747results about "Heat exchange cooling cystallization" patented technology

A process is provided for making sterile aripiprazole having an average particle size less than 100 microns but preferably greater than 25 microns employing an impinging jet crystallization procedure. The resulting bulk aripiprazole of desired particle size may be used to form a sterile freeze-dried aripiprazole formulation, which upon constitution with water and intramuscular injection releases aripiprazole over a period of at least about one week and up to about eight weeks.

The invention discloses a continuously controllable acesulfame crystallization device. The continuously controllable acesulfame crystallization device comprises: a crystal growing device, a first conveying pump, a first-grade crystallizer, a second conveying pump, a second-grade crystallizer, a third conveying pump, a thickening device, a fourth conveying pump and a crystal slurry tank; the crystal growing device comprises at least one crystal growing kettle; a discharging hole of each crystal growing kettle is connected with a stop valve in series and then is communicated with an inlet of the first conveying pump; the first-grade crystallizer comprises a first-grade crystallizing kettle, a first-grade cooler and a first-grade circulating pump; an outlet of the first conveying pump is communicated with a lower circulating hole of the first-grade crystallizer; the second-grade crystallizer comprises a second-grade crystallizing kettle, a second-grade cooler and a second-grade circulating pump; the discharging hole of the first-grade crystallizing kettle is communicated with the inlet of the second conveying pump; the outlet of the second conveying pump is communicated with the lower circulating hole of the second-grade crystallizer; the discharging hole of the second-grade crystallizing kettle is communicated with the thickening device through the third conveying pump; the outlet of the thickening device is communicated with the inlet of the crystal slurry tank through the fourth conveying pump. The crystallization device provided by the invention is high in production efficiency and an obtained acesulfame crystal has good quality and large granularity.

The present specification discloses methods of purifying one or more cannabinoids from a plant material, purified cannabinoids and pharmaceutical compositions comprising one or more cannabinoids produced by the disclosed method, methods and uses for treating a disease or condition employing such purified cannabinoids and pharmaceutical compositions.

In a process for the purification of a crude acrylic acid melt, the crude acrylic acid melt is converted, under the action of low temperatures, into a crude acrylic acid suspension consisting of acrylic acid crystals and residual melt, and the acrylic acid crystals of the crude acrylic acid suspension are freed from remaining residual melt in a wash column, the production of the acrylic acid crystals of the crude acrylic acid suspension being carried out in the presence of water, the wash column being a wash column with forced transport of the acrylic acid crystals and the wash liquid used being the melt of acrylic acid crystals purified in the wash column.

A method for generating a multihydrated hydronium ion including the steps: agitating water to reduce cluster size, mixing sulfuric acid in the water, adding a solution containing Ca3+ ions, removing precipitated Ca sulfate, cooling the resultant liquid to a form a slush, filterin out ice from the slush, distilling free water from the remaining liquid wherein the remaining liquid is H₉O₄⁺.

A method for preparing a purified cannabis extract may comprise extracting a crude extract from cannabis solids, dewatering the crude extract, removing chlorophyll from the crude extract, and distilling the crude extract thereby creating a purified cannabis extract. The extracting step may include contacting crude cannabis solids with an organic ester, thereby creating the crude extract and waste solids. The dewatering step may include contacting the crude extract with a solid dewatering agent and filtering the crude extract from the solid dewatering agent. The removing chlorophyll step may include contacting the crude extract with a solid absorbent agent, and filtering the crude extract from the solid absorbent agent.

A process and method to separate heavy water from regular water by lowering the temperature of the mixture to the melting point of the heavy water.

A process and apparatus is presented for the desalination of water by freezing seawater. The process is integrated into a liquefied natural gas regasification system.

