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227 results about "Dihydrogen oxide" patented technology

Water is a transparent, tasteless, odorless, and nearly colorless chemical substance, which is the main constituent of Earth's streams, lakes, and oceans, and the fluids of most living organisms. It is vital for all known forms of life, even though it provides no calories or organic nutrients. Its chemical formula is H₂O, meaning that each of its molecules contains one oxygen and two hydrogen atoms, connected by covalent bonds. Water is the name of the liquid state of H₂O at standard ambient temperature and pressure. It forms precipitation in the form of rain and aerosols in the form of fog. Clouds are formed from suspended droplets of water and ice, its solid state. When finely divided, crystalline ice may precipitate in the form of snow. The gaseous state of water is steam or water vapor. Water moves continually through the water cycle of evaporation, transpiration (evapotranspiration), condensation, precipitation, and runoff, usually reaching the sea.

Non-chemical water treatment method and apparatus employing ionized air purification technologies for marine application

Contaminated water, particularly, ballast water, blackwater, galley water, accommodation water, laundry water, fresh water and seawater, is disinfected by admixture of a highly reactive gas stream containing ions of oxygen and nitrogen, formed by exposure of air to short-wavelength ultraviolet radiation, and of chlorine, formed in situ by electrolysis of salt in the water. Solids removal can be accomplished by electrophoresis in the same unit employed for electrolysis to release chlorine, or in a separate unit. Heavy metals maybe removed by plating or sacrificing electrodes.
Owner:IONZ BLUEWATER SOLUTIONS +1

Dropping, aeration and biological pretreatment- super filtering combined drinking water purification process

The disclosed water-drop aeration biopretreatment-ultrafiltration combined purification technique for drinking water comprises: first, building the multistage water-drop aeration biopretreatment device; then, pumping the raw water once to remove the most ammonia nitrogen by cascade water-drop oxygenation and biological contact oxidation pretreatment and convert the micro dissolved organic into microbe cell; filtering by the protective porous ceramic-aggregate pond; followingly, leading into the ultrafiltration membrane module to reduce the micro organic, ammonia nitrogen, particulate matter, most seston, colloid, and bacteria till meeting the drinking water quality standard. This invention belongs to green technique without coagulant or chlorine, reduces cost and land area, and has wide application for small-scale drinking water treatment.
Owner:SHANGHAI WATERWORKS SHIBEI +1

Slag washing water steam recycling and white fog removing system and recycling method

The invention provides a slag washing water steam recycling and white fog removing system and a recycling method. The slag washing water steam recycling and white fog removing system comprises a slagwashing water steam chimney close to a blast furnace, at least one cooling spraying device and a hot air furnace assembly; the lower portion of the slag washing water steam chimney can contain waste slag discharged out of the blast furnace and carries out slag washing operation, the cooling spraying devices are arranged in the middle of the slag washing water steam chimney and spray atomized waterto the lower portion of the slag washing water steam chimney, the hot air furnace assembly is communicated with the blast furnace and the upper portion of the slag washing water steam chimney, the hot air furnace assembly can convey generated hot air into the blast furnace, and conveys the treated waste gas to the upper portion of the slag washing water steam chimney, the mist spraying cooling direct heat exchange manner is adopted, the cooling efficiency is high, in combination with the humidity and condensation effect of atomized water, a small amount of water is sprayed, and therefore a large amount of water steam can be recycled, water steam which is not condensed is subject to waste gas temperature rise dilution, the water steam saturability is reduced, and white smoke is prevented from being generated.
Owner:MCC CAPITAL ENGINEERING & RESEARCH

Method for producing liquid water-soluble carbon fertilizer with high-concentration organic waste water

