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Preparation method of celecoxib preparation

A preparation and cloth gel technology, which is applied in the direction of anti-inflammatory agents, pharmaceutical formulations, aerosol delivery, etc., can solve the problems of limited application, achieve pain relief, improve stability, and stable and reliable preparation quality

Inactive Publication Date: 2014-07-23
JIANGSU QINGJIANG PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Due to its certain gastrointestinal reactions, its clinical application is limited

Method used

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  • Preparation method of celecoxib preparation
  • Preparation method of celecoxib preparation
  • Preparation method of celecoxib preparation

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0027]

[0028] Weigh 0.4g Carbomer 940, 1.2g HPMC, sprinkle evenly into 67% ethanol, heat and reflux for 3 hours, cool down after swelling completely to obtain a gel matrix. Weigh 1g of celecoxib, dissolve it with an appropriate amount of ethanol, add 10g of glycerin, 2g of PEG-400, and 10g of propylene glycol as penetration enhancers into the gel matrix in sequence, and stir evenly. Adjust the pH to 6~7 with 1.0g of triethanolamine, add 67% ethanol to 100g, stir evenly, and centrifuge to remove air bubbles. The cumulative penetration per unit area of ​​this prescription is 20.38.

Embodiment 2

[0030]

[0031] Weigh 0.4g Carbomer 940, 1.2g HPMC, sprinkle evenly into 67% ethanol, heat and reflux for 3 hours, cool down after swelling completely to obtain a gel matrix. Weigh 1g of celecoxib, dissolve it with an appropriate amount of ethanol, add 10g of glycerin, 5g of PEG-400, and 15g of propylene glycol as penetration enhancers into the gel matrix in turn, and stir evenly. Adjust the pH to 6~7 with 1.0g of triethanolamine, add 67% ethanol to 100g, stir evenly, and centrifuge to remove air bubbles. The cumulative penetration per unit area of ​​this prescription is 5.966.

Embodiment 3

[0033]

[0034] Weigh 0.4g Carbomer 940, 1.2g HPMC, sprinkle evenly into 67% ethanol, heat and reflux for 3 hours, cool down after swelling completely to obtain a gel matrix. Weigh 1g of celecoxib, dissolve it with an appropriate amount of ethanol, add 15g of glycerin, 5g of PEG-400, and 5g of propylene glycol as penetration enhancers into the gel matrix in turn, and stir evenly. Adjust the pH to 6~7 with 0.5g of triethanolamine, add 67% ethanol to 100g, stir evenly, and centrifuge to remove air bubbles. The cumulative penetration per unit area of ​​this prescription is 3.208.

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PUM

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Abstract

The invention provides a preparation method of a celecoxib gel preparation. The gel preparation comprises 1 to 5% of celecoxib, 1 to 5% of gel substrate, 5 to 30% of permeation accelerant, 0.5 to 1.0% of pH regulator, and 50 to 80% of 67% alcohol. The gel preparation is in a form of semi-solid gel for transdermal absorption, which avoids nausea, emesis, gastrointestinal irritation, anabrosis and other side effects caused by oil administration, and also avoids gastrointestinal reaction and drug first-pass effect; and in addition, the concentration of a sick part is raised, the adverse reaction is reduced, and pain can be relieved for a patient. The preparation is simple in preparation process, and stable and reliable in quality.

Description

technical field [0001] The invention is an improvement on the dosage form of celecoxib, and further discloses a gel preparation of celecoxib. The invention also provides a preparation method of the preparation, which belongs to the technical field of medicine and pharmacy. Background technique [0002] Celecoxib (celecoxib) is a new generation of non-steroidal anti-inflammatory drugs (NSAIDs) developed by Pfizer, which can selectively inhibit COX-2 cyclooxygenase and prevent the production of prostaglandins, thereby achieving anti-inflammatory and anti-inflammatory effects Pain and antipyretic effect. It is mainly used clinically for osteoarthritis and rheumatoid arthritis, and can also be used for peripheral and central analgesia. [0003] Currently, only capsules are available in the market. Due to its certain gastrointestinal reactions, its clinical application is limited. Externally administered drugs are directly absorbed in the capillaries of the lesion, reducing th...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/06A61K31/635A61K47/38A61K47/34A61P29/00
Inventor 滕奇
Owner JIANGSU QINGJIANG PHARMA
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