Traditional Chinese medicine composition for treating hashimoto's thyroiditis

Abstract

The invention discloses a traditional Chinese medicine composition for treating hashimoto's thyroiditis and a preparation method and application thereof. The traditional Chinese medicine composition is prepared from 12-25 parts of wine-processed rhizoma polygonati, 18-30 parts of Chinese yam, 6-15 parts of pericarpium citri reticulatae, 3-12 parts of fructus amomi, 25-40 parts of semen coicis fried with bran, 8-16 parts of fried fructus gardeniae, 8-16 parts of rhizoma phragmitis, 8-16 parts of chrysanthemum, 8-16 parts of folium mori, 8-16 parts of radix polygonati officinalis, 10-15 parts of lily, 8-16 parts of honeysuckle, 12-25 parts of herba portulacae and 8-16 parts of radix angelicae. , 3-12 parts of platycodon grandiflorum and 3-12 parts of mint. The traditional Chinese medicine composition adopts the theory of syndrome differentiation and treatment, and clinical experiment results and animal experiment results show that the traditional Chinese medicine composition can improve clinical symptoms of patients with hashimoto's thyroiditis, can be used for treating hashimoto's thyroiditis, and has the advantages of remarkable treatment effect, high safety, homology of medicine and food and no toxic or side effect.

Description

Technical Field

[0001] The present invention relates to the field of traditional Chinese medicine compositions, and in particular to a traditional Chinese medicine composition for treating Hashimoto's thyroiditis. Background Art

[0002] Hashimoto's thyroiditis (HT), also known as chronic lymphocytic thyroiditis, is characterized by painless, diffuse goiter and high titers of thyroid autoantibodies in the serum. Approximately 50% of patients eventually develop hypothyroidism. The overall prevalence of thyroid autoantibodies in adults in my country is 14.19%, with the prevalence of anti-thyroid peroxidase autoantibodies (TPOAb) and anti-thyroglobulin antibodies (TGAb) being 10.19% and 9.7%, respectively.

[0003] Western medicine currently has no targeted treatment for Hashimoto's thyroiditis before thyrotoxicosis and hypothyroidism develop. Selenium supplementation (200 μg / day) may be recommended for patients with positive TPOAbs, which may reduce antibody titers, but evidence of long-term efficacy and safety is limited. During the thyrotoxic phase (transient hyperthyroidism), management generally relies on symptomatic treatment, such as beta-blockers to relieve symptoms like palpitations and tremors. ATDs (such as methimazole) should be avoided to prevent the onset of hypothyroidism. Thyroid function should be closely monitored (every 4-6 weeks). If patients transition to hypothyroidism, levothyroxine replacement therapy (LT4) should be initiated. Decisions during the hypothyroid phase should be made based on individual circumstances. Overt hypothyroidism (TSH >10 mIU / L and FT4 below the normal range) requires treatment; subclinical hypothyroidism (elevated TSH but normal FT4) requires individualized decision-making: Initiation of LT4 therapy is recommended for patients with TSH >10 mIU / L or TSH 4.5-10 mIU / L accompanied by hypothyroidism symptoms (such as fatigue, chills, constipation), positive TPOAb, pregnancy desire, or high cardiovascular risk. Asymptomatic patients with mildly elevated TSH (4.5-10 mIU / L) can be observed temporarily, with thyroid function tests repeated every 6-12 months. The preferred medication is levothyroxine sodium (e.g., Euthyrox), starting at a low dose (25-50 μg / day) and gradually adjusting to a maintenance dose (typically 1.6-1.8 μg / kg / day) based on TSH levels.

[0004] This disease falls under the category of "goiter" in Traditional Chinese Medicine (TCM). Depending on the stage of thyrotoxicosis and hypothyroidism, it can be termed goiter and goiter, respectively. When accompanied by benign thyroid nodules or thyroid cancer, it can be termed goiter and stone goiter, respectively. TCM treatment of HT offers significant advantages in alleviating clinical symptoms, reducing thyroid autoantibodies, and regulating the body's immune system.

