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298 results about "Co solvent" patented technology

A co solvent system is one in which a water miscible or partially miscible organic solvent is mixed with water to form a modified aqueous solution.

High-temperature-resistant sealing agent and preparation method thereof

The invention discloses a high-temperature-resistant sealing agent and a preparation method thereof, and relates to the technical field of chemical assistants, and the high-temperature-resistant sealing agent is characterized by comprising the following components in parts by weight: 25-32 parts of acidic nano silica sol, 56-65 parts of a cosolvent, 8-12 parts of a hydrolysis inhibitor, 9-12 parts of a silane coupling agent A, 5.5-6.8 parts of a silane coupling agent B and 0.01-0.015 part of a wetting agent. The high-temperature-resistant sealing agent has the effects that the high-temperature-resistant sealing agent is not yellowed, decomposed and dropped after being baked for 2 hours in an oven at the temperature of 250 DEG C, and is not corroded after being corroded by salt mist for 1000 hours.
Owner:NINGBO YADA METAL SURFACE TREATMENT

Neutral organic chelating cleaning agent for boiler

The invention discloses a neutral organic chelating cleaning agent for a boiler, and belongs to the field of chemical cleaning of boiler superheaters of thermal power plants. The cleaning agent is prepared from the following components in percentage by weight: 0.5%-5% of ethylenediamine tetraacetic acid ammonium, 0.1%-4% of acetic acid or ammonium acetate, 0.1%-3% of glycollic acid ammonium or glycollic acid, 0.1%-5% of a pH regulator, 0.1%-1% of a cosolvent, 0.2%-0.8% of a corrosion inhibitor SH369, 0.1%-0.6% of a reducing agent, 0.0%-0.3% of a defoaming agent, 0.0%-0.2% of a surfactant and 84%-93% of water, wherein the pH value of the cleaning agent is 6-8; the cosolvent is tartaric acid and / or hydroxybutyl diacid, the surfactant is nonylphenol polyoxyethylene ether, and the reducing agent is hydrazine. The cleaning agent disclosed by the invention has good dissolving capacity on oxide skin, does not generate precipitates to cause pipe blockage, is a neutral solution, is very small in corrosivity, does not generate intergranular corrosion, is beneficial to protecting various pipes of superheaters and reheaters, and is a safe and efficient superheater cleaning agent.
Owner:XIAN XIELI POWER TECH

Preparation method of dicapryl carbonate

The invention provides a preparation method of dicapryl carbonate, belongs to the field of preparation of dicapryl carbonate, and can solve the problems of unstable reaction system, low raw material conversion rate, low catalyst efficiency, poor phase contact effect, many side reactions, low product purity and poor quality in the existing preparation method of dicapryl carbonate. The preparation method of dicapryl carbonate comprises the following steps: fully mixing n-caprylic alcohol, a basic catalyst and a cosolvent, continuously dropwise adding low-grade dialkyl carbonate into the mixed solution for 5-10 hours through a liquid material distributor, carrying out ester exchange reaction, continuously extracting low-boiling-point substances, controlling the reflux quantity, and carrying out reduced pressure distillation to obtain the dicapryl carbonate. The method comprises the following steps: adding a cosolvent into a reaction solution, enabling the cosolvent with an initial addition amount to always exist in the reaction solution, after the reaction is finished, dealcoholizing by reduced pressure distillation, and removing impurities by washing to obtain a crude product of dioctyl carbonate, and rectifying to obtain a dioctyl carbonate product. The preparation method is high in raw material conversion rate and high in product yield, and the purity of the obtained product is gt; the content of impurities is low, and the method can be applied to preparation of cosmetics.
Owner:HAIKE GRP RES INST OF INNOVATION & TECH

Method of three-dimensional printing, jettable antioxidant formulation, multi-fluid kit

