54 results about "Contraceptive Effect" patented technology

The invention relates to a chitosan plural gel foaming agent suitable for a female sperm shielding and killing dual-contraception effect and a preparation method thereof, and belongs to the technical field of foaming agent production. The chitosan plural gel foaming agent suitable for the female sperm shielding and killing dual-contraception effect has a dual-contraception effect of vagina shielding and vagina sperm killing, and meanwhile has a fungal-infection-resistant effect. The foaming agent forms a medicament liquid by consisting of a matrix, a surface active agent, an auxiliary medicament, a cosolvent, an acidifier, a foaming agent, a foam stabilizing agent and a solvent, and the foaming agent and a propellent form a plural gel foaming agent according to the weight proportion of (100:10) to 20. The preparation method comprises the following steps: dissolving chitosan and carbomer into a citrate buffer solution with a certain amount; blending, heating to 80 DEG C to dissolve completely, adding the surface active agent so as to obtain a solution A; dissolving borneol, menthol crystal and stearic acid into glycerol, dissolving fully, and filtering so as to obtain a solution B; adding the solution B into the solution A, mixing fully, adding citric acid and SLS (sodium lauryl sulfate), supplying the buffer solution to the required weight, carrying out vacuum homogenizing for 2 hours, thereby obtaining the gel foaming preparation, and then adding the propellent.

Discloses is a condom. A sperm storage bag, a glans sleeve, a closed coronary sulcus zone, a strip band and a penis inlet elastic ring are connected sequentially. When a female has a sex with a male, the male wears the condom, the glans is sealed through the closed coronary sulcus zone, the sperm is closed to the glans and the sperm storage bag by the closed coronary sulcus zone after the male ejaculates, then the contraceptive effect is achieved, the penis and the inner wall of vagina are in direct contact, and the intimacy is improved.

The invention relates to an after emergency contraception medicament composition containing low-dose levonorgestrel without reducing contraceptive effect. In the medicament composition, the consumption of levonorgestrel contained by a medicament dosage unit with single-dosage medicament for emergency contraception is reduced from conventional 1.5 mg to 1.00 to 1.25 mg, and the consumption of levonorgestrel contained by the medicament dosage unit with two-dosage administration is reduced from conventional 0.75 mg to 0.50 to 0.625 mg. The composition reduces the dosage of the levonorgestrel used relative to conventional medicament dosage and reduces individual differences as well as adverse reaction, thereby having important clinical significance. The invention also provides a method for preparing the medicament composition, as well as the application of the medicament composition in the preparation of emergency contraception medicaments.

The invention discloses a nano-particle wrapped with small RNA (Ribose Nucleic Acid) for inhibiting embryo implantation, and belongs to the technical field of molecular cytology. The inhibiting effect of mir-181 to LIF (Leukemia Inhibitory Factor) protein expression is firstly determined, and the inhibiting effect of the same to embryo implantation is verified; furthermore, nanometer material polyethylene glycol-polyethylene glycol is prepared to be nano-particles wrapped with the small RNA, and the nano-particles are good in stability in mice and successful to inhibit embryo implantation. The preparation method provided by the invention is simple; contraceptive product obtained by the method inhibits embryo implantation in a non-hormonal manner to achieve the effect of contraception, thus being free from side effect to human body caused by the change of hormone, good in stability in vivo and obvious in contraceptive effect.

The invention discloses a contraceptive plug, which comprises a guide rod, at least one radial-pattern supporter windingly connected with the guide rod, and a film attached to the supporter. The guide rod can be easily placed in the interstitial portion of fallopian tube, the top end of the radial-pattern supporter can be embedded in uterine muscles to prevent the contraceptive plug from moving and falling, and the film attached to the supporter can efficiently prevent sperms entering the fallopian tube, so as to achieve contraceptive effect and achieve high success rate of contraception. Because the radial-pattern supporter is deformable compared with bumps with solid planar cross section, therefore, the inventive contraceptive plug has good flexibility.

A human epididymis protease profilin immunological contraception polypeptide is characterized in that the basic amino acid sequence of the polypeptide is amino terminal-LSEIKGVIVHRLEGVGGGMFVYGGCQGNNNN-carboxyl terminal; lysine can be used as linker to combine a plurality of the basic amino acid sequences together to compose multiple copies of series connection structure. The invention has the advantages that the product is easy to transport and preserve and the automated production of the product can be realized; the invention has effective immunogenicity and antigenicity, obvious immune effect, high effective and reversible contraceptive effect, safe use and no side effect.

An intra-uterine contraceptive device with a shape restoring temp not higher than 36.9 deg.C and an elastic value equal to 0.15-0.75 N is made up of TiNi shape memory alloy and copper through making the parts with TiNi shape memory alloy, making the parts with copper, and assembling.

