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Tildipirosin suspension injection and preparation method thereof

A suspension injection, a new technology of Tiderol, which is applied in the field of preparation of animal drugs, can solve the problems of isomer conversion and poor preparation stability, and achieve stable preparations, improved bioavailability, and low solubility Effect

Active Publication Date: 2017-07-14
SOUTH CHINA AGRI UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] Currently, the Tedirosin injection used in the domestic and foreign markets generally has the problem of isomer conversion of Tedirosin in the solution, which leads to poor stability of the preparation. Therefore, it is necessary to study new technical solutions to ensure that Tedirosin The preparation remains stable, reducing the dosage of drugs and ensuring the therapeutic effect

Method used

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  • Tildipirosin suspension injection and preparation method thereof
  • Tildipirosin suspension injection and preparation method thereof
  • Tildipirosin suspension injection and preparation method thereof

Examples

Experimental program
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Effect test

Embodiment 1

[0039] Each 100 mL Tedirosin Suspension Injection contains the following components by mass ratio: Tedirosin raw material 4g, wetting agent 0.2g, suspending agent 0.5g, preservative 0.01g, deflocculant 1.5g g, 0.5 g of pH regulator.

[0040] Wherein, the suspending agent is sodium carboxymethyl cellulose, the wetting agent is glycerol, the deflocculant is sodium tartrate, the preservative is sodium benzoate, and the pH regulator is citric acid. The properties of the obtained suspension injection are shown in Table 1.

Embodiment 2

[0042] Each 100 mL Tedirosin Suspension Injection contains the following components by mass ratio: Tedirosin API 6g, wetting agent 0.2g, suspending agent 0.8g, pH regulator 0.5g, deflocculant 1.5 g, preservative 0.01 g.

[0043] Wherein, the suspending agent is carboxymethylcellulose calcium, the wetting agent is Tween-20, the deflocculant is sodium tartrate, the preservative is phenoxyethanol, and the pH regulator is sorbic acid. The properties of the obtained suspension injection are shown in Table 1.

Embodiment 3

[0045] Each 100 mL Tedirosin Suspension Injection contains the following components by mass ratio: 2 g Tedirosin API, 0.3 g wetting agent, 1.0 g suspending agent, 1.5 g deflocculant, pH regulator 0.6g, preservative 0.02g.

[0046] Wherein, the suspending agent is povidone, the wetting agent is polyethylene glycol-300 and polyethylene glycol-400, the deflocculant is sodium tartrate, the preservative is chlorobutanol, and the pH regulator is benzoic acid. The properties of the obtained suspension injection are shown in Table 1.

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Abstract

The invention discloses a Tildipirosin suspension injection and a preparation method thereof. Every 100ml of the Tildipirosin suspension injection contains the following components in mass proportion: 2-10g of Tildipirosin, 0.2-1.0g of a wetting agent, 0.5-2g of a suspending aid, 0.01-0.1g of a preservative, 1.0-2.0g of a deflocculating agent and 0.002-0.008g of a pH regulator, wherein the deflocculating agent is sodium tartrate. The Tildipirosin suspension injection disclosed by the invention has the advantages that the wetting agent is utilized for wetting a Tildipirosin medicine, and Tildipirosin is uniformly dispersed in water in a micron-scale particle state by utilizing physical smashing, shearing and dispersing effects of the suspending aid and a multifunctional emulsifying and dispersing machine. The preparation method of the Tildipirosin suspension injection is simple and easy to operate; and compared with common injection, solubility is low, conversion of isomers does not exist, a preparation is more stable, and Tildipirosin is taken as a time-dependent medicine. The suspension injection disclosed by the invention has slow release effect and can maintain longer-time effective blood concentration of a target animal, so that medicine efficacy is obviously improved.

Description

technical field [0001] The invention relates to the technical field of preparation of animal medicines, in particular to a medicine for treating respiratory tract infection in livestock, more specifically to a tediroxin suspension injection and a preparation method thereof. Background technique [0002] With the expansion of the scale of intensive farming, the respiratory diseases, digestive system diseases and other diseases of livestock and poultry are becoming more and more serious. Respiratory tract infection is an infectious disease that is difficult to control in animal husbandry, and it will cause huge economic losses to animal husbandry production. Therefore, how to prevent and treat respiratory infections in livestock such as pigs and cattle is an important research topic for veterinarians and veterinary medicine workers. Because respiratory tract infection is generally multiple infections, there are many pathogenic factors, and there are many types of pathogens th...

Claims

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Application Information

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IPC IPC(8): A61K9/10A61K31/706A61K47/12A61P31/04A61P11/00
CPCA61K9/0019A61K9/10A61K31/706A61K47/12
Inventor 黄显会谢顺赵永达
Owner SOUTH CHINA AGRI UNIV
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