The invention discloses a method for producing a liquid water-soluble carbon fertilizer with high-concentration organic waste water and relates to a method for recycling organic waste water. The method comprises the following steps: inputting concentrated nitric acid and hydrogen peroxide from the bottom of a stirring tank which holds high-concentration organic wasted water with a water content of 50-60% and an organic matter content of 20-25% and actuating a stirring paddle which is arranged in the stirring tank, and stirring for 45-60 min to enable the organic macromolecule clusters in the waste water to be rapidly split by strong oxidation into micromolecule clusters; guiding the foams generated by the liquid materials in the stirring tank during the stirring process into a defoaming pool for natural defoaming, and discharging the resulting clear liquid into a heat-dissipation liquid storage tank; discharging the volume-stable hot clear liquid derived from most of the liquid materials in the stirring tank after the stirring operation is completed and the foams disappear into the heat-dissipation liquid storage tank; naturally cooling the hot clear liquid in the heat-dissipation liquid storage tank to produce a liquid water-soluble carbon fertilizer which is completely soluble in water, has strong dispersion and penetration properties and contains 131-171 g / L of carbon. The liquid water-soluble carbon fertilizer is applied to irrigating and rinsing of farm crops or mixed with other inorganic nutrients for pipeline transportation, drip irrigation and spray-application.
Owner:FUZHOU LYUZHOU BIOCHEM CO LTD +1

Hydrate formation and growth for hydrate-based desalination by means of enriching water to be treated

Water to be desalinated or otherwise purified is enriched by having hydrate-forming substance dissolved into it, without causing hydrate to form. Hydrate kernels are brought into contact with the enriched water to be treated, and the hydrate kernels grow outwardly into the water to be treated by incorporating dissolved molecules of the hydrate-forming substance and water from the water to be treated. Thus, substantially solid, generally spherical hydrate masses, which are preferred for hydrate-based desalination or purification, can be formed. Hydrate-forming substances can be dissolved into the water to be treated under conditions not conducive to formation of hydrate, such that hydrate does not form, using vigorous means. Hydrate-forming substance is also preferably dissolved into the water to be treated under conditions suitable for hydrate to form, but without causing hydrate to form, e.g., by being infused into the water to be treated using infusion membranes.
Owner:MARINE DESALINATION SYST L L C +1

Autonomous water source

An autonomous water source (AWS) for extracting water from ambient air and delivering it to a plant to support growth. The system is based on an adsorption-desorption-condensation (ADC) cycle using a sorption material to extract moisture from ambient air and condensing the water vapor driven off from the sorption material by subsequent heating and followed by condensation. Liquid condensate produced in this process on the condenser is collected and delivered by gravity to a plant to reduce thermal stress and to support growth. The invention provides a sustainable source of irrigation water for agriculture and forestry, including areas where no water resources exist or are not economically viable. It can be tailored in size, and therefore, output capacity, reflecting the desired water requirements of a particular application, and can be used to replace most agricultural situations now reliant on surface water drip feed systems. The device is simple, rugged, invulnerable to rain, snow, and freezing conditions, and can be designed to last for many years without service as there are few moving parts and power required for operation is provided by sunlight.
Owner:AGWEST

Method for preparing fresh-water ice by utilizing seawater and brackish water

The invention relates to a method for preparing fresh-water ice by utilizing sweater and brackish water. The existing ice marker only has a pure ice making function and does not have a desalting function. The method comprises the following steps of: performing primary filtration, secondary filtration, tertiary filtration and quaternary filtration on the seawater or the brackish water sequentially through a multi-medium filter, a security filter, a micro-filtration membrane and an ultra-filtration membrane, so as to obtain the quaternary filtered fluid; desalting the quaternary filtered fluid by virtue of a separating method of membrane distillation, forward osmosis or electro-osmosis to obtain desalted water with the purity greater than and equal to 99.9%; and obtaining the fresh-water ice through air-cooling or water-cooling condensing of the desalted water. According to the method disclosed by the invention, the fresh-water ice can be automatically prepared by utilizing the seawater or the brackish water; when the inlet water is the seawater or the brackish water with salinity higher than 2%, the fresh-water ice can be prepared through multi-medium filtration, security filtration, micro filtration, ultra-filtration and salt-water separating systems as well as an ice making system, so that the method is especially applicable to the needs of catching and fresh-keeping of ocean fishing vessels.
Owner:NINGBO WANJIE WATER TECH

