Bifunctional nucleoside hydrogel and preparation method and application thereof

A nucleoside water and dual-functional technology, which is applied in the direction of pharmaceutical formulations, medical preparations containing active ingredients, etc., can solve the problems of difficult hydrogels, poor self-assembly performance, and no Tumor activity and other issues

Inactive Publication Date: 2019-08-23
SICHUAN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, at present, most supramolecular hydrogels can only be used as carriers to deliver drugs and do not have anti-tumor activity; while some natural products have anti-tumor activity, but due to their poor self-assembly performance, it is difficult to be used as a delivery system. hydrogel

Method used

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  • Bifunctional nucleoside hydrogel and preparation method and application thereof
  • Bifunctional nucleoside hydrogel and preparation method and application thereof
  • Bifunctional nucleoside hydrogel and preparation method and application thereof

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Effect test

Embodiment 1

[0028] Embodiment 1, the preparation of bifunctional nucleoside hydrogel of the present invention

[0029] Isoguanosine (isoG) and NaB(OH) at a molar ratio of 1:1 4 Dissolve in ultrapure water, heat until fully dissolved to obtain a clear and transparent solution, and the concentration of isoguanosine in the obtained solution is 1.4wt%. The guanosine (G) added in the solution, the molar ratio of guanosine and isoguanosine is 1:1, that is, the concentration of guanosine is 1.4wt%, heated to fully dissolved, at room temperature After the solution is naturally cooled, a transparent and colorless isoGBG hydrogel is obtained, that is, the bifunctional nucleoside hydrogel of the present invention, and the concentration of the isoGBG hydrogel is 14000 μg / ml.

Embodiment 2

[0031] Embodiment 2, the preparation of bifunctional nucleoside hydrogel of the present invention

[0032] The concentration of isoguanosine and guanosine in the solution was 0.8 wt%, and the isoGBG hydrogel with a concentration of 8000 μg / ml was prepared.

Embodiment 3

[0033] Embodiment 3, the preparation of bifunctional nucleoside hydrogel of the present invention

[0034] The concentration of isoguanosine and guanosine in the solution was 0.08 wt%, and the isoGBG hydrogel with a concentration of 800 μg / ml was prepared.

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Abstract

Disclosed is a bifunctional nucleoside hydrogel. The bifunctional nucleoside hydrogel is formed by dissolving isoguanosine, guanosine and borate in water or an aqueous solution for crosslinking. The bifunctional nucleoside hydrogel integrates a carrier and a drug effect and has an obvious inhibitory effect on the activity of tumor cells, in particular to an obvious inhibitory effect on the activity of cells related to lung cancers, gliomas, osteomas, colon cancers, breast cancers, oral squamous cell carcinomas and tongue squamous carcinomas. The inhibitory effect on the activity of the oral squamous cell carcinoma cells is the best. In addition, the bifunctional nucleoside hydrogel can inhibit the growth of HSC-3 transplanted tumors of the oral squamous cell carcinoma cells in vivo. Therefore, the bifunctional nucleoside hydrogel has potential application prospects in the aspect of preparing anti-tumor drugs. Particularly, a new way can be provided for treating the oral squamous cell carcinomas.

Description

technical field [0001] The invention belongs to the field of biomedical materials, and in particular relates to a bifunctional nucleoside hydrogel and its preparation method and application. Background technique [0002] Clinically, most malignant tumor patients are in the middle and advanced stage when they are diagnosed. Chemotherapy is one of the main means of comprehensive treatment. Wide range of clinical applications. In order to overcome the defects of such drugs, the application of hydrogel drug delivery system was born. Among them, supramolecular hydrogel materials formed by self-assembly of natural products and their derivatives have been widely used in drug delivery in recent years because of their advantages such as good biocompatibility, high loading capacity, fixed-point release, and good slow-release and controlled-release effects. And cancer treatment has aroused people's extensive attention and research. However, at present, most supramolecular hydrogels ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/708A61K9/06A61K47/02A61P35/00
CPCA61K31/708A61K9/06A61K47/02A61P35/00A61K2300/00C07H23/00A61K47/34A61K9/0019A61K47/24
Inventor 赵行曾昕吉宁冯慧刘江陈谦明
Owner SICHUAN UNIV
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