114results about "Crystallization auxillary selection" patented technology

This application relates to the field of functional crystalline material preparation and microfluidic application technology, specifically disclosing a method and product for preparing formate crystals using core-shell microcapsules, including the following steps: (1) dissolving a solid alkaline raw material in a formic acid solution to prepare reaction solution a; (2) separately conveying polymer solution A and polymer solution B with phase separation characteristics, and reaction solution a, so that they are mixed at the intersection of microchannels to prepare dispersed phase b, which is then introduced into the assembly zone for phase separation assembly to form core-shell microcapsules; (3) the core-shell microcapsules are crystallized in a continuous temperature-changing crystallization zone to form formate solid; (4) the formate solid is collected, washed and dried sequentially to obtain the target product; (5) the oil layer is continuously extracted and returned to the assembly zone for recycling. The formate crystals prepared in this application not only have a large particle size, but also exhibit good size uniformity and morphological repeatability, and have the advantages of high throughput, green environmental protection, and simple operation.

A process for producing a polymorphic or pseudo-polymorphic crystalline phase from a plurality of compounds (C,D,S1,S2), comprising the steps of preparing (I) a supersaturated solution from said compounds, homogenizing (II) said supersaturated solution in an ultrasonic bath, transferring (III) the supersaturated solution into a plurality of heated tubes (54), aging (V) the solutions transferred into the tubes for a determined period, exposing said tubes (54) to a pulsed and polarized laser beam before and / or during exposure, monitoring in situ the nucleation and then the growth of co-crystals inside said tubes (54), and filtering the exposed solutions to recover co-crystals larger than a predetermined minimum size.This process is implemented to carry out co-crystallization from at least one active substance (D) and one co-former (C) in at least one first solvent (S1) and one second solvent (S2), and it further comprises two preliminary steps: establishing a phase diagram from the respective physicochemical characteristics of said active substance (D), said co-former (C), said first solvent (S1) and said second solvent (S2), and then determining, from said phase diagram thus established, concentration, temperature and exposure conditions providing a stable phase for the production of co-crystals. See Figure 4.

The invention discloses a processing method for fractionation and rapid crystallization of palm oil, which comprises the following steps: (1) heating and controlling a palm oil raw material to be fractionated to 55-65 DEG C (crystal breaking), pumping the palm oil raw material into a crystallizing tank, and then cooling the palm oil raw material to about 25 DEG C under the action of rapid cooling of cooling water (or chilled water) and stirring; (2) continuously reducing the temperature of the palm oil raw material in the crystallizing tank by using chilled water, adding a certain proportion of palm oil (solid-liquid mixture) which is completely crystallized and is in an unseparated state into the crystallizing tank at the interval of 25.0-18.0 DEG C as a seed crystal, and controlling the stirring speed of the crystallizing tank at 15-30r / min until the palm oil raw material is completely cooled and crystallized; (3) after crystallization is completed, if seed crystals need to be added into the crystallizing tank which is cooling and crystallizing, pumping the seed crystals into the crystallizing tank which needs to be added with the seed crystals through a pump; otherwise, immediately pumping into a membrane filter for filtering and separating (preventing the tank from being burnt) to obtain liquid oil and stearin. The palm oil seed crystal is added, so that the crystallization time can be shortened; and through seed crystal induction, the formation of stable-form crystals is accelerated, excessive crystallization is avoided, and the interception loss of filtration is reduced, so that the liquid oil yield is improved.

