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58results about How to "Easy to dissolve" patented technology

Method for extracting multiple active nutrient contents from sea cucumber processing liquid and application of method

The invention relates to a method for extracting multiple active nutrient contents from sea cucumber processing liquid. The method comprises the following steps: raw material collection, primary filtration, enzymolysis, rough filtration, ultrafiltration, concentration, secondary rough filtration, desalination, fermentation, centrifugation, secondary enzymolysis, secondary centrifugation, third rough filtration, secondary ultrafiltration, secondary concentration and spray drying. The invention further relates to application of the method in orally disintegrating tablets. Compared with the prior art, the method has the advantages that a prepared sea cucumber extract contains multiple nutrient contents, and the total content of sea cucumber polypeptide, small proteins, sea cucumber mucopolysaccharide and sea cucumber glycosides reaches 80%-90%; in the whole technological process, reaction conditions are mild, no organic solvent is used, nutrient contents are hardly damaged, and molecules of the extracted sea cucumber extract are relatively small; after the sea cucumber extract is fermented by using beneficial bacteria, the nutrient contents in the sea cucumber extract are easily absorbed by human bodies, and almost no peculiar smell exists; furthermore, the technological process is very suitable for the industrial expanded production.
Owner:YINGSHANG TIANHAO FOOD

Oily wastewater treatment method and whole set apparatus thereof

The invention pertains to the waste water processing technical field and relates to an oily waste water processing method and complete set of equipment thereof, which is characterized in that: firstly, the waste water is processed by an express pump and then transmitted to a steady flow cylinder by a distributor so as to be treated with demulsification and perikinetic flocculation; afterward, the waste water is transmitted to a mixing tank so as to be treated with orthokinetic flocculation; after being further charged by a high-pressure dissolved air releaser, oil-water separation is carried out to the waste water; and finally, clean water meeting the requirement of environmental protection can be obtained after the waste water is separated in an inclined tube settling zone. The processing method is characterized by simple process and equipment, low investment and low running cost.
Owner:宜兴市芳惠子环保设备厂

Medicine composition containing ceftin cyclodextrin clathrate, and its preparing method

An inclusion compound of cefuroxime axetil with high solubility, stability and activity contains cefuroxime axetil and the pharmacologically acceptable cyclodextrin chosen from alpha-cyclodextrin, beta-cyclodextrin, gamma-cyclodextrin and their derivatives. Its preparing process is also disclosed.
Owner:海南和德通医药科技信息咨询有限公司

Solid fixation alkaline agent used for reactive dye rolling braizing method dyeing

The invention discloses a solid fixation alkaline agent for pad steaming process dyeing through reactive dyes, comprising the following components in percentage by weight: 15-30 percent of alkali metal hydroxide, 60-45 percent of alkali metal carbonate, 16-10 percent of alkali metal phosphate, 1-2 percent of chelator, 2-3 percent of alkali-resistant penetrating agent, 4-8 percent of cosolvent and 1-2 percent of color light protective agent. The alkaline agent is characterized in little dosage, convenient manufacturing and transportation, etc., and has the advantages that production cost can be reduced and environmental pollution is reduced. The alkaline agent meets the requirements on efficiency increase, emission reduction and clean production, and is sufficient to replace the prior fixation soda ash for pad steaming process dyeing through reactive dyes.
Owner:夏建明 +1

Refrigerating apparatus

An object of the present invention is to keep an appropriate amount of a refrigerant to be circulated through a refrigerant circuit and prevent an overload operation of compression means due to high pressure abnormality in a refrigerating apparatus which obtains a supercritical pressure on a high pressure side. The refrigerating apparatus (R) obtains the supercritical pressure on the high pressure side. In the refrigerating apparatus (R), a refrigerant circuit (1) is formed on the high pressure side by a compressor (11), a gas cooler (46), main reducing means (62A, 62B), evaporators (63A, 63B). The refrigerating apparatus (R) comprises an oil separator (44) for separating the oil from the refrigerant sprayed from the compressor (11), an oil return circuit (73), an oil cooler (74), an oil bypass circuit (78),an electromagnetic valve (79) and a control means (C) for controlling these valves to collect a refrigerant circulated through the refrigerant circuit in the tank and discharging the refrigerant to the refrigerant circuit.
Owner:SANYO ELECTRIC CO LTD