One example of a jettable antioxidant formulation is used for three-dimensional (3D) printing. The jettable antioxidant formulation includes an antioxidant blend; a surfactant, a dispersant, or a combination thereof; a water-soluble or water-miscible organic co-solvent; and water. The antioxidant blend consists of a primary antioxidant and a secondary antioxidant.
Owner:PERRYDOT PRINTING CO LTD

Waterborne epoxy resin composite coating and preparation method thereof

The invention provides a water-borne epoxy resin composite coating and a preparation method thereof, and the water-borne epoxy resin composite coating comprises the following components in parts by mass: 70-90 parts of a water-borne epoxy emulsion component A; 10-30 parts of a curing agent component B; wherein the component A of the waterborne epoxy emulsion is prepared from the following raw materials in parts by mass: 50 to 70 parts of self-emulsifying epoxy resin, 5 to 10 parts of hydrophilic modifier, 15 to 25 parts of pigment filler, 2 to 5 parts of dispersion stabilizer, 1 to 3 parts of cosolvent and 5 to 10 parts of deionized water. Self-emulsifying modification of resin molecules is realized by adopting nonionic polyether grafted self-emulsifying epoxy resin and matching with a hydrophilic modifier with a specific hydroxyl value, an emulsifier does not need to be added, and the viscosity of a coating system is reduced from the molecular level, so that the solid content of the component A of the waterborne epoxy emulsion is more than or equal to 70%, the viscosity is less than 200mPa. S, and the technical bottlenecks of high solid content and low viscosity are broken through; and the requirement for single-time thick coating construction is met, the construction efficiency is greatly improved, and construction period prolonging and cost increasing caused by multiple times of construction are avoided.
Owner:ANHUI BAIZHI NEW MATERIAL CO LTD

Supercritical fluids regeneration of PFAS-contaminated spent media and water treatment train

A method of mitigation of persistent organic compounds absorbed on a sorbent, the method including extracting the persistent organic compounds from the sorbent with a supercritical carbon dioxide (scCO2) mixture comprising scCO2, a co-solvent, and an ion source, wherein a scCO2 to co-solvent ratio is between about 10,000:1 to 1:1, wherein a co-solvent to ion source ratio is between about 10:1 and about 1,000,000:1, and wherein the scCO2 mixture is at a pressure and a temperature, to provide an extractant containing the persistent organic compounds; and isolating the persistent organic compounds from the extractant for their reuse or end of life treatment. A composition for the mitigation of persistent organic compounds, the composition including a scCO2, an ion source, and a co-solvent, wherein a scCO2 to co-solvent ratio is between about 10,000:1 to 1:1, and wherein a co-solvent to ion source ratio is between about 10:1 and about 1,000,000:1.
Owner:UNIV OF WASHINGTON +1

Three-dimensional printing with color assist agent

A three-dimensional printing kit includes a substantially colorless fusing agent and a color assist agent. The fusing agent includes a liquid vehicle including water, a co-solvent, and an amino acid stabilizer. The fusing agent further includes an infrared (IR) absorbing pigment dispersion including an IR absorbing pigment present in an amount ranging from about 0.01 wt % active to about 1.6 wt % active, based on a total weight of the fusing agent. The color assist agent includes a liquid vehicle including water and a plasticizing co-solvent, and a dye dissolved in the liquid vehicle. Also disclosed is a method of making a colored 3D printed object.
Owner:PERIDOT PRINT LLC

Preparation method and application of asymmetric ultrafiltration membrane with high flux, high interception and controllable structure

The invention discloses a preparation method and application of a high-flux, high-interception and structure-controllable asymmetric ultrafiltration membrane, and belongs to the technical field of ultrafiltration membranes. The preparation method of the asymmetric ultrafiltration membrane comprises the following steps: mixing 20-30 parts by weight of an ethylene-vinyl acetate copolymer, 40-70 parts by weight of a good solvent, 4-20 parts by weight of a pore-foaming agent, 10-25 parts by weight of a cosolvent and 0-10 parts by weight of a plasticizer, heating and stirring, standing and defoaming to obtain a homogeneous membrane casting solution; coating a substrate with the membrane casting solution and then carrying out pre-evaporation treatment; and immersing the pre-evaporated material into a coagulating bath to carry out phase separation and solvent exchange for curing, and washing to obtain the ultrafiltration membrane. Effective preparation of the asymmetric ultrafiltration membrane with high flux, high interception and controllable structure is realized, and the preparation method is simple to operate, clear in process, high in practicability and beneficial to product industrialization.
Owner:SHAOXING SHENGJIE BIOTECHNOLOGY CO LTD

