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Olaquindox slow release particle and preparing method and application thereof

A technology of slow-release granules and olaquindox, which is applied in the field of preparation of animal drugs, can solve problems such as cross-contamination, achieve the effects of prolonging the concentration and time of action, and overcoming application defects

Active Publication Date: 2015-08-05
SOUTH CHINA AGRI UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

On the other hand, the powder type and granularity produced according to the traditional production process of olaquindox premix are prone to dust and static electricity, which can easily cause cross-contamination in the production process of different batches of feed

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0036] Embodiment 1 prepares olaquindox sustained-release granule preparation

[0037] Take each material according to the following formula ratio (taking the total mass as 100g):

[0038] Raw material of olaquindox 5%;

[0039] Stearic Acid 94%;

[0040] Ethylcellulose 1%;

[0041] S1. Heat and melt the dispersant stearic acid at 80°C, and mix well;

[0042] S2. Add the olaquindox raw material to the homogeneously mixed dispersant obtained in step S1, and stir evenly to obtain a mixed material;

[0043] S3. Add the release retarder ethyl cellulose to the mixed material obtained in step S2, and stir evenly to obtain the mixed material;

[0044] S4. Cool the mixed material obtained in step S3 to 70-90°C, and perform the stage of fluidized bed spray granulation and spheroidization, the temperature of the fluidized air in the granulation and spheroidization stage is 25°C; the fluidized bed spray liquid The linear velocity of the drops is 50 m / s;

[0045] S5. Cool, sieve, and ...

Embodiment 2

[0046] Embodiment 2 prepares olaquindox sustained-release granule preparation

[0047] Take each material according to the following formula ratio (taking the total mass as 100g):

[0048] Raw material of olaquindox 10%;

[0049] Stearic acid 88%;

[0050] Ethylcellulose 2%;

[0051] S1. Heat and melt the dispersant stearic acid at 80°C, and mix well;

[0052] S2. Add the olaquindox raw material to the homogeneously mixed dispersant obtained in step S1, and stir evenly to obtain a mixed material;

[0053] S3. Add the release retarder ethyl cellulose to the mixed material obtained in step S2, and stir evenly to obtain the mixed material;

[0054] S4. Cool the mixed material obtained in step S3 to 70-90°C, and perform the stage of fluidized bed spray granulation and spheroidization, the temperature of the fluidized air in the granulation and spheroidization stage is 25°C; the fluidized bed spray liquid The linear velocity of the drops is 50 m / s;

[0055] S5. Cool, sieve, a...

Embodiment 3

[0056] Embodiment 3 prepares olaquindox sustained-release granule preparation

[0057] Take each material according to the following formula ratio (taking the total mass as 100g):

[0058] Olaquindox 20%;

[0059] Glyceryl Monostearate 77%;

[0060] Cellulose Acetate 3%;

[0061] S1. Heat and melt the dispersant glyceryl monostearate at 80°C, and mix evenly;

[0062] S2. Add the olaquindox raw material to the homogeneously mixed dispersant obtained in step S1, and stir evenly to obtain a mixed material;

[0063] S3. adding the release retarder cellulose acetate to the mixed material obtained in the step S2, stirring evenly to obtain the mixed material;

[0064] S4. Cool the mixed material obtained in step S3 to 70-90°C, and perform the stage of fluidized bed spray granulation and spheroidization, the temperature of the fluidized air in the granulation and spheroidization stage is 25°C; the fluidized bed spray liquid The linear velocity of the drops is 60 m / s;

[0065] S5...

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Abstract

The invention discloses an olaquindox slow release particle and a preparing method and application thereof. The olaquindox slow release particle is prepared by an olaquindox raw material, a dispersing agent and a release retardant. The preparing method includes the steps of weighing the dispersing agent according to formula proportion, and heating and fusing the dispersing agent to be evenly mixed; adding olaquindox to be evenly stirred; adding the release retardant to be evenly stirred; and conducting fluidized-bed spray granulation nodulizing, cooling, screening and collecting through a scientific process. By means of the olaquindox slow release particle, absorption of olaquindox in the intestinal tract of a target animal can be reduced, the bioavailability of the olaquindox is reduced by about 10%-50%; after the animal eats the olaquindox slow release particle, the olaquindox slow release particle can be released in the intestinal tract in the whole process, and the action concentration and the action time of the olaquindox in the intestinal tract are prolonged. According to the preparing method, in the production process, dust and static electricity are not generated, and cross contamination of feed production is effectively avoided; the slow release particle is good in mobility and dispersibility, feed and drugs can be conveniently mixed, and drug application is convenient.

Description

technical field [0001] The invention belongs to the technical field of preparation of animal medicines. More specifically, it relates to a olaquindox sustained-release granule and its preparation method and application. Background technique [0002] Olaquindox is a chemically synthesized quinoxaline antibacterial drug developed by Bayer Company in Germany in the 1970s. [0003] Olaquindox has subchronic toxicity, acute toxicity and genotoxicity. Olaquindox is mixed in the standard feedstuff of rat, is fed continuously 90 days (d) by different dosage groups, the result shows that the main toxic target organ of olaquindox is liver, kidney, can cause the substantive pathological change of liver, kidney; The mice were tested by the accumulation coefficient method and the 20d accumulation test method, and the result was that the accumulation coefficient of olaquindox was 3, indicating that it had moderate to obvious accumulation toxicity, 1 / 20LD in the 20d accumulation test 50...

Claims

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Application Information

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IPC IPC(8): A61K9/16A61K31/498A61P31/04A23K1/00A23K1/17A23K20/195
Inventor 黄显会许颖刘雅红
Owner SOUTH CHINA AGRI UNIV
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