The invention discloses a slow-soluble external contraceptive membrane. The contraceptive membrane is prepared from the raw materials such as 0.05 to 1.5 parts of nonoxinol-9, 0.3 to 2 parts of super carboxymethyl starch sodium, 0.3 to 3 parts of hydroxypropyl methyl cellulose, 0.1 to 0.3 part of polyacrylic resin film agent, 1 to 3 parts of polyethylene glycol, 2 to 10 parts of lubricating agent and the like. The contraceptive membrane prepared by using the material composition has slow solubility and high medicament dissolution, and has effects of absorbing seminal fluid and killing sperms. After the contraceptive membrane prepared from the materials is put into the vagina, sexual intercourse can be performed immediately, and waiting is not needed. The stiff and smooth membrane shape is kept for 3 hours when the contraceptive membrane is not contacted with the seminal fluid, and sperm killing medicaments are slowly released, so that loss of the sperm killing medicaments in short time can be avoided; and the release of the sperm killing medicaments is accelerated when the contraceptive membrane is contacted with the seminal fluid, and the performance ensures high efficiency of the sperm killing medicaments and can improve the contraceptive effect. The membrane material has good compatibility with vaginal mucosa, has irritability resistance, flexibility and comfort, and can eliminate the stimulation effect of the nonoxinol-9 on the skin mucosa.

The invention belongs to the technical field of dispensing of pharmaceutical preparations, and particularly relates to composition capable of contracepting an offspring and preventing infection of a venereal disease and an acquired immune deficiency syndrome. The invention provides a vaginal contraceptive ointment which can prevent the infection of the venereal disease and the acquired immune deficiency syndrome and has a good contraceptive effect. Compared with an existing vaginal contraceptive ointment, the vaginal contraceptive ointment takes gossypol which makes sperms lose the motor ability as an effective contraceptive component, a traditional spermicide, namely, phenylmercuric acetate which has a greater toxic and side effect is not used any more, and the vaginal contraceptive ointment is safer and more effective; meanwhile, the antiviral property and the anti-HIV activity property of the gossypol are utilized, the bactericidal effect of double alkyl quaternary ammonium salt fungicides is assisted, the risk of spreading the venereal disease and the acquired immune deficiency syndrome through body fluids during sexual intercourse is eliminated, the infection of the venereal disease and the acquired immune deficiency syndrome during the sexual intercourse can be effectively prevented, and the composition capable of contracepting the offspring and preventing the infection of the venereal disease and the acquired immune deficiency syndrome has broad application prospect in the field of health.

The invention discloses an ultrafine crystal Cu-Mg alloy intrauterine device. An ultrafine crystal Cu-Mg alloy is taken as a copper ion source; the ultrafine crystal Cu-Mg alloy contains 0-1wt.% of Mgand the balance of Cu, but the content of the Mg is greater than 0; and the average grain size of the ultrafine crystal Cu-Mg alloy is smaller than 1 micron. The ultrafine crystal Cu-Mg alloy is taken as the copper ion source, so that corrosion is uniform; burst release of copper ions in an initial implanting stage is avoided; the copper ions are controllable in release rate and are stably released for a long period of time; excessive corrosion products are not deposited; and the ultrafine crystal Cu-Mg alloy intrauterine device is excellent in contraceptive effect and low in risk of complications, such as hemorrhage, pain and inflammation.

The invention discloses a platycodin D sperm-killing contraceptive suppository for external use. The contraceptive suppository is characterized in that the active ingredient of the suppository is platycodin D diluent; the platycodin D diluent is different concentrations of physiological saline solution of platycodin D extracts; and the suppository is solid at normal temperature. When the contraceptive suppository is used, the contraceptive suppository is quickly dissolved in vaginas at body temperature, is in a semi-liquid state and can quickly kill sperms after being in contact with the sperms and deactivate the sperms, thus playing a role in contraception. The invention also discloses a matched placing device of the contraceptive suppository. The contraceptive suppository has a good contraceptive effect and can avoid unplanned pregnancy.

The invention discloses a heart-shaped three-dimensional intrauterine device. The intrauterine device comprises a first annulus and a second annulus, wherein the upper parts of the first annulus and second annulus are wider than the lower parts; two side connecting reinforcements and two upper connecting reinforcements are arranged between the first annulus and the second annulus, the two upper connecting reinforcements are arranged on the tops of the first annulus and the second annulus, the two side connecting reinforcements are arranged on the lower parts of the first annulus and the second annulus, two first vertical reinforcements are arranged on the first annulus, two second vertical reinforcements are arranged on the second annulus; and a first annulus bending part which bends inward is arranged on the top of the first annulus, and a second annulus bending part which bends inward is arranged on the top of the second annulus. The invention can solve the problems of the prior art, greatly increase the contraceptive effect and effectively prevent the intrauterine device from dropping and displacing; and the top of the intrauterine device is depressed so that the intrauterine device can more effectively stick to the lining of the uterine cavity and the intrauterine device can be worn more comfortably and safely.

