59results about "Crystallization auxillary selection" patented technology

This application relates to the field of functional crystalline material preparation and microfluidic application technology, specifically disclosing a method and product for preparing formate crystals using core-shell microcapsules, including the following steps: (1) dissolving a solid alkaline raw material in a formic acid solution to prepare reaction solution a; (2) separately conveying polymer solution A and polymer solution B with phase separation characteristics, and reaction solution a, so that they are mixed at the intersection of microchannels to prepare dispersed phase b, which is then introduced into the assembly zone for phase separation assembly to form core-shell microcapsules; (3) the core-shell microcapsules are crystallized in a continuous temperature-changing crystallization zone to form formate solid; (4) the formate solid is collected, washed and dried sequentially to obtain the target product; (5) the oil layer is continuously extracted and returned to the assembly zone for recycling. The formate crystals prepared in this application not only have a large particle size, but also exhibit good size uniformity and morphological repeatability, and have the advantages of high throughput, green environmental protection, and simple operation.

A process for producing a polymorphic or pseudo-polymorphic crystalline phase from a plurality of compounds (C,D,S1,S2), comprising the steps of preparing (I) a supersaturated solution from said compounds, homogenizing (II) said supersaturated solution in an ultrasonic bath, transferring (III) the supersaturated solution into a plurality of heated tubes (54), aging (V) the solutions transferred into the tubes for a determined period, exposing said tubes (54) to a pulsed and polarized laser beam before and / or during exposure, monitoring in situ the nucleation and then the growth of co-crystals inside said tubes (54), and filtering the exposed solutions to recover co-crystals larger than a predetermined minimum size.This process is implemented to carry out co-crystallization from at least one active substance (D) and one co-former (C) in at least one first solvent (S1) and one second solvent (S2), and it further comprises two preliminary steps: establishing a phase diagram from the respective physicochemical characteristics of said active substance (D), said co-former (C), said first solvent (S1) and said second solvent (S2), and then determining, from said phase diagram thus established, concentration, temperature and exposure conditions providing a stable phase for the production of co-crystals. See Figure 4.

The invention discloses a processing method for fractionation and rapid crystallization of palm oil, which comprises the following steps: (1) heating and controlling a palm oil raw material to be fractionated to 55-65 DEG C (crystal breaking), pumping the palm oil raw material into a crystallizing tank, and then cooling the palm oil raw material to about 25 DEG C under the action of rapid cooling of cooling water (or chilled water) and stirring; (2) continuously reducing the temperature of the palm oil raw material in the crystallizing tank by using chilled water, adding a certain proportion of palm oil (solid-liquid mixture) which is completely crystallized and is in an unseparated state into the crystallizing tank at the interval of 25.0-18.0 DEG C as a seed crystal, and controlling the stirring speed of the crystallizing tank at 15-30r / min until the palm oil raw material is completely cooled and crystallized; (3) after crystallization is completed, if seed crystals need to be added into the crystallizing tank which is cooling and crystallizing, pumping the seed crystals into the crystallizing tank which needs to be added with the seed crystals through a pump; otherwise, immediately pumping into a membrane filter for filtering and separating (preventing the tank from being burnt) to obtain liquid oil and stearin. The palm oil seed crystal is added, so that the crystallization time can be shortened; and through seed crystal induction, the formation of stable-form crystals is accelerated, excessive crystallization is avoided, and the interception loss of filtration is reduced, so that the liquid oil yield is improved.

