325results about "Crystallization auxillary selection" patented technology

This invention provides a process for increasing the crystallinity of at least one solid material which is less than 100% crystalline, comprising contacting said solid material with solvent in which the solid material is insoluble or poorly soluble (a non-solvent); and applying ultrasound to the solid material when in contact with said non-solvent.

This invention relates to novel methods for affecting, controlling and / or directing various crystal formation, structure formation or phase formation / phase change reaction pathways or systems by exposing one or more components in a holoreaction system to at least one spectral energy pattern. In a first aspect of the invention, at least one spectral energy pattern can be applied to a crystallization reaction system. In a second aspect of the invention, at lest one spectral energy conditioning pattern can be applied to a conditioning reaction system. The spectral energy conditioning pattern can, for example, be applied at a separate location from the reaction vessel (e.g., in a conditioning reaction vessel) or can be applied in (or to) the reaction vessel, but prior to other (or all) crystallization reaction system participants being introduced into the reaction vessel.

A method of preparing particles of a substance, for example selected from a flavor, fragrance, pigment, dye, biologically active compound or a plastics material, comprises contacting the substance of a formulation (which may include the substance in conjunction with a second solvent) with a first solvent which comprises a C1-C4 hydrofluorocarbon, especially tetrafluoroethane, and subjecting the resultant mixture to a separation process, for example, by allowing the mixture to be sprayed as a mist (14) from a high pressure environment in a first vessel (2) to a low pressure environment in a second vessel (8), thereby to cause separation of a least some of the substance from the first solvent and the formation of fine particles (20) of the substance.

A device and process for crystallizing a compound using hydrodynamic cavitation comprising the steps of mixing at least one stream of a solution of such compound to be crystallized with at least one stream of an anti-solvent and passing the mixed streams at an elevated pressure through a local constriction of flow to create hydrodynamic cavitation thereby causing nucleation and the direct production of crystals.

A device and process for crystallizing a compound using hydrodynamic cavitation comprising the steps of mixing at least one stream of a solution of such compound to be crystallized with at least one stream of an anti-solvent and passing the mixed streams at an elevated pressure through a local constriction of flow to create hydrodynamic cavitation thereby causing nucleation and the direct production of crystals. The compound to be crystallized can be, for example, an active pharmaceutical ingredient.

A process of enhancing peel oil extraction from citrus fruit comprises providing a mixture containing citrus solids and water, subjecting the citrus solids and water mixture to high power ultrasonic energy under conditions sufficient to separate peel oil from the citrus solids, and recovering the peel oil. An apparatus for extracting peel oil from citrus fruit comprises an extractor, a conduit for flowing a citrus mixture containing citrus solids and water, and an ultrasonic generator for subjecting the citrus mixture to high power ultrasonic energy to separate peel oil from the citrus solids. In another embodiment, sonic energy is used to de-emulsify peel oil in a citrus mixture.

A process is provided for making sterile aripiprazole having an average particle size less than 100 microns but preferably greater than 25 microns employing an impinging jet crystallization procedure. The resulting bulk aripiprazole of desired particle size may be used to form a sterile freeze-dried aripiprazole formulation, which upon constitution with water and intramuscular injection releases aripiprazole over a period of at least about one week and up to about eight weeks.

This invention relates to controlled preparation of fine particles such as nano-crystalline films and powders with at least one solvent being in a supercritical state. It provides methods, measures, apparatus and products produced by the methods. In other aspects, the invention relates to further treatment of formed particles such as encapsulation of formed primary particles, and methods and measures for collection of formed substances in a batch wise, semi-continuous or continuous manner.

The present invention relates to the use of a high intensity, in-line rotor-stator apparatus to produce fine particles via antisolvent, reactive, salting out or rapid cooling precipitation and crystallization.

In order to recycle the fluoride, calcium fluoride having a particle size and purity suitable for the production of hydrogen fluoride is recovered from the fluoride-containing effluent or the hydrofluoric acid-containing effluent. The method involves reacting a fluoride-containing effluent or a hydrofluoric acid-containing effluent with an aqueous solution of calcium chloride under acidic conditions formed by hydrochloric acid, under which calcium fluoride has a relatively high solubility. Calcium fluoride can be precipitated with high purity and large particle size. The hydrochloric acid residue from or formed by the reaction reacts with inexpensive calcium compounds such as calcium hydroxide, calcium oxide, and calcium carbonate to produce an aqueous calcium chloride solution that is reused to treat effluents containing hydrofluoric acid . The obtained calcium fluoride can be used as a raw material for producing hydrogen fluoride, and the remaining calcium chloride aqueous solution can be provided for other industrial purposes.

It is an object of the present invention to improve the phosphorus recovery rate in a method and apparatus for removing ions to be removed in a liquid to be treated by crystallizing out crystal particles of a poorly soluble salt of the ions to be removed in the liquid to be treated in a crystallization reaction tank. As one means for attaining this object, in one embodiment of the present invention there is provided a method for removing ions to be removed in a liquid to be treated by crystallizing out crystal particles of a poorly soluble salt of the ions to be removed in the liquid to be treated in a crystallization reaction tank, which comprises adding a chemical agent required for the crystallization reaction into a part of a treated liquid flowing out from the crystallization reaction tank and dissolving the chemical agent therein, and supplying the resulting solution into the crystallization reaction tank as a circulating liquid, wherein the liquid to be treated and the circulating liquid are introduced into the crystallization reaction tank tangentially to a transverse section of the crystallization reaction tank.

