Near infrared spectrum detection method for detecting platycodon grandiflorum medicine

A near-infrared spectrum and near-infrared technology, which is applied in the directions of measuring devices, analyzing materials, and material analysis through optical means, can solve the problem of no related reports on the quality control of platycodon grandiflorum.

Inactive Publication Date: 2018-09-21
WUXI JIMIN KEXIN SHANHE PHARMA +1
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0004] In the field of drug quality control and production application, the application of near-infrared spectroscopy to the detection of raw medicinal materials, chemical drug separation, and key indi

Method used

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  • Near infrared spectrum detection method for detecting platycodon grandiflorum medicine
  • Near infrared spectrum detection method for detecting platycodon grandiflorum medicine
  • Near infrared spectrum detection method for detecting platycodon grandiflorum medicine

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Experimental program
Comparison scheme
Effect test

Embodiment 1

[0115] Embodiment 1, the platycodon saponin D content of platycodon grandiflorum medicinal material measured by near-infrared spectrometry

[0116] (1) Medicinal material sample preparation: select 30 batches of Platycodon grandiflorum medicinal materials, crush and sieve, and set aside

[0117] (2) Content determination:

[0118] Take about 2g of the powder of this product (through the No. 2 sieve), accurately weigh it, add 50ml of 50% methanol precisely, weigh it, ultrasonically treat it (power 250W, frequency 40kHz) for 30 minutes, let it cool, weigh it again, and use 50 % Methanol to make up for the lost weight, shake well, filter, accurately measure 25ml of the filtrate, put it on a water bath and evaporate to dryness, add 20ml of water to the residue, dissolve it with slight heat, shake and extract 3 times with n-butanol saturated with water, each time 20ml, combined with n-butanol, washed with 50ml of ammonia test solution, discarded the ammonia solution, washed with 5...

Embodiment 2

[0133] Embodiment 2, near-infrared spectrometry measures the moisture content of Platycodon grandiflorum medicinal material

[0134] (1) Medicinal material sample preparation: 30 batches of Platycodon grandiflora medicinal materials were selected, crushed and sieved, and set aside.

[0135] (2) Moisture determination (drying method):

[0136] Take 2-5g of the test product, weigh it accurately, spread it flat in a flat weighing bottle that has been dried to constant weight, the thickness is not more than 5mm, and the loose test product is not more than 10mm, weigh it accurately, open the bottle cap at 100-105 Dry at ℃ for 5 hours, cover the cap and move it to a desiccator, let it cool for 30 minutes, weigh it accurately, then dry it at the above temperature for 1 hour, let it cool, and weigh it until the difference between two consecutive weighings does not exceed up to 5mg. According to the lost weight, calculate the water content (%) in the test sample.

[0137] (3) Collec...

Embodiment 3

[0149] Collect several batches of Platycodon grandiflora medicinal materials; batches 1-12 respectively instead of direct detection by near-infrared spectrometer, obtain near-infrared spectrum, and calculate the content of platycodon saponin D in the collected platycodon grandiflorum medicinal materials through the quantitative calibration model as shown in the following table:

[0150]

[0151] According to the determination of the platycodon saponin D content and water content in the platycodon medicinal material collected according to the calculation, and according to the requirements of the Pharmacopoeia, all are qualified medicinal materials, and the determination time is short, efficient and convenient, saving time and effort.

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Abstract

The invention discloses a near infrared spectrum detection method for detecting a platycodon grandiflorum medicine. The method comprises the following steps: (1) smashing and sieving the platycodon grandiflorum medicine; (2) acquiring a near-infrared spectrogram of the platycodon grandiflorum medicinal powder; and (3) inputting an established standard near-infrared spectroscopy model according toa standard near-infrared spectrum and the acquired near-infrared spectrum of the platycodon grandiflorum medicine, and calculating water content of the platycodon grandiflorum medicine and the contentof platycodin D. The spectral conditions are as follows: scan times is 32, and the resolution is 8 cm<-1>, with the built-in background of the instrument as a reference, the scanning spectrum range is 4000-10000cm<-1>.

Description

technical field [0001] The invention belongs to the field of quality detection of Chinese medicinal materials, and in particular relates to a near-infrared spectrum detection method of Chinese medicinal material Bellflower. Background technique [0002] Platycodon grandiflorum, a Chinese herbal medicine, has the effects of clearing the lung, relieving the throat, eliminating phlegm, and draining pus. It is often used in combination with other Chinese herbal medicines to treat cough with excessive phlegm, chest tightness, sore throat and hoarseness, lung abscess and vomiting of pus. It is used in traditional Chinese medicine preparations such as Chuanbei Pipa Syrup, Xiaoer Xiaoji Zhike Oral Liquid, Xiaoer Yanbian Granules, etc. The Chinese Pharmacopoeia stipulates that this product is the dried root of Platycodon grandiflorum (Jacq) A.DC. This product is sold in Northeast China, North China, East China, Central China provinces and Guangdong, Guangxi (northern), Guizhou, sout...

Claims

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Application Information

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IPC IPC(8): G01N21/359
Inventor 华梦丹吴凌云於江华闵江
Owner WUXI JIMIN KEXIN SHANHE PHARMA
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