Tildipirosin-containing medicinal composition

A technology of Tedirosin and its composition, which is applied in the field of medicinal chemistry, can solve the problems of reduced therapeutic effect and achieve long half-life, good therapeutic effect and broad antibacterial spectrum

Active Publication Date: 2015-09-16
LUOYANG HUIZHONG ANIMAL MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although the dosage is increasing, the therapeutic effect is gradually decreasing

Method used

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  • Tildipirosin-containing medicinal composition
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  • Tildipirosin-containing medicinal composition

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1～4 and comparative example 1

[0016] Examples 1 to 4 are the preparation of Tederosine composition injection. Table 1 shows the mass-volume (W / V) percentage of each component in Tederosine composition injection of the present invention. The mixed solution is configured according to the content of each component in Table 1, and the volume is fixed with purified water, filtered, potted, and sterilized at 100° C. for 30 minutes to obtain Tediloxine composition injection.

[0017] Comparative example 1 is Zuprevo, a product made by Interway with Tederosine as the main component, which contains 18% Tedrosine, 8.25% citric acid monohydrate for pH adjustment, 40% propylene glycol, and the balance For water.

[0018] Table 1

[0019]

Tidiluoxin (%)

Polyvinylpyrrolidone(%)

Propylene glycol (%)

Citric acid adjusts the pH to

Example 1

1

10

/

5.5

Example 2

4

15

/

5.7

Example 3

10

20

/

5.6

Example 4

20

25

/

6.1

Comparative example 1

18

/

40

8.25%

[0020] 1. Drug stability test of injection:

[0021] Inj...

Embodiment 5

[0050] This example is a study on Tidiluoxin oral liquid with a content of 10% (W / V).

[0051] 1. Preparation of 10% Taidiluoxin Oral Liquid, the specific steps are:

[0052] (1) Add water of 60-70% of the total volume of Tediloxine oral liquid prepared in the preparation tank, stir, and adjust the pH value to 5.7-6.3 with concentrated phosphoric acid with a concentration of 85%.

[0053] (2) Add Tediloxine according to the amount.

[0054] (3) Use concentrated phosphoric acid with a concentration of 5%-100% to adjust the pH to 5.5-6.0, so that all the materials are dissolved.

[0055] (4) Add 30% g of glycerin and stir to dissolve, and warm to 50-60°C.

[0056] (5) Add water to 100ml, and then filter through a 0.45 micron filter membrane to obtain the desired Tediloxine oral solution.

[0057] 2. Therapeutic test of oral liquid

[0058] 1 Choose Du Changda ternary hybrid commercial pigs, half male and half, average weight 25.7-27.lkg, a total of 80 pigs; randomly divided into 4 groups, th...

Embodiment 6

[0078] This example is a study on Tidiluoxin soluble powder with a weight percentage of 20%.

[0079] Preparation materials: Tidiluoxin, tartaric acid, sodium tartrate, powder carrier is sucrose.

[0080] Preparation method: Take 200 g of Tederosine, 20 g of tartaric acid, 50 g of sodium tartrate, and 730 g of sucrose powder, mix uniformly in stages, pulverize, and pass through an 80-mesh sieve to obtain the soluble powder of the Tederosine composition.

[0081] Treatment effect: 90 pigs suffering from swine disease, the main clinical symptoms are coughing, wheezing, and dyspnea. The pathogen was identified as mycoplasma infection by PCR. They were randomly divided into 3 groups according to body weight: the first group was a blank control group and no drug treatment was given ; The second group was treated with Tederosine soluble powder prepared by the present invention, the usage was 100g with 200L of water, drinking water for 5 days, the third group of drug control group was florf...

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Abstract

The invention provides a tildipirosin-containing medicinal composition. The dosage form of the medicinal composition is an injection, the composition comprises, by mass/volume, 1-20% of tildipirosin, 10-25% of polyvinylpyrrolidone, an acid, and the balance of water, and the use amount of the acid makes the pH value of the composition be 5.5-6.5; and the tildipirosin is tildipirosin or a pharmaceutically acceptable salt thereof. Tildipirosin in above raw materials is a special antibiotic for livestock and poultry, does not bring a cross drug resistance problem for people, is a first selected medicine for treating animal respiratory tract diseases, and has a very good treatment effect on Streptococcus suis, Pasteurella multocida, Haemophilus parasuis, Actinobacillus pleuropneumoniae and mycoplasma.

Description

Technical field [0001] The invention relates to the field of medicinal chemistry, in particular to a pharmaceutical composition containing Tederosine. Background technique [0002] Respiratory tract infection is one of the more difficult to control infectious diseases in animal husbandry, and it has serious harm to animal husbandry production. When the respiratory tract infection is prevalent, it will cause huge economic losses to animal husbandry production. Therefore, how to prevent and treat respiratory infections in pigs, cattle and other livestock is an important research topic for veterinarians and veterinary medicine workers. Respiratory tract infections are generally multiple infections with many pathogenic factors and complex conditions. They are mainly used in animals for prevention and treatment in my country. Macrolide antibiotics are commonly used drugs for the treatment of respiratory tract infections in pigs and cattle. The macrolide antibiotics currently used in...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/706A61P31/04A61P11/00
Inventor 张许科刘兴金周德刚
Owner LUOYANG HUIZHONG ANIMAL MEDICINE
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