Method for producing electronic grade nickel sulfate from nickel powder, crystallization apparatus, and control thereof The present invention provides a method for producing nickel sulfate, and nickel sulfate produced thereby. The process includes acid leaching, copper removal, acid adjustment, concentration, cooling crystallization, drying and sieving, and secondary leaching. Oxidation In the calcination furnace, the temperature is 400 to 700°C, and 1 kg of compressed air is used for each kilogram of nickel powder. ~5m 3 The reaction time is 1.0 to 2.5 hours, and the temperature during acid immersion is controlled to 45 to 70°C. Then, add dilute sulfuric acid to control the pH to 0.5-1.5 and react for 1-3 hours. The copper removal is to replace the copper with nickel powder, and the acid conditioning is to use nickel hydroxide or The pH is adjusted to 2.5-4.5 using nickel carbonate, and the filtrate is concentrated by The cooling crystallization method is to obtain nickel sulfate crystals and return the mother liquor to the concentrate. Drying and sieving is to add the undersieved material to the crystallizer as seed crystals, and secondary leaching is to Dilute sulfuric acid is added to the leaching slag, and it is reacted with nickel sulfate or hydrogen peroxide until nickel is less than 0.1%. If the first stage is full, the second leaching is continued. The crystallizer is a crystallizer that is connected in series with a second-stage crystallizer and a third-stage crystallizer. A crystallization frame, an oscillator provided under the crystallization frame, and an oscillator provided at the exit end of the crystallization frame. The crystallization frame is a rectangular parallelepiped. The bottom of the ribs are evenly spaced, with a cross section of a circular arc. The distance between two adjacent ribs is S is 1 / 25 to 1 / 15 of the width of the crystallization frame, and either the width b or the height h of the rib The width of the crystallization frame is 1 / 100 to 1 / 150 of the width of the crystallization frame. It does not add any new impurity ions, and does not add any oxidizing agent. The nickel sulfate crystal particles produced are uniform and are free of the static generation. This avoids caking of very large particles, irregularly shaped particles and crystals.

The invention relates to a method for producing a polymorphic or pseudo-polymorphic crystalline phase from a plurality of compounds (C, D, S1, S2), the method comprising steps of preparing (I) a supersaturated solution from the compounds, homogenizing (II) the supersaturated solution in an ultrasonic bath, transferring (III) the supersaturated solution into a plurality of heated tubes (54), aging (V) the solutions transferred into the tubes for a predetermined period of time, exposing the tubes (54) to a polarized pulsed laser beam before and / or during exposure, followed in situ by nucleation and then growing cocrystals inside the tubes (54), and filtering the exposed solutions in order to recover cocrystals having a size greater than a predetermined minimum size. This method is carried out in order to obtain cocrystallization from at least one active substance (D) and a coformer (C) in at least a first solvent (S1) and a second solvent (S2).

The invention relates to a eutectic freeze crystallization apparatus of liquid, comprising: a eutectic freeze crystallization chamber (200) comprising an internal space having a first portion and a second portion and configured to receive said liquid via a feeding inlet arranged within the eutectic freeze crystallization chamber; mixing means arranged within the internal space at the first portion and configured to mix the liquid therein; a cooling element configured to cool the liquid within the internal space for lowering temperature of the liquid such that ice and salt crystals will be formed within the liquid; and conveyor means extending at least within the internal space and configured to convey at least part of the ice and salt crystals from the liquid towards a first outlet arranged at the second portion and to feed out via the first outlet the at least part of the ice and salt crystals from the internal space of the eutectic freeze crystallization chamber. The ice and salt crystals are separated in a separation unit (333).

The invention relates to the technical field of salt preparation systems, in particular to a sodium chloride and sodium sulfate large-particle salt preparation system, which comprises a crystallization separation module, a sodium chloride and sodium sulfate large-particle salt preparation module and a sodium chloride and sodium sulfate large-particle salt preparation module, the fine crystal elimination and crystallization module comprises a crystal grading and growing kettle, a thickener and a centrifugal machine, a solution is evaporated and crystallized through the crystal separation module and conveyed to the fine crystal elimination and crystallization module, and the fine crystal elimination and crystallization module carries out grading and growing on the solution and forms crystals with different particle sizes; and the floating fine crystal is conveyed to the fine crystal eliminating and dissolving module again to carry out fine crystal dissolving on the unsaturated solution, the dissolved solution is conveyed to the fine crystal eliminating and crystallizing module again, and after the sinking particle crystal is thickened, centrifugal dewatering is carried out to form a crystal with a large crystal form particle size and a large crystal form particle size. And the crystal is round and regular in morphology, so that the crystal is good in flowability, anti-caking, high in strength and not easy to break, and industrial subsequent treatment is greatly reduced.