Method of generating fresh water and fresh-water generator

The present invention is a water processing method comprising the steps of separating boron-containing water in a reverse osmosis membrane module to provide a permeated water and subjecting a part of the obtained permeated water to boron removal using an adsorbent, wherein the water subjected to the boron removal is mixed with the water not subjected to the boron removal of the permeated water to provide a mixed water. The present invention provides economic water processing method and apparatus that remove the boron from boron-containing water.
Owner:TORAY IND INC

Lactobacillus plantarum with inhibitory activity to alpha-glucosidase

The invention discloses lactobacillus plantarum with the inhibitory activity to alpha-glucosidase. The lactobacillus plantarum is classified and named as Lactobacillus plantarum, is preserved on August 29, 2017 in China General Microbiological Culture Collection Center and has a preservation number of CGMCC NO.14573. By screening, the lactobacillus plantarum has in-vitro inhibitory activity to alpha-glucosidase; the survival rate of the lactobacillus plantarum reaches up to 71.04% under an acid condition that the pH value is 2.0 and is 77.14% in 2.0% cholate deionized water, the tolerances of the lactobacillus plantarum to artificially simulated saliva and intestinal fluid are higher than 90%, the tolerance of the lactobacillus plantarum to gastric fluid reaches 52.49%, and after artificially simulated fluid is sequentially digested, the survival rate reaches 88.27%; the lactobacillus plantarum has good effects on the prevention and treatment of diabetes mellitus type 2; the lactobacillus plantarum is added with a protection agent so as to prepare freeze-drying battier powder with a high viable count, and the viable count reaches up to 87% of the viable count before freeze-drying; and besides, the lactobacillus plantarum further has a good fermentation effect.
Owner:INST OF AGRO FOOD SCI & TECH CHINESE ACADEMY OF AGRI SCI

Combined processing technology for slightly polluted raw water

The invention discloses a combined processing technology for slightly polluted raw water. The raw material water firstly enters into a first ozone contact tank for pre-ozonation, then enters into a flocculation sedimentation tank for sedimentation treatment, after sedimentation, the water enters into a secondary ozone contact tank for ozonation decomposition, then enters into a carbon sand filtering tank for filtering, the filtered water enters into a membrane processing system, the membrane-processed water enters into a clean water tank for dispatching and storing and are disinfected in the clean water tank by adding chlorine, and the water enters into a suction well and is conveyed to a water distribution network via a pump set in a clean water pump house. The combined processing technology of the invention has the advantages that: the finished water coming from the processed slightly polluted raw water can not only be guaranteed to reach the sanitary standard for drinking water, but also meet higher requirements in some indexes, and is eliminated in microbial overweight risk and effectively removed in humic acid and cryptosporidium and giardia. Additionally , compared with the prior art, the combined processing technology combined with advanced treatment process helps to saves land occupations of a sand filtering tank and a disinfection contact tank and enable water quality upgrading construction of an existing water factory with a compact field to be implemented.
Owner:SHANGHAI MUNICIPAL ENG DESIGN INST GRP

Water purifier and water purification method

To provide a water purifier containing: a diluting unit configured to bring targeted water into contact with a nonvolatile compound-containing aqueous solution via a semi-permeable membrane to separate water from the targeted water by the membrane, and to dilute the nonvolatile compound-containing aqueous solution with the separated water; a separating unit configured to heat the diluted aqueous solution so as to separate water vapor from the diluted aqueous solution, and to obtain the concentrated aqueous solution; a condensing unit configured to cool the separated water vapor to generate water; an evaporating unit configured to collect, as purified water, part of the generated water, and to evaporate the rest of the generated water under the reduced pressure to obtain water vapor; and an absorbing unit configured to allow the concentrated aqueous solution obtained by the separating unit to absorb the water vapor obtained by the evaporating unit.
Owner:FUJIFILM CORP

Two-stage sea water desalination method based on hydration and two-stage sea water desalination device based on hydration

