217 results about "Hypertensive disease" patented technology

Compounds shown by the above formula or salt thereof show a strong angiotensin II antagonistic activity and hypotensive action and CNS activity, and are useful as therapeutic agents of circulatory diseases such as hypertensive diseases and heart diseases (e.g. hypercardia, heart failure, cardiac infarction), strokes, cerebral apoplexy, nephritis, atherosclerosis, Alzheimer's disease, senile dementia, etc.

The invention provides a health-care tea drink with a blood pressure lowering effect. The health-care tea drink comprises black tea, burdock, hawthorn, chrysanthemum, lotus leaf, seed of feather cockscomb, dandelion, root of kudzu vine, dogbane leaf, ovientvine, fructus liquidambaris, poria cocos, plantain seed, coix seed, morinda root, uncaria, astragalus, root of bidentate achyranthes, corydalis tuber, rhodiola rosea, cocklebur fruit, liquoric root, bamboo shavings and sea tangle. The health-care tea drink can be drunk in daily life for preventing and treating hypertension; stabilization ofblood pressure of a patient with the hypertension can be promoted and the incidence of the hypertension can be prevented by drinking the health-care tea drink provided by the invention for long time;and since the in-vivo blood pressure is reduced in daily tea drinking habit, the repeated illness and accidents caused by interrupted administration of medicines can also be prevented.

An application of an invented medicinal composition in preparing the medicines for treating primary hypertension and protecting heart and kidney is disclosed.

The invention discloses a preparation method for metoprolol salt, which includes the steps of utilizing p-(2-methoxyethyl) phenol and epoxy chloropropane as raw materials and water or ethanol as dissolvent, and obtaining 3-[4-(2-methoxyethyl phenoxy)]-1,2-epoxypropane under the action of strong alkali; and utilizing water as dissolvent, carrying reaction between the 3-[4-(2-methoxyethyl phenoxy)]-1,2-epoxypropane and isopropylamine so that metoprolol alkali is obtained, and then carrying out reaction between the metoprolol alkali and saturated monohydric alcohol liquor of organic acid or saturated monohydric alcohol liquor of hydrochloric acid, so that the metoprolol salt is obtained. Clinically, hydrochloride, succinate, fumarate or tartrate of the compound is utilized as common medicinefor treating hypertensive disease, coronary disease, congestive heart failure and arrhythmia. The raw materials of the preparation method are cheap and easy to obtain, the water and the ethanol are utilized as the dissolvent so as to hardly cause pollution, the method is convenient in operation, high in purity of the prepared metoprolol salt, high in yield, lower in cost and extremely suitable for mass production.

Disclosed herein is the treatment of vision loss in a mammal by transplanting an effective amount of hNT-Neuron cells. The treatment can be accomplished by injecting the cells into the retinal area of the eye. Additionally, the cells can be injected into the visual cortex of the brain. Conditions to be treated are vision loss due to optic nerve damage, including glaucoma, optic nerve sheath meningioma and glioma, Graves' ophthalmopathy, benign or malignant orbital tumors, metastatic lesions, tumors arising from the adjacent paranasal sinuses or middle cranial fossa, giant pituitary adenomas, brain tumors or abscesses, cerebral trauma or hemorrhage, meningitis, arachnoidal adhesions, pseudotumor cerebri, cavernous sinus thrombosis, dural sinus thrombosis, encephalitis, space-occupying brain lesions, severe hypertensive disease or pulmonary emphysema.