Polishing agent for alkaline non-cyanide zincate zinc plating and process for preparing polishing agent composition

The invention is a basic cyanogen-free zincate zincification brightener and its combination brightener, using at least a nitrogen-containing heterocyclic compound 0.5-5.0mol, at least a hydroxy amine 0.5-4.0mol, and at least an acyl- or sulphonyl- containing di-t-amine 0.5-5.0mol to make random copolymerization reaction with epoxy chloropropane 4.0-10.0mol to generate a copolymer; and its making method: heating and mixing them together with a proper amount of water, the temperature controlled under return temperature and the time 0.5-2 hours, then raising temperature to return temperature and preserving heat for 4-10hours; the invention is extremely easy to dissolve in water, and when applied to basic cyanogens-free zincification technique, able to obtain excellent-performance and all-mirror brightness coating and has low cost.
Owner:JIANGMEN DESHANG KEZUO TECHNOLOGY INDUSTRIAL CO LTD

Preparation method of oxidized bacterial cellulose solution

The invention discloses a preparation method of an oxidized bacterial cellulose solution, and belongs to the field of dissolution of bacterial cellulose. The preparation method comprises the followingsteps: purifying, crushing, homogenizing and performing ultrasonic treatment to bacterial cellulose, then oxidizing by a mixed oxidizing system of TEMPO / NaBr / NaClO, then washing, performing dry crushing or dewatering to obtain oxidized bacterial cellulose powder or an oxidized bacterial cellulose slurry, dissolving the oxidized bacterial cellulose powder or the oxidized bacterial cellulose slurryby using an aqueous alkaline dissolving agent solution, then standing at a low temperature for freezing, and thawing to obtain the transparent oxidized bacterial cellulose solution. The preparation method is simple and easy to implement, a technology is easy to control, the reagent dosage is relatively low, and the cost is saved; by the preparation method, the cellulose can be effectively dissolved to directly obtain the oxidized bacterial cellulose solution; the oxidized bacterial cellulose solution can be widely applied to the field of packaging, biomedical materials, intelligent hydrogels,membrane preparation, preparation of specially-shaped hydrogels and the like, so that the application field of the bacterial cellulose is widened.
Owner:TIANJIN UNIV OF SCI & TECH

Medicine composition containing cefateram cyclodextrin capsule and its preparing method

A composite medicine with high solubility, stability and activity and low hemolytic irritation contains cefteram ester and the pharmacologically acceptable dextrin chosen from beta-cyclodextrin and its derivatives. Its preparing process is also disclosed.
Owner:海南和德通医药科技信息咨询有限公司

Laminating water-based surface treatment agent, surface treatment method and surface treated material

A laminating water-based surface treatment agent according to the present invention includes a chitosan derivative, a carboxyl compound having at least one carboxyl group in a molecule, and water. The content mass ratio of the chitosan derivative / the carboxyl compound falls within a range of 1.0 / 0.5 to 1.0 / 3.0. The laminating water-based surface treatment agent of the present invention can form an undercoating excellent in HF-resistance, electrolyte resistance, and solvent resistance, and also can sufficiently secure laminating adherence for a long term under more extreme environments required for a packaging material for a battery case or a tab lead for, e.g., a lithium ion secondary battery for automobiles.
Owner:SHOWA DENKO PACKAGING CO LTD

