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Hypotensive compound preparation and preparation method thereof

A compound, blood pressure lowering technology, applied in the field of medicine

Inactive Publication Date: 2013-03-06
TIANJIN WUQING BEIYANG CHEM
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, they all have certain limitations and side effects in use.

Method used

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  • Hypotensive compound preparation and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0008] Embodiment 1: tablet

[0009] Name of raw material

Dosage

Temopril Hydrochloride

2g

Olmesartan medoxomil

20g

microcrystalline cellulose

45g

lactose

36g

Sodium carboxymethyl cellulose

10g

pregelatinized starch

55g

Magnesium stearate

1.6g

purified water

Appropriate amount

Co-made

1000 pieces

[0010] Note: Temopril hydrochloride is calculated as Temopril

[0011] Process: Take each raw material, crush it through a 100-mesh sieve, and set aside; pass each auxiliary material through a 60-mesh sieve, and set aside; except magnesium stearate, take each raw and auxiliary material separately, put them in a high-speed mixing granulator and mix them evenly. Add an appropriate amount of water-based soft material, granulate at 24 mesh, dry in a fluidized bed at 50 degrees, granulate at 24 mesh, add magnesium stearate, mix evenly, press into tablets...

Embodiment 2

[0012] Example 2: chewable tablet

[0013] Name of raw material

Dosage

Temopril Hydrochloride

4g

Olmesartan medoxomil

20g

Mannitol

160g

Sorbitol

105g

Sodium carboxymethyl cellulose

10g

Sucralose

5g

essence

Appropriate amount

Magnesium stearate

1.6g

purified water

Appropriate amount

Co-made

1000 pieces

[0014] Note: Temopril hydrochloride is calculated as Temopril

[0015] Process: take each raw material and auxiliary material, and crush them through a 100-mesh sieve, and set aside; except for magnesium stearate, take each raw material and auxiliary material separately, mix them evenly in a high-speed mixing granulator, add an appropriate amount of water to make a soft material, 24 mesh Granulate, dry in a fluidized bed at 50 degrees, granulate into 24 meshes, add magnesium stearate, mix evenly, and compress into tablets.

Embodiment 3

[0016] Example 3 Capsules

[0017] Name of raw material

[0018] Process: Take the above-mentioned raw materials, grind them through 80-mesh sieves respectively, and set aside; each auxiliary material respectively pass through 60-mesh sieves, and set aside; except magnesium stearate, take each raw and auxiliary materials respectively, mix them evenly according to the method of equal increase, and add an appropriate amount of Water-based soft material, granulated with 18 mesh, dried in a fluidized bed at 60 degrees, granulated with 24 mesh, added with magnesium stearate, mixed evenly, filled into empty capsule shells, and obtained.

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PUM

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Abstract

The invention relates to a hypotensive compound preparation and a preparation method thereof. According to the invention, temocapril and olmesartan medoxomil are adopted as active components, and are combined with appropriate medical auxiliary materials, such that the preparation is prepared. The composition can be prepared into oral tablets or capsules which are used in treating hypertension. The effect of the preparation is better than hypotensive effects of single temocapril or olmesartan medoxomil.

Description

technical field [0001] The invention relates to a preparation of a hypotensive compound and a preparation method thereof, belonging to the technical field of medicine. Background technique [0002] Hypertension is the most prevalent cardiovascular disease in the world today, and it is also an important risk factor for coronary heart disease, stroke and renal failure. Patients with hypertension not only have increased blood pressure and abnormal hemodynamics, but also often accompanied by It is a systemic disease with sugar and lipid metabolism disorders and damage to target organs such as the heart, brain, and kidneys. There are many antihypertensive drugs clinically, including diuretics, β-blockers, angiotensin converting enzyme inhibitors (ACE-I), angiotensin II (ATII) receptor antagonists, calcium antagonists and α- blockers. However, they all have certain limitations and side effects in use. Therefore, antihypertensive drugs with small side effects, good tolerance, an...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/554A61K31/4178A61P9/12
Inventor 陈维瑜
Owner TIANJIN WUQING BEIYANG CHEM
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