myelination process of the axons is further promoted, and the nerve conduit has a good application prospect. Therefore, the regeneration of peripheral nerves is better promoted.

The invention discloses a minimally invasive resection device for pediatric surgery tumor. The resection device includes a first main body; the first main body is a cylindrical rod, and the two ends of the first main body are opened; one end of the first main body is fixedly connected to an installation plate; the surface on the side, away from the first main body, of the installation plate is provided with connecting plates; a guiding rod is fixedly connected between the two connecting plates; the surfaces of connecting rods are respectively and slidingly provided with sleeves; and the surfaces on the sides, away from the installation plate, of the two sleeves are respectively and fixedly connected to fixing clamps. Through the arrangement of a roller, medical silk suture can be arrangedon the roller and passes out through a catheter, so that the medical silk suture can be sleeved on tumor; the medical silk suture can be tightened by rotating the roller, so that the tumor can be cut,and more complete cutting can be achieved; and the front end of the device is small, so that the device can be conveniently inserted into a patient.

A making technology of a dog salmon skin picture comprises the following steps: 1, raw dog salmon surface skin making: cutting the skin of dog salmon from the back, and nondestructively stripping to obtain a dog salmon surface skin; 2, carrying out salt preserving anticorrosion treatment of the raw dog salmon surface skin, immersing the dog salmon surface skin in water, degreasing, liming the degreased dog salmon surface skin, pickling, allowing the internal surface of the dog salmon surface skin to face an acupuncturing template, softly pressing the internal surface of the dog salmon surface skin by acupunctures of the acupuncturing template, and processing by using a tanning agent to form leather; and 3, finishing to obtain dog salmon skin leather, sewing the dog salmon skin leather onto a lining surface through a natural silk thread, and allowing the bone plate of the dog salmon skin leather to face outside to obtain the dog salmon skin picture. The dog salmon skin picture produced in the invention has the characteristics of strong stereo perception, simple and elegant feeling, no deformation, no shedding or fading, easy long-term preservation, high class, and high acceptance by consumers, and the making technology has the advantages of simplicity and low production cost. The making technology can be widely used a production technology of dog salmon skin pictures.

The invention discloses a silk anticoagulation intravascular stent coating and a preparation method thereof. The preparation method comprises the following steps: dividing silkworm silk into two groups, twisting and combining one group of silkworm silk to obtain a silk thread group, taking the other group of silkworm silk as a monofilament group, and then boiling with deionized water for degumming, wherein the silk thread group is woven into a tubular structure by adopting a braiding machine, silk of the monofilament group is dissolved in a lithium bromide neutral salt solution to prepare a silk fibroin dissolving solution, then the silk fibroin dissolving solution is poured into a dialysis bag, the dialysis bag poured with the silk fibroin dissolving solution is placed in a container containing deionized water, and continuous dialysis is performed to obtain a silk fibroin solution; and the silk fibroin aqueous solution is concentrated by adopting a rotary evaporator, a proper amount of a cross-linking agent is added to react, the silk fibroin tubular braided fabric with the coating is impregnated layer by layer, and the coating anticoagulant drug hirudin is subjected to alternately or mixedly impregnating for multiple times to obtain the silk anticoagulant intravascular stent coating. The coating has excellent biomechanical properties and lasting anticoagulant activity.

The invention discloses a flexible impact-resistant composite automobile body and a production process thereof. The automobile body is an automobile body or an assembled combination formed by subjecting multilayer composite rubber, multilayer soft silk sutures or soft steel wires and a framework spring or leaf spring to high-temperature vulcanization, as well as can be made into an automobile body or assembled combination with impact-resistant and bulletproof functions by means of embedding multilayer ballistic fabrics into multilayer composite rubber. By the aid of formulation optimization and process improvement, mechanical strength and impact resistance of the automobile body materials are enhanced effectively so as to improve mechanical property thereof. The machined automobile body is lightweight, high in mechanical strength, good in toughness and high in impact resistance, fragility and fatigability of traditional automobile bodies are avoided, and requirements on automobile securitization and light weight pursued by modern people are met safely.