[0005] Traditional Chinese Medicine (TCM) treatment of Hashimoto's thyroiditis boasts a distinct "preventive" approach and holistic approaches. Compared to Western medicine's passive intervention model, which primarily relies on thyroid hormone replacement, TCM emphasizes "prevention before illness occurs, and prevention of progression after illness." During the compensatory phase of thyroid function, TCM modulates immune imbalances through methods such as soothing the liver and regulating qi, strengthening the spleen and kidneys, and resolving phlegm and dispersing nodules, thereby blocking the persistent damage to the thyroid caused by autoantibodies. Clinical practice demonstrates that TCM formula combinations can address multiple targets—for example, regulating the Th1 / Th2 cell balance to correct immune imbalances, inhibiting thyroid peroxidase antibody (TPOAb) production, and improving thyroid follicular microcirculation. Furthermore, by harmonizing the liver and spleen, TCM can alleviate anxiety and depression, regulate intestinal flora, and address comorbidities such as anxiety and depression. Specialized external treatments such as acupoint application and moxibustion offer synergistic benefits without the risk of hormone dependency. Especially for patients in the subclinical stage, early TCM intervention can effectively delay disease progression, reduce the need for lifelong replacement therapy, and significantly enhance patients' quality of life while improving thyroid function. This demonstrates the advantages of combining prevention with treatment, addressing both the symptoms and the root cause.

[0006] Long-term medication use can lead to toxic side effects and dependency, potentially causing liver and kidney damage. Traditional Chinese medicines that are both natural and safe, while also offering nutritional and health benefits, combine natural safety with the potential to enhance nutritional and health benefits. This concept, rooted in traditional Chinese medicine's philosophy of health preservation, advocates the use of food to supplement medicine and promote longevity. From a green, safe, and healthy perspective, using food-based substances for the treatment of Hashimoto's thyroiditis offers unique advantages and significant efficacy.

[0007] Based on the TCM concept of "preventing disease before it occurs rather than treating it", the application of TCM prescriptions with both medicinal and edible properties to intervene in Hashimoto's thyroiditis early and prevent the occurrence and development of hyperthyroidism and hypothyroidism has obvious cost-effectiveness for any country, especially developing countries. The research and application of TCM prescriptions with both medicinal and edible properties will surely become a new hot spot in the field of hyperthyroidism and hypothyroidism prevention. Summary of the Invention

[0008] The present invention provides a traditional Chinese medicine composition for treating Hashimoto's thyroiditis. The traditional Chinese medicine composition effectively treats Hashimoto's thyroiditis and has the advantages of significant therapeutic effect, high safety, homology of medicine and food, and no toxic side effects.

[0009] To achieve the above-mentioned purpose, the technical solution adopted by the present invention is: a traditional Chinese medicine composition for treating Hashimoto's thyroiditis, comprising the following components in parts by weight: 12-25 parts of polygonatum wine, 18-30 parts of yam, 6-15 parts of tangerine peel, 3-12 parts of amomum villosum, 25-40 parts of fried coix seed with bran, 8-16 parts of fried gardenia, 8-16 parts of reed rhizome, 8-16 parts of chrysanthemum, 8-16 parts of mulberry leaf, 8-16 parts of polygonatum, 10-15 parts of lily, 8-16 parts of honeysuckle, 12-25 parts of purslane, 8-16 parts of angelica dahurica, 3-12 parts of platycodon, and 3-12 parts of mint.

[0010] Furthermore, a traditional Chinese medicine composition for treating Hashimoto's thyroiditis comprises the following components in parts by weight: 12-20 parts of Polygonatum odoratum, 18-25 parts of yam, 6-12 parts of dried tangerine peel, 3-9 parts of Amomum villosum, 25-35 parts of fried Coix seed with bran, 8-12 parts of fried Gardenia jasminoides, 8-12 parts of Phragmites australis, 8-12 parts of chrysanthemum, 8-12 parts of mulberry leaves, 8-12 parts of Polygonatum odoratum, 10-18 parts of lily, 8-12 parts of honeysuckle, 12-18 parts of purslane, 8-12 parts of Angelica dahurica, 3-9 parts of Platycodon grandiflorum, and 3-9 parts of mint.

[0011] Furthermore, a traditional Chinese medicine composition for treating Hashimoto's thyroiditis comprises the following components in parts by weight: 15 parts of Polygonatum odoratum, 20 parts of yam, 9 parts of dried tangerine peel, 6 parts of Amomum villosum, 30 parts of fried Coix seed with bran, 10 parts of fried Gardenia jasminoides, 10 parts of Phragmites australis, 10 parts of chrysanthemum, 10 parts of mulberry leaf, 10 parts of Polygonatum odoratum, 12 parts of lily, 10 parts of honeysuckle, 15 parts of Portulaca oleracea, 10 parts of Angelica dahurica, 6 parts of Platycodon grandiflorum, and 6 parts of mint.

