Self-circulating crystallizer and multistage continuous crystallization method

Abstract

The invention relates to a self-circulating crystallizer and a multistage continuous crystallization method. The crystallizer sequentially comprises a kettle head, an upper cylinder body, a middle cylinder body and a bottom hole-shrinkage cylinder body with a W-shaped bottom from top to bottom, wherein a steam outlet and / or a feeding hole are / is arranged on the kettle head, an annular spraying pipe is arranged at the lower part of the kettle head; a middle straight cylinder section is arranged in the middle cylinder body, a flow guiding cylinder is arranged in the middle straight cylinder section, and a stirrer is arranged in the flow guiding cylinder; the diameter of the middle cylinder body is larger than that of the upper cylinder body, and the diameter of the upper cylinder body is larger than that of the middle cylinder body; and the lower part of the upper cylinder body and the upper part of the middle cylinder body are respectively connected with the circumference of the top ofthe middle straight cylinder section via a hole-shrinkage transition section, and a discharging hole is formed in the W-shaped bottom. The invention provides the method for realizing multistage continuous evaporation, cooling or reaction crystallization through the series connection of the crystallizer, the prepared crystals are large in granularity and uniform in particle size, the problems thatthe product granularity is small, equipment is seriously scaled, a pipeline is blocked, and the like in the continuous crystallization process are improved, and the operation period of the continuouscrystallization process is prolonged.

Description

technical field [0001] The invention belongs to the technical fields of medicine and chemical industry, and relates to a self-circulating crystallizer and a multi-stage continuous crystallization method, which is applicable to various crystallization processes such as reaction crystallization, evaporation crystallization, and cooling crystallization. Background technique [0002] In the production of pharmaceutical and chemical industries, according to the operation mode, the crystallization process is divided into two modes: continuous crystallization and intermittent crystallization; according to the physical and chemical characteristics such as the solubility of the substance system, the crystallization process is divided into reaction crystallization, evaporation crystallization, cooling crystallization, and dissolution. Crystalline and other forms. The batch crystallization process is a crystallization process in which raw materials are added at one time, then different...

AI Technical Summary

Problems solved by technology

[0007] Aiming at the problems existing in the existing continuous crystallization technology and equipment, the present invention provides a high-efficiency self-circulation crystallizer and a multi-stage continuous crystallization method, through the specific configuration of the crystallizer and process material flow and operation control, the crystallization system can be stably regulated The degree of supersaturation can effectively control the nucleation and growth of crystals, and achieve the particle size classification of crystal particles, so as to improve the continuous crystallization process. Problems such as small product particle size, serious equipment fouling, pipeline blockage, short operating cycle, etc., improve the stability of the continuous crystallization process Operation cycle to ensure product quality

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