Method for producing electronic grade nickel sulfate from nickel powder, crystallization apparatus, and control thereof The present invention provides a method for producing nickel sulfate, and nickel sulfate produced thereby. The process includes acid leaching, copper removal, acid adjustment, concentration, cooling crystallization, drying and sieving, and secondary leaching. Oxidation In the calcination furnace, the temperature is 400 to 700°C, and 1 kg of compressed air is used for each kilogram of nickel powder. ~5m 3 The reaction time is 1.0 to 2.5 hours, and the temperature during acid immersion is controlled to 45 to 70°C. Then, add dilute sulfuric acid to control the pH to 0.5-1.5 and react for 1-3 hours. The copper removal is to replace the copper with nickel powder, and the acid conditioning is to use nickel hydroxide or The pH is adjusted to 2.5-4.5 using nickel carbonate, and the filtrate is concentrated by The cooling crystallization method is to obtain nickel sulfate crystals and return the mother liquor to the concentrate. Drying and sieving is to add the undersieved material to the crystallizer as seed crystals, and secondary leaching is to Dilute sulfuric acid is added to the leaching slag, and it is reacted with nickel sulfate or hydrogen peroxide until nickel is less than 0.1%. If the first stage is full, the second leaching is continued. The crystallizer is a crystallizer that is connected in series with a second-stage crystallizer and a third-stage crystallizer. A crystallization frame, an oscillator provided under the crystallization frame, and an oscillator provided at the exit end of the crystallization frame. The crystallization frame is a rectangular parallelepiped. The bottom of the ribs are evenly spaced, with a cross section of a circular arc. The distance between two adjacent ribs is S is 1 / 25 to 1 / 15 of the width of the crystallization frame, and either the width b or the height h of the rib The width of the crystallization frame is 1 / 100 to 1 / 150 of the width of the crystallization frame. It does not add any new impurity ions, and does not add any oxidizing agent. The nickel sulfate crystal particles produced are uniform and are free of the static generation. This avoids caking of very large particles, irregularly shaped particles and crystals.

The invention discloses a method for separating high-purity chlorogenic acid and neochlorogenic acid from a stevia rebaudiana chlorogenic acid product based on membrane coupling extraction crystallization. The method comprises the following steps: preparing a first to-be-treated solution by taking the stevia rebaudiana chlorogenic acid product as a raw material; treating the first to-be-treated liquid through an ultrafiltration membrane and a nanofiltration membrane in sequence to obtain a trapped fluid II, concentrating the trapped fluid II, and adjusting the pH value to obtain a second to-be-treated liquid; extracting the second to-be-treated liquid with an ethyl acetate-n-butyl alcohol saturated aqueous solution to obtain a raffinate phase I and an extract phase I; adjusting the pH of the raffinate phase I to obtain a third to-be-treated solution; extracting the third to-be-treated liquid with an ethyl acetate-n-butyl alcohol saturated aqueous solution to obtain a raffinate phase II and an extract phase II; drying the extract phase I, crystallizing, pulping and purifying to obtain high-purity chlorogenic acid; and drying the extract phase II, crystallizing, pulping and purifying to obtain the high-purity neochlorogenic acid. According to the method, membrane separation, solvent extraction and fractional crystallization are coupled, and high-efficiency and high-selectivity separation and purification of chlorogenic acid and neochlorogenic acid in a stevia rebaudiana chlorogenic acid product are realized.

The invention relates to a method for producing a polymorphic or pseudo-polymorphic crystalline phase from a plurality of compounds (C, D, S1, S2), the method comprising steps of preparing (I) a supersaturated solution from the compounds, homogenizing (II) the supersaturated solution in an ultrasonic bath, transferring (III) the supersaturated solution into a plurality of heated tubes (54), aging (V) the solutions transferred into the tubes for a predetermined period of time, exposing the tubes (54) to a polarized pulsed laser beam before and / or during exposure, followed in situ by nucleation and then growing cocrystals inside the tubes (54), and filtering the exposed solutions in order to recover cocrystals having a size greater than a predetermined minimum size. This method is carried out in order to obtain cocrystallization from at least one active substance (D) and a coformer (C) in at least a first solvent (S1) and a second solvent (S2).

In the crystallization system of the lithium hexafluorophosphate of the present invention, a first-stage crystallization kettle is connected to a lithium hexafluorophosphate mother liquor supply source through a lithium hexafluorophosphate mother liquor supply line; further connected to the lithium hexafluorophosphate mother liquor supply source through a mother liquor heat exchange line connected with a mother liquor heat exchanger; and further connected to a second-stage crystallization kettle through a first mother liquor delivery line configured to deliver lithium hexafluorophosphate mother liquor, a second-stage crystallization kettle is connected to a third-stage crystallization kettle through a second mother liquor delivery line configured to deliver lithium hexafluorophosphate mother liquor, a third-stage crystallization kettle is connected to a fourth-stage crystallization kettle through a crystalline particle delivery line configured to deliver small crystalline particles in the third-stage crystallization kettle; and further connected to a next process device through a first discharging line, and a fourth-stage crystallization kettle is connected to a next process device through a second discharging line. The crystallization system of lithium hexafluorophosphate of the present invention enables different crystallization stages to be carried out separately in different crystallization kettles, so as to realize continuous feeding and continuous discharging in the course of crystallization.