[0012] According to the causes of Hashimoto's thyroiditis, it can be concluded that the main pathogenesis of Hashimoto's thyroiditis is liver depression and spleen deficiency, and internal accumulation of fire and heat. The main therapeutic methods of this Chinese medicine composition are to strengthen the spleen and promote qi, clear away heat and dissipate evil, and moisten dryness and promote body fluid.

[0013] This recipe consists of Polygonatum sibiricum (huangjing), Chinese yam, dried tangerine peel, Amomum villosum, stir-fried coix seed with bran, stir-fried gardenia, reed root, chrysanthemum, mulberry leaf, Polygonatum odoratum, lily bulb, honeysuckle, purslane, angelica dahurica, Platycodon grandiflorum, and mint. All of these herbs are traditional Chinese medicines with edible and medicinal properties. This recipe boasts the effects of invigorating the spleen and promoting qi, clearing heat and dispelling pathogenic factors, and moistening dryness and promoting fluid production. Explanation: Chinese yam has a neutral nature and enters the spleen, lung, and kidney meridians. It is warming and tonic without being harsh, and has a subtle fragrance without being dry. The "Shennong Bencao Jing" describes it as "treating injuries to the middle, replenishing deficiency and debility, eliminating cold and heat pathogenic factors, and strengthening the middle and increasing qi and strength." Polygonatum sibiricum is a neutral tonic and enters the spleen, lung, and kidney meridians. The "Compendium of Materia Medica" describes it as "the best tonic for the uterus," tonifying without causing congestion and strengthening the spleen and promoting digestion. Together, these two herbs serve as the main ingredients, strengthening the spleen and tonifying the middle, tonifying the body's vital energy, and supporting the body's vital energy to dispel pathogenic factors. Amomum villosum has a pungent, dispersing, warming, and aromatic aroma, promoting qi and eliminating dampness, invigorating the spleen and regulating the stomach. Tangerine peel is pungent, bitter, and warm, entering the spleen and lung meridians. It regulates qi and strengthens the spleen, dries dampness and resolves phlegm, eliminates stagnation in the middle burner, and relieves qi stagnation. Coix seed is sweet, mild, and cool, tonifying the spleen, stomach, and lung meridians. It is cool in nature, clears heat without damaging the spleen and stomach, and dissipates dampness to prevent greasy nourishment and spleen obstruction. These three herbs work together as ministers, tonifying the middle burner while promoting circulation, tonifying the spleen without stagnation, and harmonizing ascending and descending functions to regulate qi in the middle burner. Phragmites australis is sweet and cold, entering the lung and stomach meridians, effectively clearing heat from the lungs and stomach and channeling it downward. Gardenia jasminoides is bitter and cold, entering the heart, lungs, and triple burner, effectively clearing fire pathogens from the triple burner, clearing the heart and relieving restlessness. Portulaca oleracea is sour and cold, entering the liver and large intestine meridians, clearing heat and purging fire, detoxifying and cooling the blood. Together, these three herbs clear heat from the triple burner and internal organs. Honeysuckle enters the lung, heart, and stomach meridians, while mulberry leaves and chrysanthemum enter the lungs and liver. These three herbs are sweet, cold, and light in nature, clearing and dispersing, and together they clear stagnant fire and prevent heat and fire from stagnation. Lily bulbs and Polygonatum odoratum are sweet and slightly cold, one entering the heart and lungs, the other nourishing the lungs and stomach. Together, they promote fluid production and moisten dryness, promoting the rise of yang and the response of yin. The other herbs serve as adjuvants, dispersing heat from the upper body, clearing heat from the middle, and channeling heat downward, nourishing yin and promoting fluid production to prevent the onset of heat and fever. Goiter is located in the upper part of the body, so Angelica dahurica, Platycodon grandiflorum, and Mentha chinensis serve as adjuvants. Their pungent, dispersing, and ascending properties guide the herbs upward, clearing the head and eyes, and directly reaching the affected area. Together, these herbs strengthen the spleen and promote qi, clearing heat and dispersing pathogenic factors, moistening dryness and promoting fluid production. They are primarily used for patients with Hashimoto's thyroiditis characterized by liver depression and spleen deficiency, and internal heat and fever.

[0014] A medicine for treating Hashimoto's thyroiditis is prepared by mixing an extract of a traditional Chinese medicine composition with a pharmaceutically acceptable carrier into oral liquid, granules, capsules, tablets and dripping pills.