Method for controlling diseases of melon

The invention discloses a method for controlling diseases of melon, in order to solve the problem of serious diseases during a storage period after the melon fruits are harvested. The method comprises the following step of spraying: during the four periods, namely melon young fruit period (two weeks after flowering), quick swelling period of fruits (three weeks after flowering), forming period of overlapping curve (four weeks after flowering) and 48 hours before harvesting, uniformly spraying 0.5-1.5mmol / l of completely dissolved acetylsalicylic acid treating fluid on the surface of the fruits, and uniformly spraying in a circumference form by keeping a nozzle being 5-10cm away from the surface of the fruits while spraying, wherein spraying amount is 40-45 L / mu. At present, a fruit and vegetable anticorrosion induce resistance treatment is mainly concentrated on the period after harvesting; the method is used for spraying in field before the harvesting; the adopted acetylsalicylic acid (ASA) is low in cost and is easy to dissolve; the operation method is simple; the acetylsalicylic acid has an obvious induced resistance function; the field latent infection rate and the attack rate of the fruits during the storage period are reduced; the quality of the fruits is improved.
Owner:GANSU AGRI UNIV

Earthworm-like bait and production process thereof

InactiveCN101874565AEasy to dissolveReduces the hassle of baitingAnimal feeding stuffFishingProtein contentAdhesive
The invention discloses an earthworm-like bait and a production process thereof. The earthworm-like bait comprises the following components in percentage by weight: 10-30 percent of earthworm, 5-20 percent of fish meal, 5-20 percent of insect powder, 20-50 percent of starch, 5-20 percent of bean flour, 5-20 percent of sesame powder and 5-20 percent of adhesive. The invention has the advantages that the viscosity of earthworm mucus is larger, the earthworm mucus is a natural adhesive, and after the alive earthworm mucus is pulped and then is mixed with other feed ingredients, the activity of digestive enzymes in earthworm body fluid and coelomic fluid can be retained; the bait is not easy to dissolve and disperse in water, can float for a longer time on a fresh water surface and is a good active bait; the bait has high protein content and is prepared into an earthworm-like granule being popular to fish; and the trouble of frequently baiting a fishhook is reduced, and the baiting ratio of fish is improved.
Owner:刘蒙榕

Chili oil and preparation method thereof

The invention discloses a preparation method of chili oil, and relates to the field of seasonings. The method comprises the following steps: frying seasoning chili for 3-10 minutes at the temperature of 80-100 DEG C, and baking for 5-15 minutes, thereby obtaining seasoning chili powder; frying flavor blending chili for 3-10 minutes at the temperature of 90-110 DEG C, baking for 5-15 minutes at the temperature of 85-95 DEG C, heating to the temperature of 90-110 DEG C, frying for 3-10 minutes, and baking at the temperature of 85-95 DEG C for 5-15 minutes, thereby obtaining the flavor blending chili powder; preparing color blending pepper powder by adopting the method for preparing the flavor blending chili powder; and heating 55-60 parts of edible oil to 110-130 DEG C, adding 2-5 parts of the seasoning chili powder, 30-35 parts of the flavor blending chili powder and 8-10 parts of the color blending chili powder, and sealing and storing so as to obtain the chili oil. The chili oil which is good in pungency degree, flavor degree and color can be obtained, and is relatively healthy, and relatively rich in flavor.
Owner:武汉大汉口食品有限公司

Rapid dissolving method for ultrahigh molecular weight polyacrylonitrile

The invention relates to a rapid dissolving method for ultrahigh molecular weight polyacrylonitrile. The method comprises the following steps: (1) grinding ultrahigh molecular weight polyacrylonitrile solid particles, sieving with a 50-300 mesh sieve so as to obtain ultrahigh molecular weight polyacrylonitrile powder; (2) slowly adding the ultrahigh molecular weight polyacrylonitrile powder in a solvent with a temperature of 0 to 25 DEG C under mechanical stirring with a rotation speed of 200-1000 revolution per minute, after adding ultrahigh molecular weight polyacrylonitrile powder, heating the solvent to a temperature of 60 to 120 DEG C under mechanical stirring with a rotation speed of 200-1000 revolution per minute, maintaining the temperature for 6 to 12 hours so as to obtain a ultrahigh molecular weight polyacrylonitrile solution, and finally filtering. The rapid dissolving method for ultrahigh molecular weight polyacrylonitrile has the advantages that the dissolving temperature is low, the energy consumption is saved, and the swelling time is greatly reduced so as to quickly finish the dissolution; furthermore, the dissolution operation is convenient, the equipment is simple, and the method is easy to carry out in engineering.
Owner:DONGHUA UNIV