This invention provides an oscillating baffled reactor apparatus for preparing crystalline particles of at least one substance comprising: a reactor vessel; means for supplying a first flowing stream; means for oscillating fluid within the reactor vessel; a plurality of baffles; source of ultrasonic radiation; and means for collecting said particles.

The invention relates to controlled preparation of fine particles such as nano-crystalline films and powders with at least one solvent being in a supercritical state. It provides methods, measures, apparatus and products produced by the methods. In other aspects the invention relates to further treatment of formed particles such as encapsulation of formed primary particles, and methods and measures for collection of formed substances in a batch wise, semi-continuous or continuous manner.

The present invention includes compositions and methods for preparing micron-sized or submicron-sized particles by dissolving a water soluble effective ingredient in one or more solvents; spraying or dripping droplets solvent such that the effective ingredient is exposed to a vapor-liquid interface of less than 50, 100, 150, 200, 250, 200, 400 or 500 cm−1 area / volume to, e.g., increase protein stability; and contacting the droplet with a freezing surface that has a temperature differential of at least 30° C. between the droplet and the surface, wherein the surface freezes the droplet into a thin film with a thickness of less than 500 micrometers and a surface area to volume between 25 to 500 cm−1.

Process for preparing a cocrystal of an active substance and a cocrystal former, the process involving precipitating the active substance and the cocrystal former together from solution or suspension, in the presence of a supercritical or near-critical fluid, in particular using a GAS, SAS, SEDS or SAS-EM process. The invention also provides a cocrystal prepared using such a process, and its use as a seed crystal in a subsequent process for precipitating a cocrystal of an active substance and a cocrystal former.

The present invention relates to a antisolvent solidification process wherein a liquid medium comprising at least one organic or inorganic compound which is to be solidified is forced through a membrane into one or more antisolvents, or wherein one or more antisolvents are forced through a membrane into a liquid medium comprising at least one organic or inorganic compound which is to be solidified, yielding a composition comprising solid particles comprising said organic and / or inorganic compound(s).

A carrier for use for separation purpose and a method for separation of a compound enable a chemical reaction to be performed in a liquid phase, a compound of interest to be separated from the liquid phase after the completion of the reaction readily, the separated compound to be evaluated by structural analysis or the like while the compound is being bound to the carrier, and the compound to be separated from the carrier readily. A carrier for separation is also provided which has a reaction site capable of reacting with other compound(s) on a benzene ring, and a long-chain group having a specified carbon atom(s) at each of the ortho-position and the para-position of the reaction site through an oxygen atom.

This invention relates to novel methods for affecting, controlling and / or directing various reactions and / or reaction pathways or systems by exposing one or more components in a holoreaction system to at least one spectral energy pattern. In a first aspect of the invention, at least one spectral energy pattern can be applied to a reaction system. In a second aspect of the invention, at least one spectral energy conditioning pattern can be applied to a conditioning reaction system. The spectral energy conditioning pattern can, for example, be applied at a separate location from the reaction vessel (e.g., in a conditioning reaction vessel) or can be applied in (or to) the reaction vessel, but prior to other reaction system participants being introduced into the reaction vessel.

Applying a strong static DC electric field to supersaturated aqueous glycine solutions resulted in the nucleation of the γ polymorph attributed to the electric-field induced orientation of the highly polar glycine molecules in large preexisting solute clusters, helping them organize into a crystalline structure. A method to induce crystallization and to prepare polymorphs and / or morphologies of materials by using a static electric field to cause nucleation and crystal growth to occur in a supersaturated solution in such a way as to obtain a crystal structure that would not normally appear without the use of the static electric field. Aqueous glycine solutions were prepared by combining solid glycine and water. Supersaturated solutions were generated by heating the tubes to 62-64° C. and holding them at that temperature in an ultrasonicator overnight. Once the glycine was completely dissolved, the solutions were slowly cooled to room temperature. A chamber was constructed consisting of two brass electrodes separated by a 5 mm insulating gap, with a hole drilled down through the center, parallel to the gap-electrode interface, with a diameter large enough to accommodate the test tube. A DC voltage was applied across the electrodes, large enough to produce electric fields in the range of 400,000 to 800,000 V / m. Tests tubes containing the aged solutions were placed in the high-voltage chamber. Exposure of the aged solutions to fields of 600,000 V / m resulted in crystallization typically within 30-90 min. The onset of nucleation was observed visually by the formation of a needle-shaped crystallite.

The present invention relates to a high yield process to prepare high purity crystalline glycolic acid using a multi-loop crystallization process characterized by high liquid and / or solid recycle, said process suitable for large scale purification and producing high purity glycolic acid with low diglycolic acid content.