An absorption liquid for absorbing asphalt fume and oil mist exhaust gas, a preparation method and application thereof

ActiveCN120714422BDispersed particle separationPoly(ethylene glycol) dimethyl etherPolyethylene glycol
The application provides an absorption liquid for absorbing asphalt fume and oil mist waste gas, a preparation method and application, and relates to the field of waste gas treatment. The absorption liquid is prepared from the following raw materials in mass percentage: polyethylene glycol dimethyl ether 60-80%; demulsifier 5-15%; dispersion polymerization inhibitor 3-10%; oxidant carrier 1-3%; slow-release particles 2-9%; cosolvent 5-12%; and defoaming agent 0.1-1%. In the application, the anti-adhesion and polymerization resistance performance are improved through the compounding of various solvents, the continuous operation cycle of the equipment is prolonged to more than 90 days, the pressure difference of the filler is increased by less than 5%, and the frequent shutdown problem caused by asphalt fouling in the traditional technology is completely solved; meanwhile, the demulsification is efficient, the removal rate is high, and another possibility is provided for efficient, green and economic deep treatment of waste gas.
Owner:TIANJIN RANDYS IND EQUIP

An intermediate processing solution for a chemical nickel-gold process and a chemical gold preparation method

PendingCN122406199AActive agentDisplacement reactions
The application discloses an intermediate processing liquid for an electroless nickel immersion gold (ENIG) production line and a chemical gold preparation method. The intermediate processing liquid is applied between the electroless nickel plating and immersion gold processes, and comprises (a) a pH buffer and a metal ion complexing agent: a total concentration of 50-150 g / L; (b) an adsorptive corrosion inhibitor: a concentration of 0.5-5.0 g / L; (c) a low-foam non-ionic surfactant: a concentration of 0.01-10 g / L; (d) an auxiliary antioxidant: a concentration of 0.5-30 g / L; (e) a dissolving agent: a concentration of 1-50 ml / L; (f) a pH regulator: an appropriate amount, which is added to maintain the pH value of the intermediate processing liquid at 4.0-6.5; and (g) deionized water: a balance, so that the concentrations of the above components reach the set target values; and the intermediate processing liquid has a design use temperature of 20-45 DEG C. The intermediate processing liquid removes residual nickel ions on the board surface and in micropores through strong complex cleaning, and blocks the pollution to the subsequent gold tank; meanwhile, the preferential adsorption of the corrosion inhibitor molecules at the nickel layer grain boundaries forms a controllable molecular-level protective film, effectively adjusts the immersion gold replacement reaction kinetics, and prevents the occurrence of intergranular corrosion (black plate).
Owner:HENAN JINSHUO SEMICON MATERIALS CO LTD

Compositions comprising chlorhexidine and a depigmenting complex

A complex consisting of lipoic acid or a salt thereof, a chelating agent such as a salt of ethylene diamine tetraacetic acid (EDTA) or analogous compounds and an ester of ascorbic acid with long-chain fatty acids, in particular ascorbyl palmitate inhibits the pigmentation of teeth induced by chlorhexidine and salts thereof. In addition to the depigmenting complex, the formulations of the invention, in the form of gels, mouthwashes, toothpastes or periodontal sprays, may contain other ingredients such as hyaluronic acid or hyaluronates, glycerophosphocholine, sweeteners, flavourings, buffering agents, viscosifying agents, mucoadhesive and filming agents, solvents, co-solvents, surfactants.
Owner:RICERFARMA

