55 results about "Contraceptive Effect" patented technology

Contraceptive intrauterine devices made of thin film shape memory alloy materials. The devices are formed in three-dimensional shapes which contact uterus tissue of a human or other mammal to prevent conception. In certain embodiments, structural features such as tails, fenestrations, ridges or grooves are formed on the devices to enhance the contraceptive effect.

Contraceptive intrauterine devices made of thin film shape memory alloy materials. The devices are formed in three-dimensional shapes which contact uterus tissue of a human or other mammal to prevent conception. In certain embodiments, structural features such as tails, fenestrations, ridges or grooves are formed on the devices to enhance the contraceptive effect.

The invention relates to a chitosan plural gel foaming agent suitable for a female sperm shielding and killing dual-contraception effect and a preparation method thereof, and belongs to the technical field of foaming agent production. The chitosan plural gel foaming agent suitable for the female sperm shielding and killing dual-contraception effect has a dual-contraception effect of vagina shielding and vagina sperm killing, and meanwhile has a fungal-infection-resistant effect. The foaming agent forms a medicament liquid by consisting of a matrix, a surface active agent, an auxiliary medicament, a cosolvent, an acidifier, a foaming agent, a foam stabilizing agent and a solvent, and the foaming agent and a propellent form a plural gel foaming agent according to the weight proportion of (100:10) to 20. The preparation method comprises the following steps: dissolving chitosan and carbomer into a citrate buffer solution with a certain amount; blending, heating to 80 DEG C to dissolve completely, adding the surface active agent so as to obtain a solution A; dissolving borneol, menthol crystal and stearic acid into glycerol, dissolving fully, and filtering so as to obtain a solution B; adding the solution B into the solution A, mixing fully, adding citric acid and SLS (sodium lauryl sulfate), supplying the buffer solution to the required weight, carrying out vacuum homogenizing for 2 hours, thereby obtaining the gel foaming preparation, and then adding the propellent.

The fixed extended cycle method of female hormonal contraception includes continuous daily administration of daily dosage units of a monophasic preparation to a woman over a time period of n×21 days, wherein n=2, 3, 4 or 5, immediately followed by a seven-day pill-break in which the monophasic preparation is not administered. Each of the daily dosage units contains from 0.5 to 3.0 mg of dienogest and from 10 to 30 μg of ethinyl estradiol. In addition to effective contraceptive action the method significantly reduces the bleeding rate, is simple and is effective in treating acne, dysmenorrhea and / or endometriosis.

Discloses is a condom. A sperm storage bag, a glans sleeve, a closed coronary sulcus zone, a strip band and a penis inlet elastic ring are connected sequentially. When a female has a sex with a male, the male wears the condom, the glans is sealed through the closed coronary sulcus zone, the sperm is closed to the glans and the sperm storage bag by the closed coronary sulcus zone after the male ejaculates, then the contraceptive effect is achieved, the penis and the inner wall of vagina are in direct contact, and the intimacy is improved.

The invention relates to an after emergency contraception medicament composition containing low-dose levonorgestrel without reducing contraceptive effect. In the medicament composition, the consumption of levonorgestrel contained by a medicament dosage unit with single-dosage medicament for emergency contraception is reduced from conventional 1.5 mg to 1.00 to 1.25 mg, and the consumption of levonorgestrel contained by the medicament dosage unit with two-dosage administration is reduced from conventional 0.75 mg to 0.50 to 0.625 mg. The composition reduces the dosage of the levonorgestrel used relative to conventional medicament dosage and reduces individual differences as well as adverse reaction, thereby having important clinical significance. The invention also provides a method for preparing the medicament composition, as well as the application of the medicament composition in the preparation of emergency contraception medicaments.

This invention relates to a method of producing an auto induced biological barrier against spermatozoids and / or other microorganisms including viruses and / or pre cancers or non invasive cancers involving the production of an autoimmune reaction in a host in need of such auto-inducement. The invention is characterized in that it comprises the steps of producing heat shock proteins inside vaginal and cervical mucosal cells and releasing said heat shock proteins into the vaginal cavity thus inducing an autoimmune response through a trigger and / or stimulation of both innate and adaptive systems and, as a consequence, the production of: a contraceptive effect through the elimination of the migration or free movement of individual or populations of spermatozoids and / or an inhibition of the maturation and / or capacitation process of the same and / or a neutralization or destruction of the same; a prophylactic effect through an elimination of the migration or free movement of individual or populations of other microorganisms including viruses and / or a neutralization or destruction of the same; a prophylactic effect against pre cancers; a therapeutic effect against non invasive cancers. The invention also relates to a device for using said method comprising a hollow body (1) provided with a heat source on the inside as well as with a means (13, 27) of removal of said hollow body from the vaginal or rectal cavity and a means (6, 8, 10) capable of exchanging heat originating from the hollow body.