The invention provides methods for (a) prolonging time to hospitalization for heart failure; (b) prolonging time to first hospitalization for heart failure; (c) reducing the total number of days a patient with heart failure spends in the hospital for heart failure for a single hospital stay (i.e., reducing the duration of a single hospital stay for a patient with heart failure); (d) reducing the total number of days a patient spends in the hospital for heart failure for multiple hospital stays (i.e., two or more hospital stays); (e) reducing the number of hospital admissions for heart failure; (f) reducing mortality and reducing hospitalizations for heart failure (e.g., the total number of days in the hospital and / or the number of hospital visits); (g) increasing the left ventricular ejection fraction in a heart failure patient; (h) treating a sexual dysfunction (e.g., erectile dysfunction and female sexual dysfunction) (j) treating a headache in a heart failure patient by administering a non-steroidal antiinflammatory compound (i.e., NSAIDs); (k) treating a heart failure patient who has a history of hypertension (but who is not currently diagnosed with hypertension); (l) improving the quality of life in a heart failure patient based on the Minnesota Living with heart failure questionnaire; (m) decreasing the levels of B-type natriuretic peptide; (n) treating hypertension in a heart failure patient; (o) lowering blood pressure in a heart failure patient; (p) treating labile hypertension; (q) treating idiopathic hypertension; (r) increasing patient compliance with medication dosing in a heart failure patient; (s) treating hypertension in a patient with a dilated heart; (t) treating ischemic disease and / or coronary artery disease; and (u) reducing cardiomegaly in a patient in need thereof comprising administering to the patient a therapeutically effective amount of (i) a hydralazine compound or pharmaceutically acceptable salt thereof, (ii) isosorbide dinitrate and / or isosorbide mononitrate, and (iii) optionally at least one compound selected from the group consisting of angiotensin converting enzyme inhibitors, β-adrenergic antagonists, angiotensin II antagonists, aldosterone antagonists, cardiac glucosides (digitalis), and diuretic compounds.

The invention discloses a hypertension patient monitoring method based on a grassroots medical platform. The hypertension patient monitoring method comprises that the grassroots medical platform monitors the blood pressure value of a user at the preset time with a preset monitoring period according to a user diagnosis and treatment plan acquired from a network hospital platform; the grassroots medical platform compares the blood pressure value of the user at the preset time with the blood pressure threshold at the corresponding time in the user diagnosis and treatment plan, and the comparison result within the preset monitoring period is recorded; the grassroots medical platform determines a blood pressure monitoring result within the monitoring period according to the comparison result within the preset monitoring period, and sends a blood pressure adjusting plan corresponding to the blood pressure monitoring result to the user in order to make the user execute the blood pressure adjusting plan. The invention also discloses a grassroots medical platform. The grassroots medical platform is in butt joint with the network hospital platform, parameter monitoring, prompting and intervention are carried to a hypertension patient according to the user diagnosis and treatment plan, and therefore the treatment progress of the hypertension patient is accelerated, and the treatment effect of the hypertension patient is improved.

The invention discloses a traditional Chinese medicine for treating apoplexy sequela, hypertension, hyperlipidemia and hyperviscosemia. The traditional Chinese medicine is prepared from the following bulk pharmaceutical chemicals as active ingredients in parts by weight: 100-120 parts of radix astragali seu hedysari, 10-15 parts of radix paeoniae rubra, 10-12 parts of herbs of false chinese swertia, 8-10 parts of rhizoma ligustici chuanxiong, 8-10 parts of semen persicae, 3-5 parts of flos carthami, 8-10 parts of lumbricus, 20-25 parts of radix salviae miltiorrhizae, 8-10 parts of hirudo, 10-15 parts of radix dipsaci, 12-15 parts of herba taxilli, 8-10 parts of cortex eucommiae, 28-30 parts of raw hawthorn, 4-5 parts of ramulus cinnamomi, 8-10 parts of bulbus allii macrostemonis, 12-15 parts of radix cyathulae, 18-20 parts of radix puerariae, 5-6 parts of scorpio, 28-30 parts of folium ginkgo, 25-30 parts of herba erigernotis, 8-10 parts of rhizoma alismatis, 28-30 parts of poria, 25-30 parts of semen ziziphi spinosae, 18-20 parts of semen cassiae, 18-20 parts of scorched medicated leaven and 10-15 parts of fructus ligustri lucidi. The traditional Chinese medicine can achieve the efficacies of invigorating qi and promoting blood circulation, promoting circulation and removing stasis, stimulating the menstruational flow and dissipating the phlegm, and tonifying the kidney and reducing the blood pressure, and is a first-choice medicament of the patients with apoplexy sequela, hypertension, hyperlipidemia and hyperviscosemia, and has obvious treatment effect.