Dihydroquercetin oil-soluble microcapsules based on a microfluidic chip, and a preparation method and application thereof

PendingCN122320903ALactobacillusActive agent
This invention discloses a method for preparing dihydroquercetin oil-soluble microcapsules based on a microfluidic chip, along with its applications. The preparation method involves: uniformly dissolving dihydroquercetin and a co-solvent under heating conditions to obtain a dispersed phase; uniformly dissolving a surfactant and oil under heating conditions, followed by adding lactobacillus fermentation lysate to obtain a mixture; subjecting the mixture to high-pressure homogenization to obtain a continuous phase; using a microfluidic chip, pumping the dispersed and continuous phases into corresponding channels of the chip via a syringe pump; at the chip's intersection, shearing, compressing, and encapsulating the dispersed phase in the continuous phase to form monodisperse dihydroquercetin oil-soluble microcapsules. The method employed in this invention utilizes the precise fluid control capabilities of a microfluidic chip to achieve uniform and controllable microcapsule particle size and structure, ensuring continuous and repeatable processing with high encapsulation efficiency, and effectively improving the solubility and stability of dihydroquercetin.
Owner:CHONGQING CHAOWEI CHEMICAL ENERGY TECHNOLOGY CO LTD +1

A soluble liquid formulation containing flonicamid and acetamiprid

The application provides a soluble liquid agent containing flonicamid and acetamiprid, and a preparation method and application thereof. The soluble liquid agent is composed of flonicamid, acetamiprid, a solvent, a cosolvent, a surfactant, a pH regulator, a penetration enhancer and ethanol. The application reduces ecological toxicity by selecting suitable auxiliaries, has the advantages of small drift, slow evaporation, strong adhesion, good spreading, wetting and adhesion effects on targets, long retention time, rainwater erosion resistance, and improved pesticide penetration, so that the pesticide can act faster. In addition, the soluble liquid agent prepared by the application can meet the requirements of pest control under different water qualities and meet the requirements of field application under complex climate conditions. The soluble liquid agent of the application is an agricultural insecticide with good insecticidal effect, simple production process and no environmental pollution.
Owner:HEBEI GREAT BIOTECHNOLOGY CO LTD

Inkjet inks containing amine modified silicone

PendingUS20260193483A1Polymer scienceBackbone chain
An inkjet ink that includes (A) a terpene phenol resin, (B) a solvent system containing (B1) ethanol and (B2) a cosolvent, and (C) an amine modified silicone that includes a silicone backbone (main chain) and one or more organoamine side chains attached to the silicone backbone, the inkjet ink being characterized by extended decap times and superior adhesion to a variety of substrates, A printed article including the inkjet ink in dried form, and a method of forming a printed image with a thermal inkjet printhead are also provided.
Owner:KAO CORP

Oral care composition as well as preparation method and application thereof

The invention relates to the technical field of oral care compositions, in particular to an oral care composition and a preparation method and application thereof.The oral care composition comprises a first composition and a second composition, the first composition comprises an anti-sensitive agent, a cosolvent, a first thickening agent, a surfactant and a first auxiliary, and the second composition comprises an anti-sensitive agent, a cosolvent, a second thickening agent, a surfactant and a second auxiliary; the first composition comprises phthalimide peroxyhexanoic acid, a cosolvent, a first thickening agent, a first auxiliary agent and deionized water, the second composition comprises phthalimide peroxyhexanoic acid, a cosolvent, a second thickening agent, a second auxiliary agent and deionized water, at least one of the cosolvent, the first auxiliary agent and the second auxiliary agent contains a flavoring agent, and the first composition and the second composition are separately stored before use. The anti-sensitive agent is prevented from being in contact with the phthalimide peroxyhexanoic acid before use. According to the invention, the first composition and the second composition are respectively and independently stored, so that natural decomposition and activity attenuation of phthalimide peroxycaproic acid in the shelf life of the product are inhibited, and the product is ensured to retain high effective active oxygen content after being stored for a long time.
Owner:INTERDENTAL TECHNOLOGY (GUANGZHOU) CO LTD