[0015] When the extracts of the raw materials provided by the present invention are prepared into oral liquid, the extracts of the raw materials are dissolved in distilled water, filtered, and the pH value is adjusted to prepare the oral liquid.

[0016] When the extracts of various raw materials provided by the present invention are made into granules, the extracts of various raw materials and diluent lactose or corn starch are evenly mixed, granulated, and dried to make the granules.

[0017] When the extract provided by the invention is prepared into capsules, the extracts of various raw materials and carrier lactose or corn starch are evenly mixed, granulated, and then filled into capsules to prepare the capsules.

[0018] When the extracts of the raw materials provided by the present invention are made into tablets, the raw materials are mixed with lactose or corn starch, and lubricant magnesium stearate is added when necessary, mixed evenly, granulated, and then compressed into tablets.

[0019] The method for preparing the drug for treating Hashimoto's thyroiditis of the present invention comprises the following steps:

[0020] The invention discloses a method for preparing a preparation of the present invention. The invention provides a method for preparing the preparation of the present invention. The method comprises the following steps: taking a prescribed amount of polygonatum sibiricum, yam, tangerine peel, amomum villosum, fried coix seed with bran, fried gardenia jasmine, reed root, chrysanthemum, mulberry leaf, polygonatum, lily, honeysuckle, purslane, angelica dahurica, platycodon grandiflorum, and mint, decocting the mixture twice with water, each time for 1 to 2 hours, combining the decoctions, filtering the mixture, concentrating the filtrate, adding 85% ethanol by volume for alcohol precipitation, filtering off the precipitate, recovering the filtrate, and concentrating the mixture at 80°C to a relative density of 1.30 to 1.36 to obtain an extract; and preparing the obtained extract and pharmaceutically acceptable excipients into an oral solution, capsule, tablet, granule, or pill.

[0021] The invention provides an application of the traditional Chinese medicine composition for treating Hashimoto's thyroiditis in preparing a composition for treating Hashimoto's thyroiditis.

[0022] Compared with the prior art, the present invention has the following beneficial effects: the Chinese medicine composition effectively treats Hashimoto's thyroiditis, exhibiting significant therapeutic efficacy, medicinal and edible properties, high safety, and no toxic side effects. The Chinese medicine composition of the present application is scientifically and rationally formulated, exhibits significant efficacy, and can be formulated into a variety of dosage forms, promising broad clinical application prospects. BRIEF DESCRIPTION OF THE DRAWINGS

[0023] Figure 1 : Effects of Chinese herbal medicine composition on antibodies in rats with Hashimoto's thyroiditis.

[0024] Effect on TGAb. DETAILED DESCRIPTION

[0025] The present invention will be further described below with reference to the embodiments.

[0026] Example 1

[0027] A method for preparing a traditional Chinese medicine composition for treating Hashimoto's thyroiditis comprises the following steps:

[0028] Take 15 parts of polygonatum with wine, 20 parts of yam, 9 parts of dried tangerine peel, 6 parts of amomum villosum, 30 parts of coix seed fried with bran, 10 parts of stir-fried gardenia, 10 parts of reed rhizome, 10 parts of chrysanthemum, 10 parts of mulberry leaf, 10 parts of polygonatum, 12 parts of lily, 10 parts of honeysuckle, 15 parts of purslane, 10 parts of the root of angelica dahurica, 6 parts of platycodon, and 6 parts of mint.

[0029] Take specified amounts of wine-fermented polygonatum, yam, dried tangerine peel, amomum villosum, fried coix seed with bran, fried gardenia, reed root, chrysanthemum, mulberry leaf, polygonatum, lily, honeysuckle, purslane, angelica dahurica, platycodon, and mint, add water and boil twice, each time for 1 to 2 hours, combine the decoctions, filter, concentrate the filtrate, add 85% ethanol by volume for alcohol precipitation, filter out the precipitate, recover the filtrate and concentrate it at 80°C to a relative density of 1.30 to 1.36 to obtain an extract for later use; add corn starch to the obtained extract, mix evenly, granulate, and dry to prepare granules.

[0030] Take with 200ml of warm water, half an hour after meal, 1 bag at a time, 2 times a day.