The invention relates to a eutectic freeze crystallization apparatus of liquid, comprising: a eutectic freeze crystallization chamber (200) comprising an internal space having a first portion and a second portion and configured to receive said liquid via a feeding inlet arranged within the eutectic freeze crystallization chamber; mixing means arranged within the internal space at the first portion and configured to mix the liquid therein; a cooling element configured to cool the liquid within the internal space for lowering temperature of the liquid such that ice and salt crystals will be formed within the liquid; and conveyor means extending at least within the internal space and configured to convey at least part of the ice and salt crystals from the liquid towards a first outlet arranged at the second portion and to feed out via the first outlet the at least part of the ice and salt crystals from the internal space of the eutectic freeze crystallization chamber. The ice and salt crystals are separated in a separation unit (333).

To provide an improved method for producing a diphenylmethane derivative which is effective as a sodium-dependent glucose cotransporter (SGLT) inhibitor.SOLUTION: The present invention relates to a method for producing a compound of the formula Ia implemented by a convergent synthesis method. The method comprises: reacting a compound of the formula 2 with a compound of the formula 3, and subjecting the resultant to a cyclization reaction to obtain a compound of the formula 4; subjecting the resultant to dehydration or amidation, reacting the resultant with a compound of the formula 5, and performing reduction to obtain a compound of the formula 6; and reacting the resultant with a compound of the formula 7 and performing deprotection and reduction.SELECTED DRAWING: Figure 1

The invention relates to the technical field of salt preparation systems, in particular to a sodium chloride and sodium sulfate large-particle salt preparation system, which comprises a crystallization separation module, a sodium chloride and sodium sulfate large-particle salt preparation module and a sodium chloride and sodium sulfate large-particle salt preparation module, the fine crystal elimination and crystallization module comprises a crystal grading and growing kettle, a thickener and a centrifugal machine, a solution is evaporated and crystallized through the crystal separation module and conveyed to the fine crystal elimination and crystallization module, and the fine crystal elimination and crystallization module carries out grading and growing on the solution and forms crystals with different particle sizes; and the floating fine crystal is conveyed to the fine crystal eliminating and dissolving module again to carry out fine crystal dissolving on the unsaturated solution, the dissolved solution is conveyed to the fine crystal eliminating and crystallizing module again, and after the sinking particle crystal is thickened, centrifugal dewatering is carried out to form a crystal with a large crystal form particle size and a large crystal form particle size. And the crystal is round and regular in morphology, so that the crystal is good in flowability, anti-caking, high in strength and not easy to break, and industrial subsequent treatment is greatly reduced.

The invention discloses a built-in calcium fluoride crystallizer based on a coagulative precipitation tank, a first guide cylinder and a second guide cylinder are respectively fixed on opposite side walls in the coagulative precipitation tank, a fluorine-containing wastewater inlet pipeline conveys fluorine-containing wastewater into the first guide cylinder, a calcium-containing medicament inlet pipeline conveys a calcium-containing medicament into the second guide cylinder, and the first guide cylinder and the second guide cylinder are communicated with each other. The first propeller and the second propeller are fixed in the first guide cylinder and the second guide cylinder respectively, the first propeller vertically pushes flow downwards, the second propeller vertically pushes flow upwards, the stirrer can stir liquid in the coagulating basin, and the crystal discharging device can regularly discharge crystal precipitates at the bottom of the coagulating basin into the cyclone separator. The cyclone separator can perform cyclone separation on large-particle crystals and small-particle crystals, the large-particle crystals are discharged from a crystal outlet of the cyclone separator, and the small-particle crystals are discharged from a water outlet of the cyclone separator along with water flow and enter the coagulating basin. The medicament cost is reduced, and the improvement cost is low.