The invention relates to a nanometer Chinese medicine element anion far infrared electromagnetic wave pollution preventing and blood pressure reducing health care coat which belongs to the technical field of production of multifunctional health fabric trappings and clothes. The hypertension is a common frequently-occurring disease which is harmful to the health of the human body, seriously influences the cardio-cerebral system and other systems, is very difficult to cure and causes the blood pressure to raise often as soon as the people forget taking medicines. In the invention, micro element anion far infrared electromagnetic wave pollution preventing mixed nanomaterials are added into a multifunctional spinning solution for producing fabrics, and micro element anion far infrared electromagnetic wave pollution preventing material molecules are slowly and continuously released through contacting with skin, therefore, the in-vivo element balance is effectively regulated, the blood pressure circulation and the blood vessel elasticity are enhanced, and the immunity and the capacity of resisting diseases are improved. Therefore, the invention is a natural dressing therapy which can stably reduce the blood pressure and keep the body healthy and the vigor plentiful in the daily dressing.

The invention relates to a composition and a preparation process, a testing process and an application thereof. The composition comprises a therapeutically effective amount of candesartan or pharmaceutically acceptable ester or salt, a therapeutically effective amount of amlodipine or other pharmaceutically acceptable salt, 70-150 parts of mannitol or lactose, 2-5 parts of croscarmellose sodium or cross-calcium carboxymethyl cellulose and 5-40 parts of microcrystalline cellulose or corn starch. The composition is easy to prepare, low in production cost, utilizes accessories of unique prescription, and the like, can be prepared into oral preparation in forms of tablets, capsules, granules and the like by means of pharmaceutics, can be checked by different checking processes, has high quality, has functions of treating hypertension, angina pectoris and kidney diseases and has effect of myocardial protection.

The invention relates to Chinese medicinal capsules for treating hypertension. The capsules are processed from bark of eucommia, wild chrysanthemum, peach kernel powder, root of red-rooted salvia, felicitous plant, safflower, corydalis tuber, bighead atractylodes rhizome, root of kudzu vine, glossy privet fruit, feather cockscomb seed, flower of Chinese scholartree, fleeceflower root, pseudo-ginseng, selfheal spike, uncaria, earthworm, bark of tree peony root, hawthorn, lotus plumule, semen coicis, folium ginkgo bilobae and medlar. The capsules have the effects of promoting blood circulation and removing blood stasis, regulating vital energy and restoring menstrual flow, clearing heat and removing toxin, cooling blood and stopping bleeding, calming the liver to stop the wind, nourishing yin and tonifying liver and kidney, tonifying the spleen to benefit the lung and softening blood vessel and has good meridian activating and pressure releasing effects. A pure Chinese medicinal product can be used for various types of hypertension patients, is low in cost, has good in therapeutic effect, does not have any toxic or side effect, is not required to be decocted, and is convenient to carry and take; and the capsules are clinically used for curing 1,000typical cases, and the effectiveness ratio reaches 100 percent.

The invention relates to a construction and preparation method of a recombinant adeno-associated virus recombinant (rAAV-miRNA-21<*> / rAAV-anti-miRNA-21<*>) that is able to regulate human miRNA-21<*>, more specifically to cloning of hsa-miR-21<*> and its antisense sequence hsa-anti-miR-21<*>, a packaging preparation method of recombinant adeno-associated virus recombinants containing hsa-miR-21<*> and hsa-anti-miR-21<*>, as well as pharmaceutical application of the recombinant adeno-associated virus recombinants. With a length of 21nt, the hsa-miR-21<*> is non-coding RNA. A chemical synthesis method is utilized to construct pAAV-D(+)-miR-21<*> and pAAV-D(+)-anti-miR-21<*> expression plasmids. A three-plasmid calcium phosphate cotransfection method is utilized to prepare target segment-containing recombinant adeno-associated viruses and purify them, wherein the pAAV-D(+)-miR-21<*> can obviously lower the blood pressure level of spontaneously hypertensive rats and improve the heart function simultaneously. Therefore, the hsa-miR-21<*> expression sequence-containing recombinant adeno-associated virus is conformed to have the possibility to be used as a drug for clinical treatment of hypertension and other related diseases.