The application discloses a method for digesting and separating fluorinated aluminum by program, which comprises the following steps: placing a catalyst with metal elements supported on alumina as a carrier into a reaction container of a cluster digestion device, adding hydrochloric acid and / or nitric acid, setting a digestion program, introducing inert gas for pre-pressurization, performing primary digestion, and simultaneously starting a condensation reflux atomizer; after the program is completed, adding hydrofluoric acid, setting a digestion program, and performing secondary digestion; after the digestion is completed, entering a cooling and crystallization program, performing cooling and crystallization, and separating to obtain a sample solution to be detected and a solid; the solid is dried and calcined to obtain fluorinated aluminum crystals, and the liquid is used for detecting the content of metal elements. The method is applied to the digestion treatment of the alumina sample with metal elements supported thereon, has a large sample treatment range, complete digestion, no volatile loss of elements, and can separate AlF3 in an alpha crystal form through the program digestion of the digestion device.

The disclosure relates to methods for crystallization of active pharmaceutical ingredients (APIs), wherein the crystallization and crystal growth is controlled. According to the method solid amorphous nanosized API and an aqueous solution comprising one or more polymers and / or copolymers are contacted so as to form a suspension comprising nanosized API in crystalline form.

A process for treating fluids for the removal of sulphate therefrom, the process comprising passing a fluid containing a sulphate and carbonate through a fluidized bed reactor; and, loading sulphate to said fluidized bed reactor at a rate that is greater than 1 kg of sulphate per square metre of said fluidized bed reactor per hour (kg SO4 / m2 / hr); thereby co-precipitating the sulphate and carbonate. The process must maintain the supersaturation levels of calcium sulphate within a predefined range of 100-450% and provides a loading rate of sulphate in the reactor that is greater than 1 kg of sulphate per square metre of reactor per hour (kg SO4 / m2 / hr).

The invention relates to a eutectic freeze crystallization apparatus of liquid, comprising: a eutectic freeze crystallization chamber comprising an internal space having a first portion and a second portion and configured to receive said liquid via a feeding inlet arranged within the eutectic freeze crystallization chamber; mixing means arranged within the internal space at the first portion and configured to mix the liquid therein; a cooling element configured to cool the liquid within the internal space for lowering temperature of the liquid such that ice and salt crystals will be formed within the liquid; and conveyor means extending at least within the internal space and configured to convey at least part of the ice and salt crystals from the liquid towards a first outlet arranged at the second portion and to feed out via the first outlet the at least part of the ice and salt crystals from the internal space of the eutectic freeze crystallization chamber.

A static mixer crystallizer device includes at least one side wall defining a channel extending from a first end to a second end along a longitudinal axis. The channel receives a flow of a solution from the first end of the channel and expels the solution from the second end of the channel. The solution is a supersaturated solution comprising a fluid and dissolved salts. The device include a first structure disposed within the channel, the first structure comprising at least one surface comprising at least one of a reentrant surface, a crenellation, a concavity, or a corrugation configured to affect the flow of the solution through the channel to increase the turbidity thereof and accelerate a rate of crystal growth within the solution. The solution exiting the second end of the channel comprises salt crystals precipitated from the supersaturated solution.

The invention relates to a method for initiating the crystallization of a solute present in a solution (S) at a concentration that makes it metastable, comprising the application of one or more plasma pulses to the solution (S).

The invention discloses efficient crystallization equipment for p-hydroxyacetophenone, and belongs to the technical field of p-hydroxyacetophenone production, and the efficient crystallization equipment is technically characterized by comprising a supporting table, the equipment can flexibly switch medicament forms according to process parameters such as feed liquid concentration, temperature and stirring rate, when feed liquid is in a high-viscosity state, liquid medicaments are easier to uniformly mix, and the crystallization efficiency is improved. When a crystallization system needs to be stabilized for a long time, the solid medicament can prolong the action period, reduce the supplementing frequency, adapt to intermittent and continuous production processes, is small in dosage and high in stability, does not need to be additionally provided with a dissolving device, and reduces energy consumption; according to the present invention, the automatic control is achieved, the manual operation error is reduced, the continuous production process is formed through the arranged crystallization treatment mechanism, the previous process creates the high-quality condition for the subsequent process, and the advantages of easy agent selective addition and good crystallization effect are provided.