Production process of black tea powder bread

The invention discloses a production process of black tea powder bread and belongs to the field of food processing. The double-screw extruding process is adopted to be combined with the ultramicro crushing integrated technology for preparing black tea powder. The black tea coarse powder is placed into a feeding groove of a double-screw extruding machine at a velocity being 25 to 30kg / h, simultaneously, water is used for humidifying the black tea coarse powder in a spraying form at an auxiliary material inlet part of the extruding machine, the rotating speed and the temperature of the extruding machine are respectively set into 100r / min to 140r / min and 130DEG C and 150 DEG C, and the humidification quantity is 2kg / h to 3kg / h. The double-screw extruding powder is subjected to the ultramicrocrushing under the conditions of the feeding quantity being 20kg to 30kg, the crushing machine rotating speed being 5000r / min to 5500r / min and the crushing time being 5min to 10min, and black tea ultramicro powder is obtained. The bread made from the black tea ultramicro powder has thick black tea fragrance, fine tissue and good eating quality.
Owner:FUJIAN BEICHILE FOOD

Oligosaccharides plant induced-resistance agent effervescent tablet and preparation method thereof

The invention discloses an oligosaccharides induced-resistance agent effervescent tablet and a preparation method thereof. The oligosaccharides induced-resistance agent effervescent tablet comprises the following raw materials by weight percent: 0.5-40.0 percent of plant induced-resistance agent raw powders, 18.0-30.0 percent of solid organic acid, 30.0-40.0 percent of carbonate, 10.0-15.0 percentof a drier, 1.0-1.5 percent of a glidant and 1.0-13 percent of a promoter. Compared with the prior art, the invention has the advantages of easy dissolution in water, convenient transportation and storage, no agglomeration due to moisture and convenient use.
Owner:深圳市沃科生物工程有限公司

Cable deicing device

The invention provides a cable deicing device comprising a motor device, a roller, a rotating shaft, a motor, a cable, a connecting rod, a connecting shaft, a deicing device, a heating device, an electric heating wire, a power supply and a switch device. According to the cable deicing device, the ice layer can be heated so as to facilitate the dissolution of the ice layer in the process; and the deicing operation can be automatically performed, the advantages of time saving, labor saving and the like in the process can be realized and the existing cable is overcome. The cable freezes due to the low temperature in winter. When the mass of the ice is high, the cable is enabled to break, which has certain potential safety hazards. The device has great market potential and is popularized in the market.
Owner:郭盈涛

Synthetic fiber paper for highly heat-resistant circuit board with negative thermal expansion coefficient and preparation method and application

The invention relates to synthetic fiber paper for a highly heat-resistant circuit board with negative thermal expansion coefficient and a preparation method and application. The synthetic fiber paper is prepared from the following components in percentage by weight: 10-90% of structural fiber and the balance of viscose fibers, wherein the viscose fibers are fibers with negative thermal expansion coefficient and are selected from poly-p-phenylene terephthamide precipitation fibers and / or poly (p-phenylene terephthalamide) pulp. The preparation method comprises the following steps: preparing the structural fibers and viscose fibers into papermaking pulp; papermaking and moulding by a wet process; and hot-rolling and calendering to prepare the synthetic fiber paper. X-Y axis thermal expansion coefficient (CTE) in a plane of the synthetic fiber paper is negative and can offset CTE of thermosetting resin in a substrate of a printed circuit board, so that the printed circuit board is relatively stable and reliable, and the synthetic fiber paper can be applied to preparing a reinforcing material of the substrate of the printed circuit board.
Owner:深圳昊天龙邦复合材料有限公司

