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Enteric quick-dissolving tablets contg. aconitine, and its prepn. method

A technology of aconitine and immediate-release tablets, which is applied in the field of drugs containing organic compounds, can solve problems such as intestinal irritation, and achieve the effects of improved bioavailability, high bioavailability, and small gastrointestinal irritation

Active Publication Date: 2007-01-31
YUNNAN HAOPY PHARM LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] Before proposing the present invention, we have studied the kinetic process of the absorption of aconitine drugs in the clinical application of the adverse reactions to the strong stimulation of the gastrointestinal tract, and made the drugs into enteric-coated tablets in an attempt to avoid The drug can stimulate the stomach and avoid the inactivation caused by the complete or partial decomposition of the drug in the gastric juice, but experiments show that ordinary enteric-coated tablets cannot avoid the stimulation of the intestinal tract

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment Construction

[0016] (1) Formula and preparation process of the present invention

[0017] 1. Aconitin enteric-coated immediate-release tablets

[0018] According to the components and contents specified in the examples in Table 1, after mixing the ultra-fine and over 1000 mesh aconitin with other auxiliary materials, pulverize and mix, pass through 100 mesh, conventionally granulate, and tablet to obtain the tablet core . Dissolve cellulose acetate phthalate in acetone, and dissolve shellac in 95% ethanol. When using the two liquids, add diethyl phthalate, mix evenly, and then use. Coating according to the coating method to obtain the finished product, each tablet contains 0.2 mg and 0.4 mg of aconitin (specification).

[0019] Disintegrants, tablet core excipients

Enteric coating materials, solvents

implement

example

Grass Aconitum

white

cross-linked carboxymethyl cellulose

sodium

stearic acid

magnesium

...

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PUM

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Abstract

A fast-release enteric tablet containing aconitine is proportionally prepared from aconitine-type medicine, fast-releasing additive, enteric polymer, plasticizer and solvent through superfine pulverizing, mixing, tabletting and coating.

Description

Technical field [0001] The invention relates to medicines containing organic compounds, especially oral preparations containing aconitine and a preparation method of the preparations. Background technique [0002] Aconitine, a drug with analgesic and anti-inflammatory effects, is aconitine alkaloid isolated from Ranunculaceae Aconitum. It is mainly used to treat diseases such as rheumatism, rheumatoid and osteoarthritis. The history of existing more than 20 years of similar compound, its preparation includes injection, tablet, oral liquid, soft capsule. The injection is often accompanied by severe pain and redness at the injection site during use, and the patient's compliance is not good; after taking the common oral dosage form, the mouth feels numb and has strong irritation to the digestive tract. Studies have shown that aconitine cannot be dispersed, and if the local concentration is too high, it will strongly irritate mucous membranes and o...

Claims

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Application Information

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IPC IPC(8): A61K9/20A61K31/439A61K47/38A61P29/00
Inventor 李彪
Owner YUNNAN HAOPY PHARM LTD
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