The invention discloses an absorbable suture, which is prepared from a suture main body obtained by intertwining and weaving multiple strands of silk thread, and then processing the suture main body. The number of silk threads is 8-140, and the silk thread is Natural mulberry silk. The invention also provides a preparation method of the absorbable suture. The absorbable suture of the present invention uses natural silk as raw material to obtain high-purity, high-strength absorbable silk suture, which can not only be used for general soft tissue surgical suture, but also can be used for meniscus, rotator cuff tissue, tendon and ligament Surgical suturing of tissues that repair slowly and have high mechanical requirements, such as tissues, meets clinical needs.

The invention discloses an antibacterial silk thread suture line with a dual-photoresponse function and a preparation method of the antibacterial silk thread suture line. The zinc nitrate hexahydrate,ammonia water and hexamethylenetetramine are used as main raw materials, after one-step reaction, the main raw materials react with sodium citrate, hydroxypropyl methyl cellulose, carbon powder and lignin, and an obtained product is subjected to freeze drying and microwave treatment to obtain porous zinc oxide; the porous zinc oxide is loaded on the silk thread to obtain the antibacterial silk thread suture line with the dual-photoresponse function, the antibacterial performance of the porous zinc oxide can be further enhanced under the excitation of yellow light, and the zinc oxide is heatedunder the excitation of near-infrared light, so that the degradation of the suture line is accelerated. The method has the advantages of simple and safe process, no need of adding an organic solvent,simple operation method, low requirements on equipment, and suitableness for large-scale production and industrialization.

The invention relates to a simple inside-to-outside meniscus stitching instrument. The simple inside-to-outside meniscus stitching instrument comprises a suture needle, a handle and a round needle; the handle is connected with the suture needle; the suture needle comprises a needle body and a needle head connected with the needle body, the needle head is of a solid structure, and the needle head is provided with a hole for penetrating through a silk suture; and the tip of the round needle is a blunt head. According to the technical scheme of the simple inside-to-outside meniscus stitching instrument, the round needle is in a half circular arc shape, the cross section is circular, and the included angle between the needle head and the needle body is 0 degree to 30 degrees. The simple inside-to-outside meniscus stitching instrument is used for solving the high cost of the stitching instrument, can be reused, and gives patients more choice rights; and secondly, the needle head of the suture needle of the inside-to-outside meniscus stitching instrument only needs a hole for penetrating and passing through the silk suture, and the simple inside-to-outside meniscus stitching instrument is basically a solid structure and hard enough no to zigzag in a joint easily.

The invention relates to the technical field of animal model construction, and discloses a construction method of a novel brain metastatic tumor animal model. The construction method disclosed by the invention comprises the following steps: separating a left common carotid artery and a left common carotid artery branch of the neck of a mouse; rotating the head of the mouse, lifting up a common carotid artery traction silk suture, and then temporarily blocking the common carotid artery; lifting up the telecentric end of the external carotid artery, and leading tumor cell suspension into an internal carotid artery towards the proximal end; and after completing leading in the tumor cell suspension, closing an external carotid artery, and opening the common carotid artery. According to the construction method, the pathophysiological process of human tumor brain metastasis is well simulated, the bleeding amount and the probability of tumor cell leakage in the modeling operation are reduced, the modeling success rate is increased, and the death rate of a model is reduced; and the prepared brain metastasis tumor animal model avoids metastasis of multiple organs, the whole-body tumor load of the mouse is reduced, and the mouse model prepared by the construction method can be used for researching the metastasis mechanism and tumor microenvironment of the brain metastasis tumor.

The invention discloses a vacuum sealing drainage device with a skin stretch function. The vacuum sealing drainage device comprises a dressing board, the top of the dressing board is fixedly connectedwith a base a and a base b, the base a and the base b are symmetrically arranged, rotatable silk thread tightening devices are mounted on the base a and the base b, two symmetrically arranged suctiontubes are arranged in the dressing board, one end of each suction tube penetrates the dressing board and extends outward, and a thread guide device a and a thread guide b are fixedly connected to thetop of the dressing board. The vacuum sealing drainage device not only has the functions of rapid wound closure, infection control, reduction of wound interstitial edema, and promotion of wound granulation tissue growth that traditional VSD devices have, but also has the skin stretch function of a skin stretcher, and has effect of reducing wounds while closing and covering the wounds. In addition, the vacuum sealing drainage device is easy to use, easy to install, and good in practicability.