The invention relates to novel methods for affecting, controlling and / or directing various reactions and / or reaction pathways or systems by exposing one or more components in a holoreaction system to at least one spectral energy pattern. In a first aspect of the invention, at least one spectral energy pattern can be applied to a reaction system. In a second aspect of the invention, at least one spectral energy conditioning pattern can be applied to a conditioning reaction system. The spectral energy conditioning pattern can, for example, be applied at a separate location from the reaction vessel (e.g., in a conditioning reaction vessel) or can be applied in (or to) the reaction vessel, but prior to other reaction system participants being introduced into the reaction vessel.

Process for preparing a cocrystal of an active substance and a cocrystal former, the process involving precipitating the active substance and the cocrystal former together from solution or suspension, in the presence of a supercritical or near-critical fluid, in particular using a GAS, SAS, SEDS or SAS-EM process. The invention also provides a cocrystal prepared using such a process, and its use as a seed crystal in a subsequent process for precipitating a cocrystal of an active substance and a cocrystal former.

We disclose a process for the removal of phosphorous and ammonia from an aqueous stream by contacting the aqueous stream with magnesium and base in a first zone having a first pH, to form an (n−1)th mixed stream and a first portion of struvite; separating the (n−1)th mixed stream from the first portion of struvite; removing at least some struvite from the first portion of struvite; contacting the (n−1)th mixed stream with base in an nth zone, wherein n is an integer incrementing from 2 to nmax, wherein nmax is an integer from 2 to about 5, and wherein the nth zone has an nth pH higher than the (n−1)th pH, to form an nth mixed stream and an nth portion of struvite, except no base is added and the nth pH need not be higher than the (n−1)th pH when n=nmax; separating the nth mixed stream from the nth portion of struvite; returning the nth portion of struvite to the (n−1)th zone; and, if n<nmax, incrementing n and repeating the second contacting, second separating, and returning steps, or, if n=nmax, releasing the nth mixed stream to a treated water tank. We also disclose a system which can be used for performing the method.

The present invention provides a method of producing a co-crystal, the method comprising the steps of, providing a first substance and a second substance, wherein the first and second substances are compatible to form a co-crystal, mixing said first and second substances together, and exposing the mixture of said first and second substances to prolonged and sustained conditions of pressure and shear, sufficient to form a co-crystal of said first and second substance.The prolonged and sustained conditions of pressure and shear are preferably applied in an extrusion process. Associated compositions and uses thereof are also provided.

A method and an apparatus for separating dry matter from liquid includes an enclosed separation environment capable of being pressure regulated. Within the enclosed separation environment, a suspension is brought into contact with at least one filter so as to accumulate dry matter on the at least one filter. The filter with the dry matter passes through at least one set of rollers such that liquid is removed from the dry matter on the at least one filter to form a substantially dry filter cake. Thereafter, the substantially dry filter cake is removed from the at least one filter. The above steps are performed in the enclosed separation environment either under vacuum or overpressure. The invention may be used in various fields such as the food industry.

The invention provides a solventing-out crystallization technique device and method through auxiliary control of films, and belongs to the technical field of crystallization engineering. When a crystallization solution is added to a raw material pot, a solventing-out agent is added to a material-liquid pot, electronic scales, a computer, a stirring device and temperature controlling devices are started, and after a system is stable, squirm pumps of the material-liquid pot are started, so that solventing-out agents can circulate between the material-liquid pot and a film assembly; and after the solventing-out agent is stable in circulation, the squirm pump connected to the raw material pot is started so that the crystallization solution enters the film assembly. The solventing-out agent and the crystallization solution which are in sufficient contact in the film assembly can perform nucleation growth in the film assembly, and then the solventing-out agent and the crystallization solution, after the nucleation growth, can flow into an external storing pot for filtration and post-treatment; and the solventing-out agent and the crystallization solution can also perform nucleation growth outside the film assembly, and after solutes are wholly dissolved, filtration is performed. The electronic scales record the addition quantity of the solventing-out agent in a real-time manner, and the addition quantity of the solventing-out agent is systematically controlled through controlling films and operation conditions, so that ideal crystal products are obtained.

A composition for reducing deposition of a mineral salt from an aqueous supersaturated solution onto a solid surface in contact with the aqueous supersaturated solution which composition comprises a dispersion of either (i) seed crystals of the mineral salt in an aqueous solution of the mineral salt or (ii) seed crystals of a salt isomorphous with the mineral salt in an aqueous solution of the isomorphous salt wherein the dispersed seed crystals are of Mean particle size of less than 2.5 microns.

The present invention relates to crystalline 1,2-Propanediol solvate of N-(2-chloro-6-methylphenyl)-2-[[6-[4-(2-hydroxyethyl)-1-piperazinyl]-2-methyl-4-pyrimidinyl]amino]-5-thiazolecarboxamide compound of formula-1b, its process for the preparation and its use in the preparation of anhydrous crystalline form (N-6) and monohydrate of N-(2-chloro-6-methylphenyl)-2-[[6-[4-(2-hydroxy ethyl)-1-piperazinyl]-2-methyl-4-pyrimidinyl]amino]-5-thiazolecarboxamide. [formula] 1,2-Propanediol solvate Formula-1b.