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Pharmaceutical composition containing tedirosin

A technology of tediloxine and a composition, applied in the field of medicinal chemistry, can solve problems such as reduced therapeutic effect, and achieve the effects of long half-life, broad antibacterial spectrum and good therapeutic effect

Active Publication Date: 2019-04-05
LUOYANG HUIZHONG ANIMAL MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although the dosage is increasing, the therapeutic effect is gradually decreasing

Method used

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  • Pharmaceutical composition containing tedirosin
  • Pharmaceutical composition containing tedirosin
  • Pharmaceutical composition containing tedirosin

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1～4 and comparative example 1

[0016] Examples 1-4 are the preparation of Tedirosin composition injection, Table 1 shows the mass volume (W / V) percentage content of each component in Tedirosin composition injection in the present invention, The mixed solution was prepared according to the contents of each component in Table 1, filtered to volume with purified water, potted, and sterilized at 100° C. for 30 minutes to obtain the Tedirosin composition injection.

[0017] Comparative example 1 is the commodity Zuprevo of Intervet Company with Tedirosin as the main component, which contains 18% Tedirosin, 8.25% citric acid monohydrate is used to adjust the pH value, 40% propylene glycol, and the balance for water.

[0018] Table 1

[0019]

Tateroxin (%)

Polyvinylpyrrolidone(%)

Propylene Glycol(%)

Citric acid to adjust the pH to

Example 1

1

10

/

5.5

Example 2

4

15

/

5.7

Example 3

10

20

/

5.6

Example 4

20

25

/

6...

Embodiment 5

[0050] This example is a study on Tediroxin Oral Liquid with a content of 10% (W / V).

[0051] One, the preparation of 10% Tideroxin Oral Liquid, the specific operation steps are:

[0052] (1) Add 60-70% water of the total volume of the prepared Tediroxin Oral Liquid into the preparation tank, stir, and adjust the pH value to 5.7-6.3 with 85% concentrated phosphoric acid.

[0053] (2) Add Tedirosin according to the amount.

[0054] (3) Use concentrated phosphoric acid with a concentration of 5%-100% to adjust the pH value to 5.5-6.0 to dissolve all the materials.

[0055] (4) Add 30% g of glycerin and stir to dissolve, warm to 50-60°C.

[0056] (5) Add water to 100ml, then filter through a 0.45 micron membrane filter to obtain the required Tediroxin oral liquid.

[0057] 2. Treatment test of oral liquid

[0058] 1. Select Dudu's long-term three-way hybrid commercial pigs, half male and half male, with an average body weight of 25.7-27.1kg, 80 in total; randomly divided into...

Embodiment 6

[0078] This example is a study on Tedirosin soluble powder with a weight percent content of 20%.

[0079] Preparation materials: tedirosin, tartaric acid, sodium tartrate, and sucrose as the carrier for the powder.

[0080] Preparation method: Take 200 g of taiderocin, 20 g of tartaric acid, 50 g of sodium tartrate, and 730 g of sucrose powder, mix them uniformly step by step, grind them, and pass through an 80-mesh sieve to obtain the soluble powder of the taideroxin composition.

[0081] Treatment effect: 90 sick pigs, the main clinical symptoms are cough, panting, dyspnea, identified as mycoplasma infection by PCR pathogen, were randomly divided into 3 groups according to body weight: the first group is the blank control group, no drug treatment The 2nd group treats with the Tedirosin soluble powder prepared by the present invention, and usage is 100g mixed with water 200L, drinking water, uses in succession 5 days, the 3rd group of drug control group is florfenicol soluble...

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Abstract

The invention provides a tildipirosin-containing medicinal composition. The dosage form of the medicinal composition is an injection, the composition comprises, by mass / volume, 1-20% of tildipirosin, 10-25% of polyvinylpyrrolidone, an acid, and the balance of water, and the use amount of the acid makes the pH value of the composition be 5.5-6.5; and the tildipirosin is tildipirosin or a pharmaceutically acceptable salt thereof. Tildipirosin in above raw materials is a special antibiotic for livestock and poultry, does not bring a cross drug resistance problem for people, is a first selected medicine for treating animal respiratory tract diseases, and has a very good treatment effect on Streptococcus suis, Pasteurella multocida, Haemophilus parasuis, Actinobacillus pleuropneumoniae and mycoplasma.

Description

technical field [0001] The invention relates to the field of medicinal chemistry, in particular to a pharmaceutical composition containing tedirosin. Background technique [0002] Respiratory tract infection is one of the difficult-to-control infectious diseases in animal husbandry, which seriously harms animal husbandry production. When respiratory infection is prevalent, it will cause huge economic losses to livestock production. Therefore, how to prevent and treat respiratory infections in livestock such as pigs and cattle is an important research topic for veterinarians and veterinary medicine workers. Because respiratory tract infection is generally multiple infections, with many pathogenic factors and complex conditions, it is mainly used for prevention and treatment of animals in my country. Macrolide antibiotics are a class of commonly used drugs for the treatment of respiratory tract infections in pigs and cattle. The macrolide antibiotics currently used in the tr...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/706A61P31/04A61P11/00
Inventor 张许科刘兴金周德刚
Owner LUOYANG HUIZHONG ANIMAL MEDICINE
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