The invention relates to a process for obtaining an amino acid in crystalline form, from a salt of said amino acid in aqueous solution, in the presence of carbon dioxide under pressure, said process being carried out in a forced circulation crystallizer (1), the latter comprising a chamber (2) having a lower part (3) and an upper part (4), the lower part (3) containing an aqueous liquid medium (6) comprising the amino acid and the upper part (4) containing carbon dioxide under pressure (7), and an external circuit (8) to this chamber (2) supplied with aqueous solution of said amino acid (5) and bringing it into the upper part (4) of the chamber (2), said external circuit (8) being connected to the chamber (2) from an outlet (9) located in the lower position of the chamber (2) to at least one inlet (10, 17) located in the upper position of the chamber (2), passing through a heat exchanger (11),said process comprising the following steps: the forced circulation crystallizer (1) is supplied with aqueous solution (5) of said salt, through at least one inlet (12, 12') in the external circuit (8) opening into the upper part (4) of the chamber (2) via the inlet (10); the aqueous solution (5) of said salt arriving in the upper part (4) of the chamber (2) from at least the inlet (10,17) by means of a distributor (13) emitting downward jets (14) towards the lower part (3) of the chamber (2); carbon dioxide is injected into the external circuit (8) and / or into the upper part (4) of the chamber (2) to obtain a pressurized carbon dioxide environment in the upper part (4) above the aqueous liquid medium (6); a juice containing the amino acid in crystalline form is collected at the bottom of the chamber (2) and conveyed to a purification module (15), and a juice substantially free of amino acid in crystalline form is drawn off and recirculated into the external circuit (8); and said amino acid is obtained in crystalline form in the purification module (15).

A method of preparing solid particles of a material is described, the method comprising the steps of: controlling the supply of a first liquid phase, the first liquid phase comprising a solution of a first material through a membrane, the membrane defining a plurality of pores; controlling the supply of a second liquid phase, the second liquid phase comprising a solution of a second material; reacting the first and second materials to produce a third liquid phase comprising a solution of a third material; and supersaturating the third liquid phase to form solid particles of the third material.

The application belongs to the technical field of biological medicine, and specifically provides a cefotaxime acid and a continuous preparation method thereof. The method comprises the following steps: firstly, mixing 7-ACA suspension liquid with triethylamine solution; then, condensing the mixture with AE-active ester solution; then, extracting and separating the condensate liquid twice through an extraction separation device and methylene chloride back extraction to obtain an aqueous phase; reacting the aqueous phase with hydrochloric acid to obtain cefotaxime acid crystallization liquid; finally, taking part of the cefotaxime acid crystallization liquid to prepare seed crystal mixture liquid, adding the remaining cefotaxime acid crystallization liquid and crystallization solvent into the seed crystal mixture liquid at a specific speed to obtain cefotaxime acid. The method realizes continuous preparation of cefotaxime acid, significantly shortens the preparation period, improves the production efficiency, reduces the side reaction and product degradation, lays a foundation for preparing high-quality cefotaxime acid, and is beneficial to industrial production.

The invention belongs to the technical field of battery positive electrode materials, and relates to a synthesis device and a synthesis method of cobalt carbonate, the synthesis device comprises a first-stage reaction kettle, a second-stage reaction kettle, a first-stage thickener and a second-stage thickener which are sequentially connected along the material flow direction; the discharge hole of the first-stage reaction kettle is communicated with the feed hole of the second-stage reaction kettle through an overflow pipeline; a discharge hole of the second-stage reaction kettle is communicated with a feed hole of the first-stage thickener through an overflow pipeline; an overflow outlet of the first-stage thickener is communicated with a feeding hole of the second-stage thickener; and an overflow outlet of the second-stage thickener is communicated with a reflux inlet of the first-stage reaction kettle through a reflux pipeline. The synthesis device provided by the invention can realize continuous and efficient production, can adapt to synthesis of large-particle-size cobalt carbonate, and improves the stability of the product reaction process, the operation efficiency and the product quality.