The invention belongs to the field of gas hydrate technology application and particularly relates to a sea water desalination method and a two-stage sea water desalination device. The method comprises the following steps: generating a carbon dioxide hydrate from carbon dioxide and sea water by a first-stage sea water desalination system and then resolving the carbon dioxide hydrate so as to obtain fresh water; generating a propane hydrate from propane and sea water by a second-stage sea water desalination system and then resolving the propane hydrate so as to obtain fresh water. The Two-stage sea water desalination device comprises a first-stage sea water desalination device and a second-stage sea water desalination device which are connected in series; each stage of sea water desalination device comprises a gas-liquid supplying and mixing unit, a gas hydrate generating and conveying unit, and a gas hydrate dissociating and resolving unit. The device and the method are high in efficiency, low in energy consumption and easy to achieve.
Owner:江苏溢坤医疗科技有限公司

A treatment method for coal gasification ash water reuse

ActiveCN102285722ASpeed up the softening processGood for softeningTreatment using complexing/solubilising chemicalsDihydrogen oxideEnvironmental engineering
The invention provides a treatment method for recycling gasification ash water. A treatment process is performed in a sedimentation tank; and the sedimentation tank comprises a first water tank, a second water tank and a third water tank which are connected with one another in sequence. The method comprises the following steps: (1) mixing the ash water and lime water at an inlet of the first water tank, entering the first water tank to perform softening reaction, standing and settling, and overflowing supernatant to the second water tank, wherein the weight of the lime water is 2.5-5 percent of the weight of the ash water; and (2) introducing pure aqueous alkali with mass percentage concentration of 5-10 percent into the second water tank, mixing the pure aqueous alkali and the supernatant which is obtained in the step 1 and reacting, standing and settling, and overflowing the supernatant to the third water tank for further sedimentation, wherein the obtained supernatant is recycled as industrial circulating water, and the weight of the pure aqueous alkali is 1-2 percent of the weight of the ash water. The treatment method is convenient to operate and has a good softening effect; and the scaling tendency of a heat exchanger and the like is greatly reduced through the ash water which is subjected to the softening treatment.
Owner:SHANGHAI HUAYI ENERGY CHEM

Complete water dispenser of water purifier

The invention relates to a complete water dispenser of a water purifier, which comprises a shell, a hot tank and / or cold tank, an outlet faucet and a control device, wherein a normal-pressure water bag is arranged in the water dispenser; the water inlet of the normal-pressure water bag is connected with the water outlet of a magnetic valve or electric valve; the water inlet of the magnetic valve or electric valve is connected with a water outlet of the water purifier by a first water pipe; the control device controls the opening and closing of the magnetic valve or electric valve according tothe detection signals of an upper water level detection device and a lower water level detection device; and the water purifier is a water purifier of which the outlet water bears certain pressure, such as a reverse osmosis water purifier. In the invention, the linkage between the water dispenser and the water purifier is built by a pressure signal in interconnected water pipes. As the water in the normal-pressure water bag is isolated from the outside air, secondary pollution is avoided; the normal-pressure water bag can be washed and changed periodically; and the use and manufacturing cost of the normal-pressure water bag are lower than those of a pressure water tank.
Owner:江苏正本净化节水科技实业有限公司

Drinking water dispenser of taking water from air and purifying

The invention is a water dispenser taking water from the air and purifying the water, including a compressor, a water maker, a sterilizing UV lamp, an activated carbon purifier, etc. The refrigerating agent is compressed by the compressor, then condensed by a condenser and enters in the water maker for evaporating and absorbing heat, the external air and the water maker convect mandatorily to exchange heat by a fan, the water in the air condenses outside the water maker and then flows into a water receiving disc at the lower part of the water maker, the UV lamp above the water receiving disc sterilizes the water in the water receiving disc, and the water sterilized is filtered by the activated carbon purifier and flows in a hot-cold drinking water containers. One part of the condensing heat of the refrigerating agent gas is radiated by a tube fin condenser and one part can be used to heat the purified water in the hot drinking water container, one part of the cold quantity generated by the evaporation of the refrigerating agent liquid is used for the water maker to make water and the other part is used to cool the purified water in the cold drinking water container, thus the user can directly taking hot or cold water from the hot and cold tapsrespectively.
Owner:SHANGHAI JIAO TONG UNIV

