Method for calculating tolerance dosage of sugar alcohol and function sugar of human body

Abstract

The invention relates to a method for calculating tolerance dosage of sugar alcohol and function sugar of the human body. Xylitol is taken as an example, and the method comprises the following steps that mice with the volume of 200 g are selected as experimental animal objects, the mice with the volume of 200 g are divided into six experimental groups and one control group, and there are ten numbered mice of each group; the mice of six experimental mice are fed with the xylitol of different dosages in a filling mode every day; the mice of the control group are fed with saccharose in the filling mode; sufficient drinking water and ordinary feed are provided for the experimental mice; the mice are checked every night, and the diarrheal mice are counted; the feeding mode lasts for 14 days; the maximum tolerated dosage of the xylitol of the mice of each group is obtained according to diarrhea conditions of the mice on the last day, intestinal segment slice images of all the mice and the result of content of diamine oxidase; according to a drug dosage reduction formula between the experimental animal and the human, the maximum tolerated dosage of the mouse is converted to obtain the tolerance dosage of the xylitol of the human body. In an animal experiment mode, the range of the tolerance dosage of the sugar alcohol and the function sugar of the human body is obtained more accurately.

Description

technical field [0001] The invention belongs to the technical field of sugar alcohol application, in particular to a method for calculating the human body's tolerance to sugar alcohol and functional sugar. Background technique [0002] The many benefits of sugar alcohols to the human body are self-evident, but excessive intake also has certain adverse effects on the human body. For example, excessive daily intake of sugar alcohols can cause diarrhea and so on. Because sugar alcohol is not decomposed by gastric enzymes, it directly enters the intestines. Because of its different molecular structure and sugar in the small intestine, the absorption time is slower than glucose. A large amount of intake in a short period of time will cause borborygmus and diarrhea. At the same time, some companies have also It is stated that the daily intake of xylitol should not exceed 50 g, maltitol should not exceed 100 g, L-arabinose should not exceed 120 g, sorbitol should not exceed 50 g,...

AI Technical Summary

Problems solved by technology

[0002] The many benefits of sugar alcohols to the human body are self-evident, but excessive intake also has certain adverse effects on the human body. For example, excessive daily intake of sugar alcohols can lead to diarrhea, etc.

Because sugar alcohol is not decomposed by gastric enzymes, it directly enters the intestines. Because of its different molecular structure and sugar in the small intestine, the absorption time is slower than glucose. A large amount of intake in a short period of time will cause borborygmus and diarrhea. At the same time, some companies have also It is stated that the daily intake of xylitol should not exceed 50 g, maltitol should not exceed 100 g, L-arabinose should not exceed 120 g, sorbitol should not exceed 50 g, etc., but there is a lack of corresponding experimental methods and As evidenced by experimental data, the regulations on dosage are too broad and do not have significant guiding significance for the amount of sugar alcohol added in products

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