The invention relates to a Tildipirosin acetone solvent compound and a preparation method. An X-ray powder diffraction spectrum of the Tildipirosin acetone solvent compound has characteristic peaks at a diffraction angle 2theta which is equal to 6.12 degrees plus or minus 0.2 degrees, 8.48 degrees plus or minus 0.2 degrees, 9.39 degrees plus or minus 0.2 degrees, 9.98 degrees plus or minus 0.2 degrees, 10.32 degrees plus or minus 0.2 degrees, 11.40 degrees plus or minus 0.2 degrees, 13.46 degrees plus or minus 0.2 degrees, 13.90 degrees plus or minus 0.2 degrees, 14.58 degrees plus or minus 0.2 degrees, 15.78 degrees plus or minus 0.2 degrees, 16.64 degrees plus or minus 0.2 degrees, 17.20 degrees plus or minus 0.2 degrees, 17.94 degrees plus or minus 0.2 degrees, 18.88 degrees plus or minus 0.2 degrees, 19.58 degrees plus or minus 0.2 degrees, 20.16 degrees plus or minus 0.2 degrees, 20.64 degrees plus or minus 0.2 degrees, 22.10 degrees plus or minus 0.2 degrees, 22.74 degrees plus or minus 0.2 degrees, 23.38 degrees plus or minus 0.2 degrees, 24.64 degrees plus or minus 0.2 degrees and 26.30 degrees plus or minus 0.2 degrees. The preparation method is simple, and a prepared product is block-shaped, has a complete crystal habit and has the characteristics of good fluidity, high bulk density and good stability.