The invention relates to the field of medicines, and particularly relates to a traditional Chinese medicinal composition for treating hypertension. The composition is prepared from the following raw materials in parts by weight: 100-300 parts of gastrodia elata, 500-1500 parts of eucommia ulmoides, 300-900 parts of apocynum venetum, 100-300 parts of earthworm, 100-300 parts of uncaria rhynchophylla, 100-300 parts of achyranthes root, 300-600 parts of salvia miltiorrhiza, 300-900 parts of seaweed, 300-900 parts of astragalus membranaceus, 250-500 parts of radix paeoniae alba, 300-900 parts of cassia occidentalis, 100-300 parts of tabasheer, 250-500 parts of scutellaria baicalensis, 300-900 parts of gynostemma pentaphylla, 200-400 parts of pseudo-ginseng, 200-400 parts of ligusticum wallichii and the like. The composition can be used for treating headache, dizziness, numbness of limbs, insomnia and other symptoms caused by hypertension, is prepared from traditional Chinese medicinal materials, is safe and effective, does not have remarkable side effects, and can be used for assistant treatment of cervical spondylosis, insufficient brain blood supply and other diseases.

A water-soluble extract of red sage root containing danshinolic acid B, danshensu and proshikonic acid, its preparing process, and its application in preparing the angiotonin converzyme depressant medicines for treating hypertension, and hypertension accompanied by heart failure or diabetes or nephrosis are disclosed.

A Chinese medicine for treating hypertension and preventing cerebral infarction is prepared from 17 Chinese-medicinal materials including Chinese angelica root, Chuan-xiong rhizome, red sage root, peach kernel, etc through proportioning. Its advantages are high curative effect and no by-effect.

The invention belongs to the field of medicament, and particularly relates to a medicinal composition used for tonifying qi and invigorating pulse, a preparation method thereof and application thereof. The invention provides a brand-new medicinal composition with functions of tonifying qi and invigorating pulse for treating cardiovascular and cerebrovascular diseases. The medicinal composition is prepared from the following raw material medicaments in part by weight: 9 to 16 parts of astragalus, 2 to 5 parts of acanthopanax bark, 1 to 5 parts of rhubarb, 2 to 5 parts of hawthorn fruit, 3 to 6 parts of Sanchi, 2 to 5 parts of Szechuan lovage rhizome, and 2 to 9 parts of Chinese angelica. The medicinal composition has the effects of tonifying original qi, tonifying spleen and dredging channels, and can be used for treating the diseases such as coronary disease (myocardial infarction and angina pectoris), ischemic and hemorrhagic cerebrovascular accidents (cerebral infarction and cerebral hemorrhage), high blood pressure, hyperlipidaemia, fatty liver and the like.

The invention discloses a prediction method of high blood pressure based on incremental neural network model. The method comprises the steps that a database of daily data of high blood pressures is built; a neural network model is trained; daily living data are collected and sent to a server, and are saved to a daily data sheet of a user; daily data are extracted from the daily data sheet of the user, and form an N dimensional vector, after the normalization is done, the data are input in a hypertensive pathological neural network model to conduct probabilistic prediction of the hazard level of high blood pressure; the value W of the hazard level of high blood pressure is judged whether or not being larger than or equal to 3 using a smart home high blood pressure care equipment; when a user receives a warning from an annunciator, the user goes to the hospital to check, the check results are sent back to the server through the smart home high blood pressure care equipment, the servers judges whether or not the check results are correct; an incremental calculation method is carried out when the check results are incorrect, and the neural network model is dynamically corrected. The method and system are accurate in prediction, and the neural network model is tailor made for every user.

The invention discloses a traditional Chinese medicinal composition for treating hypertension, and the traditional Chinese preparation comprises the following effective components in parts by weight: uncaria alcohol extract 5-20 parts and radish seed water extract 3-12 parts. The invention also discloses a preparation method of the composition, and the preparation method is simple and easy for operation. The traditional Chinese medicinal composition disclosed by the invention has good antihypertensive effect and can be used for treating hypertension due to hyperactivity of the liver-yang. Also, the composition can improve vertigo, headache, tinnitus, dryness and uncomfortable feeling of eyes, giddiness, ache and weakness at waist and knees, asthenia, constipation and other symptoms.

