The invention discloses a manufacturing method of a high temperature cable with super flexibility. The method comprises the following steps: (1), an insulating layer with polytetrafluoroethylene material is extruded and formed on a conductor, and line conductors are formed; (2), the line conductors are centralized and intertwisted, and a cable core is formed; (3), a mica tape is used to wrap the cable core, and a mica belting layer is formed; (4), copper mesh is braided at the periphery of the mica belting layer, and a copper mesh braid ply is formed; (5), fluororubber is used to extrude and form a fluororubber layer outside the copper mesh braid ply, and an embryo covering is formed; and (6), by using an electron accelerator, the embryo covering is processed to an irradiation crosslinking fluororubber covering. The cable manufactured through the method is provided with the copper mesh braid ply, the mica belting layer and the irradiation crosslinking fluororubber covering, so that the cable has the advantages of good tensile strength, small resilience and permanent deformation, ozone resistance, ultraviolet radiation resistance, oil resistance, various chemical corrosion resistance, and good high temperature resistance and flexibility.