Application of platycodin D to preparation of drug for treating melanoma metastasis

A technology of platycodon saponin and melanoma cells, which is applied in the field of medicine, can solve the problems of unsatisfactory, large toxic and side effects, slow curative effect of Chinese patent medicine on melanoma, etc., and achieve the effect of reducing the number

Inactive Publication Date: 2015-09-09
INST OF SPECIAL ANIMAL & PLANT SCI OF CAAS
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] At present, there is no effective method for treating melanoma clinically. Although chemotherapy drugs have certain curative effects on malignant melanoma, they have relatively large toxic and side effects; Chinese patent medicines have slow and unsatisfactory curative effects on melanoma. Targeted anti-metastatic drugs are one of the strategies with great medical value
There is no report that platycodon saponin D inhibits the metastasis of B16F10 melanoma cells

Method used

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  • Application of platycodin D to preparation of drug for treating melanoma metastasis
  • Application of platycodin D to preparation of drug for treating melanoma metastasis
  • Application of platycodin D to preparation of drug for treating melanoma metastasis

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0022] Preparation of platycodon saponin D capsules

[0023] Monomer platycodon saponin D 500g, medicinal starch 250g, wet granulation with 80% ethanol, granulate, dry, pack into capsules, 0.2g per capsule.

Embodiment 2

[0025] Preparation of platycodon saponin D tablet

[0026] Monomer platycodon saponin D 500g, starch 250g, dextrin 500g, appropriate amount of 50% ethanol, granulate, granulate, dry, compress into tablets, 0.2g per tablet.

Embodiment 3

[0028] Preparation of platycodon saponin D drop pills

[0029] Heat 750g of polyethylene glycol 4000 on a water bath for 1 hour to obtain a molten liquid, add 250g of Platycodon saponin D monomer, and keep it in a heat preservation pot at 65°C for about 1 hour. Dropping with a dropping pill machine, the dropping speed is about 110 pills / min, the dropping temperature is 65-70°C, cooled in liquid paraffin, the weight of the prepared pill is about 60mg, and the weight of the pill after drying according to the regulations is about 40-45mg.

[0030] The above description is only an example for clear description, rather than limiting the implementation. For those of ordinary skill in the art, without departing from the method of the present invention, some improvements and supplements can also be made, and these improvements and supplements should also be regarded as the protection scope of the present invention.

[0031] The following tests show the anti-tumor metastasis activit...

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PUM

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Abstract

The invention discloses application of platycodin D to preparation of a drug for treating melanoma metastasis. Platycodin D can be used for remarkably inhibiting melanoma metastasis and has the effects of reducing the in-vitro cellular activity of melanoma, inhibiting cell migration and invasion capacities of the melanoma, inhibiting the adhesive capacity of a melanoma cell and a vascular endothelial cell and reducing the amount of pulmonary metastasis foci in bodies of rats. A pharmacodynamic method proves that platycodin D has the advantages of multiple approaches and multiple target points in anti-tumor metastasis, so that the clinical application of platycodin D on the aspect of anti-tumor metastasis has the scientific basis.

Description

technical field [0001] The invention discloses a use of platycodon saponin D in preparing a medicine for treating melanoma metastasis, which is a new medical application of platycodon saponin D and belongs to the technical field of medicine. Background technique [0002] The failure of most tumor treatments is due to the occurrence of tumor metastasis in different degrees and in different locations, which has caused great difficulties in the treatment and cure of tumors. Comprehensive treatment of cancer with surgery, radiotherapy and chemotherapy can curb the development of tumors in major parts, but cannot curb the characteristics of tumor metastasis. The process of tumor metastasis involves multiple steps and links, and its mechanism is extremely complex, which brings great difficulties to the treatment of tumors. [0003] Malignant melanoma is a malignant tumor derived from epidermal melanocytes, accounting for about 3% of all malignant tumors. According to the da...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/704A61P35/04
Inventor 郑斯文王英平李伟宋艳玲
Owner INST OF SPECIAL ANIMAL & PLANT SCI OF CAAS
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