[0031] Example 2

[0032] A method for preparing a traditional Chinese medicine composition for treating Hashimoto's thyroiditis comprises the following steps:

[0033] Take 15 parts of polygonatum with wine, 20 parts of yam, 9 parts of dried tangerine peel, 6 parts of amomum villosum, 30 parts of coix seed fried with bran, 10 parts of stir-fried gardenia, 10 parts of reed rhizome, 10 parts of chrysanthemum, 10 parts of mulberry leaf, 10 parts of polygonatum, 12 parts of lily, 10 parts of honeysuckle, 15 parts of purslane, 10 parts of the root of angelica dahurica, 6 parts of platycodon, and 6 parts of mint.

[0034] Take specified amounts of Huangjing (Symph. glutinosa), yam, dried tangerine peel, amomum villosum, fried coix seed with bran, fried gardenia, reed root, chrysanthemum, mulberry leaf, polygonatum, lily, honeysuckle, purslane, angelica dahurica, platycodon, and mint, add water and boil twice, each time for 1 to 2 hours, combine the decoctions, filter, concentrate the filtrate, add 85% ethanol by volume for alcohol precipitation, filter out the precipitate, recover the filtrate and concentrate it at 80°C to a relative density of 1.30 to 1.36 to obtain an extract for later use; dissolve the obtained extract in distilled water, filter, adjust the pH value, and prepare an oral solution.

[0035] Example 3

[0036] A method for preparing a traditional Chinese medicine composition for treating Hashimoto's thyroiditis comprises the following steps:

[0037] Take 15 parts of polygonatum with wine, 20 parts of yam, 9 parts of dried tangerine peel, 6 parts of amomum villosum, 30 parts of coix seed fried with bran, 10 parts of stir-fried gardenia, 10 parts of reed rhizome, 10 parts of chrysanthemum, 10 parts of mulberry leaf, 10 parts of polygonatum, 12 parts of lily, 10 parts of honeysuckle, 15 parts of purslane, 10 parts of the root of angelica dahurica, 6 parts of platycodon, and 6 parts of mint.

[0038] Take specified amounts of Huangjing (Symphaea rhizoma), Chinese yam, dried tangerine peel, Amomum villosum, stir-fried coix seed with bran, stir-fried gardenia jasmine, reed root, chrysanthemum, mulberry leaf, polygonatum, lily, honeysuckle, purslane, angelica dahurica, platycodon grandiflorum, and mint, add water and boil twice, each time for 1 to 2 hours, combine the decoctions, filter, concentrate the filtrate, add 85% ethanol by volume for alcohol precipitation, filter out the precipitate, recover the filtrate and concentrate it at 80°C to a relative density of 1.30 to 1.36 to obtain an extract for later use; add diluent cyclodextrin or corn starch to the obtained extract, mix evenly, granulate, dry, and then fill into capsules to prepare capsules.

[0039] Animal experiments

[0040] 1. Drug preparation

[0041] A method for preparing a traditional Chinese medicine composition for treating Hashimoto's thyroiditis comprises the following steps:

[0042] Same as the prescription in Example 1.

[0043] 2 Experimental Design

[0044] Twelve SPF female Sprague-Dawley rats, approximately 6 weeks old and weighing 200 ± 20 g, were purchased from Weitong Lihua Laboratory Animal Co., Ltd. (Beijing, China, Laboratory Animal Qualification License No. SCXK2021-0006). The experimental animals were housed at the Experimental Animal Center of Beijing University of Chinese Medicine, with room temperature maintained at 18–22°C, relative humidity at 30%–70%, and natural light conditions. All animals had free access to standard chow. Four of the 12 rats were randomly selected as the normal control group (Ctrl) and fed with normal saline. In this study, a rat model of Hashimoto's thyroiditis was established using 0.064% iodine solution combined with subcutaneous injection of porcine Tg. Successfully established rats were randomly divided into three groups (n=4): a model group (Hashimoto's thyroiditis) and a group with an equivalent dose of a traditional Chinese medicine composition (TCM). The equivalent dose of the Chinese medicine composition was calculated for experimental animals according to the "Equivalent Dose Ratio Table for Humans and Animals Based on Body Surface Area." Both the control and model groups were gavaged with an equal volume of normal saline (1 ml / 100 g). During the dosing period, the control group was fed with normal saline, while the remaining groups were fed with 0.064% iodine solution. Six weeks after the intervention, blood was drawn from the abdominal aorta under 1% sodium pentobarbital anesthesia for serum.