A new and improved hybrid “framed-frameless” copper-releasing contraceptive device (IUD) which is a combination of a plastic retention arm of reduced dimensions to adapt to uterine cavities of smaller size, particularly regarding their transverse width at the fundal level of the uterus, and whose retention arm has a centrally located extension of varying length to be connected with hollow copper tubes which functions as the frameless stem of the IUD, and which consists of loosely connected hollow tubes, threaded on a length of suture, or a thin plastic or metallic stem, or a thin polymeric drug eluting stem, allowing release of copper ions, from the outside and from the inside of the tubes, in the uterine cavity thereby enhancing the contraceptive effect, and of which the bottom tube, is crimped onto the lower end of the stem, including a separate metallic ion-releasing fiber, holding all copper tubes together.

The invention discloses a nano-particle wrapped with small RNA (Ribose Nucleic Acid) for inhibiting embryo implantation, and belongs to the technical field of molecular cytology. The inhibiting effect of mir-181 to LIF (Leukemia Inhibitory Factor) protein expression is firstly determined, and the inhibiting effect of the same to embryo implantation is verified; furthermore, nanometer material polyethylene glycol-polyethylene glycol is prepared to be nano-particles wrapped with the small RNA, and the nano-particles are good in stability in mice and successful to inhibit embryo implantation. The preparation method provided by the invention is simple; contraceptive product obtained by the method inhibits embryo implantation in a non-hormonal manner to achieve the effect of contraception, thus being free from side effect to human body caused by the change of hormone, good in stability in vivo and obvious in contraceptive effect.

The invention discloses a contraceptive plug, which comprises a guide rod, at least one radial-pattern supporter windingly connected with the guide rod, and a film attached to the supporter. The guide rod can be easily placed in the interstitial portion of fallopian tube, the top end of the radial-pattern supporter can be embedded in uterine muscles to prevent the contraceptive plug from moving and falling, and the film attached to the supporter can efficiently prevent sperms entering the fallopian tube, so as to achieve contraceptive effect and achieve high success rate of contraception. Because the radial-pattern supporter is deformable compared with bumps with solid planar cross section, therefore, the inventive contraceptive plug has good flexibility.

A human epididymis protease profilin immunological contraception polypeptide is characterized in that the basic amino acid sequence of the polypeptide is amino terminal-LSEIKGVIVHRLEGVGGGMFVYGGCQGNNNN-carboxyl terminal; lysine can be used as linker to combine a plurality of the basic amino acid sequences together to compose multiple copies of series connection structure. The invention has the advantages that the product is easy to transport and preserve and the automated production of the product can be realized; the invention has effective immunogenicity and antigenicity, obvious immune effect, high effective and reversible contraceptive effect, safe use and no side effect.

An intra-uterine contraceptive device with a shape restoring temp not higher than 36.9 deg.C and an elastic value equal to 0.15-0.75 N is made up of TiNi shape memory alloy and copper through making the parts with TiNi shape memory alloy, making the parts with copper, and assembling.

The invention discloses a slow-soluble external contraceptive membrane. The contraceptive membrane is prepared from the raw materials such as 0.05 to 1.5 parts of nonoxinol-9, 0.3 to 2 parts of super carboxymethyl starch sodium, 0.3 to 3 parts of hydroxypropyl methyl cellulose, 0.1 to 0.3 part of polyacrylic resin film agent, 1 to 3 parts of polyethylene glycol, 2 to 10 parts of lubricating agent and the like. The contraceptive membrane prepared by using the material composition has slow solubility and high medicament dissolution, and has effects of absorbing seminal fluid and killing sperms. After the contraceptive membrane prepared from the materials is put into the vagina, sexual intercourse can be performed immediately, and waiting is not needed. The stiff and smooth membrane shape is kept for 3 hours when the contraceptive membrane is not contacted with the seminal fluid, and sperm killing medicaments are slowly released, so that loss of the sperm killing medicaments in short time can be avoided; and the release of the sperm killing medicaments is accelerated when the contraceptive membrane is contacted with the seminal fluid, and the performance ensures high efficiency of the sperm killing medicaments and can improve the contraceptive effect. The membrane material has good compatibility with vaginal mucosa, has irritability resistance, flexibility and comfort, and can eliminate the stimulation effect of the nonoxinol-9 on the skin mucosa.

