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Quality control method of eucommia bark blood pressure lowering preparation for treating high blood pressure

A quality control method and technology for hypertension, which can be used in testing pharmaceutical preparations, medical preparations containing active ingredients, measuring devices, etc., and can solve problems such as poor reproducibility, poor specificity of quality standards, and poor stability.

Active Publication Date: 2006-06-14
贵州汉方药业有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The original standard is included in the sixth volume of drug standards of the Ministry of Health. The quality standard has shortcomings such as low specificity, poor reproducibility, and poor stability.

Method used

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  • Quality control method of eucommia bark blood pressure lowering preparation for treating high blood pressure

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0093] Example 1 of the present invention: Detection of Duzhong Jiangya Capsules, Duzhong Jiangya Capsules are prepared according to the applicant's production process and directly provided by the applicant.

[0094] Identification: (1) Take 3g of the contents of this product, grind it, add 30ml of ether, heat to reflux for 30 minutes, filter, discard the ether solution, add 30ml of methanol to the drug residue, heat to reflux for 40 minutes, filter, and evaporate the filtrate to dryness. Add 30ml of water to the residue to dissolve and filter. The filtrate is adjusted to pH 2 with dilute hydrochloric acid, and extracted with ethyl acetate 3 times, 25ml each time. The ethyl acetate solution is combined and evaporated to dryness. The residue is dissolved by adding 1ml of methanol as a test品solution. In addition, take 1g of Scutellaria baicalensis control material and prepare the control material solution in the same way. Then take an appropriate amount of baicalin reference substan...

Embodiment 2

[0104] Example 2 of the present invention: detection of compound Duzhong tablets (Duzhong Jiangya tablets); Compound Duzhong tablets (Duzhong Jiangya tablets) are produced and prepared by our company according to the standards of the National Pharmacopoeia.

[0105] Identification: (1) Take 20 tablets of this product, remove the sugar coating from the sugar-coated tablets, grind finely, weigh 0.1g, add 5ml ether, heat to reflux for 10 minutes, filter, discard the ether solution, add 5ml methanol to the drug residue, and heat to reflux for 10 After filtering, the filtrate was evaporated to dryness, the residue was dissolved by adding 1ml of water, filtered, the filtrate was adjusted to pH 1 with dilute hydrochloric acid, extracted with ethyl acetate once, 25ml each time, combined ethyl acetate liquid, evaporated to dryness, residue Add 0.5ml of methanol to dissolve it as the test solution. Separately take 0.1g of Scutellaria baicalensis control medicinal material and prepare a cont...

Embodiment 3

[0115] Embodiment 3 of the present invention: detection of Eucommia ulmoides ulmoides blood pressure particles. Eucommia ulmoides ulmoides pressure particles are prepared according to our company's production process and are directly provided by our company.

[0116] Identification: (1) Take 20g of this product, grind it, add 50ml of ether, heat to reflux for 60 minutes, filter, discard the ether solution, add 50ml of methanol to the medicine residue, heat to reflux for 90 minutes, filter, evaporate the filtrate to dryness, add water to the residue 60ml to dissolve, filter, the filtrate is adjusted to pH 6 with dilute hydrochloric acid, and extracted with ethyl acetate 3 times, 40ml each time, the ethyl acetate solution is combined, evaporated to dryness, and the residue is dissolved by adding 5ml of methanol, as the test solution ; Take another 3g of Scutellaria baicalensis reference material and prepare a solution of the reference material in the same way; then take an appropria...

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Abstract

A quality control method for the Chinese medicine í‹Antihypertenssive Duzhong medicineíŒ to treat hypertension includes such steps as examining its characteristics, identifying scutellaria root, uncaria stem with hooks and motherwort, and measuring the content of scutelloside.

Description

Technical field: [0001] The invention relates to a quality control method of a eucommia antihypertensive preparation for treating hypertension, in particular to the quality control of a pharmaceutical composition for treating hypertension, and belongs to the field of drug quality standards. Background technique: [0002] Duzhong antihypertensive preparation is a modified product of "Compound Duzhong Tablets (Duzhong Antihypertensive Tablets)" modified by the applicant's unit. The original standard contains the sixth volume of the Ministry of Health Drug Standards. The quality standard has shortcomings such as poor specificity, poor reproducibility, and poor stability. We have improved the quality standards of the original tablets and modified preparations, added TLC identification and content determination, and overcome the shortcomings of the original quality standards. The improved standard has strong operability, good reproducibility, small measurement deviation, good stabilit...

Claims

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Application Information

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IPC IPC(8): A61K36/74A61K36/46A61P9/12G01N30/90G01N33/15
Inventor 张劲翼
Owner 贵州汉方药业有限公司
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