Olaquindox slow release particle and preparing method and application thereof

Abstract

The invention discloses an olaquindox slow release particle and a preparing method and application thereof. The olaquindox slow release particle is prepared by an olaquindox raw material, a dispersing agent and a release retardant. The preparing method includes the steps of weighing the dispersing agent according to formula proportion, and heating and fusing the dispersing agent to be evenly mixed; adding olaquindox to be evenly stirred; adding the release retardant to be evenly stirred; and conducting fluidized-bed spray granulation nodulizing, cooling, screening and collecting through a scientific process. By means of the olaquindox slow release particle, absorption of olaquindox in the intestinal tract of a target animal can be reduced, the bioavailability of the olaquindox is reduced by about 10%-50%; after the animal eats the olaquindox slow release particle, the olaquindox slow release particle can be released in the intestinal tract in the whole process, and the action concentration and the action time of the olaquindox in the intestinal tract are prolonged. According to the preparing method, in the production process, dust and static electricity are not generated, and cross contamination of feed production is effectively avoided; the slow release particle is good in mobility and dispersibility, feed and drugs can be conveniently mixed, and drug application is convenient.

Description

technical field

[0001] The invention belongs to the technical field of preparation of animal medicines. More specifically, it relates to a olaquindox sustained-release granule and its preparation method and application. Background technique

[0002] Olaquindox is a chemically synthesized quinoxaline antibacterial drug developed by Bayer Company in Germany in the 1970s.

[0003] Olaquindox has subchronic toxicity, acute toxicity and genotoxicity. Olaquindox is mixed in the standard feedstuff of rat, is fed continuously 90 days (d) by different dosage groups, the result shows that the main toxic target organ of olaquindox is liver, kidney, can cause the substantive pathological change of liver, kidney; The mice were tested by the accumulation coefficient method and the 20d accumulation test method, and the result was that the accumulation coefficient of olaquindox was 3, indicating that it had moderate to obvious accumulation toxicity, 1 / 20LD in the 20d accumulation test 50...