The invention relates to the technical field of lithium compound purification and crystallization, in particular to a lithium hydroxide solution multi-stage cooling crystallization device and a working method thereof.The lithium hydroxide solution multi-stage cooling crystallization device comprises a raw material liquid storage tank, a concentrator, a filter, a first-stage crystallizer, a second-stage crystallizer, a third-stage crystallizer, a centrifugal separator and a drying machine; the first-stage crystallizer, the second-stage crystallizer and the third-stage crystallizer are connected in series through a delivery pump, the third-stage crystallizer comprises a kettle body, a jacket is arranged in the kettle body, a feeding hole is formed in the top of the kettle body, and a discharging hole is formed in the bottom of the kettle body; by means of the unique design of the sealing cover, the discharging inner cavity and the built-in discharging channel, fine crystals scraped on the inner wall are collected and guided out of the kettle at the moment of generation. The problem of secondary pollution caused by a traditional wall scraping mechanism is thoroughly solved, secondary nucleation induced by fine grains is avoided from the source, and the method is the key for obtaining products with narrow particle size distribution.

The invention relates to the technical field of melamine, and discloses a production method and system of melamine. The generation method comprises the following steps: taking urea as a raw material to react to obtain melamine, and collecting mixed gas containing the melamine; the method comprises the following steps: sequentially carrying out cooling filtration, fluidization crystallization and gas-solid separation on the mixed gas containing melamine, and collecting solids to obtain a melamine product; the fluidized crystallization comprises the following steps: the cooled and filtered mixed gas and medium particles enter a fluidized bed crystallizer for fluidized crystallization to obtain mixed gas containing melamine crystals, and the mixed gas containing the melamine crystals is discharged from the top of the fluidized bed crystallizer.

The invention relates to a device and to a process for the continuous, controlled crystallization of metal salt crystals, in particular lithium carbonate crystals. These crystals can be produced with a high degree of homogeneity and on a large scale.

The application provides a slow-release device, a rubidium-titanium potassium phosphate oxide crystal and a preparation method thereof, and belongs to the technical field of electro-optic crystals and nonlinear optical crystals. The application provides a slow-release device, which comprises a hollow inner tube and a hollow outer tube sleeved outside the hollow inner tube; the hollow inner tube and the hollow outer tube are both closed structures provided with slow-release holes at the top; the diameter of the slow-release hole is 0.3-3 mm. The slow-release device provided by the application can avoid crystal cracking, and the prepared rubidium-titanium potassium phosphate oxide crystal has the advantages of high resistivity and uniform resistivity distribution.

Payload systems for processing chemical substances under various gravity levels, such as hypergravity and / or microgravity. The payload systems may include a hypergravity thermal payload system configured to enable melt or cooling of a sample under hypergravity. Alternatively, or in addition, the payload systems may include a gravity-independent thermal payload system for enabling melt or cooling of a sample under various gravity levels, such as microgravity. Alternatively, or in addition, the payload systems may include a hypergravity crystallization payload system configured to enable crystallization of a chemical substance under hypergravity. Alternatively, or in addition, the payload systems may include a gravity-independent crystallization system configured to enable crystallization of a chemical substance in various gravity levels, such as microgravity.

Disclosed herein are electro-dialytic crystallizers and methods of use thereof. For example, described herein are electro-dialytic crystallizer systems comprising an electro-dialysis module and a crystallizer module in liquid communication with the electrodialysis module. The electrodialysis module is configured to receive an aqueous feedwater solution and form a diluate stream and a brine stream, the aqueous feedwater solution comprising an ionic component, the diluate stream having a lower concentration of the ionic component relative to the aqueous feedwater solution, and the brine stream having a higher concentration of the ionic component relative to the aqueous feedwater solution. The crystallizer module is configured to receive the brine stream and form crystals comprising the ionic component and a supernatant. Also disclosed herein are methods of use of any of the systems disclosed herein, for example using the system to treat the aqueous feedwater solution.WO

The disclosure relates to methods for crystallization of active pharmaceutical ingredients (APIs), wherein the crystallization and crystal growth is controlled. According to the method solid amorphous nanosized API and an aqueous solution comprising one or more polymers and / or copolymers are contacted so as to form a suspension comprising nanosized API in crystalline form.

