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Oral medicinal preparation of hairy holly root total aglycon, preparation method and application thereof

A technology of holly holly, total aglycon, applied in the field of extract of holly holly, which can solve the problems of ignoring the research, effect and application status of holly holly total aglycon, etc.

Inactive Publication Date: 2009-09-02
北京凯瑞创新医药科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] However, the existing technology puts the research focus on the radix radix glycosides, and ignores the research on the total aglycones of radix radix radiata, and its effect and application have been in a blank state.

Method used

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  • Oral medicinal preparation of hairy holly root total aglycon, preparation method and application thereof
  • Oral medicinal preparation of hairy holly root total aglycon, preparation method and application thereof
  • Oral medicinal preparation of hairy holly root total aglycon, preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0160] Take 50g of total aglycones of holly holly, add chitosan 20g, polyvinylpyrrolidone 20g, carbomer 10g, poloxamer 50g, lecithin 50g, micropowder silica gel 50g, beta cyclodextrin 100g, starch 150g, vibrating mill Ultrafine pulverization and mixing for 30 minutes, sub-packaging to make a powder.

Embodiment 2

[0162] Take 50g of total aglycones of hollywort and 10g of total flavonoid aglycones of Pueraria radiata, add chitosan 5g, carbomer 5g, poloxamer 14g, lecithin 10g, micropowder silica gel 10g, beta cyclodextrin 20g, carboxymethyl starch Sodium 6g, microcrystalline cellulose 70g, heavy-pressure grinding supermicrocomputer ultrafine pulverization for 30 minutes, adding 70% ethanol to combine for 10 minutes, making pellets, grading and rounding, drying, polishing, sub-packaging, and making pill.

Embodiment 3

[0164] Take 50 g of total aglycones of Ilex radix, add 1 g of chitosan, 5 g of lecithin, 43 g of dextrin, and 1 g of aspartame, stir evenly, dry-press granules, and pack separately to make granules.

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Abstract

The invention discloses an oral medicinal preparation of hairy holly root total aglycon, a preparation method and an application thereof, pertaining to the field of traditional Chinese medicine. Total glycosides extracted from hairy holly roots are hydrolyzed to obtain total aglycon which is then added with special auxiliary materials for preparing a highly efficient preparation, thereby greatly increasing the bioavailability of the hairy holly root total aglycon. The preparation has significant curative effects in the treatment of coronary arteriosclerotic cardiopathy, acute myocardial infarction, thromboangitis obliterans, central retinitis, tonsillitis, pharyngolaryngitis, child pneumonia, chilblain, burn and scald, hypertension, hyperlipemia, hyperglycemia and other diseases.

Description

technical field [0001] The invention relates to a traditional Chinese medicine hollywort extract, in particular to an extract of total aglycone from hollyhock, and the medicinal use of the extract. It belongs to the field of traditional Chinese medicine. Background technique [0002] Ilex pubescens is the dry root of Ilex pubescens Hook.et Arm, a plant of the Ilex family. It is produced in Guangdong, Guangxi, Fujian, Jiangxi, Zhejiang, Taiwan and other places in my country. It is a commonly used traditional Chinese medicine in southern China. Pain relief, heat-clearing and detoxifying effects are widely used in the treatment of coronary heart disease, angina pectoris and thromboangiitis obliterans, central retinitis, tonsillitis, pharyngitis, infantile pneumonia, chilblains, burns and other diseases. Scholars at home and abroad attach great importance to its curative effect. [0003] Modern research shows that the main chemical components of Ilex pubescens are total saponins...

Claims

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Application Information

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IPC IPC(8): A61K36/185A61K9/16A61K9/20A61K9/48A61K47/40A61K47/36A61K47/34A61K47/32A61P3/06A61P3/10A61P9/10A61P9/12A61P9/14A61P11/00A61P11/04A61P17/02A61P27/02A61K125/00A61K47/10
Inventor 魏永利周小明
Owner 北京凯瑞创新医药科技有限公司
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