The invention belongs to the technical field of dispensing of pharmaceutical preparations, and particularly relates to composition capable of contracepting an offspring and preventing infection of a venereal disease and an acquired immune deficiency syndrome. The invention provides a vaginal contraceptive ointment which can prevent the infection of the venereal disease and the acquired immune deficiency syndrome and has a good contraceptive effect. Compared with an existing vaginal contraceptive ointment, the vaginal contraceptive ointment takes gossypol which makes sperms lose the motor ability as an effective contraceptive component, a traditional spermicide, namely, phenylmercuric acetate which has a greater toxic and side effect is not used any more, and the vaginal contraceptive ointment is safer and more effective; meanwhile, the antiviral property and the anti-HIV activity property of the gossypol are utilized, the bactericidal effect of double alkyl quaternary ammonium salt fungicides is assisted, the risk of spreading the venereal disease and the acquired immune deficiency syndrome through body fluids during sexual intercourse is eliminated, the infection of the venereal disease and the acquired immune deficiency syndrome during the sexual intercourse can be effectively prevented, and the composition capable of contracepting the offspring and preventing the infection of the venereal disease and the acquired immune deficiency syndrome has broad application prospect in the field of health.

The invention discloses an ultrafine crystal Cu-Mg alloy intrauterine device. An ultrafine crystal Cu-Mg alloy is taken as a copper ion source; the ultrafine crystal Cu-Mg alloy contains 0-1wt.% of Mgand the balance of Cu, but the content of the Mg is greater than 0; and the average grain size of the ultrafine crystal Cu-Mg alloy is smaller than 1 micron. The ultrafine crystal Cu-Mg alloy is taken as the copper ion source, so that corrosion is uniform; burst release of copper ions in an initial implanting stage is avoided; the copper ions are controllable in release rate and are stably released for a long period of time; excessive corrosion products are not deposited; and the ultrafine crystal Cu-Mg alloy intrauterine device is excellent in contraceptive effect and low in risk of complications, such as hemorrhage, pain and inflammation.

The invention discloses a platycodin D sperm-killing contraceptive suppository for external use. The contraceptive suppository is characterized in that the active ingredient of the suppository is platycodin D diluent; the platycodin D diluent is different concentrations of physiological saline solution of platycodin D extracts; and the suppository is solid at normal temperature. When the contraceptive suppository is used, the contraceptive suppository is quickly dissolved in vaginas at body temperature, is in a semi-liquid state and can quickly kill sperms after being in contact with the sperms and deactivate the sperms, thus playing a role in contraception. The invention also discloses a matched placing device of the contraceptive suppository. The contraceptive suppository has a good contraceptive effect and can avoid unplanned pregnancy.

The invention discloses a heart-shaped three-dimensional intrauterine device. The intrauterine device comprises a first annulus and a second annulus, wherein the upper parts of the first annulus and second annulus are wider than the lower parts; two side connecting reinforcements and two upper connecting reinforcements are arranged between the first annulus and the second annulus, the two upper connecting reinforcements are arranged on the tops of the first annulus and the second annulus, the two side connecting reinforcements are arranged on the lower parts of the first annulus and the second annulus, two first vertical reinforcements are arranged on the first annulus, two second vertical reinforcements are arranged on the second annulus; and a first annulus bending part which bends inward is arranged on the top of the first annulus, and a second annulus bending part which bends inward is arranged on the top of the second annulus. The invention can solve the problems of the prior art, greatly increase the contraceptive effect and effectively prevent the intrauterine device from dropping and displacing; and the top of the intrauterine device is depressed so that the intrauterine device can more effectively stick to the lining of the uterine cavity and the intrauterine device can be worn more comfortably and safely.

A sperm reducing agent compound with contraceptive effect comprises an aqueous solution, a binding agent and a lubricant. The binding agent is polysaccharide accounting for 0.3 to 10 percent of the compound (weight); the lubricant is alcohol accounting for 0.5 to 10 percent of the compound (weight); the stickiness of the compound is above 9,000cst (centistokes) so as to mix the compound with female genitalia liquid and sperm and form high-stickiness colloid, thus preventing sperm from swimming, sealing cervix and further achieving contraceptive effect.