Oxiracetam compound and pharmaceutical composition thereof

The invention relates to an oxiracetam compound, which has two crystal water molecules. In X-ray powder diffraction pattern obtained through Cu-Kalpha ray measurement, the characteristic peaks of the oxiracetam compound are shown in positions wherein 2theta is 17.3 degrees, 19.1 degrees, 21.6 degrees, 23.2 degrees, 27.0 degrees, 28.4 degrees, 30.0 degrees, 31.0 degrees, 31.7 degrees, 33.2 degrees, 36.9 degrees, 39.3 degrees, 40.2 degrees, 45.7 degrees and 51.2 degrees. The invention also relates to a preparation method of the oxiracetam compound, and a pharmaceutical composition containing the oxiracetam compound. The oxiracetam compound and the pharmaceutical composition thereof provided by the invention have the characteristic of high stability.
Owner:江西新先锋医药有限公司

Natural circulating steam injection boiler fed with high salt-containing softened water and water circulating method

The invention discloses a natural circulating steam injection boiler fed with high salt-containing softened water and a water circulating method, and belongs to the fields of natural circulating steam pocket water power technology and stage evaporation technology. A steam pocket is divided into a net section and a salt section, boiler feed water is directly introduced into a vertical down pipe of the net section of the steam pocket, and the evaporation heating surface of the net section is arranged on the heating surface of a hearth. The feed water of the salt section of the steam pocket is supplied by the boiler water of the net section, the evaporation heating surface of the salt section is arranged in a flue at the tail of the boiler, and the sewerage is directly led out by a steam-water separation device on the salt section of the boiler. The blow-down rate of the boiler is 5 to 15 percent, and the evaporation capacity of the salt section is 5 to 40 percent of the total evaporation capacity. Under the same blow-down rate, the boiler water of the net section and salt section heating surfaces of the boiler has low salt content; the heating surfaces have good corrosion resistance, hydrodynamic characteristic and safe heat transfer; and the heating surface of the salt section is convenient for overhauling. The fuel of the boiler can be coal, oil, natural gas and other combustible solids, and is suitable for high-capacity thick oil thermal recovery steam injection boilers.
Owner:TSINGHUA UNIV

Bifunctional nucleoside hydrogel and preparation method and application thereof

Disclosed is a bifunctional nucleoside hydrogel. The bifunctional nucleoside hydrogel is formed by dissolving isoguanosine, guanosine and borate in water or an aqueous solution for crosslinking. The bifunctional nucleoside hydrogel integrates a carrier and a drug effect and has an obvious inhibitory effect on the activity of tumor cells, in particular to an obvious inhibitory effect on the activity of cells related to lung cancers, gliomas, osteomas, colon cancers, breast cancers, oral squamous cell carcinomas and tongue squamous carcinomas. The inhibitory effect on the activity of the oral squamous cell carcinoma cells is the best. In addition, the bifunctional nucleoside hydrogel can inhibit the growth of HSC-3 transplanted tumors of the oral squamous cell carcinoma cells in vivo. Therefore, the bifunctional nucleoside hydrogel has potential application prospects in the aspect of preparing anti-tumor drugs. Particularly, a new way can be provided for treating the oral squamous cell carcinomas.
Owner:SICHUAN UNIV

Water Softener With Closed-Pressure Aeration

A water conditioning system that both softens and improves the smell of water by removing dissolved ferrous iron and hydrogen sulfide from the water includes: a water softening tank, a cation exchange media situated in the water softening tank, a brine tank, a programmable control valve which regulates flow through the system and the periodic rejuvenation of the cation exchange media using flow from the brine tank, a valve that assists in providing a flow of aerated, pressurized water to the system, and an adapter with a bottom portion and a flow control valve that control the volume of the gaseous pocket that is created in the top portion of the water softening tank.
Owner:HANDY SCOTT R

Method for the desalination or purification of water by distillation of a spray (spray pump)

