The invention discloses a method for synthesizing
cefoxitin acid. 7-aminocephalosporanic acid is adopted as a
raw material and reacts with
sodium methylate under protection of a protection agent, methoxy is introduced into the seventh bit of 7-aminocephalosporanic acid, and
methoxide complex is obtained; after the reaction is finished, 2-
thiophene acetyl chemical
reagent is dropwise added for reacting, then solidifying
enzyme is added to obtained wet feed in an alkaline solution for
hydrolysis, and after
hydrolysis is completed, solidifying
enzyme is filtered out; after the reaction is finished, a benzathine diacetate water solution is dropwise added to reaction liquid, crystals are separated out, and a compound I is obtained; the compound I and an
ammonia methoxyl
acylation reagent act, a carbamyl methoxyl group is introduced to the third bit of the compound I, and
cefoxitin acid is obtained. The synthesis process is simple, the steps are easy and convenient, implementation is easy, the yield is effectively increased, production cost is reduced, the production steps are reduced, the obtained product is high in purity, the
impurity content is low, the color
gradation is good, product quality is effectively improved,
drug use safety is improved, and the method is suitable for
mass production.