Preparation method of compound platycodon grandiflorum and moutan bark inhaling preparation for atomization

A technology for inhalation preparation and Cortex Moutan is applied in the field of preparation of inhalation preparation of compound Platycodon grandiflorum for atomization, and achieves the effects of convenient and quick method, alleviation of side effects and high controllability

Inactive Publication Date: 2017-06-13
ANHUI UNIVERSITY OF TRADITIONAL CHINESE MEDICINE +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] The present invention aims to provide a preparation method for inhalation preparation of compound Platycodon grandiflorum cortex for atomization, and the technical problem to be solved is to overcome the gastrointestinal adverse reactions caused by it on the basis of ensuring the synergistic effect of paeonol and Platycodon grandiflorum

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0024] In the present embodiment, the preparation method of compound Platycodon grandiflorum Moutan cortex inhalation preparation for atomization is as follows:

[0025] 1. Take 100g of 1,2-propanediol, add 900g of water for injection, stir and mix evenly, which is the solvent, and set aside;

[0026] 2. Weigh 5g of Platycodon grandiflorum extract (total saponin content is 66.12%, platycodon saponin D content is 2.45%), paeonol extract 0.3g (paeonol content is 95.12%), tangerine peel oil 0.05g and hydrogen sulfite Add 0.1 g of sodium, add the solvent and set the volume to 1000 ml, stir evenly, add dilute hydrochloric acid to adjust the pH to 4.0, and obtain the initial solution.

[0027] 3. Take the initial solution, filter it with an 80-mesh filter cloth under high static pressure, pass the filtrate through a 0.22 micron filter membrane, and filter it under reduced pressure to obtain the final solution.

[0028] 4. Pour the obtained final solution into a washed 20ml ampoule ...

Embodiment 2

[0030] 1. Take 100g of 1,2-propanediol, add 900g of water for injection, stir and mix evenly, which is the solvent, and set aside;

[0031] 2. Weigh 7.5g of Platycodon grandiflorum extract (total saponin content is 68.93%, platycodon grandiflora saponin D content is 2.77%), paeonol extract 0.5g (paeonol content is 92.28%), peppermint oil 0.05g and sulfurous acid Add 0.1 g of sodium hydrogen, add the solvent and set the volume to 1000 ml, stir evenly, add dilute hydrochloric acid to adjust the pH to 4.0, and obtain the initial solution;

[0032] 3. Take the initial solution, filter it with an 80-mesh filter cloth under high static pressure, pass the filtrate through a 0.22 micron filter membrane, and filter it under reduced pressure to obtain the final solution;

[0033] 4. Pour the obtained final solution into a washed 25ml ampoule and seal it; after sealing, place the ampoule in an autoclave and sterilize it at 121°C and 104KPa for 15 minutes to obtain the compound bellflower...

Embodiment 3

[0035] 1. Take 50g of 1,2-propanediol, take 50g of 95% ethanol, add 900g of water for injection, stir and mix evenly, it is the solvent, and set aside;

[0036] 2. Weigh 10g of Platycodon grandiflorum extract (total saponin content is 66.12%, platycodon saponin D content is 2.45%), paeonol extract 3g (paeonol content is 92.28%), orange peel oil 0.5g and sodium bisulfite 1 g, add the solvent to make up to 1000 ml, stir evenly, add dilute hydrochloric acid to adjust the pH to 4.0, and obtain the initial solution.

[0037] 3. Take the initial solution, filter it with an 80-mesh filter cloth under high static pressure, pass the filtrate through a 0.22 micron filter membrane, and filter it under reduced pressure to obtain the final solution.

[0038] 4. Pour the obtained final solution into a washed 15ml ampoule and seal it; after sealing, place the ampoule in an autoclave and sterilize it at 121°C and 104KPa for 15 minutes to obtain the compound bellflower peony for atomization S...

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Abstract

The invention discloses a preparation method of compound platycodon grandiflorum and moutan bark inhaling preparation for atomization. The preparation method comprises the following steps of; adding a co-solvent into water for injection, and uniformly stirring and mixing the two to obtain a solvent; adding 3-100g of platycodon grandiflorum extract, 0.1-10g of paeonol extract, 0.01-0.5g of a corrigent and 0.01-0.5g of an antioxidant, fixing the volume to 1000-10000mL, uniformly stirring the mixture, and adjusting the pH to 4.0 to obtain an initial solution; successively roughly and finely filtering the obtained initial solution to obtain a final solution; and filling an ampoule bottle with the final solution, and performing encapsulation, sterilizing, leakage detection and packaging to obtain a finished product. According to the compound platycodon grandiflorum and moutan bark inhaling preparation obtained by the invention, the content of total saponins per ml is not less than 2mg, the content of platycodin D is not less than 0.1mg, and the content of paeonol is not less than 0.2mg.

Description

technical field [0001] The invention relates to the field of traditional Chinese medicine formulation design, in particular to a method for preparing a compound platycodon root moutan cortex inhalation preparation for atomization. Background technique [0002] In recent years, with the accelerated pace of urbanization, environmental pollution, especially air pollution, has become more and more serious. It has been reported that air pollutants mainly include: nitrogen oxides, hydrocarbons, sulfur oxides, particulate matter (PM), pathogenic bacteria, etc. How to prevent air pollution from damaging the lungs and related physiological structures, the largest gas exchange organ in the body, has become an urgent problem to be solved. Platycodon grandifloram (Jacq.) A.DC. is commonly used as a traditional Chinese medicine for treating lung diseases. It is a perennial herb suitable for planting in both the north and the south. It is mainly produced in Anhui, Henan, Shandong, Liaoni...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/71A61K36/65A61K9/12A61P11/00A61K31/12A61K31/704
CPCA61K9/0075A61K9/0078A61K9/008A61K9/12A61K31/12A61K31/704A61K36/346A61K36/65A61K36/71A61K2300/00
Inventor 王举涛桂双英陈明葛鼎王素梅屈海防
Owner ANHUI UNIVERSITY OF TRADITIONAL CHINESE MEDICINE
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