Hypotensive compound preparation and preparation method thereof
A compound, blood pressure lowering technology, applied in the field of medicine
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Embodiment 1
[0008] Embodiment 1: tablet
[0009] Name of raw material
Dosage
Temopril Hydrochloride
2g
Olmesartan medoxomil
20g
microcrystalline cellulose
45g
lactose
36g
Sodium carboxymethyl cellulose
10g
pregelatinized starch
55g
Magnesium stearate
1.6g
purified water
Appropriate amount
Co-made
1000 pieces
[0010] Note: Temopril hydrochloride is calculated as Temopril
[0011] Process: Take each raw material, crush it through a 100-mesh sieve, and set aside; pass each auxiliary material through a 60-mesh sieve, and set aside; except magnesium stearate, take each raw and auxiliary material separately, put them in a high-speed mixing granulator and mix them evenly. Add an appropriate amount of water-based soft material, granulate at 24 mesh, dry in a fluidized bed at 50 degrees, granulate at 24 mesh, add magnesium stearate, mix evenly, press into tablets...
Embodiment 2
[0012] Example 2: chewable tablet
[0013] Name of raw material
Dosage
Temopril Hydrochloride
4g
Olmesartan medoxomil
20g
Mannitol
160g
Sorbitol
105g
Sodium carboxymethyl cellulose
10g
Sucralose
5g
essence
Appropriate amount
Magnesium stearate
1.6g
purified water
Appropriate amount
Co-made
1000 pieces
[0014] Note: Temopril hydrochloride is calculated as Temopril
[0015] Process: take each raw material and auxiliary material, and crush them through a 100-mesh sieve, and set aside; except for magnesium stearate, take each raw material and auxiliary material separately, mix them evenly in a high-speed mixing granulator, add an appropriate amount of water to make a soft material, 24 mesh Granulate, dry in a fluidized bed at 50 degrees, granulate into 24 meshes, add magnesium stearate, mix evenly, and compress into tablets.
Embodiment 3
[0016] Example 3 Capsules
[0017] Name of raw material
[0018] Process: Take the above-mentioned raw materials, grind them through 80-mesh sieves respectively, and set aside; each auxiliary material respectively pass through 60-mesh sieves, and set aside; except magnesium stearate, take each raw and auxiliary materials respectively, mix them evenly according to the method of equal increase, and add an appropriate amount of Water-based soft material, granulated with 18 mesh, dried in a fluidized bed at 60 degrees, granulated with 24 mesh, added with magnesium stearate, mixed evenly, filled into empty capsule shells, and obtained.
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