Preparation method of 3-(piperazine-1-yl) propane-1-sulfonic acid

The invention relates to a preparation method of 3-(piperazine-1-yl) propane-1-sulfonic acid, and relates to the technical field of organic chemical synthesis. The preparation method of the 3-(piperazine-1-yl) propane-1-sulfonic acid comprises the following steps: feeding and stirring, dropwise adding and mixing, carrying out temperature-controlled reaction, and purifying and drying. The cosolvent activates amino groups and inhibits side reactions, complete reaction of the substrate 1, 3-propane sultone is ensured through excessive piperazine, generation of by-products is reduced in the dropwise adding process, the temperature control reaction equilibrium rate is achieved, purification treatment is conducted through the pulping agent in the final purification and drying stage, reaction impurities are effectively removed, and it is finally guaranteed that the product purity meets the pharmaceutical grade requirement; the whole technological process is simple, the production period is shortened, and labor and time cost is reduced.
Owner:SHANDONG WANNA BIOTECHNOLOGY CO LTD

Environment-friendly nano solubilizer for oil field and preparation method of environment-friendly nano solubilizer

The invention relates to the technical field of chemical auxiliaries for oilfield exploitation, and particularly discloses an environment-friendly nano solubilizer for an oilfield and a preparation method of the environment-friendly nano solubilizer. A preparation method of an environment-friendly nano solubilizer for an oil field comprises the following steps: S1, uniformly mixing N, N-dimethylformamide and hydroxyethyl cellulose in an inert atmosphere, then adding an organic base catalyst, uniformly mixing, heating to 35-45 DEG C, adding aromatic acyl chloride, heating to 75-85 DEG C, reacting for 4-6 hours, cooling, carrying out solid-liquid separation, washing, drying and crushing to obtain modified cellulose; s2, uniformly mixing a cosolvent, xanthan gum, a salt solution and a composite surfactant at 30-40 DEG C, adding the modified cellulose, uniformly mixing, and dispersing to obtain the environment-friendly nano solubilizer. The environment-friendly nano solubilizer prepared by the invention has relatively low interfacial tension and relatively high viscosity reduction rate.
Owner:SHAANXI SHANGNAN DONGZHENG CHEM CO LTD

A loratadine liniment and a preparation method thereof

The application belongs to the field of pharmaceutical preparations and relates to a chlorpheniramine maleate liniment, which contains chlorpheniramine maleate 1 part, a cosolvent 100-140 parts, a stabilizer 12-25 parts and a binder 5-15 parts. The solubility and stability of chlorpheniramine maleate are improved, and the content of related substances in the preparation is reduced by optimizing the types and proportions of the cosolvent and the stabilizer. The full dissolution of chlorpheniramine maleate and excipients is facilitated by optimizing the preparation process, in particular the dissolution step of chlorpheniramine maleate and the stabilizer. The preparation process is simple, suitable for industrial production and convenient for market promotion.
Owner:SHANDONG NEW TIME PHARMA CO LTD

High-alkali-resistance textile degreaser as well as preparation method and application thereof

The invention discloses a high-alkali-resistance textile degreaser as well as a preparation method and application thereof, and relates to the technical field of textile pretreatment. The method comprises the following steps: S1, carrying out a neutralization reaction on fatty acid methyl ester sulfonic acid and a mixed alkali solution of sodium hydroxide and alkanolamine, and controlling the pH value of a reaction endpoint to be 6.0-7.5 to obtain a mixed salt of sodium fatty acid methyl ester sulfonic acid and alkanolamine; s2, adding an alkyl polyglucoside aqueous solution into the mixed salt obtained in the step S1 to form mixed micelles; s3, fatty acid ester ethoxylate and a bio-based cosolvent are added into the mixed micelle obtained in the step S2, homogenization treatment is conducted, and homogeneous microemulsion is obtained; and S4, cooling the microemulsion obtained in the step S3, adding a chelating dispersant and water, and uniformly mixing to form the high-alkali-resistance textile degreaser. The textile degreaser prepared through dication modification and micelle recombination has good alkali resistance, excellent low-temperature water solubility and full-bio-based environmental protection characteristics, and is suitable for pretreatment of textiles such as cotton, polyester and the like.
Owner:GUANGDONG HONGHAO CHEM CO LTD