A condom is configured to include a space such that a front glans part of the condom does not excessively come into contact with the penis of a man by selecting a material having moderate elasticity such as soft synthetic resin or synthetic latex rubber or a foamed rubber material conforming thereto or the like for the front part of the condom made from a soft rubber material; and includes embossed sponge layers or fine soft hairs additionally laminated on the inside and outside of the condom, to provide an excellent moisturizing effect such that an excellent contraceptive effect and a sexual pleasure-increasing effect can be simultaneously obtained when a user wears the condom, thereby providing multiple effects such as contributing to the treatment of patients with chronic dyspareunia or patients with anorgasmia and the like.

The invention relates to the technical field of processes for preparing contraceptive products, in particular to a process for preparing a contraceptive drug in a traditional Chinese medicine formula. The process for preparing the contraceptive drug comprises the following steps of: firstly, preparing materials A, B and C, wherein a preparation process of the material A comprises the steps of weighing equal portions of black fungus and palm root, stewing the black fungus and palm root to be tender after cleaning, and then adding brown sugar and simmering to obtain the pasty material A; the preparation process of the material B comprises the steps of weighing equal portions of eggplant flower, drying after cleaning, and grinding to obtain the powdery material B; and the preparation process of the material C comprises the steps of weighing persimmon calyx with stems, baking after cleaning, and grinding with a non-iron appliance to obtain the powdery material C; secondly, mixing 1 part of material A, 1.5-2.5 parts of material B and 2.5-3.5 parts of material C by weight; and thirdly, baking the mixed material, and grinding into powder, thus the contraceptive drug is obtained. The contraceptive drug produced by adopting the process in the invention can realize a lasting contraceptive effect by adopting a manner of ovulation inhibiting, contains no western-medicine hormone or chemical and has no toxic or side effect to a human body.

The present invention relates to a condom capable of preventing its self-body from being fallen out in sexual life. It is characterized by that on the condom body surface are set one or several cords, said cords and said condom body are connected into one whole body, so that said invention can utilize adsorption action of said cords to attain the goal of preventing condom from being fallen out, and can obtain good contraceptive effect.

The invention discloses a Chinese medical oral contraceptive pill, which is compounded by selecting natural traditional Chinese medicines such as Radix Lithospermi Root of Sinkiang Arnebia, Herba Eupatorii, and the like and combining the formula of the traditional Chinese medicine theory with the modern advanced technology. The contraceptive effect is remarkable, without the toxic and side effect. Especially, the fertility can be recovered soon after pill withdrawal.

The invention relates to a chitosan plural gel foaming agent suitable for a female sperm shielding and killing dual-contraception effect and a preparation method thereof, and belongs to the technical field of foaming agent production. The chitosan plural gel foaming agent suitable for the female sperm shielding and killing dual-contraception effect has a dual-contraception effect of vagina shielding and vagina sperm killing, and meanwhile has a fungal-infection-resistant effect. The foaming agent forms a medicament liquid by consisting of a matrix, a surface active agent, an auxiliary medicament, a cosolvent, an acidifier, a foaming agent, a foam stabilizing agent and a solvent, and the foaming agent and a propellent form a plural gel foaming agent according to the weight proportion of (100:10) to 20. The preparation method comprises the following steps: dissolving chitosan and carbomer into a citrate buffer solution with a certain amount; blending, heating to 80 DEG C to dissolve completely, adding the surface active agent so as to obtain a solution A; dissolving borneol, menthol crystal and stearic acid into glycerol, dissolving fully, and filtering so as to obtain a solution B; adding the solution B into the solution A, mixing fully, adding citric acid and SLS (sodium lauryl sulfate), supplying the buffer solution to the required weight, carrying out vacuum homogenizing for 2 hours, thereby obtaining the gel foaming preparation, and then adding the propellent.

The invention relates to contraceptive. The contraceptive is characterized by comprising the following components by mass in single dosage: 10-50mu g of gestodene, 1.5-10mg of nomegestrol, 0.2-0.5mg of levonorgestrel, 1-20mg of drospirenone, 0.5-10mg of cyproterone, 10-20mu g of ethinyloestradiol, 40-80g of saccharose and 5-20mu g of mestranol. The sum of the content of the ethinyloestradiol and the content of the mestranol is not more than 30mu g; and the sum of the content of the cyproterone, the content of the ethinyloestradiol and the content of the saccharose is 2-20mg. The contraceptive adopts the means that multiple progestational hormones and estrogenic hormones are mixed for use so as to reduce the estrogenic hormones, so that the obtained contraceptive can guarantee less injury to a human body under the condition with better contraceptive effect.

