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Vitamin CE effervescent tablets and preparation method thereof

A technology for vitamins and effervescent tablets, which is applied in pharmaceutical formulations, medical preparations containing active ingredients, and food ingredients as taste modifiers, etc. and other problems to achieve the effect of enhancing immunity, short disintegration time and good fluidity

Inactive Publication Date: 2017-11-21
山东健康源生物工程有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] Currently, vitamin effervescent tablets appearing on the market are often limited to vitamin C, and effervescent tablets with combinations of several vitamins rarely appear. Now, a single type of vitamin effervescent tablets can no longer meet the needs of people who value self-care in their lives.

Method used

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  • Vitamin CE effervescent tablets and preparation method thereof
  • Vitamin CE effervescent tablets and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0023] 1 Preparation condition screening

[0024] 1.1 Selection of acid source and alkali source

[0025] Alkali sources commonly used in effervescent tablets include sodium bicarbonate, potassium carbonate, potassium bicarbonate, calcium carbonate, etc. The effervescent tablet made with sodium bicarbonate as the alkali source can disintegrate rapidly in water, and the pH value of the effervescent solution is suitable for the stability of vitamin C, so sodium bicarbonate is selected as the alkali source in the present invention. Commonly used acid sources include tartaric acid, citric acid, fumaric acid, malic acid, etc. On the basis of the fixed alkali source being sodium bicarbonate, a selection test was carried out on the above acid sources, and the results are shown in Table 1.

[0026] Table 1 acid source optimization test

[0027]

[0028] As can be seen from the test result of table 1, use tartaric acid as acid source, its granulation effect is good, effervescent d...

Embodiment 2

[0046] 2 Preparation of Vitamin CE Effervescent Tablets

[0047] The preparation method of vitamin CE effervescent tablet comprises the following steps:

[0048] (1) Weigh the following components in parts by weight: vitamin C 50g, vitamin E 12g, lactose 800g, sodium bicarbonate 600g, tartaric acid 550g, aspartame 45g, sweet orange essence 15g and polyethylene glycol 6000 10g ;

[0049] (2) Dissolve polyethylene glycol 6000 in 50% ethanol to prepare a polyethylene glycol solution, crush the weighed sodium bicarbonate and lactose, pass through a 80-mesh sieve, and mix evenly in a tank mixer ;

[0050] (3) Add the mixed sodium bicarbonate and lactose into the polyethylene glycol solution, granulate with a oscillating granulator, and pass through a 20-mesh sieve. The obtained wet granules are dried at 40°C, and then sized with a oscillating granulator. 20 mesh sieve;

[0051] (4) Weigh 50g of polyethylene glycol 6000, crush it through an 80-mesh sieve, sieve the weighed tarta...

Embodiment 3

[0055] 2 Preparation of Vitamin CE Effervescent Tablets

[0056] The preparation method of vitamin CE effervescent tablet comprises the following steps:

[0057] (1) Weigh the following components in parts by weight: vitamin C 150g, vitamin E 50g, lactose 1500g, sodium bicarbonate 1500g, tartaric acid 1200g, aspartame 98g, sweet orange flavor 50g and polyethylene glycol 6000 15g ;

[0058] (2) Dissolve polyethylene glycol 6000 in 50% ethanol to prepare a polyethylene glycol solution, crush the weighed sodium bicarbonate and lactose, pass through a 100-mesh sieve, and mix evenly in a tank mixer ;

[0059] (3) Add the mixed sodium bicarbonate and lactose into the polyethylene glycol solution, granulate with a oscillating granulator, and pass through a 30-mesh sieve. The obtained wet granules are dried at 45°C, and then sized with a oscillating granulator. 30 mesh sieve;

[0060] (4) Weigh 80g of polyethylene glycol 6000, crush it through a 100-mesh sieve, sieve the weighed t...

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Abstract

The invention relates to the technical field of health foods, and in particular relates to vitamin CE effervescent tablets. The vitamin CE effervescent tablets are prepared from the following components in parts by weight: 50-150 parts of vitamin C, 10-50 parts of vitamin E, 800-1600 parts of lactose, 600-1500 parts of sodium bicarbonate, 500-1200 parts of tartaric acid, 60-120 parts of a lubricant, 40-100 parts of a sweetening agent and 15-50 parts of a flavoring agent. The vitamin CE effervescent tablets provided by the invention are finely prepared by a scientific formula, can be consumed as a nutritional supplement for a long term, and has the functions of oxidation resistance and immunity enhancement; and the preparation of the vitamin CE effervescent tablets is simple, the prepared tablets have smooth surfaces and uniform effervescent gas production, the solution after disintegration is clear, transparent and fragrant and sweet in mouthfeel, and the tablets have the characteristics of a solid preparation as well as a liquid preparation, and are convenient to carry and safe and effective in use.

Description

(1) Technical field [0001] The invention relates to the field of health food, in particular to a vitamin CE effervescent tablet and a preparation method thereof. (2) Background technology [0002] Vitamin C is a basic and commonly used clinical drug or nutritional supplement. It is one of the antioxidant vitamins. It has the functions of enhancing immunity and anti-oxidation, and can promote the formation of collagen. Vitamin C participates in the hydroxylation reaction in the body. It is necessary for the formation of bone, tooth, connective tissue and non-epithelial tissue intercellular adhesion. It can maintain the normal function of teeth, bone and blood vessels, increase the resistance to disease, and is an essential nutrient for the human body. One of the elements, widely used in the prevention and treatment of many diseases. [0003] Vitamin E is a fat-soluble vitamin, and its hydrolyzed product is tocopherol, which is one of the most important antioxidants. Vitamin...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A23L2/40A23L2/52A23L2/60A23L33/15A23P10/28A61K9/46A61K31/375A61K31/355A61P37/04A61P39/06
CPCA23L2/40A23L2/52A23L2/60A23L33/15A23P10/28A23V2002/00A61K9/0007A61K9/2013A61K9/2018A61K9/2031A61K31/355A61K31/375A23V2200/16A23V2250/708A23V2250/712A61K2300/00
Inventor 刘永刚
Owner 山东健康源生物工程有限公司
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