[0045] 3 Experimental Results

[0046] Figure 1 The TGAb levels of experimental animals after 6 weeks of drug intervention are shown. TGAb levels in rats with Hashimoto's thyroiditis were significantly higher than those in the normal group. After 6 weeks of TCM intervention, TGAb levels in rats in the TCM group were significantly lower than those in the Hashimoto's thyroiditis group. (See Appendix.) Figure 1)

[0047] 4 Conclusion

[0048] The Chinese medicinal composition of the present invention is used for treating Hashimoto's thyroiditis and can improve the antibody level of rats with Hashimoto's thyroiditis and improve autoimmune abnormalities.

[0049] The embodiments of this specific implementation method are all preferred embodiments of the present invention, and are not intended to limit the scope of protection of the present invention. Therefore, all equivalent changes based on the concept and technical solution of the present invention should be included in the scope of protection of the present invention.

Claims

1. A Chinese medicine composition for treating Hashimoto's thyroiditis, characterized in that: The invention comprises the following components in parts by weight: 12-25 parts of polygonatum wine, 18-30 parts of yam, 6-15 parts of dried tangerine peel, 3-12 parts of amomum villosum, 25-40 parts of coix seed fried with bran, 8-16 parts of fried gardenia, 8-16 parts of reed rhizome, 8-16 parts of chrysanthemum, 8-16 parts of mulberry leaf, 8-16 parts of polygonatum, 10-15 parts of lily, 8-16 parts of honeysuckle, 12-25 parts of purslane, 8-16 parts of angelica dahurica, 3-12 parts of platycodon grandiflorum and 3-12 parts of mint.

2. The Chinese medicine composition for treating Hashimoto's thyroiditis according to claim 1, characterized in that The invention comprises the following components in parts by weight: 12-20 parts of polygonatum wine, 18-25 parts of yam, 6-12 parts of dried tangerine peel, 3-9 parts of amomum villosum, 25-35 parts of coix seed fried with bran, 8-12 parts of fried gardenia, 8-12 parts of reed rhizome, 8-12 parts of chrysanthemum, 8-12 parts of mulberry leaf, 8-12 parts of polygonatum, 10-18 parts of lily, 8-12 parts of honeysuckle, 12-18 parts of purslane, 8-12 parts of angelica dahurica, 3-9 parts of platycodon grandiflorum, and 3-9 parts of mint.

3. A Chinese medicine composition for treating Hashimoto's thyroiditis according to claim 1, characterized in that: The invention comprises the following components in parts by weight: 15 parts of polygonatum wine, 20 parts of yam, 9 parts of dried tangerine peel, 6 parts of amomum villosum, 30 parts of coix seed fried with bran, 10 parts of fried gardenia, 10 parts of reed rhizome, 10 parts of chrysanthemum, 10 parts of mulberry leaf, 10 parts of polygonatum, 12 parts of lily, 10 parts of honeysuckle, 15 parts of purslane, 10 parts of angelica dahurica, 6 parts of platycodon grandiflorum and 6 parts of mint.

4. A Chinese medicine composition for treating Hashimoto's thyroiditis according to claim 1, characterized in that: All components of the Chinese medicine composition are Chinese medicines that can be used as both medicine and food.

5. A drug for treating Hashimoto's thyroiditis, characterized in that: The extract of the traditional Chinese medicine composition according to any one of claims 1 to 3 and a pharmaceutically acceptable carrier are prepared into a medicine in the form of oral liquid, capsule, tablet, granule or pill.

6. A method for preparing the Chinese medicine composition for treating Hashimoto's thyroiditis according to claim 1, characterized in that: The following steps are involved: The invention discloses a method for preparing a preparation of the present invention. The invention provides a method for preparing the preparation of the present invention. The method comprises the following steps: taking a prescribed amount of polygonatum sibiricum, yam, tangerine peel, amomum villosum, fried coix seed with bran, fried gardenia jasmine, reed root, chrysanthemum, mulberry leaf, polygonatum, lily, honeysuckle, purslane, angelica dahurica, platycodon grandiflorum, and mint, decocting the mixture twice with water, each time for 1 to 2 hours, combining the decoctions, filtering the mixture, concentrating the filtrate, adding 85% ethanol by volume for alcohol precipitation, filtering out the precipitate, recovering the filtrate, and concentrating the mixture at 80°C to a relative density of 1.30 to 1.36 to obtain an extract for later use; and preparing the extract and pharmaceutically acceptable excipients into oral liquid, capsule, tablet, granule, or pill.

7. Use of the traditional Chinese medicine composition for treating Hashimoto's thyroiditis according to any one of claims 1 to 3 in preparing a medicament for treating Hashimoto's thyroiditis.

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