The invention discloses a silk suture line with antibacterial and hemostatic effects and a preparation method of the silk suture line. The silk suture line is prepare from the following raw materials in parts by weight: 40-50 parts of aromatic polyester, 25-35 parts of fibroin, 15-20 parts of polygonum multiflorum powder, 20-25 parts of gum tragacanth, 14-18 parts of gelatin, 11-14 parts of polyethylene glycol monododecyl ether sodium sulfate, 5-15 parts of glycerin, 1-5 parts of lanoline, 3-7 parts of squalane, 3-8 parts of azone, 20-30 parts of sweet potato starch, 10-15 parts of an adhesive, 6-10 parts of rhizoma corydalis powder, 6-10 parts of dipotassium glycyrrhizinate, 8-10 parts of sodium sarcosinate, 5-10 parts of tea polyphenol, 3-5 parts of cattail pollen powder, 3-7 parts of palm wax and 12-18 parts of notoginseng. The silk suture line with the antibacterial and hemostatic effects and the preparation method thereof, the silk suture line has good blood compatibility and histocompatibility, is free of inflammatory reaction and free of repellency and bad reaction in a human body, has the effect of promoting wound healing, and is convenient to use; and the treatment time is shortened.

The invention discloses an endoscopic dura mater closing system and a use method thereof. The endoscopic dura mater closing system acts on a dura mater notch (6) through an endoscope channel (7), andcomprises a filling (1), an artificial dura mater (2), a pressing assembly and a medical silk suture (5). The dura mater notch (6) is filled with the filling (1), and the artificial dura mater (2) isplaced outside the dura mater notch (6); the medical silk suture (5) penetrates through the filling (1), the dura mater notch (6), the artificial dura mater (2) and the pressing assembly in sequence;the pressing assembly is located on the artificial dura mater (2), and after the filling (1) and the artificial dura mater (2) are installed in place, the pressing assembly is pushed by tweezers to press the artificial dura mater (2) on the dura mater notch (6). A more reliable approach is provided for endoscopic dura mater closing, close fit of the filling (1) and the dura mater notch (6) is guranateed, and operation is convenient.

The invention discloses a drug-loaded degradable and absorbable medical suture and a preparation method thereof. According to the suture, a polylactic acid-based material serves as a silk thread base body, the silk thread base body, a middle drug-loaded layer and an outer lubricating layer are bonded into a whole through drug-loaded protein hydrogel, and the suture is prepared through a special synthesis technology; the prepared suture can effectively control the degradation and absorption period in the human skin; the innovative combination of the polylactic acid silk thread base body and the drug-loaded coating layer can effectively improve the antibacterial, hemostatic and anti-inflammatory effects of the suture; and the outer lubricating layer can effectively improve the lubricity of the suture, reduce the pain of a patient in the operation process and improve the operation operability. The raw materials of the suture can be degraded and absorbed and have good biocompatibility and physiological activity, and the preparation method is simple in process, convenient to operate, wide in raw material source, and good in application prospects.

The invention discloses a preparation method of a medical surgical suture. The method comprises the following steps of adding 5-hydantoin acetic acid modified polylysine, polyethylene glycol hydroxy acid modified polylactic acid, a sodium alginate-based polycaprolactone copolymer, gamma-cyclodextrin and hydroxybutyl methyl cellulose into a high-speed mixer according to a mass ratio; mixing for 20-30 minutes at the rotating speed of 70-90 r / min to obtain a mixture; then feeding the mixture into a double-screw extruder, granulating, cooling, drying and cutting to obtain master batch; carrying out melt spinning on the master batch to form a silk thread with the diameter of 0.02-0.05 mm; and putting the silk thread into medical alcohol to be disinfected for 2-3h; and finally, performing vacuumdrying to obtain the medical surgical suture. The prepared medical surgical suture has the advantages of being complete in absorption, high in tensile strength, good in biocompatibility and capable of promoting cell growth and has the advantages of sterilizing, diminishing inflammation and stopping bleeding.