The invention discloses a chrysanthemum extract with contraceptive effect and a plant contraceptive thereof, and the method comprises the following steps: placing chrysanthemum and pure water in an extraction tank, heating to boiling, reducing the temperature to 75-85 DEG C, keeping slight boiling for 1-3 hours, and then carrying out solid-liquid separation to obtain an extraction crude liquid; concentrating under reduced pressure to obtain a total chrysanthemum extract; eluting the total chrysanthemum extract twice through macroporous resin to obtain a chrysanthemum extract; the plant contraceptive contains the chrysanthemum extract. After the chrysanthemum extract extracted by the invention is used for any day after menstruation is clean and before ovulation, the intimal thickness can be obviously reduced, and an effective contraception effect is achieved. The plant contraceptive disclosed by the invention only needs to be used for one day and cannot be missed; the beverage can be drunk after being dissolved in water, and is simple and convenient.

To produce a medicament with a menstruating contraceptive effect, it consists of a sequential oral dosage unit of mifepristone followed by vaginal administration of a dosage unit of misoprostol 36-48 hours later. The invention is convenient to use, adopts oral and vaginal medication, and the dosage is small, the effect is good, the bleeding time is shorter than conventional medical abortion, and anxiety and pain can be relieved without any complication.

The invention relates to the technical field of medical and nursing appliances and particularly discloses bacteriostatic contraceptive gel containing total alkaloids of sophora alopecuroides for the gynecology department. The bacteriostatic contraceptive gel is prepared from the following components: total alkaloids of sophora alopecuroides, a contraceptive effective ingredient, agave Americana extract, VC ethyl ether, a wetting agent, xanthan gum, matrix and deionized water. The contraceptive gel has the effects of contraceptive gel and the effects of bacteriostatic gel, has an effect of efficiently killing sperms of human bodies with the response rate of 100 percent, has a relatively strong inhibition effect and a bacteriostatic rate being 94 percent or more by adding the total alkaloidsof sophora alopecuroides, can avoid the side effect of long-time use of traditional synthesized chemical contraceptive ingredients on the vagina as far as possible while ensuring the contraceptive effect, does not influence the acid environment and normal flora in the vagina by repeated use and is suitable for nursing before and after sexual intercourses and daily nursing for reproductive organsof males and females.

The invention relates to contraceptive. The contraceptive is characterized by comprising the following components by mass in single dosage: 10-50mu g of gestodene, 1.5-10mg of nomegestrol, 0.2-0.5mg of levonorgestrel, 1-20mg of drospirenone, 0.5-10mg of cyproterone, 10-20mu g of ethinyloestradiol, 40-80g of saccharose and 5-20mu g of mestranol. The sum of the content of the ethinyloestradiol and the content of the mestranol is not more than 30mu g; and the sum of the content of the cyproterone, the content of the ethinyloestradiol and the content of the saccharose is 2-20mg. The contraceptive adopts the means that multiple progestational hormones and estrogenic hormones are mixed for use so as to reduce the estrogenic hormones, so that the obtained contraceptive can guarantee less injury to a human body under the condition with better contraceptive effect.

The invention relates to a contraceptive device which comprises a plug, a ring-shaped groove, a base and a pull ball, wherein the plug is bullet-shaped, the plug is placed in a navicular fossa of male urethra, the ring-shaped groove is formed behind the plug, the base is arranged behind the ring-shaped groove, the ring-shaped groove is matched with an external urethral orifice and engaged with a smaller end of the base to be fixed in the position of the external urethral orifice to prevent the ejection of sperm, and the pull ball is arranged at the rear part of the base to provide convenience to pull the contraceptive device out of the male urethra. Based on the special physiological characteristics of a male, the contraceptive device is placed in a male urethra to prevent the sperm from entering a female vagina, so as to achieve the purpose of contraception. The contraceptive device has a low cost, is easy to manufacture, is simple and rapid to operate, can be repeatedly used, and is economical. Besides, the contraceptive effect is safe and reliable and the skin of the penis is fully exposed so that both the man and the woman experience sexual pleasure.