A sperm reducing agent compound with contraceptive effect comprises an aqueous solution, a binding agent and a lubricant. The binding agent is polysaccharide accounting for 0.3 to 10 percent of the compound (weight); the lubricant is alcohol accounting for 0.5 to 10 percent of the compound (weight); the stickiness of the compound is above 9,000cst (centistokes) so as to mix the compound with female genitalia liquid and sperm and form high-stickiness colloid, thus preventing sperm from swimming, sealing cervix and further achieving contraceptive effect.

A condom is configured to include a space such that a front glans part of the condom does not excessively come into contact with the penis of a man by selecting a material having moderate elasticity such as soft synthetic resin or synthetic latex rubber or a foamed rubber material conforming thereto or the like for the front part of the condom made from a soft rubber material; and includes embossed sponge layers or fine soft hairs additionally laminated on the inside and outside of the condom, to provide an excellent moisturizing effect such that an excellent contraceptive effect and a sexual pleasure-increasing effect can be simultaneously obtained when a user wears the condom, thereby providing multiple effects such as contributing to the treatment of patients with chronic dyspareunia or patients with anorgasmia and the like.

The invention relates to the technical field of processes for preparing contraceptive products, in particular to a process for preparing a contraceptive drug in a traditional Chinese medicine formula. The process for preparing the contraceptive drug comprises the following steps of: firstly, preparing materials A, B and C, wherein a preparation process of the material A comprises the steps of weighing equal portions of black fungus and palm root, stewing the black fungus and palm root to be tender after cleaning, and then adding brown sugar and simmering to obtain the pasty material A; the preparation process of the material B comprises the steps of weighing equal portions of eggplant flower, drying after cleaning, and grinding to obtain the powdery material B; and the preparation process of the material C comprises the steps of weighing persimmon calyx with stems, baking after cleaning, and grinding with a non-iron appliance to obtain the powdery material C; secondly, mixing 1 part of material A, 1.5-2.5 parts of material B and 2.5-3.5 parts of material C by weight; and thirdly, baking the mixed material, and grinding into powder, thus the contraceptive drug is obtained. The contraceptive drug produced by adopting the process in the invention can realize a lasting contraceptive effect by adopting a manner of ovulation inhibiting, contains no western-medicine hormone or chemical and has no toxic or side effect to a human body.

The invention relates to contraceptive. The contraceptive is characterized by comprising the following components by mass in single dosage: 10-50mu g of gestodene, 1.5-10mg of nomegestrol, 0.2-0.5mg of levonorgestrel, 1-20mg of drospirenone, 0.5-10mg of cyproterone, 10-20mu g of ethinyloestradiol, 40-80g of saccharose and 5-20mu g of mestranol. The sum of the content of the ethinyloestradiol and the content of the mestranol is not more than 30mu g; and the sum of the content of the cyproterone, the content of the ethinyloestradiol and the content of the saccharose is 2-20mg. The contraceptive adopts the means that multiple progestational hormones and estrogenic hormones are mixed for use so as to reduce the estrogenic hormones, so that the obtained contraceptive can guarantee less injury to a human body under the condition with better contraceptive effect.

The invention discloses a chrysanthemum extract with contraceptive effect and a plant contraceptive thereof, and the method comprises the following steps: placing chrysanthemum and pure water in an extraction tank, heating to boiling, reducing the temperature to 75-85 DEG C, keeping slight boiling for 1-3 hours, and then carrying out solid-liquid separation to obtain an extraction crude liquid; concentrating under reduced pressure to obtain a total chrysanthemum extract; eluting the total chrysanthemum extract twice through macroporous resin to obtain a chrysanthemum extract; the plant contraceptive contains the chrysanthemum extract. After the chrysanthemum extract extracted by the invention is used for any day after menstruation is clean and before ovulation, the intimal thickness can be obviously reduced, and an effective contraception effect is achieved. The plant contraceptive disclosed by the invention only needs to be used for one day and cannot be missed; the beverage can be drunk after being dissolved in water, and is simple and convenient.

To produce a medicament with a menstruating contraceptive effect, it consists of a sequential oral dosage unit of mifepristone followed by vaginal administration of a dosage unit of misoprostol 36-48 hours later. The invention is convenient to use, adopts oral and vaginal medication, and the dosage is small, the effect is good, the bleeding time is shorter than conventional medical abortion, and anxiety and pain can be relieved without any complication.