Preparation method of Cu2-xSe nanochip

The invention relates to a preparation method of a Cu2-xSe chip. The preparation method comprises following steps: (1) preparing a copper precursor solution; (2) preparing a selenium precursor solution; (3) performing filling reflux to generate the Cu2-xSe chip; and (4) washing the Cu2-xSe chip and performing liquid removing to obtain the Cu2-xSe chip in the invention. In the preparation method, a polyol is employed as a solvent, ethanediamine is employed as a reducing agent, and an inorganic copper salt is employed as a precursor so that dissolution is easy to carry out and the preparation method is low in requirement on devices. Not only is a problem of environmental pollution solved but also a product preparation cost is reduced. By means of a solution chemical synthesis method under normal pressure, the preparation method is simple in technology, is easy to control, is less in discharge and is good in safety. The Cu2-xSe chip is good in dispersing performance, is uniform in appearance, is high in crystallization degree and is suitable for large-scale industrial production.
Owner:天津恒电空间电源有限公司 +1

Washing method implemented by washing machine

The invention discloses a washing method implemented by a washing machine. The washing method has the advantages that rinsing and washing are completed in a combined manner by a washing and pre-rinsing combining step, so that national standards on rinsing and washing parameters can be met, and energy consumption can be reduced.
Owner:NANJING LG PANDA APPLIANCES

Hollow part electroforming furrow filling method

The filling method of the groove during the electroforming of the hollow part belongs to the domain of the electroform process. The filling of the grove is performed twice layers respectively: the first layer chooses the diffluent plastic to be the bottom layer (3); the second layer adopts the homogeneity plastic mixing with the certain percent of the metal powder, the layer is served as the electric layer (4), it has the good capability of conducting and engine machining. If the hole passing the liquid used for washing is obligated on the bottom of the first material, the filling material after the electroforming can be dissolved to wipe off better. The invention is fit for the mallow parts, especially, it is fit for the thin route to fill the grove before the electroforming and wipe off the filling material after the electroforming. The process is easy. The period of filling and pulling off the model is short. The core model produced by the invention has many merits such as the low size precision, the good electric ability and without the remaining filling material after the pulling off the model.
Owner:NANJING UNIV OF AERONAUTICS & ASTRONAUTICS

Settleable anti-rusting water-based grinding fluid and preparation method thereof

The invention provides a settleable anti-rusting water-based grinding fluid which is characterized by being prepared from the following components in percentage by mass: 5-15% of a settling agent, 5-10% of a flocculating agent, 15-30% of a lubricant, 25-30% of an anti-rusting agent, 1-2% of a bactericide, 1-5% of a coupling agent, 1-2% of a defoaming agent and the balance of water, wherein the settling agent is organic sulfur. By the adoption of the settleable anti-rusting water-based grinding fluid, the problem that fine dust such as iron powder and oil stone powder cannot be effectively settled in the grinding process is solved, and the grinding fluid can be in long-term and stable lubrication property and washing property in the machining process, and is long in service life, excellent in anti-rusting property and excellent in comprehensive property.
Owner:马艳荣

Chaihuang preparation and its quality control method

The present invention discloses a Chinese medicine Chaihuang preparation. It is made up by using (by weight portion) 100-150 portions of bupleurum root, 6-12 portions of scutellaria root and proper quantity of auxiliary material through a certain preparation process. Besides, said invention also provides a quality control method of said Chailhuang preparation.
Owner:SICHUAN BAILI PHARM CO LTD