The present invention provides a continuous falling film melt crystallizer, including a cylinder, wherein a feeding port and a discharging port are respectively provided in a top region and a bottom of the cylinder; crystallization zones are sequentially provided within the cylinder in several levels from top to bottom; each crystallization zone is provided with multiple vertically arranged crystallization tubes; heat exchange tubes are sleeved onto respective crystallization tube, with crystallization tubes and heat exchange tubes in adjacent crystallization zones being in one-to-one correspondence and in communication with each other; crystallization tubes in the top level and the crystallization tubes in the bottom level are in communication with the feeding port and the discharging port, respectively; a cooling / heating medium inlet / outlet communicating with top ends of the heat exchange tubes is provided on the cylinder for each level of crystallization zone, and in the bottom level of the crystallization zones, a cooling / heating medium inlet / outlet communicating with bottom end of the heat exchange tubes is provided in a lower region of the cylinder. In the present invention, cooling / heating medium inlet / outlets are additionally arranged in the middle of the cylinder, such that the heat exchange uniformity between a material supply to be purified and a cold medium in the upper region and lower region of the cylinder can be improved, and a uniformity of crystallization in the upper region and lower region of the cylinder is further improved.

The application discloses a method for digesting and separating fluorinated aluminum by program, which comprises the following steps: placing a catalyst with metal elements supported on alumina as a carrier into a reaction container of a cluster digestion device, adding hydrochloric acid and / or nitric acid, setting a digestion program, introducing inert gas for pre-pressurization, performing primary digestion, and simultaneously starting a condensation reflux atomizer; after the program is completed, adding hydrofluoric acid, setting a digestion program, and performing secondary digestion; after the digestion is completed, entering a cooling and crystallization program, performing cooling and crystallization, and separating to obtain a sample solution to be detected and a solid; the solid is dried and calcined to obtain fluorinated aluminum crystals, and the liquid is used for detecting the content of metal elements. The method is applied to the digestion treatment of the alumina sample with metal elements supported thereon, has a large sample treatment range, complete digestion, no volatile loss of elements, and can separate AlF3 in an alpha crystal form through the program digestion of the digestion device.

The disclosure relates to methods for crystallization of active pharmaceutical ingredients (APIs), wherein the crystallization and crystal growth is controlled. According to the method solid amorphous nanosized API and an aqueous solution comprising one or more polymers and / or copolymers are contacted so as to form a suspension comprising nanosized API in crystalline form.

A process for treating fluids for the removal of sulphate therefrom, the process comprising passing a fluid containing a sulphate and carbonate through a fluidized bed reactor; and, loading sulphate to said fluidized bed reactor at a rate that is greater than 1 kg of sulphate per square metre of said fluidized bed reactor per hour (kg SO4 / m2 / hr); thereby co-precipitating the sulphate and carbonate. The process must maintain the supersaturation levels of calcium sulphate within a predefined range of 100-450% and provides a loading rate of sulphate in the reactor that is greater than 1 kg of sulphate per square metre of reactor per hour (kg SO4 / m2 / hr).

The invention relates to a eutectic freeze crystallization apparatus of liquid, comprising: a eutectic freeze crystallization chamber comprising an internal space having a first portion and a second portion and configured to receive said liquid via a feeding inlet arranged within the eutectic freeze crystallization chamber; mixing means arranged within the internal space at the first portion and configured to mix the liquid therein; a cooling element configured to cool the liquid within the internal space for lowering temperature of the liquid such that ice and salt crystals will be formed within the liquid; and conveyor means extending at least within the internal space and configured to convey at least part of the ice and salt crystals from the liquid towards a first outlet arranged at the second portion and to feed out via the first outlet the at least part of the ice and salt crystals from the internal space of the eutectic freeze crystallization chamber.

A static mixer crystallizer device includes at least one side wall defining a channel extending from a first end to a second end along a longitudinal axis. The channel receives a flow of a solution from the first end of the channel and expels the solution from the second end of the channel. The solution is a supersaturated solution comprising a fluid and dissolved salts. The device include a first structure disposed within the channel, the first structure comprising at least one surface comprising at least one of a reentrant surface, a crenellation, a concavity, or a corrugation configured to affect the flow of the solution through the channel to increase the turbidity thereof and accelerate a rate of crystal growth within the solution. The solution exiting the second end of the channel comprises salt crystals precipitated from the supersaturated solution.