Method for separating calcium and sulfur from industrial byproduct gypsum

The invention provides a method for separating calcium and sulfur in industrial byproduct gypsum. The method comprises the following steps: mixing and stirring industrial byproduct gypsum and a cosolvent solution to react, and filtering after reacting for a period of time to obtain a first filtrate and a first filter residue; adding alkali metal hydroxide into the first filtrate to form calcium hydroxide slurry, and introducing carbon dioxide to precipitate calcium ions in the first filtrate to obtain a product calcium carbonate and second filtrate; adding calcium chloride into the second filtrate, reacting sulfate ions in the second filtrate with the added calcium chloride at a certain temperature, and filtering to obtain calcium sulfate and a third filtrate mainly containing potassium chloride; alkali metal chlorine salt is used as a cosolvent, the solubility of calcium sulfate in a liquid phase is improved, and then separation of calcium sulfate and impurities in the byproduct gypsum is achieved through solid-liquid separation; compared with an organic solvent as a phase transfer solution, solid-liquid separation with alkali metal chlorine salt as a cosolvent is more convenient and quicker, and the cost is low.
Owner:WUHAN INST OF TECH

Fusing agent compositions

Examples of the present disclosure are directed toward fusing agent compositions. An example fusing agent composition includes a radiation absorber, a co-solvent mixture, and a balance of water. In various examples, the radiation absorber is present in an amount ranging from about 0.005 weight percent (wt %) to about 1.0 wt % of a total weight of the fusing agent composition, wherein the radiation absorber absorbs radiation at a wavelength range within the visible light spectrum.
Owner:PERIDOT PRINT LLC

Aramid pulp and method of making, battery separator and method of making and use

This application provides an aramid slurry and its preparation method, a battery separator and its preparation method, and its application. The aramid slurry comprises aramid fibers, a non-protic strongly polar solvent, and a co-solvent. The co-solvent has a pH value of 5–7.5 at 25°C and 101.325 kPa; the rotational viscosity of the aramid slurry is 500 mPa·s–5000 mPa·s. The aramid slurry of this application eliminates the need for strong alkaline co-solvents such as sodium hydroxide or potassium hydroxide to dissolve the aramid, avoiding the damage to aramid molecules caused by such co-solvents, extending the operating time window, and improving the stability of the slurry. The slurry can be stably stored for more than 168 hours, reducing the difficulty of production operations and the investment in personnel and equipment, thus facilitating large-scale production. Furthermore, the rotational viscosity of the aramid slurry formed in this application has a suitable range; within this range, the slurry not only exhibits good stability but also provides ideal separator performance.
Owner:SINOMA LITHIUM BATTERY SEPARATOR CO LTD +1

A cable cooling liquid, its preparation method and use

The application provides a cable cooling liquid and a preparation method and application thereof, and belongs to the technical field of cooling liquids, and comprises the following raw materials: perfluorobutyl methyl ether, 1,1,2,2-tetrafluoroethyl-2,2,3,3-tetrafluoropropyl ether, a plasticizer, a cosolvent, a chelating agent, a retarder, a flame retardant and an antioxidant. The cooling liquid prepared by the technical scheme provided by the application can achieve the purposes of excellent heat conduction capacity and corrosion resistance to cable materials.
Owner:GUANGDONG LINE GIANT CABLE

Hydrolysis type easy-to-peel rubber tape based on cotton cloth base material and preparation method of hydrolysis type easy-to-peel rubber tape