The invention relates to application of telmisartan and aliskiren or medicinal salts thereof in preparing a combined medicament for treating hypertension. The invention also provides the combined medicament for treating hypertension, wherein the combined medicament contains unit preparations of different specifications, and the preparations administrated simultaneously, respectively or in turn are prepared from telmisartan and aliskiren or medicinal salts thereof and pharmaceutically acceptable carriers. The invention also provides a preparation method and application of the combined medicament. The medicinal preparations are three-layer tablets so as to avoid interaction of the aliskiren and the telmisartan, improve the medicament stability and facilitate long-term storage. The composition preparations are used for treating medium and high hypertension patients and hypertension patients whose blood pressure cannot be fully controlled after being treated by angiotensin II receptor antagonists or renin inhibitors.

Disclosed is a Chinese medicinal composition for treating hyperlipemia, hypertension and coronary disease, which comprises the following constituents (by weight portions): haw 6-9 parts, root of red rooted saliva 3-4 parts, leech 2.5-3.5 parts, abalone shell 4-6 parts, white peony root 4-6 parts, chrysanthemum flower 3-5 parts, selfheal 3-5 parts, mulberry leaf 2.5-3.5 parts, cassia seed 3-5 parts, safflower 2-3 parts, hooked uncaria 2.5-3.5 parts, and plantain seed 0.5-1.5 parts, and green tea 2-4 parts. The composition can be made into pills or capsules.

The present invention relates to a chewing gum comprising functional ingredients of mulberry leaves, which allows high absorption of the functional ingredients of mulberry leaves, and a method for the preparation of the chewing gum. This chewing gum containing functional ingredients of mulberry leaves includes: 15-30% (w / w) gum base, 60-80% (w / w) sugar alcohol, 0.1-0.5% (w / w) tenderizer, 0.1 -1.0% (w / w) humectant, 0.1-0.5% (w / w) emulsifier, 0.5-2.5% (w / w) flavoring agent, 0.01-10.0% (w / w) functional ingredients of mulberry leaves and 0.1-2.0% (w / w) fruit juice concentrate. This chewing gum containing functional ingredients of mulberry leaves can be practically applied to prescribed food and food replacement for patients suffering from constipation, diabetes and hypertension.

The invention provides potassium-free sodium-reducing granulated edible salt. The potassium-free sodium-reducing granulated edible salt comprises the following components in percentage by weight: 50-75% of sodium chloride, 1-30% of yeast extract and the balance of auxiliary materials, wherein the sum of the weight percentages of the components is 100%. The potassium-free sodium-reducing granulatededible salt is designed according to the principle that saltiness and freshness are synergistic and salt is reduced but flavor is not reduced; under the condition that potassium chloride is not added, the purpose of reducing the salt by more than 25% can be achieved; the potassium-free sodium-reducing granulated edible salt is different from common sodium-reducing salt added with the potassium chloride in the market; due to the fact that the potassium chloride is not added, the sodium-reducing salt is also suitable for hypertension patients who take hypotensive drugs, and is more widely available than the common sodium-reducing salt. Through a granulating process, the sodium-reducing salt is more attractive in appearance and more convenient to use; and meanwhile, an anti-caking agent doesnot need to be added.

The invention discloses a flour compound suitable for hypertensive disease patients. The flour compound is made of semen Raphani, medlar, burdock roots, ginkgo leaves, radix puerariae, herba epimedii, chrysanthemum, rhynchophylla, eucommia, tabasheer, hawthorn, ginseng, mulberry leaves, Chinese yam, sweet potatoes, pea flour and whole wheat flour. The invention also discloses a preparation method of the flour compound. By eating the flour compound provided in the invention, blood pressure rise can be effectively controlled, and the adverse effects caused by drug therapy can be reduced.

The invention provides a preparation method of a verapamil hydrochloride delayed-release tablet. The method comprises the steps of: (1) preparation of a tablet core containing drug verapamil hydrochloride; (2) preparation of a coated granule; and (3) coating pressing. The invention also provides a verapamil hydrochloride delayed-release tablet provided by the method. Based on the variation law of blood pressure circadian rhythm in hypertensive patients, the tablet can rapidly release the active drug after taken and delayed for a proper period of time in vivo. The verapamil hydrochloride delayed-release tablet of the invention has the advantages of simple prescription and process, fewer operation step, short production cycle, low equipment requirement, good reproducibility and low cost, thus being very conducive to the realization of industrial mass production.

