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Choline particle and preparation method and application thereof

A technology of choline and granules, which is applied in the field of choline granules and its preparation, can solve the problems of increased use cost, poor friability, and high explosion-proof requirements, and achieve high practicability, moderate particle size, and good particle fluidity Effect

Pending Publication Date: 2020-03-31
HANGZHOU MINSHENG HEALTHCARE CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The ethanol granulation process has some disadvantages: 1. High explosion-proof requirements for equipment and complicated process, which increase the cost of use; 2. After ethanol granulation, there are more fine powders, the particles are easy to absorb moisture, and the fluidity is poor; 3. The surface of the particles is not smooth after tableting. Smooth, large difference in tablet weight, low tablet hardness (poor friability)

Method used

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  • Choline particle and preparation method and application thereof
  • Choline particle and preparation method and application thereof
  • Choline particle and preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0030] 1. Crush the choline bitartrate through a 20-mesh sieve for later use.

[0031] 2. Dissolve hydroxypropyl methylcellulose in water to make a solution with a concentration of 4%.

[0032] 3. Take 2 parts of crushed and sieved choline bitartrate, add 1 part of low-substituted hydroxypropyl cellulose, place in a high-speed shear wet mixing granulator, and mix for 5 minutes under the condition of 100r / min; add hydroxypropyl cellulose 0.1 part of propyl methylcellulose solution was granulated, and the granulation conditions were mixed for 5 minutes at a stirring speed of 100r / min; then the material passed through a sieve with an aperture of 5mm, and was processed by a granulator with a rotating speed of 1000r / min. grain.

[0033] 4. Put the wet granules into the fluidized bed for drying. Drying conditions: air inlet temperature 60°C, stop drying when the granule moisture reaches (2±0.5)%, take out the material and granulate through a 15-mesh sieve to obtain dry Granules, t...

Embodiment 2

[0035] 1. Grind the choline bitartrate through a 40-mesh sieve for later use.

[0036] 2. Dissolve hydroxypropyl methylcellulose in water to make a solution with a concentration of 6%.

[0037] 3. Take 4 parts of crushed and sieved choline bitartrate, add 2 parts of low-substituted hydroxypropyl cellulose, place in a high-speed shear wet mixing granulator, and mix for 10 minutes under the condition of 120r / min; add hydroxypropyl cellulose 1 part of propyl methylcellulose solution was granulated, granulation conditions: mixed for 10 minutes at a stirring paddle speed of 120r / min; then the material passed through a sieve with a pore size of 5mm, and was processed by a granulator with a rotating speed of 1500r / min. grain.

[0038] 4. Put the wet granules into the fluidized bed for drying. Drying conditions: air inlet temperature 70°C, stop drying when the granule moisture reaches (2±0.5)%, take out the material and granulate through a 20-mesh sieve to obtain dry Granules, that ...

Embodiment 3

[0040] 1. Crush the choline bitartrate through a 60-mesh sieve for later use.

[0041] 2. Dissolve hydroxypropyl methylcellulose in water to make a solution with a concentration of 8%.

[0042] 3. Take 6 parts of crushed and sieved choline bitartrate, add 3 parts of low-substituted hydroxypropyl cellulose, place in a high-speed shear wet mixing granulator, and mix for 15 minutes under the condition of 140r / min; add hydroxypropyl cellulose Dissolve 2 parts of propyl methylcellulose and granulate. Granulation conditions: Mix for 15 minutes at a stirring paddle speed of 140r / min; then the material passes through a sieve with a pore size of 5mm, and is granulated by a granulator with a speed of 2000r / min. grain.

[0043] 4. Put the wet granules into the fluidized bed for drying. Drying conditions: air inlet temperature 80°C, stop drying when the granule moisture reaches (2±0.5)%, take out the material and pass through a 30-mesh sieve for granulation to obtain dry Granules, that ...

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Abstract

The present invention discloses a choline particle and a preparation method and an application thereof. The preparation method comprises the following preparation steps: step one, crushing choline topass a 20-100 mesh sieve; step two: dissolving a first binder in water to obtain a binder solution; and step three: after mixing the choline processed in the step one with a second binder, putting themixture into a granulator, and adding the binder solution obtained in the step two for granulation to obtain the choline particle. The binder is dissolved in water, then the choline is granulated, the prepared granule is uniform and moderate in size, good in fluidity, and not easy to absorb moisture; and a prepared pressed tablet is smooth on surface, small in difference in tablet weight, good inhardness (good in friability), and good in disintegration.

Description

technical field [0001] The invention relates to the field of functional food, in particular to a choline granule and its preparation method and application. Background technique [0002] Choline is an indispensable basic component in humans and animals. It is usually called B vitamins or vitamin B4. It is a low-molecular organic compound necessary for maintaining physiological functions in animals. It can be synthesized in animals, but it often needs to be in It is added in the feed and is the most widely used vitamin. It can regulate fat metabolism and transformation in animals, prevent fat deposition and tissue degeneration in liver and kidney, etc. Accordingly, more nutritionists still include it in the vitamin category. Choline is now a commonly used additive in human food. The U.S. Code of Federal Regulations lists choline as a "generally recognized as safe" product; the European Union's 1991 regulation lists choline as a product that is allowed to be added to baby f...

Claims

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Application Information

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IPC IPC(8): A23L33/10A23L33/15A23P10/20
CPCA23L33/10A23L33/15A23P10/20A23V2002/00A23V2200/30A23V2250/304A23V2250/7048A23V2250/704
Inventor 冯旭俊黄丽佳钟建荣杨善岩
Owner HANGZHOU MINSHENG HEALTHCARE CO LTD
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