A kind of preparation method of 2-(4-chlorophenethyl)-2-tert-butyl oxirane

The invention discloses a preparation method of 2-(4-chlorophenethyl)-2-tert-butyl oxirane, which is characterized in that: the 2-(4-chlorophenethyl)-2-tert-butyl oxirane Ethane is produced by the methylation reaction of 4,4-dimethyl-1-(4-chlorophenyl)-3-pentanone, dimethyl sulfide, and dimethyl sulfate under alkaline conditions; The steps are: first, dimethyl sulfide and dimethyl sulfate are synthesized into salt at 20-30°C, and then the resulting salt is combined with 4,4-dimethyl-1-(4-chlorobenzene)-3 - Pentanone reacts at 30-40°C to generate 2-(4-chlorophenethyl)-2-tert-butyloxirane, and at the same time, dimethyl sulfide is released. The invention has the advantages of: using dimethyl sulfide as a solvent has a low boiling point of sulfide, is easy to desolventize, can be recycled repeatedly, consumes little solvent, greatly shortens the production cycle, and improves production efficiency.
Owner:NANTONG PAISIDI PESTICIDE CHEM

Method for preparing lutein visual function intensifying egg by nondestructively penetrating avian eggshell membrane

The invention discloses a method for preparing a lutein visual function intensifying egg by nondestructively penetrating an avian eggshell membrane. The method comprises the steps of enzymolysis treatment of the eggshell membrane, treatment with a lutein penetrating agent, vacuum packaging and ultrahigh pressure treatment and the like. According to the method provided by the invention, mainly through firstly carrying out the enzymolysis treatment on the eggshell membrane of an egg, the permeability of the eggshell membrane is ameliorated; the penetrability of an eggshell is promoted through the ultrahigh pressure treatment; thus, the penetration efficiency of lutein and the content of the lutein in the egg are improved; further, the problems that the lutein is low in enrichment content, and further, is difficult to control, long in production period and high in production cost and the like in a conventional method are solved; meanwhile, after the treatments of the above steps, the physical characteristics of the color, the aroma and the taste of the egg cannot be changed either; the storage of a lutein functional egg is facilitated; and moreover, the method is green, environment-friendly, safe and reliable in treatment process.
Owner:宣城九只鸭健康科技有限公司 +1

Synthesized soap powder

The invention discloses a synthesized soap powder comprising sodium carbonate, methyl cellulose, anhydrous sodium sulphate, dodecylbenzene sulfonic acid, alkylphenol ether (TX-10), lauroyl diethanolamide, alkaline protease, a fluorescent powder, a rose essence and a puffed powder. The synthesized soap powder has the advantages of reasonable formula, strong detergency, large whiteness, no phosphorus, no toxicity and small pollution, and is easy to dissolve.
Owner:SUZHOU CITY WUZHONG DISTRICT TAIHU LIGHT TEXTILE

Method for extracting sodium thiocyanate from ADA desulfurization waste liquid

The invention provides a method for extracting sodium thiocyanate from an ADA desulfurization waste liquid, and relates to the technical field of extraction of sodium thiocyanate, wherein the ADA desulfurization waste liquid includes the following steps: (1) directly taking the ADA desulfurization waste liquid, decolorizing, filtering, and collecting mother liquor; (2) carrying out decompression evaporation concentration operation on the collected mother liquor, to obtain a concentrated material solution; (3) adding an ethanol aqueous solution slowly into the concentrated material solution, and cooling down to 35-45 DEG C while stirring; and (4) filtering, collecting a filtrate, carrying out decompression evaporation concentration, carrying out cooling crystallization, and carrying out centrifugal separation to prepare sodium thiocyanate. The technical problems that an ADA desulfurization waste liquid needs to be subjected to high-temperature evaporation and centrifugal separation to extract mixed salts in the earlier stage of the prior art, resulting in high energy consumption and high separation equipment requirements are effectively solved, high-efficiency dissolution of thiocyanate by the ethanol aqueous solution system is achieved, and the dissolution amount of impurity salts is guaranteed to reach low level at low temperature, so as to achieve the technical effect of precipitating sodium thiocyanate crystals from the mixed solvent rapidly.
Owner:江苏燎原环保科技股份有限公司