The invention relates to a device for detecting blood pressure data. The device comprises a blood pressure measuring unit with an air pump, an inflatable cuff and a pressure sensor, wherein the pressure sensor is connected with a computer processing unit through an A / D conversion interface; the computer processing unit comprises a central processing unit CPU for operation, a memorizer, a communication interface and a human-computer interface; the computer processing unit is also connected with a pickup for acquiring voice of a user and a voice module for processing an audio frequency signal acquired by the pickup and converting the audio frequency signal into a digital signal; and the communication interface of the computer processing unit is connected with a data communication module for sending the blood pressure data and voice data to a network server. A doctor can make more accurate diagnosis according to a curve which is generated by the blood pressure data of multiple measurements and voice description of the user; and the device is expected to greatly improve the capabilities of diagnosing and controlling hypertensive disease.

The invention discloses a healthcare and nutrition ostrich egg liquid, which is mainly used for preventing and treating a hypertensive disease, and belongs to the fields of prevention and health protection of traditional Chinese medicines. The healthcare and nutrition ostrich egg liquid disclosed by the invention is prepared from the following components: ostrich eggs, semen coicis, mature vinegar, astragalus membranaceus, peach kernel, flowers carthami, angelica sinensis tail, ligusticum wallichii, radix paeoniae rubra, earthworm, hawthorn, rhizoma alismatis, polygonum multiflorum, radix rehmanniae recen, semen cassiae and liquorice. The healthcare and nutrition ostrich egg liquid has the efficacies of benefiting qi, nourishing blood, promoting blood circulation to remove blood stasis, relieving pain, nourishing the blood to expel wind, warming and activating meridians and reducing phlegm; the effective rate is 90%; the recovery rate is 80%; the average cure time needs three treatment courses (one month as one treatment course); the cure time for patients with serious conditions needs 0.5-1 year; and the healthcare and nutrition ostrich egg liquid can be scientifically taken according to the requirements, and has a relatively good market development prospect.

The invention discloses an application of sunflower leaves for preparing foods and health-care foods for reducing blood pressure in an auxiliary way. The research of the inventor indicates that the sunflower leaves have obvious effects on promoting digestion and strengthening the stomach, reducing fever and causing diuresis and reducing blood pressure, have explicit mechanism of action, have no toxic side effect on human bodies, and can be widely used for preparing the foods and health-care foods for reducing blood pressure in an auxiliary way. The prepared foods and health-care foods can be applied to all people and especially patients with hypertension.

The present invention relates to a Chinese patent medicine for curing hypertensive disease, including the components of salvia miltiorrhiza, Herba Cephalanoploris, herba gynostemae, cassia seed, ginkgo biloba, common selfheal, hawkthorn, honey and dogbane leaf. Herba Cephalanoploris and hawkthorn are cleaned and decontaminated, then milled and filtered after dipping in water, and the drug liquid is for standby; danshen, herba gynostemae, ginkgo biloba, common selfheal, dogbane leaf and cassia seed are cleaned and decontaminated, decocted for twice and filter; the filtrate mixed with the drug liquid and added with honey is decompressed and condensed to 1 / 3 of the original volume; the drug liquid is placed until the temperature decreases to less than 40 DEG C and then added with ethanol for 24-hour settlement; the supernatant is filtered so as to recover ethanol. pH value is adjusted to 5.5 to 6.5 and water is added to 10,000ml. After shaking, standing, filtering, filling and sterilizing, the Chinese patent medicine is obtained. According to clinical observation, the present invention has the effect of reducing hypertension and hyperlipemia, softening blood vessels, and seeking both temporary and permanent solutions.

The invention relates to a depressurization chewing gum and a preparation method thereof, belonging to the technical field of gum. 2-40 percent by weight of Eucommia ulmoides depressurization active component or Eucommia ulmoides component depressurization active component, 50-97 percent of sugar alcohol and 1-10 percent of food additive are added into chewing gum so that the chewing gum becomes a health care food which is beneficial to the crowd with hypertension symptoms. The invention changes the characteristic of single function of the traditional chewing gum, endows the chewing gum with multiple functions of prevention and treatment of light and moderate hypertension diseases, adjuvant therapy of a severe hypertension disease, and the like and achieves the effect of promoting body health.