Crude product crystallization device and crystallization method for preparing tildipirosin

Abstract

The invention discloses a crude product crystallization device for preparing tildipirosin, and relates to the technical field of tildipirosin preparation, wherein the crude product crystallization device comprises a crystallization kettle, a heating sleeve arranged on the outer wall of the lower part of the crystallization kettle in a sleeving manner and a motor arranged at the top of the crystallization kettle; feeding pipes are arranged on the two sides of the top surface of the crystallization kettle, and a rotating shaft is rotationally arranged in the middle of the inner top surface of the crystallization kettle; a stirring rod is arranged at the bottom end of the rotating shaft; and a rotating shaft body is sleeved with a flow guide mechanism used for distributing liquid medicine. An added solution can conveniently drop on the surface layer of an original solution in a kettle body through a flow baffle and a liquid discharge pipe in the flow guide mechanism, and the added solution can be conveniently mixed in the deep layer of the original solution under the action of centrifugal force during rotation through the arrangement of a liquid guide assembly and a sleeve, and the added solution is quickly dispersed and mixed into the original solution, so that the mixing uniformity of the two solutions is improved; and the crystal purity of the prepared crude tildipirosin product is improved, and the operation efficiency of the crude tildipirosin product during preparation is improved.

Description

technical field [0001] The invention relates to the technical field of preparation of tedirosin, in particular to a crude product crystallization device and a crystallization method for preparing tedirosin. Background technique [0002] Tedirosin is a new type of sixteen-membered ring macrolide semi-synthetic antibiotic for animals; Tedirosin is a broad-spectrum antibacterial drug, which has strong activity against some Gram-positive and Gram-negative bacteria. Antibacterial activity, especially sensitive to pathogenic bacteria that cause respiratory diseases in pigs and cattle. Therefore, the aquaculture industry has a large demand for tadirosin. When producing tadirosin, it is necessary to use crystallization kettles to prepare tadirosin; [0003] However, when the existing crystallization kettle used for the new preparation of tedrol is dosing, the added medicinal liquid all drops on the surface layer of the original solution inside the kettle body, and the added solutio...

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Problems solved by technology

[0003] However, when the existing crystallization kettle used for the new preparation of Tedrol is adding medicine, the added medicine liquid is all dripped into the original solution inside the kettle body The added solution cannot directly reach the deep layer of the original solution, and it needs to be mixed through long-term stirring, and the uniformity of the mixing is poor, resulting in low purity of the crystallization of the crude product of Tedirosin; therefore, The above problems need to be improved

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