Medicine dispensing device

The invention discloses a medicine dispensing device. The medicine dispensing device comprises a transfusion end insertion needle, a medicine dispensing insertion needle and a power device interface. A first channel used for making a transfusion container and a medicine dispensing container communicated is formed between the transfusion end insertion needle and the medicine dispensing insertion needle, and a second channel used for making the medicine dispensing container and a power device communicated is formed between the medicine dispensing insertion needle and the power device interface; when the medicine dispensing insertion needle is inserted into the medicine dispensing container, one end of the first channel and one end of the second channel are connected with each other through an inner cavity of the medicine dispensing container, so that a reverse cycle channel from transfusion end insertion needle to the medicine dispensing insertion needle to the power device interface is formed; liquid in the transfusion container and dispense medicines in the medicine dispensing container are driven by the power device, so that the automatic medicine dispensing process that medicines are dissolved in the forward direction and reflowing is conducted in the reverse direction is completed in the reverse cycle channel. The device is simple in construction, medicines are convenient to dissolve and dispense, the operation is simple and saves labor, and the device is safe and reliable to use. By means of the device, medicine dispensing can be quickly completed under pollution free conditions, the medicine dissolving and dispensing labor intensity of nurses is reduced, and work efficiency is improved.
Owner:李春旭

Coarse cereal protein sausage and preparation method thereof

The invention relates to a coarse cereal protein sausage. The coarse cereal protein sausage is prepared by adding coarse cereal protein powder which is 5-10% by weight of total meat into meat stuffing. The invention also relates to a preparation method of the coarse cereal protein sausage. According to the invention, the coarse cereal protein powder is added into the sausage, so that compared withcommon coarse cereal sausages, the prepared coarse cereal protein sausage has more exquisite mouth feel. The protein extracted from coarse cereals is easier to dissolve than that of the coarse cereals. Besides, the coarse cereal protein can be increased as required on the premise of not influencing the taste, so that the coarse cereal protein sausage has good taste, high protein content and richamino acid composition, and the method effectively improves the nutritional value of the sausage and also has the effect of improving the flavor.
Owner:HEILONGJIANG BAYI AGRICULTURAL UNIVERSITY

Freeze-drying method for preparing ganciclovir

The invention discloses a freeze-drying method of ganciclovir. The condensation temperature is set as -30 to -20 DEG C in advance during freeze-drying, the vacuum degree is controlled as 0.1-0.3 mbar,the operation time is 2000-2200 min, then the temperature is set as 30-40 DEG C, the vacuum degree is controlled as 0.1-0.3 mbar, and the operation time is 100-300 min; and then heat preservation isconducted for 60-120 min at 30-40 DEG C. According to the freeze-drying method, a constant temperature gradient is adopted to conduct freeze drying in each freeze-drying stage, thus the number and size of crystal nucleus of a product solution reach the most appropriate degree, the phenomenon of product shrinkage is greatly reduced, the dried product is more loose and porous, and dissolving is easier after water is added.
Owner:WUXI KAIFU PHARMA

Process for synthetizing 2-thiopheneacetyl chloride

InactiveCN104016962AReduce dosageLow boiling pointOrganic chemistry2-thiopheneacetic acidFiltration
The invention relates to a process for synthetizing 2-thiopheneacetyl chloride. The method comprises the following steps: dissolving 2-thiopheneacetic acid in dichloromethane, heating in the presence of nitrogen, dropping thionyl chloride in the state of keeping the system slightly boiling and holding the temperature for 2-3 hours after the dropping is completed; finally, carrying out suction filtration, desolvation and reduced pressure distillation to obtain the product 2-thiopheneacetyl chloride. The process disclosed by the invention has the positive effects that the dichloromethane low in boiling point is adopted as the solvent, so that the desolvation is easy and the product content is not influenced; SO2 and HCl produced in the reaction can be volatilized along with the dichloromethane through keeping a proper reaction temperature, so that the reaction can be fully carried out and the reaction yield is increased; the volatilized dichloromethane is cooled through cold saline and can be recycled after being washed by water; the process is mild in reaction condition, little in catalyst amount and simple; compared with an existing synthesis process, the process disclosed by the invention has obvious economic benefit and environmental benefit and is beneficial to industrial production.
Owner:SHANGQIU KOREATA CHEM
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