The invention relates to a method for continuously preparing high-bulk density methionine crystals. The process of the method is as follows: a hydrolysate, which is obtained from reaction of 5-(beta-methylthioethyl)hydantoin and a potassium carbonate solution, is mixed with an outside circular material from a DTB neutralization crystallizer with a gas phase neutralization section, the mixture is cooled and enters a liquid distributor in a neutralization area in the upper part of the crystallizer, the mixture is sprayed in drops or trickles into carbon dioxide gas for neutralization reaction, and then falls naturally into a crystallization area in the lower part to be mixed with a material in the area, the mixture grows on tiny crystals in a system to form crystals with larger grain sizes, and meanwhile new crystal nucleuses are formed; in a deposition area in the middle part of the crystallization area, the crystals with larger grain sizes sink into a washing leg, the tiny crystals circulate along with the outside circular material, a part of the outside circular material is used for washing the crystals in the washing leg, and the other part of the outside circular materials is mixed with the hydrolysate; the crystals in the washing leg are separated, washed and then dried to obtain the high-bulk density methionine product.

It is an object of the present invention to provide a method for producing microparticles, which can produce monodispersed microparticles, causes no clogging with a product due to self-dischargeability, requires no great pressure, and is excellent in productivity, wherein a fluid in which at least one kind of microparticle materials is dissolved is introduced between two processing surfaces arranged to be opposite to each other to be able to approach to and separate from each other, at least one of which rotates relative to the other, to be formed into a thin film fluid, and the thin film fluid is cooled or heated (warmed) to allow saturation solubility to change, thereby separating microparticles.

Cannabidiol (CBD) is a cannabinoid designated chemically as 2-[(1R,6R)-3-Methyl-6-(1-methylethenyl)-2-cyclohexen-1-yl]-5-pentyl-1,3-benzenediol. Its empirical formula is C₂₁H₃₀O₂ and its molecular weight is 314.46. CBD is a cannabinoid that naturally occurs in the Cannabis sativa L. plant. CBD is a white to pale yellow crystalline solid which is insoluble in water and soluble in organic solvents. The present invention encompasses the surprising recognition that certain CBD preparations which are prepared from a botanical origin are more effective in treating diseases or disorders than preparations of CBD which are synthetic or purified to the extent no other impurities in the form of other cannabinoids are present. Prior CBD compositions have been prepared such that no psychoactive components, e.g., tetrahydrocannabinol (THC), remain in the final CBD preparation. Surprisingly, the absence of such minor impurities reduces the efficacy of CBD treatment. Such CBD preparations are characterized by chemical components and/or funtional properties that distinguish them from prior CBD compositions. One or more components of the preparations described herein provide an unexpectedly synergistic effect when utilized in combination.

A MEG reclamation process includes the step of increasing above 2,000 ppm the divalent metal salts concentration of a rich (wet) MEG feed stream flowing into a precipitator. The increasing step includes routing a salts-saturated MEG slipstream from the flash separator it to the precipitator. The slipstream may be mixed with a fresh water feed stream, a portion of the rich MEG feed stream, or some combination of the two. The rich MEG feed stream also may be split into two streams, with a portion of the stream being heated and routed to the flash separator and the other portion being combined as above with the removed slipstream. The process can be performed on the slipstream after dilution and prior to entering the precipitator or after being loaded into the precipitator. Removal of the insoluble salts may be done in either a batch or continuous mode.

A process is described for recovering alkali-chloride and alkali-sulfate salts from a salt solution. The salt solution comprises alkali metal, chloride and sulfate ions and is directed to a hydrous salt crystallization unit which crystallizes hydrated sulfate salts that comprise sulfate and at least one alkali metal. A purged solution from the hydrous salt crystallization unit is directed to a chloride salt crystallization unit while the hydrated sulfate salt crystals are melted to form an aqueous sulfate solution which is directed to a sulfate crystallization unit. Anhydrous sulfate salts are crystallized from the aqueous sulfate solution to form sulfate salt crystals comprising sulfate and at least one alkali metal. In the chloride salt crystallization unit, chloride salt is crystallized to form chloride salt crystals. A purge from the chloride salt crystallization unit is directed to the hydrous salt crystallization unit.

A device and method for simultaneously concentrating a plurality of samples in small volumes based on the principle of cystallization. The device comprises a device for concentrating a plurality of samples comprising: a first temperature control means (12) having a plurality of container means (40/50) for containing said plurality of samples; a second complementary temperature control means (11) having a plurality of conducting means (22) which are adapted to be inserted in respective samples in said plurality of container means (40/50); and insulating means (30) for insulating said first temperature control means (12) from said temperature control means (11) such than an amount of heat from said plurality of samples is dissipated through said plurality of conducting means (22).