The invention relates to a method for initiating the crystallization of a solute present in a solution (S) at a concentration that makes it metastable, comprising the application of one or more plasma pulses to the solution (S).

The invention discloses efficient crystallization equipment for p-hydroxyacetophenone, and belongs to the technical field of p-hydroxyacetophenone production, and the efficient crystallization equipment is technically characterized by comprising a supporting table, the equipment can flexibly switch medicament forms according to process parameters such as feed liquid concentration, temperature and stirring rate, when feed liquid is in a high-viscosity state, liquid medicaments are easier to uniformly mix, and the crystallization efficiency is improved. When a crystallization system needs to be stabilized for a long time, the solid medicament can prolong the action period, reduce the supplementing frequency, adapt to intermittent and continuous production processes, is small in dosage and high in stability, does not need to be additionally provided with a dissolving device, and reduces energy consumption; according to the present invention, the automatic control is achieved, the manual operation error is reduced, the continuous production process is formed through the arranged crystallization treatment mechanism, the previous process creates the high-quality condition for the subsequent process, and the advantages of easy agent selective addition and good crystallization effect are provided.

The invention relates to a process for obtaining an amino acid in crystalline form, from a salt of said amino acid in aqueous solution, in the presence of carbon dioxide under pressure, said process being carried out in a forced circulation crystallizer (1), the latter comprising a chamber (2) having a lower part (3) and an upper part (4), the lower part (3) containing an aqueous liquid medium (6) comprising the amino acid and the upper part (4) containing carbon dioxide under pressure (7), and an external circuit (8) to this chamber (2) supplied with aqueous solution of said amino acid (5) and bringing it into the upper part (4) of the chamber (2), said external circuit (8) being connected to the chamber (2) from an outlet (9) located in the lower position of the chamber (2) to at least one inlet (10, 17) located in the upper position of the chamber (2), passing through a heat exchanger (11),said process comprising the following steps: the forced circulation crystallizer (1) is supplied with aqueous solution (5) of said salt, through at least one inlet (12, 12') in the external circuit (8) opening into the upper part (4) of the chamber (2) via the inlet (10); the aqueous solution (5) of said salt arriving in the upper part (4) of the chamber (2) from at least the inlet (10,17) by means of a distributor (13) emitting downward jets (14) towards the lower part (3) of the chamber (2); carbon dioxide is injected into the external circuit (8) and / or into the upper part (4) of the chamber (2) to obtain a pressurized carbon dioxide environment in the upper part (4) above the aqueous liquid medium (6); a juice containing the amino acid in crystalline form is collected at the bottom of the chamber (2) and conveyed to a purification module (15), and a juice substantially free of amino acid in crystalline form is drawn off and recirculated into the external circuit (8); and said amino acid is obtained in crystalline form in the purification module (15).

The invention discloses a method for simultaneously preparing high-content isochlorogenic acid A and high-content isochlorogenic acid C. The method comprises the following steps: dissolving a stevia rebaudiana polyphenol product in purified water, and adjusting the pH value to obtain a treating fluid 1; adsorbing the treating fluid 1 through macroporous adsorption resin, jacking the treating fluid 1 through purified water, and mixing effluent liquid during adsorption and purified water jacking to obtain effluent liquid 1; concentrating the effluent 1 by using a reverse osmosis membrane, adjusting the pH value to obtain a treating fluid 2, and extracting the treating fluid 2 by using an ethyl acetate saturated aqueous solution to obtain a raffinate phase I and an extract phase I; adjusting the pH value of the raffinate phase I, and extracting with an ethyl acetate-n-butyl alcohol saturated aqueous solution to obtain a raffinate phase II and an extract phase II; after drying the extract phase I, sequentially crystallizing and recrystallizing to obtain high-purity isochlorogenic acid C; and drying the extract phase II, and sequentially crystallizing, pulping and purifying to obtain the high-purity isochlorogenic acid A. The method comprises the following steps: removing impurities by adopting macroporous adsorption resin, extracting by adopting a solvent step by step, carrying out crude separation on the isochlorogenic acid A and the isochlorogenic acid C, and carrying out subsequent crystallization and refining to obtain the high-content isochlorogenic acid A and the high-content isochlorogenic acid C.