The present invention relates to a novel crystalline form of enavogliflozin, and a preparation method therefor. The novel crystalline form of enavogliflozin, according to the present invention, has thermodynamic stability and a hygroscopic property that are superior to those of a conventionally reported crystalline form of enavogliflozin, and thus has excellent long-term storage and pharmaceutical stability. In addition, the time to reach Cmax is shorter than that of the conventionally reported crystalline form of enavogliflozin such that drug effects can be rapidly exhibited, and thus the present invention can be effectively used.

The invention belongs to the technical field of amino acid separation, and particularly discloses a method for recovering alanine from a high-salt alanine-containing aqueous solution. The pH value of the solution is adjusted to be close to the isoelectric point (5.0-7.0) of alanine, a polyamide nanofiltration membrane with the molecular weight cut-off of 150-300 Da is adopted for cross-flow filtration, and selective separation of alanine (the cut-off rate is larger than or equal to 85%) and sodium chloride (the cut-off rate is smaller than or equal to 40%) is achieved under the operation pressure of 0.5-4.0 MPa. Concentrating the trapped fluid until the concentration of the alanine is greater than or equal to 15%, and then adding a seed crystal at an isoelectric point for gradient crystallization to obtain the high-purity alanine. The preferable scheme comprises microfiltration pretreatment, two-stage nanofiltration series connection (the first stage is 1.0-2.5 MPa desalination and the second stage is 3.0-4.0 MPa concentration) and a seed crystal induced crystallization process. The method is suitable for fermentation waste liquid or pharmaceutical wastewater containing more than or equal to 6wt% of NaCl and 0.1-2wt% of alanine, the recovery rate is more than 90%, the energy consumption is less than 0.5 kWh / m, and no chemical addition is needed in the whole process.

In the BHET crystallization process, the BHET solution is introduced into a crystallizer located at the bottom of the crystallizer and equipped with agitator blades arranged coaxially with the draft tube. The draft tube is arranged coaxially with the inner wall of the tank, and multiple heat exchange plates, through which a cooling fluid circulates, are placed in the gap formed between the inner wall of the tank and the draft tube. The thrust of the agitator blades drives the solution through the gap, and the large heat exchange area with the heat exchange plates allows for efficient cooling without excessive agitation of the liquid. The resulting suspension is rich in BHET crystals and low in fines, and is discharged from the crystallizer and sent to the subsequent BHET processing step.

The present invention relates to a technology for flow crystallization. The system includes a vessel having a bottom surface defining a first plane, the vessel containing at least two planar magnetic surfaces, the magnetic surfaces spaced apart along the first plane and substantially parallel to a second plane, the magnetization vector of each of the magnetic surfaces being perpendicular to the plane, the vessel being configured such that the first plane is substantially perpendicular to the second plane, and cavities formed between the planar magnetic surfaces are configured to receive a racemic mixture containing different enantiomers, with each magnetic surface interacting differently with each of the different enantiomers, thereby enabling enantioselective crystallization. Thus, the system of the present invention is based on enantioseparation of crystals using magnetic surfaces.

A refining method according to the present invention is a refining method for crystallizing a compound with at least one crystal form, including: setting, as a target wavelength, a specific infrared wavelength at which a specific crystal form precipitates from a solution of the compound dissolved in a solvent; and using an infrared radiation apparatus capable of emitting infrared radiation including the target wavelength to evaporate the solvent and precipitate the specific crystal form while irradiating the solution with infrared radiation including the target wavelength. The specific infrared wavelength is preferably set as the target wavelength based on an infrared absorption spectrum of the crystal form and the dissolution rate of the compound in the solvent.