The invention discloses a hydrolysis type easy-to-peel rubber adhesive tape based on a cotton cloth base material and a preparation method thereof, and relates to the technical field of adhesive tapes, the hydrolysis type easy-to-peel rubber adhesive tape sequentially comprises a first release layer, a first rubber adhesive layer, a cotton cloth base material layer, a second rubber adhesive layer and a second release layer from top to bottom; the first rubber adhesive layer and the second rubber adhesive layer are mutually independently prepared from the following raw materials in parts by weight: 80 parts of thermoplastic styrene-butadiene rubber, 20-25 parts of ethylene acrylate rubber, 78-82 parts of tackifying resin, 5-8 parts of a water repellent agent, 0.8-1.2 parts of an antioxidant, 3-5 parts of citric acid, 2-4 parts of PVA microspheres, 3-5 parts of a hydrolysis catalyst, 3-5 parts of a dispersing agent and 8-10 parts of a cosolvent. And 100 to 130 parts of a solvent. The adhesive tape has high initial adhesion and can be quickly removed without residual adhesive.
Owner:SUZHOU MAIGE TAPE TECH CO LTD

Sealed single dose container of an aqueous levethylenin

The present invention relates to a blow-potting (BFS) sealed single dose container comprising a pharmaceutical composition of an aqueous solution for oral administration, said composition comprising levothyroxine or liothyronin or a pharmaceutically acceptable salt thereof, water and one or more co-solvents and being alcohol-free, exhibiting a pH of 8.1 to 8.7, an average density of 1.18 to 1.23 g / ml (g / mL) and a viscosity of 20 to 60 cps, preferably, the pharmaceutically acceptable salt is levothyroxine sodium.
Owner:尤利亚·采蒂

Synthesis method of 2-(4-methoxyphenyl)-4, 6-bis (2, 4-dihydroxyphenyl)-1, 3, 5-triazine

The invention relates to the technical field of ultraviolet absorbents, and discloses a synthesis method of 2, 4, 6-tri [(1, 1-biphenyl)-4-yl]-1, 3, 5-triazine, which comprises the following steps: S1, heating and mixing amine hydrochloride or choline salt and Lewis acid to prepare a eutectic solvent; s2, 2, 4-dichloro-6-(4-methoxyphenyl)-1, 3, 5-triazine and resorcinol are used as raw materials, the eutectic solvent and the cosolvent are added, the mixture is heated for a reaction, and 2-(4-methoxyphenyl)-4, 6-bis (2, 4-dihydroxyphenyl)-1, 3, 5-triazine is prepared. According to the preparation method, UV627-A and resorcinol are taken as raw materials, and a compounded functional deep eutectic solvent (DES) and a cosolvent are added for reaction and post-treatment, so that high-purity UV627-B can be obtained.
Owner:YIDU HUAYANG CHEM CO LTD

An external use long-acting efinaconazole composition, a preparation method and application thereof

The application provides a long-acting external use efinaconazole composition, a preparation method and application, and belongs to the technical field of pharmaceutical compositions.The long-acting external use efinaconazole composition comprises the following components in percentage by weight: efinaconazole 0.5-3%, a film forming agent 3-7%, a gel agent 2-3%, a plasticizer 3-7%, a cosolvent 0.78-1.56% and a solvent in a residual amount.The application forms a eutectic mixture of efinaconazole and lactic acid, improves the solubility and permeability of the active ingredient, dissolves in the solvent of an ethanol system, and adds the film forming agent and the plasticizer, so that a drug depot is formed on the surface of the skin through the film forming principle, the drug is released slowly, the clinical compliance is improved, the frequency of drug administration is reduced, the bioavailability of the drug in the stratum corneum is increased, the effectiveness and safety of the drug can be improved, the basic theory of pharmacoeconomics is met, and the clinical value of the product is improved.
Owner:JIANGSU SEMPOLL PHARMA