The invention relates to a process for obtaining an amino acid in crystalline form, from a salt of said amino acid in aqueous solution, in the presence of carbon dioxide under pressure, said process being carried out in a forced circulation crystallizer (1), the latter comprising a chamber (2) having a lower part (3) and an upper part (4), the lower part (3) containing an aqueous liquid medium (6) comprising the amino acid and the upper part (4) containing carbon dioxide under pressure (7), and an external circuit (8) to this chamber (2) supplied with aqueous solution of said amino acid (5) and bringing it into the upper part (4) of the chamber (2), said external circuit (8) being connected to the chamber (2) from an outlet (9) located in the lower position of the chamber (2) to at least one inlet (10, 17) located in the upper position of the chamber (2), passing through a heat exchanger (11),said process comprising the following steps: the forced circulation crystallizer (1) is supplied with aqueous solution (5) of said salt, through at least one inlet (12, 12') in the external circuit (8) opening into the upper part (4) of the chamber (2) via the inlet (10); the aqueous solution (5) of said salt arriving in the upper part (4) of the chamber (2) from at least the inlet (10,17) by means of a distributor (13) emitting downward jets (14) towards the lower part (3) of the chamber (2); carbon dioxide is injected into the external circuit (8) and / or into the upper part (4) of the chamber (2) to obtain a pressurized carbon dioxide environment in the upper part (4) above the aqueous liquid medium (6); a juice containing the amino acid in crystalline form is collected at the bottom of the chamber (2) and conveyed to a purification module (15), and a juice substantially free of amino acid in crystalline form is drawn off and recirculated into the external circuit (8); and said amino acid is obtained in crystalline form in the purification module (15).

The invention discloses MET ecological material integrated equipment which comprises a pretreatment mechanism, a phosphorus removal and precipitation mechanism, a sludge concentration and transfer mechanism, a phosphorus resource recycling mechanism and a tail water and by-product treatment mechanism. The phosphorus removal precipitation mechanism is used for converting dissolved phosphorus into solid precipitates and discharging sludge with the solid precipitates, the sludge concentration mechanism is used for concentrating the discharged sludge and conveying the sludge to the phosphorus resource recycling mechanism, and the phosphorus resource recycling mechanism is used for separating phosphorus ions from the concentrated sludge. The tail water and byproduct treatment mechanism is used for deeply purifying the tail water and recycling byproducts after pickling and regenerating the byproducts.

The disclosure relates to methods for crystallization of active pharmaceutical ingredients (APIs), wherein the crystallization and crystal growth is controlled According to the method solid amorphous nanosized API and an aqueous solution comprising one or more polymers and / or copolymers are contacted so as to form a suspension comprising nanosized API in crystalline form.

The application discloses a berberine hydrochloride extraction device and relates to the technical field of natural product extraction equipment. The device comprises a supporting frame, a water receiver, a cooler one and an external controller. The water receiver is fixedly connected to the top end of the supporting frame. The cooler one is fixedly connected to the top end of the water receiver. The middle part of the cooler one is provided with a cooling mechanism. The top part of the cooler one is provided with an adjusting mechanism. The cooling mechanism comprises a water inlet valve body opening fixedly communicated with the bottom end of the cooler one and a water outlet valve body opening fixedly communicated with the top end of the cooler one. The device prolongs the flow time of materials in the cooling water through the conical spiral flow guide pipe three, and increases the heat exchange contact area. Meanwhile, the combined design of the shunt pipe, the segmentation groove and the inclined plate makes the material liquid be dispersed and then gathered again, promotes the internal liquid movement of the material liquid, avoids local temperature difference, significantly improves the cooling uniformity and ensures the uniformity of berberine hydrochloride crystal particles.