A system enables the use of solar heat energy together with electromagnetic energy and optionally energy produced during fermentation of organic products to produce fresh water from salt water, wastewater and water vapor contained in the atmosphere. The resulting fresh water can optionally be rendered drinkable by adding mineral salts at the desired concentration. A method and reactors combine electromagnetic and solar heating steps and optionally heat exchanges with a hot gas originating from combustion, to evaporate droplets of a spray produced from salt water or wastewater. The vapor obtained is separated from the salt particles or agglomerated impurities during evaporation using a cyclone system. The vapor can then be transported over a large distance before being condensed by bearings, in order to separate the water from any additives or impurities that may be present. Additives can be used to lower the vapor pressure of the liquid water and to facilitate droplet fractionation.
Owner:UGOLIN NICOLAS

Apparatus, systems and methods for management of raw water and emissions utilizing heat and/or pressure energy within combustion gas sources

The invention relates to methods, systems and apparatus for distributed management of raw water and internal combustion engine (ICE) gas emissions generated during industrial operations. One aspect of the invention at least partially utilizes a hot gas air knife to increase or partially increase surface area between a raw water and a hot gas in order to vaporize a proportion of the aqueous phase of the raw water and concentrate contaminants within a residual raw water concentrate. The water vapor generated by the vaporization process may be demisted, discharged directly to the atmosphere or alternatively condensed and captured for use. Another aspect relates to how the liquids and gasses interact to continuously flush the surfaces of the system which may help mitigate scaling issues. The invention may help facilitate rapid transfer of ICE combustion gas particulate and ICE combustion gas chemicals onto and into the raw water as it concentrates.
Owner:HORIZON OILFIELD SOLUTIONS

Ancillary embodiments and modifications to a polyphasic pressurized homogenizer

Ancillary embodiments and modifications to a homogenizer unit that increases its applicability to a wide spectrum of chemical or physical-chemical reactions and properties. Methods of introducing reactants and devices that present a tortuous pathway to reactants are placed at a strategic locus (or loci) that delay or modify flow pathways to gases, liquids, aerosols, particulates, or any combination thereof. Reactions of a chemical, physical-chemical, and thermo-chemical nature between a wide variety of matter are possible and readily achieved with the correct solvent(s), reactant(s), or pressure under controlled conditions of pressure, temperature, chemical concentrations, and other impingements. Various well-recognized or established principles are used to expedite reactions. These include ‘Boyle's Gas Law’, surface-to-volume relationships, anion and cation substitutions, heat absorption by water, gas solubility factors, stoichiometric chemistries, surface tension reactions, dissolution constants, and others.
Owner:ALCHEM ENVIRONMENTAL IP

Homogeneous immunoassay based method for synchronous fluorescence detection of multiple disease markers

The invention relates to interdisciplinary fields of biology, medicine, material, chemistry and virology, and discloses a homogeneous immunoassay based method for synchronous fluorescence detection of multiple disease markers. The method comprises the specific steps of: first, covalently coupling different fluorescent dyes with antibodies of different disease markers, and dissolving in water or other solvents to obtain a reaction solution A; second, mixing the solution A with a graphene oxide solution to obtain a reaction solution B; third, mixing the reaction solution A, the reaction solution B and water or other solvents to obtain a solution C; and fourth, adding an antigen solution into the mixed solution C, transferring the mixed solution to a fluorescence cuvette, measuring synchronous fluorescence intensity, and conducting quantitative analysis and multi-index analysis and diagnosis. The method has advantages of simpleness, rapidness, high sensitivity, high specificity and low cost, and can realize high-throughput detection, multiple index analysis diagnosis and remote diagnosis.
Owner:WUHAN UNIV

Poria pericarpium citri reticulatae ginger juice tea

The present invention relates to the field of foods, and specifically relates to poria pericarpium citri reticulatae ginger juice tea. The poria pericarpium citri reticulatae ginger juice tea is characterized by composing by weight: 80-85% of condensed poria pericarpium citri reticulatae ginger juice, 8-15% of ginger juice, 1-3% of brown sugar, and the balance being honey water. The condensed poria pericarpium citri reticulatae ginger juice is prepared by using poria and pericarpium citri reticulatae with the ratio by weight of 5:1-10:1, adding dates, hawthorn, Chinese yam and water, boiling for 5 minutes, filtering residue, and condensing to half of the original volume. The poria pericarpium citri reticulatae ginger juice tea has the effects of warm up and replenishing blood, fending off cold and tonifying qi, and strengthening spleen and stomach.
Owner:SHENYANG XINDA INFORMATION SCI & TECH

