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A kind of traditional Chinese medicine composition for treating hypertension and preparation method thereof

A composition and high blood pressure technology, applied in the direction of drug combination, pharmaceutical formula, medical preparations containing active ingredients, etc.

Active Publication Date: 2011-12-07
李运伦 +2
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Therefore, there are still few pure Chinese medicine preparations with definite antihypertensive effect, few side effects, and clear market prospects; Chinese patent medicine preparations that can improve the substance metabolism disorder in patients, pay attention to target organ protection, and reverse the adverse remodeling of blood vessels are rare; Screening drugs under the guidance of Therapeutic Theory, extracting their antihypertensive active components, and adopting "antihypertensive mechanism design, active component synergistic combination, and combined target comprehensive intervention" antihypertensive traditional Chinese medicine preparations are still blank

Method used

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  • A kind of traditional Chinese medicine composition for treating hypertension and preparation method thereof
  • A kind of traditional Chinese medicine composition for treating hypertension and preparation method thereof
  • A kind of traditional Chinese medicine composition for treating hypertension and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0086] With radish and Uncaria as raw materials, prepare the medicine of the present invention, the method is as follows:

[0087] (1) Extract Uncaria 3 times with 75vol% ethanol, 2 hours each time, the amount of ethanol is 10 times the mass of Uncaria, combine the Uncaria extract, concentrate the ethanol under reduced pressure to obtain a concentrated solution, the concentrated solution is the drug quality 1-2 times; the concentrated solution is added with concentrated ammonia water to adjust the pH to 10, then extracted with chloroform until it is colorless, the extracts are combined, the chloroform is recovered to dryness, and a dry paste is obtained; the dry paste is ultrasonically dissolved with 1wt% hydrochloric acid, and the filtrate Degrease with chloroform, take the water phase, adjust the pH to 9-10 with ammonia water, then extract with chloroform, combine the extracts, wash with water until neutral, dehydrate with anhydrous sodium sulfate, recover the chloroform from...

Embodiment 2

[0091] With radish and Uncaria as raw materials, prepare the medicine of the present invention, the method is as follows:

[0092] (1) Extract Uncaria 3 times with 70wt% ethanol, 2 hours each time, the amount of ethanol is 12 times the mass of Uncaria, combine the Uncaria extract, concentrate the ethanol under reduced pressure to obtain a concentrated solution, the concentrated solution is the drug quality 1-2 times; add concentrated ammonia water to the concentrated solution to adjust the pH to 9-10, then extract it with chloroform until it is colorless, combine the extracts, recover the chloroform to dryness, and obtain a dry paste; the dry paste is dissolved with 5wt% hydrochloric acid ultrasonically, and suction filtered , the filtrate is degreased with chloroform, the water phase is taken, and the pH is adjusted to 9-10 with ammonia water, then extracted with chloroform, the combined extracts are washed with water until neutral, dehydrated with anhydrous sodium sulfate, th...

Embodiment 3

[0096] With radish and Uncaria as raw materials, prepare the medicine of the present invention, the method is as follows:

[0097] (1) Extract Uncaria 3 times with 80wt% ethanol, 2 hours each time, the amount of ethanol is 12 times the mass of Uncaria, combine Uncaria extract, concentrate ethanol under reduced pressure to obtain a concentrated solution, the concentrated solution is the drug quality 1-2 times; the concentrated solution is added with concentrated ammonia water to adjust the pH to 9-10, then extracted with chloroform until it is colorless, the extracts are combined, and the chloroform is recovered to dryness to obtain a dry paste; the dry paste is ultrasonically dissolved with 1wt% hydrochloric acid, and filtered by suction , the filtrate is degreased with chloroform, the water phase is taken, and the pH is adjusted to 9-10 with ammonia water, then extracted with chloroform, the combined extracts are washed with water until neutral, dehydrated with anhydrous sodiu...

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Abstract

The invention discloses a traditional Chinese medicinal composition for treating hypertension, and the traditional Chinese preparation comprises the following effective components in parts by weight: uncaria alcohol extract 5-20 parts and radish seed water extract 3-12 parts. The invention also discloses a preparation method of the composition, and the preparation method is simple and easy for operation. The traditional Chinese medicinal composition disclosed by the invention has good antihypertensive effect and can be used for treating hypertension due to hyperactivity of the liver-yang. Also, the composition can improve vertigo, headache, tinnitus, dryness and uncomfortable feeling of eyes, giddiness, ache and weakness at waist and knees, asthenia, constipation and other symptoms.

Description

technical field [0001] The invention relates to a medicine for treating hypertension and a preparation method thereof, in particular to a medicinal composition extracted from traditional Chinese medicine components and having the effect of treating hypertension and a preparation method thereof. Background technique [0002] Hypertension (EH) is the most common cardiovascular disease with an incidence rate as high as 10-20%. It has become a common and frequently-occurring disease worldwide, seriously threatening the quality of life and health of human beings. At present, antihypertensive drugs with clear pharmacological effects and evidence-based medical evidence are mainly chemical drug products of multinational pharmaceutical groups, and most of them have certain side effects. The antihypertensive traditional Chinese medicines that have been researched and developed (such as Niuhuang Jiangya Pills, Zhenju Jiangya Tablets, Fufang Uncaria Tablets, and Qingxuan Jiangya Tablets...

Claims

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Application Information

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IPC IPC(8): A61K36/74A61P9/12
Inventor 李运伦周洪雷齐冬梅
Owner 李运伦
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