The invention relates to a method for preparing high-performance polyacrylonitrile-based carbon fiber protofilament through dry spraying and wet spinning, which comprises the following steps: preparing a polyacrylonitrile spinning stock solution; filtering and metering the polyacrylonitrile spinning stock solution after the demonomerization and deaeration; squeezing obtained materials through a spinning jet for forming fine spinning streams for entering a coagulating bath for coagulating forming through an air section; and carrying out drafting, water washing, drying densification, steam drafting and drying hot forming to obtain the high-performance polyacrylonitrile-based carbon fiber. The fiber firstly passes through a section of air layer, and then enters the coagulating bath for spinning forming by a wet method. The fine streams of the spinning solution is in a cylindrical shape after leaving spinneret orifices under the action of the gas-liquid interface tension, a primary cuticular layer is formed, and the cuticular structure is smooth. The method has the advantages of simple process, easy control and relatively low cost. In addition, the method also has the advantages that the spinning speed is high, the production efficiency can be improved, in addition, the surface of the obtained protofilament is smooth, the residual quantity of the solvents is greatly reduced, the quality homogenization degree of the protofilament is improved, and the mechanical property is excellent.