Simple method for removing nitrate nitrogen in water body

The invention discloses a simple method for removing nitrate nitrogen in water body. The method is characterized in that: a solid state or plastic state material containing organic carbon source is added to the water body to form an environment of the local oxygen-deficient water body; the nitrate nitrogen is transformed into nitrogen in the oxygen-deficient environment through a combined action of the organic carbon source and denitrifying bacterium, and the nitrogen escapes from the water and enters into atmosphere, such that the nitrate nitrogen in the water body is removed. The method provided by the present invention is especially applicable for water quality treatments for eutrophic lakes and reservoirs, marine ecology recovery and rivers having high nitrate content.
Owner:甄建伟

Method for calculating tolerance dosage of sugar alcohol and function sugar of human body

The invention relates to a method for calculating tolerance dosage of sugar alcohol and function sugar of the human body. Xylitol is taken as an example, and the method comprises the following steps that mice with the volume of 200 g are selected as experimental animal objects, the mice with the volume of 200 g are divided into six experimental groups and one control group, and there are ten numbered mice of each group; the mice of six experimental mice are fed with the xylitol of different dosages in a filling mode every day; the mice of the control group are fed with saccharose in the filling mode; sufficient drinking water and ordinary feed are provided for the experimental mice; the mice are checked every night, and the diarrheal mice are counted; the feeding mode lasts for 14 days; the maximum tolerated dosage of the xylitol of the mice of each group is obtained according to diarrhea conditions of the mice on the last day, intestinal segment slice images of all the mice and the result of content of diamine oxidase; according to a drug dosage reduction formula between the experimental animal and the human, the maximum tolerated dosage of the mouse is converted to obtain the tolerance dosage of the xylitol of the human body. In an animal experiment mode, the range of the tolerance dosage of the sugar alcohol and the function sugar of the human body is obtained more accurately.
Owner:ZHEJIANG HUAKANG PHARMA

Preparation of targeted CT (computed tomography) contrast agent of second generation polyamide-amine dendrimer stabilized gold nanoparticle based on folate modification

InactiveCN102940894AThe hydrothermal synthesis method is simpleEasy to operateIn-vivo testing preparationsDendrimerDispersity
The invention relates to a preparation method of a targeted CT (computed tomography) contrast agent of a second generation polyamide-amine dendrimer stabilized gold nanoparticle based on folate modification, which comprises the following steps: preparing a gold nanoparticle under water bath conditions by using an amino-terminal second generation polyamide-amine dendrimer as a stabilizer; dialyzing, performing drying treatment, then modifying covalent bonds on amino groups of the dendrimer on the surface of the nanoparticle with targeted reagent folate, and subsequently performing full acetylation treatment on the residual amino groups on the surface of the dendrimer; dialyzing the solution subjected to the reaction, and performing freeze-drying treatment to obtain the final product; and evaluating the in-vitro and in-vivo CT contrast performance of the product. According to the invention, the cost of raw materials is relatively low; the preparation process is mild; the preparation method is simple and easy to implement; and the prepared folate-modified dendrimer stabilized gold nanoparticle has favorable stability, water solution dispersity and biocompatibility and reinforced targeted tumor CT contrast effect, thereby having potential targeted CT contrast application prospects.
Owner:DONGHUA UNIV +1

Steroid analogues for neuroprotection

Provided are steroid analogues functionalized with polar substituents at the C3 and / or C20 positions of the steroid ring system that exhibit improved water solubility. Also provided are pharmaceutical compositions comprising the steroid analogues and methods using the novel steroid analogues for the treatment and prevention of neurodegeneration in a patient following injury to the central nervous system.
Owner:EMORY UNIVERSITY
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