The object taking device comprises an outer sleeve, an inner sleeve arranged in the outer sleeve, a first memory metal elastic wire connected to one end of the inner sleeve and a bag body, the two ends of the first memory metal elastic wire are fixedly connected to the outer side of a guide ring, a connecting supporting rod is arranged at the guide ring, and the bag body is fixedly connected to the outer side of the first memory metal elastic wire. The end, located on the outer side of the guide ring, of the connecting supporting rod is provided with an extruding and dividing mechanism for dividing a large cut object, and the extruding and dividing mechanism is connected with the bag body, according to the object taking device for the gynecologic abdominal cavity operation, the silk thread net is arranged in the bag body, and the silk thread net is matched with the bag body to achieve the effect of collecting the cut object; meanwhile, after the large resection object is collected, the large resection object can be directly separated and resected into small blocks through the silk thread net, the resection object can be conveniently taken out, the large resection object does not need to be additionally cut through surgical instruments, the surgical difficulty is effectively reduced, and the device is convenient to use in the gynecological abdominal surgery.

The invention relates to a device for treating anal fistula. The device comprises: a silk thread; magnetic beads, wherein the magnetic beads are of a spherical structure, the number of the magnetic beads is multiple, and the multiple magnetic beads are connected to the silk thread; a plugging structure, wherein the plugging structure is fixedly connected to the middle of the silk thread and used for plugging an inner opening of the anal fistula. The device for treating anal fistula, provided by the invention, can replace a probe for use, and cannot damage tissues around the fistula; through the magnetism of the magnetic beads, the magnetic beads at the anal fistula inner opening can be conveniently sucked out from the anus, fingers do not need to stretch into the anus for blind finding, and operation is easy and convenient; after the device penetrates through the fistula, the magnetic beads at the two ends of the silk thread are attracted to form a closed-loop structure, continuous pressing force is generated on tissue in a closed loop through magnetic attraction force between the magnetic beads, the tissue in the closed loop is subjected to avascular necrosis, the silk thread is not prone to breakage, and the use reliability is improved. The plugging structure can reliably plug the inner opening of the anal fistula, dirt is prevented from entering the fistula, and healing is facilitated.

The invention discloses a method for making a respirator protective cover, which includes the following steps: A: Prepare a waterproof cloth and a double-headed zipper, cut the waterproof cloth into two equal-sized rectangles, and then spread a waterproof cloth between the two waterproof cloths. Polyethylene foamed cotton, use sealant to fix polyethylene foamed cotton and two waterproof cloths, and then use silk thread to sew the edges of the waterproof cloths in turn to complete the production of the protective cover body; B: open a liquid level on the protective cover body Observation port, and suture the surroundings of the liquid level observation port with silk thread; C: Then fix the two side cloths of the double-ended zipper and the two ends of the sewn protective cover body respectively, when the double-ended zipper is sealed and locked, the The protective cover body forms a sleeve. The invention solves the problem that external water vapor easily enters the respirator through the cracks when the glass is shaken and cracks are generated.

The invention discloses a method for collecting hepatic portal vein blood of cynomolgus monkeys, and relates to the technical field of blood collection. Comprising the following steps: preoperative preparation work; cutting up and down along the middle abdominal line of the animal by taking the navel as a base point; after the abdominal cavity is exposed, the jejunum section of the animal is slightly pulled out of the abdominal cavity; a vein on the mesentery of the jejunum section is separated, the telecentric end is ligated, the proximal end is clamped by a vein clamp, and then a silk thread penetrates through the vein; a small opening is cut in the distal end of the vein, a catheter is inserted, after the catheter is inserted into the vein by 0.8-1.2 cm, a silk thread placed in advance is knotted, and the vein clamp is removed; the catheter is continuously inserted by 7-8 cm, and whether the catheter reaches the hepatic portal vein or not is detected by going deep into the abdominal hepatic portal vein with the hand; the catheter is fixed; resetting the ileum, leading the catheter out of the abdominal cavity, and closing the abdominal cavity; a small opening is formed in the abdominal wall on the right side, and the catheter is connected with the Port and buried subcutaneously.