The invention discloses an MET composite ecological treatment assembly which comprises a settling chamber, a cyclone separator, a sludge buffer tank, a screw conveyor, an acidolysis reaction chamber, an ion adsorption chamber and a crystallization drying chamber which are connected in sequence, and the settling chamber converts dissolved PO4 < 3-> into solid precipitates through Fe < 3 + >; the outlet end of the settling chamber is provided with an annular porous sludge discharge pipe network for dynamic anti-silting sludge discharge, the cyclone separator is used for intensively and rapidly separating high-solid-content sludge based on three-phase separation, and the sludge buffer tank is used for temporarily storing the sludge and slowly stirring to maintain a flow state; the spiral conveyor quantitatively conveys phosphorus to the acidolysis reaction chamber in a nitrogen sealing mode, an upper-layer radial flow turbine and a lower-layer axial flow paddle are arranged in the acidolysis reaction chamber to form double-layer stirring to dissociate phosphorus into a liquid phase, and a lanthanum-loaded resin adsorption column is arranged in the ion adsorption chamber and used for separating phosphorus and heavy metal ions. And the crystallization drying chamber is used for carrying out gradient crystallization drying on the separated phosphorus salt and controlling the grain size of crystals.

The invention relates to the technical field of adsorption materials, in particular to a composite adsorption material, a preparation method thereof and a growth method of nanoscale iron sulfide crystals. The growth method of the nanoscale FeS crystal comprises the following steps: mixing a Fe < 2 + > source precursor solution and a S < 2-> source precursor solution, adding a surfactant, and stirring in a sealed manner to obtain a precursor solution; uniformly adsorbing the magnetic nanoparticles on the surface of the magnetic rod, and forming a magnetic substrate material on the surface of the magnetic rod; vertically placing a magnetic rod in the precursor solution to form a closed reaction system; gradient heating is conducted on the reaction system, the temperature is increased to a preset final temperature and kept, and nanoscale FeS crystals are generated on the surface of the magnetic substrate; during heating and keeping, the temperature of the bottom end area of the magnetic bar is always kept higher than that of the top end area, a preset temperature difference is formed, and then the magnetic bar is naturally cooled to the room temperature. The prepared composite adsorption material has extremely high recovery efficiency and adsorption rate on the gold element in the water body, and can be recycled for multiple times, so that the single-time use cost is reduced.

The present disclosure relates to a method of producing particles that include first particles each having a core portion, a gap portion, and an outer portion and each made of a nickel-containing transition metal composite hydroxide. In the method of producing particles according to the present disclosure, a pH of the Taylor vortex reaction field at a liquid temperature of 25° C. is 12.5 or less, a first crystallization is performed in which the crystallization is allowed to proceed at an oxygen concentration of the Taylor vortex reaction field of 3.5 vol % or less, a second crystallization is performed in which the oxygen concentration of the Taylor vortex reaction field is changed to a range of 5 vol % to 65 vol % and the crystallization is allowed to proceed, and a duration of the first crystallization is from 40% to 90% of a total crystallization duration.

The application belongs to the technical field of biological medicine, and particularly relates to a sterile cefepime hydrochloride and a direct preparation method thereof. The method comprises the following steps: firstly, 7-MPCA solution and AE active ester solution are simultaneously subjected to condensation reaction through a solid alkali catalyst column; then, the condensation liquid is subjected to extraction and phase separation, twice pH adjustment and crystallization, active carbon decolorization and sodium sulfite reduction to obtain cefepime hydrochloride to be crystallized; then, a part of the cefepime hydrochloride to be crystallized is prepared into a seed crystal mixed solution, the remaining cefepime hydrochloride to be crystallized and a crystallization solvent are added into the seed crystal mixed solution at a specific speed to obtain sterile cefepime hydrochloride. The method realizes continuous production of sterile cefepime hydrochloride, greatly shortens the preparation period of sterile cefepime hydrochloride, reduces side reactions and product degradation, and the obtained cefepime hydrochloride product is high in quality and yield and stable, and is beneficial to industrial production.

Provided is a solvate of a compound (A) represented by the following formula and a method of manufacturing the solvate. A solvent forming the solvate includes a cyclic ether compound (B) having a carbon atom, an oxygen atom, and a hydrogen atom, which is 0.05 to 2.0 moles per mole of the compound (A).X and Y represent an oxygen atom, a sulfur atom, a nitrogen atom, or a carbon atom,at least one of X or Y represents a nitrogen atom,Z represents an atom group that forms a 5- to 7-membered aromatic ring with —X—C═C—Y—,L1 and L2 represent an alkylene group having 2 to 4 carbon atoms, R3 to R6 represent a substituent,q, r, v, and w represent specific integers,in a case where v represents an integer of 2 to 4, a plurality of R5's are not linked to each other to form a ring.